Fibroblast growth factor-2 levels are elevated in the cerebrospinal fluid of multiple sclerosis patients

Neuroscience Letters

Volumn 435, Issue 3, 2008, Pages 223-228

  Sarchielli, Paola ^a   Di Filippo, Massimiliano ^a,b   Ercolani, Maria Vittoria ^a   Chiasserini, Davide ^a   Mattioni, Alessia ^a,b   Bonucci, Michele ^a,b   Tenaglia, Serena ^a,b   Eusebi, Paolo ^a   Calabresi, Paolo ^a,b  

^a UNIVERSITY OF PERUGIA   (Italy)

^b IRCCS FONDAZIONE SANTA LUCIA   (Italy)

Author keywords

Cerebrospinal fluid; Clinically isolated syndrome; Demyelination; Fibroblast growth factor 2; Multiple sclerosis

Indexed keywords

FIBROBLAST GROWTH FACTOR 2; GADOLINIUM; MYELIN;

ADULT; ARTICLE; BRAIN ATROPHY; CEREBROSPINAL FLUID; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE COURSE; FEMALE; HUMAN; IMMUNOASSAY; MALE; MULTIPLE SCLEROSIS; NEUROLOGIC DISEASE; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL;

ADULT; DISABILITY EVALUATION; FEMALE; FIBROBLAST GROWTH FACTOR 2; HUMANS; IMMUNOASSAY; MAGNETIC RESONANCE IMAGING; MALE; MULTIPLE SCLEROSIS; SEVERITY OF ILLNESS INDEX; STATISTICS AS TOPIC;

EID: 41549104070     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2008.02.040     Document Type: Article

References (27)

1. Armstrong R.C., Le T.Q., Flint N.C., Vana A.C., and Zhou Y.X. Endogenous cell repair of chronic demyelination. J. Neuropathol. Exp. Neurol. 65 (2006) 245-256
2. Barnett M.H., and Sutton I. The pathology of multiple sclerosis: a paradigm shift. Curr. Opin. Neurol. 19 (2006) 242-247
3. Butt A.M., and Dinsdale J. Fibroblast growth factor 2 induces loss of adult oligodendrocytes and myelin in vivo. Exp. Neurol. 192 (2005) 125-133
4. Butt A.M., and Dinsdale J. Opposing actions of fibroblast growth factor-2 on early and late oligodendrocyte lineage cells in vivo. J. Neuroimmunol. 166 (2005) 75-87
5. Diemel L.T., Wolswijk G., Jackson S.J., and Cuzner M.L. Remyelination of cytokine- or antibody-demyelinated CNS aggregate cultures is inhibited by macrophage supplementation. Glia 45 (2004) 278-286
6. Frost E.E., Nielsen J.A., Le T.Q., and Armstrong R.C. PDGF and FGF2 regulate oligodendrocyte progenitor responses to demyelination. J. Neurobiol. 54 (2003) 457-472
7. Goddard D.R., Berry M., Kirvell S.L., and Butt A.M. Fibroblast growth factor-2 induces astroglial and microglial reactivity in vivo. J. Anat. 200 (2002) 57-67
8. Gonzalez A.M., Berry M., Maher P.A., Logan A., and Baird A. A comprehensive analysis of the distribution of FGF-2 and FGFR1 in the rat brain. Brain Res. 70 (1995) 1201-1226
9. Johansson A., Larsson A., Nygren I., Blennow K., and Askmark H. Increased serum and cerebrospinal fluid FGF-2 levels in amyotrophic lateral sclerosis. Neuroreport 14 (2003) 1867-1869
10. Kettlun A.M., Cartier L., García L., Collados L., Vásquez F., Ramírez E., and Valenzuela M.A. TIMPs and MMPs expression in CSF from patients with TSP/HAM. Life Sci. 72 (2003) 2863-2876
11. Koziol J.A., Lucero A., Sipe J.C., Romine J.S., and Beutler E. Responsiveness of the Scripps neurologic rating scale during a multiple sclerosis clinical trial. Can. J. Neurol. Sci. 26 (1999) 283-289
12. Kruchkova Y., Ben-Dror I., Herschkovitz A., David M., Yayon A., and Vardimon L. Basic fibroblast growth factor: a potential inhibitor of glutamine synthetase expression in injured neural tissue. J. Neurochem. 77 (2001) 1641-1649
13. Kurtzke J.F. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology 33 (1983) 1444-1452
14. Liu X., Mashour G.A., Webster H.F., and Kurtz A. Basic FGF and FGF receptor 1 are expressed in microglia during experimental autoimmune encephalomyelitis: temporally distinct expression of midkine and pleiotrophin. Glia 24 (1998) 390-397
15. Lublin F.D., and Reingold S.C. Defining the clinical course of multiple sclerosis: results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis. Neurology 46 (1996) 907-911
16. Ma J., Qiu J., Hirt L., Dalkara T., and Moskowitz M.A. Synergistic protective effect of caspase inhibitors and bFGF against brain injury induced by transient focal ischaemia. Br. J. Pharmacol. 133 (2001) 345-350
17. Madiai F., Hussain S.R., Goettl V.M., Burry R.W., Stephens Jr. R.L., and Hackshaw K.V. Upregulation of FGF-2 in reactive spinal cord astrocytes following unilateral lumbar spinal nerve ligation. Exp. Brain Res. 148 (2003) 366-376
18. Magy L., Mertens C., Avellana-Adalid V., Keita M., Lachapelle F., Nait-Oumesmar B., Fontaine B., and Baron-Van Evercooren A. Inducible expression of FGF2 by a rat oligodendrocyte precursor cell line promotes CNS myelination in vitro. Exp. Neurol. 184 (2003) 912-922
19. McQualter J.L., and Bernard C.C. Multiple sclerosis: a battle between destruction and repair. J. Neurochem. 100 (2007) 295-306
20. Messersmith D.J., Murtie J.C., Le T.Q., Frost E.E., and Armstrong R.C. Fibroblast growth factor 2 (FGF2) and FGF receptor expression in an experimental demyelinating disease with extensive remyelination. J. Neurosci. Res. 62 (2000) 241-256
21. Polman C.H., Reingold S.C., Edan G., Filippi M., Hartung H.P., Kappos L., Lublin F.D., Metz L.M., McFarland H.F., O'Connor P.W., Sandberg-Wollheim M., Thompson A.J., Weinshenker B.G., and Wolinsky J.S. Diagnostic criteria for multiple sclerosis: 2005 revisions to the "McDonald Criteria". Ann. Neurol. 58 (2005) 840-846
22. Rosenberg S.S., Ng B.K., and Chan J.R. The quest for remyelination: a new role for neurotrophins and their receptors. Brain Pathol. 16 (2006) 288-294
23. Rovaris M., Inglese M., van Schijndel R.A., Sormani M.P., Rodegher M., Comi G., and Filippi M. Sensitivity and reproducibility of volume change measurements of different brain portions on magnetic resonance imaging in patients with multiple sclerosis. J. Neurol. 247 (2000) 960-965l
24. Ruffini F., Furlan R., Poliani P.L., Brambilla E., Marconi P.C., Bergami A., Desina G., Glorioso J.C., Comi G., and Martino G. Fibroblast growth factor-II gene therapy reverts the clinical course and the pathological signs of chronic experimental autoimmune encephalomyelitis in C57BL/6 mice. Gene Ther. 8 (2001) 1207-1213
25. Yang S.Y., and Cui J.Z. Expression of the basic fibroblast growth factor gene in mild and more severe head injury in the rat. J. Neurosurg. 89 (1998) 297-302
26. Yoshimura S., Teramoto T., Whalen M.J., Irizarry M.C., Takagi Y., Qiu J., Harada J., Waeber C., Breakefield X.O., and Moskowitz M.A. FGF-2 regulates neurogenesis and degeneration in the dentate gyrus after traumatic brain injury in mice. J. Clin. Invest. 112 (2003) 1202-1210
27. Zittermann S.I., and Issekutz A.C. Basic fibroblast growth factor (bFGF, FGF-2) potentiates leukocyte recruitment to inflammation by enhancing endothelial adhesion molecule expression. Am. J. Pathol. 168 (2006) 835-846