Role of PKC-δ on substance P-induced chemokine synthesis in pancreatic acinar cells

American Journal of Physiology - Cell Physiology

Volumn 294, