Basic FGF and FGF receptor 1 are expressed in microglia during experimental autoimmune encephalomyelitis: Temporally distinct expression of midkine and pleiotrophin

GLIA

Volumn 24, Issue 4, 1998, Pages 390-397

  Liu, Xia ^a,c   Mashour, George A ^b   Webster, Henry Def ^a   Kurtz, Andreas ^b  

^a NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^b GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c REGENERON PHARMACEUTICALS INC   (United States)

Author keywords

Demyelination; Heparin binding growth factors; Microglia; Multiple sclerosis

Indexed keywords

CARRIER PROTEIN; CYTOKINE; FGFR1 PROTEIN, RAT; FIBROBLAST GROWTH FACTOR 2; FIBROBLAST GROWTH FACTOR RECEPTOR; FIBROBLAST GROWTH FACTOR RECEPTOR 1; MIDKINE; NERVE GROWTH FACTOR; PLEIOTROPHIN; PROTEIN TYROSINE KINASE;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL; ARTICLE; BIOSYNTHESIS; DISEASE MODEL; GENE EXPRESSION; GENETICS; LEWIS RAT; METABOLISM; MICROGLIA; PATHOLOGY; RAT;

ANIMALS; CARRIER PROTEINS; CYTOKINES; DISEASE MODELS, ANIMAL; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FIBROBLAST GROWTH FACTOR 2; GENE EXPRESSION; MICROGLIA; NERVE GROWTH FACTORS; RATS; RATS, INBRED LEW; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 1; RECEPTORS, FIBROBLAST GROWTH FACTOR;

EID: 0032402369     PISSN: 08941491     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-1136(199812)24:4<390::AID-GLIA4>3.0.CO;2-1     Document Type: Article

References (58)

1. Asai, T., Wanaka, A., Kato, H., Masana, Y., Seo, M., and Tohyama, M. (1993) Differential expression of two members of FGF receptor gene family, FGFR-1 and FGFR-2 mRNA, in the adult rat central nervous system. Brain Res. Mol. Brain Res., 17:174-178.
2. Bansal, R., Kumar, M., Murray, K., and Pfeiffer, S.E. (1996) Regulation of FGF receptors in the oligodendrocyte lineage. Mol. Cell. Neurosci., 7:263-275.
3. Beck, J., Rondot, P., Jullien, P., Wietzerbvin, J., and Lawrence, D.A. (1995) IGF-1 gene disruption results in reduced brain size, CNS hypomyelination, and loss of hippocampal granule and striatal parvalbumin-containing neurons. Neuron, 14:717-730.
4. Bloch, B., Normand, E., Kovesdi, I., and Bohlen, P. (1992) Expression of the HBNF (heparin-binding neurite-promoting factor) gene in the brain of fetal, neonatal and adult rat: An in situ hybridization study. Brain Res. Dev. Brain Res., 70:267-278.
5. Bohlen, P. and Kovesdi, I. (1991) HBNF and MK, members of a novel gene family of heparin-binding proteins with potential roles in embryogenesis and brain function. Prog. Growth Factor Res., 3:143-157.
6. Burgess, W.H. and Maciag, T. (1989) The heparin-binding (fibroblast) growth factor family of proteins. Annu. Rev. Biochem., 58:575-606.
7. Carson, M.J., Begringer, R.R., Brinster, R.L., and McMorris, F.A. (1993) Insulin-like growth factor increases brain growth and central nervous system myelination in transgenic mice. Neuron, 10:729-740.
8. Choudhuri, R., Zhang, H.T., Donnini, S., Ziche, M., and Bicknell, R. (1997) An angiogenic role for the neurokines midkine and pleiotrophinin tumorigenesis. Cancer Res., 57:1814-1819.
9. Eckenstein, F.P. (1994) Fibroblast growth factors in the nervous system. J. Neurobiol., 25:1467-1480.
10. Follesa, F., Wrathall, J., and Mocchetti, M. (1994) Regional and temporal pattern of expression of nerve growth factor and basic fibroblast growth factor mRNA in rat brain following electroconvulsive shock. Brain Res. Mol Brain Res., 22:1-8.
11. Frodin, M., and Gammeltoft, S. (1994) Insulin-like growth factors act synergistically with basic fibroblast growth factor to promote chromaffine cell proliferation. Proc. Natl. Acad. Sci. USA, 91:1771-1775.
12. Garver, R.I. Jr., Radford, D.M., Donis-Keller, H., Wick, M.R., and Milner, P.G. (1994) Midkine and pleiotrophin expression in normal and malignant breast tissue. Cancer, 74:1584-1590.
13. Gomez-Pinilla, F., Lee, J.W., and Cotman, C.W. (1992) Basic FGF in adult rat brain: Cellular distribution and response to entorhinal lesion and fimbria-fornix transection. J. Neurosci., 12:345-355.
14. Grinspan, J.B., Stern, J.L., Franceschini, B., Yasuda, T., and Pleasure, D. (1994) Protein growth factors as potential therapies for central nervous system demyelinative disorders. Ann. Neurol., 36:S140-S142.
15. Grothe, C. and Meisinger, C. (1995) Fibroblast growth factor (FGF)-2 sense and antisense MRNA and FGF receptor type 1 MRNA are present in the embryonic and adult rat nervous system: Specific detection by nuclease protection assay. Neurosci. Lett., 197(3):175-178.
16. Grothe, C., Zachmann, K., and Unsicker, K. (1991) Basic FGF-like immunoreactivity in the developing and adult rat brainstem. Comp. Neurol., 305:328-336.
17. Klagsbrunn, M. (1989) The firbroblast growth factor family: Structural and biological properties. Prog. Growth Factor Res., 1:207-235.
18. Kojima, S., Muramatsu, H., Amanuma, H., and Muramatsu, T. (1995) Midkine enhances fibrinolytic activity of bovine endothelial cells. J. Biol. Chem., 270:9590-9596.
19. Koshinaga, M., Sanon, H.R., and Whitemore, S.R. (1993) Altered acidic and basic fibroblast growth factor expression following spinal cord injury. Exp. Neurol., 120:32-48.
20. Kretschmer, P.J., Fairhurst, J.L., Decker, M.M., et al. (1991) Cloning, characterization and developmental regulation of two members of a novel human gene family of neurite outgrowth-promoting proteins. Growth Factors, 5:99-114.
21. Kurtz, A., Schulte, A.M., and Wellstein, A. (1995) Pleiotrophin and midkine in normal development and tumor biology. Crit. Rev. Oncogen., 6:151-177.
