Synthesis and hybridization properties of 2′-O-(tetrazol-5-yl)ethyl-modified oligonucleotides

Tetrahedron

Volumn 64, Issue 19, 2008, Pages 4370-4376

  Saneyoshi, Hisao ^a,b   Tamaki, Keigo ^a,b   Ohkubo, Akihiro ^a,b   Seio, Kohji ^a,b   Sekine, Mitsuo ^a,b  

^a TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

(1H Tetrazol 5 yl)ethyl; 2 O Modified oligonucleotide; Cyanoethyl; pH dependent hybridization

Indexed keywords

2' O (1H TETRAZOL 5 YL)ETHYLADENOSINE; 2' O [(1 N CYANOETHYLTETRAZOL 5 YL)ETHYL] 6 N PHENOXYACETYL 3',5' O (1,1,3,3 TETRAISOPROPYLDISILOXANE 1,3 DIYL)ADENOSINE; 2' O [(1 N METHYLTETRAZOL 5 YL)ETHYL] 6 N PHENOXYACETYL 3',5' O (1,1,3,3 TETRAISOPROPYLDISILOXANE 1,3 DIYL)ADENOSINE; 2' O [(1 N METHYLTETRAZOL 5 YL)ETHYL] 6 N PHENOXYCAETYLADENOSINE; 2' O [(2 N CYANOETHYLTETAZOL 5 YL)ETHYL] 5' O (4,4' DIMETHOXYTRITYL) 6 N PHENOXYACETYLADENOSINE 3' (2 CYANOETHYL N,N DIISOPROPYLPHOSPHORAMIDITE; 2' O [(2 N CYANOETHYLTETRAZOL 5 YL)] 5' O (4,4' DIMETHOXYTRITYL) 6 N PHENOXYACETYLADENOSINE; 2' O [(2 N CYANOETHYLTETRAZOL 5 YL)ETHYL] 6 N PHENOXYACETYLADENOSINE; 2' O [2 (TETRAZOL 5 YL)ETHYL]ADENOSINE; 2' O CYANOETHYLADENOSINE; 3',5' O (1,1,3,3 TETRAISOPROPYLDISILOXANE 1,3 DIYL) 2' O [2 (TETRAZOL 5 YL)ETHYL]ADENOSINE; 5' O (4,4' DIMETHOXYTRITYL) 2' O [(1 N METHYLTETRAZOL 5 YL)ETHYL] 6 N PHENOXYACETYLADENOSINE; 5' O (4,4' DIMETHOXYTRITYL) 2' O [(1 N METHYLTETRAZOL 5 YL)ETHYL] 6 N PHENOXYACETYLADENOSINE 3' 2 CYANOETHYL N,N DIISOPROPYLPHOSPHORAMIDITE; 6 N PHENOXYACETYL 3',5' O (1,1,3,3 TETRAISOPROPYLDISILOXANE 1,3 DIYL) 2' O [2 TETRAZOL 5 YL)ETHYL]ADENOSINE; ADENOSINE DERIVATIVE; OLIGODEOXYNUCLEOTIDE DERIVATIVE; OLIGONUCLEOTIDE; TETRAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMICAL REACTION; CHEMICAL STRUCTURE; HETERONUCLEAR MULTIPLE BOND CORRELATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYBRIDIZATION; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; PROTON TRANSPORT; SOLID PHASE SYNTHESIS; STEREOSPECIFICITY; THERMODYNAMICS;

EID: 41549138170     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tet.2008.02.075     Document Type: Article

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