gem-difluorination of aminoalkynes via highly reactive dicationic species in superacid HF-SbF5: Application to the efficient synthesis of difluorinated cinchona alkaloid derivatives

Journal of Organic Chemistry

Volumn 73, Issue 7, 2008, Pages 2875-2878

  Cantet, Anne Céline ^a   Carreyre, Hélène ^a   Gesson, Jean Pierre ^a   Jouannetaud, Marie Paule ^a   Renoux, Brigitte ^a  

^a UNIVERSITÉ DE POITIERS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

DIFLUORINATED CINCHONA ALKALOID; GEM DIFLUORINATION;

DERIVATIVES; FLUORINATION; REGIOSELECTIVITY; SYNTHESIS (CHEMICAL);

AMINO ACIDS;

10,11 DIDEHYDROQUINIDINE ACETATE; 10,11 DIHYDROQUINIDINE; ALKYNE DERIVATIVE; AMIDE; AMINE; AMMONIA; CATION; CINCHONA ALKALOID; FLUORIDE ION; IMIDE; LEWIS ACID; NITROGEN DERIVATIVE; QUINIDINE; QUININE; UNCLASSIFIED DRUG; VINYL DERIVATIVE;

ARTICLE; CHEMICAL REACTION; CYCLIZATION; DRUG ISOLATION; DRUG SYNTHESIS; FLUORINATION; LOW TEMPERATURE; MOLECULAR MODEL; PROTON TRANSPORT; STEREOCHEMISTRY;

ALKYNES; AMIDES; AMINES; ANTIMONY; CATIONS; CINCHONA ALKALOIDS; CRYSTALLOGRAPHY, X-RAY; FLUORIDES; HALOGENATION; HYDROCARBONS, FLUORINATED; HYDROFLUORIC ACID; IMIDES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; STEREOISOMERISM;

EID: 41649099527     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo702441p     Document Type: Article

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