22. Lassman, H., Suchanek, G., and Ozawa, K. (1994) Histopathology and the blood-cerebrospinal fluid barrier in multiple sclerosis. Ann. Neurol., 36:S42-S46.
23. Levey, A.I., Bolan, J.P., Rye, O.B., Hallanger, A.E., Demuth, R.M., Mesulam, M.-M., and Wainer, B.H. (1986) A light and electron microscopic procedure for sequential double antigen localization using diaminobenzidene and benzidine dihydrochloride. J. Histochem. Cytochem., 34:1449-1457.
24. Liu, H.M., and Chen, H.H. (1994) Correlation between FGF expression and cell proliferation in experimental brain infarct: Studied with proliferating nuclear antigen immunohistochemistry. J. Neuropathol. Exp. Neurol., 53:118-126.
25. Liu, X., Yao, D.L., Bondy, C.A., et al. (1994) Astrocytes express insulin-like growth factor-I (IGF-1) and its binding protein, IGFBP-2, during demyelination induced by experimental autoimmune encephalomyelitis. Mol. Cell Neurosci., 5:418-430.
26. Liu, X., Yao, D.L., and Webster, H.D. (1995) Insulin-like growth factor I treatment reduces clinical deficits and lesion severity in acute demyelination induced by experimental autoimmune encephalomyelitis. Multiple Sclerosis, 1:2-9.
27. Loret, C., Janet, T., Labourdette, G., Schneid, H., and Binoux, M. (1991) FGFs stimulate IGF binding protein synthesis without affecting IGF synthesis in rat astroblasts in primary culture. Glia, 4:378-383.
28. Martin, R. and McFarland, H.F. (1995) Immunological aspects of experimental allergic encephalomyelitis and multiple sclerosis. Crit. Rev. Clin. Lab. Sci., 32:121-182.
29. Matsumoto, K., Wanaka, A., Takatsuji, K., Muramatsu H., Muramatsu, T., and Tohyama, M. (1994) A novel family of heparin-binding growth factors, pleiotrophin and midkine, is expressed in the developing rat cerebral cortex. Brain Res. Dev. Brain Res., 79(2):229-241.
30. McKinnon, R.D., Matsui, T., Dubois-Dalcq, M., and Aaronson, S.A. (1990) FGF modulates the PDGF-driven pathway of oligodendrocyte development. Neuron., 5:603-614.
31. McMorris, R.A., Smith, T.M., DeSalvo, S., and Furlanetto, R.W. (1986) Insulin-like growth factor I/somatomedin C: A potent inducer of oligodendrocyte development. Proc. Natl. Acad. Sci. USA, 83:822-826.
32. Menon, V.K. and Landerholm, T.E. (1994) Intralesion injection of basic fibroblast growth factor alters glial reactivity to neural trauma. Exp. Neurol., 129:142-154.
33. Michikawa, M., Kikuchi, S., Muramatsu, H., Muramatsu, T., and Kim, S.U. (1993) Retinoic acid responsive gene product midkine has neurotrophic functions for mouse spinal cord and dorsal root ganglion neurons in culture. J. Neurosci. Res., 35:530-539.
34. Mitsiades, T.A., Muramatsu, T., Muramatsu, H., and Thesleff, I. (1995a) Midkine (MK), a heparin binding growth/differentiation factor, is regulated by retinoic acid and epithelial-mesenchymal interactions in the developing mouse, and effects cell proliferation and morphogenesis. J. Cell Biol., 129:267-281.
35. Mitsiadis, T.A., Salmivirta, M., Muramatsu, T., Muramatsu, H., Rauvala, H., Lehtonen, E., Jalkanen, M., and Thesleff, I. (1995b) Expression of the heparin binding cytokines midkine and pleiotrophin is associated with epithelial-mesenchymal interactions during fetal development and organogenesis. Development, 121:37-51.
36. Muramatsu, H. and Muramatsu, T. (1991) Purification of recombinant midkine and examination of its biological activities: Functional comparison of new heparin-binding factors. Biochem. Biophys. Res. Commun., 177:652-658.
37. Muramatsu, H., Shirahama, H., Yonezawa, S., Maruta, H., and Muramatsu, T. (1993) Midkine, a retinoic acid inducible growth/ differentiation factor: Immunohistochemical evidence for the function and distribution. Dev. Biol., 159:392-402.
38. Nakamoto, M., Matsubara, S., Miyauchi, T., Obama, H., Ozawa, M., and Muramatsu, T. (1992) A new family of heparin binding growth/differentiation factors: Differential expression of the midkine (MK) and HB-GAM genes during mouse development. J. Biochem., 112:346-349.
39. Nurcombe, V., Fraser, N., Herlaar, E., and Heath, K. (1992) MK: A pluripotent embryonic stem-cell-derived neuroregulatory factor. Development, 116:1175-1183.
40. Panoskaltsis-Mortari, A. and Bucy, R.P. (1995) In situ hybridization with digoxigenin labeled RNA probes: Facts and artifacts. Biotechniques, 18:300-307.
41. Presta, M., Urbinati, C., Dell'era, P., et al. (1995) Expression of basic fibroblast growth factor and its receptors in human fetal microglia. Int. J. Dev. Neurosci., 13:29-39.
42. Raine, C.S. (1994) The Dale E. McFarlin memorial lecture: The immunology of the multiple sclerosis lesion. Ann. Neurol., 36:S61-S72.
43. Raulo, E., Julkunen, I., Merenmies, J., Pihlaskari, R., and Rauvala, H. (1992) Secretion and biological activities of heparin-binding growth-associated molecule neurite outgrowth-promoting and mitogenic actions of the recombinant and tissue-derived protein. J. Biol. Chem., 267:11408-11416.
44. Reilly, J.F. and Kumari, V.G. (1996) Alterations in fibroblast growth factor receptor expression following brain injury. Exp. Neurol., 140:139-150.
45. Satoh, J., Muramatsu, H., Moretto, G., Muramatsu, T., Chang, K.J., Kim, S.T., Cho J.M., and Kim, S.U. (1993) Midkine that promotes survival of fetal human neurons is produced by fetal human astrocytes in culture. Brain Res. Dev. Brain Res., 75:201-205.
46. Shimojo, M., Nakajima, K., Takei, N., Hamanoue, M., and Koshaka, S. (1991) Production of fibroblast growth factor in cultured rat brain microglia. Neurosci. Lett., 123:229-231.
47. Swanborg, R.H. (1995) Experimental autoimmune encephalomyelitis in rodents as a model for human demyelinating disease. Clin. Immunol. Immunopathol., 77:4-13.
48. Tsirka, S.E., Gualandris, A., Amaral, D.G., and Strickland, S. (1995) Exitotoxin-induced neuronal degeneration and seizure are mediated by tissue plasminogen activator. Nature, 377:340-344.
49. Unsicker, K., Reichert, H., Schmidt, R., Pettmann, B., Labourdette, G., and Sensenbrenner, M. (1986) Astroglial and fibroblast growth factors have neurotrophic functions for cultured peripheral and central nervous system neurons. Proc. Natl. Acad. Sci., USA, 84:5459-5463.
50. Walicke, P.A., Cowan, W.M., Baird, N.U., and Guillemin, R. (1986) Fibroblast growth factor promotes survival of dissociated hippocampal neurons and enhances neurite extension. Proc. Natl. Acad. Sci., USA, 83:3012-3016.
51. Wanaka, A., Carroll, S.L., and Milbrandt, J. (1993) Developmentally regulated expression of pleiotrophin, a novel heparin-binding growth factor, in the nervous system of the rat. Brain Res. Dev. Brain Res., 72:133-144.
52. Webster, deF.H. (1997) Growth factors and myelin regeneration in multiple sclerosis. Multiple Sclerosis, 3:113-120.
53. Wewetzer, K., Rauvala, H., and Unsicker, K. (1995) Immunocytochemical localization of the heparin binding growth associated molecule HB-GAM in the developing and adult rat brain. Brain Res., 693:31-38.
54. Wisniewski, T., Lalowski, M., Baumann, M., Rauvala, H., Raulo, E., Nolo, R., and Frangione, B. (1996) HB-GAM is a cytokine present in Alzheimer's and Down syndrome lesions. Neuroreport, 7:667-671.
55. Yao, D.-L., Liu, X., Hudson, L.D., and Webster, H.D. (1995) Insulin like growth factor 1 treatment reduces demyelination and up-regulates gene expression of myelin-related proteins in experimental autoimmune encephalomyelitis. Proc. Natl Acad. Sci. USA, 92:6190-5194.
56. Yasuda, T., Grinspan, J., Stern, J., Franceschini, B., Baunerman, P., and Pleasure, D. (1995) Apoptosis occurs in the oligodendroglial lineage, and is prevented by basic fibroblast growth factor. J. Neurosci. Res., 40:306-317.
57. Yasuhara, O., Schwab, C., Matsuo, A., Kim, S.U., Steele, J.C., Akiguchi, I., Kimura, J., McGeer, E.G., and McGeer, P.L. (1996) Midkine-like immunoreactivity in extracellular neurofibrillary tangles in brains of patients with parkinsonism-dementia complex of Guam. Neurosci. Lett., 205:107-110.
58. Yoshida, Y., Goto, M., Tsutsui, J., Ozawa, M., Sato, E., Osame, M., and Muramatsu, T. (1995) Midkine is present in the early stage of cerebral infarct. Brain Res. Dev. Brain Res., 85:25-30.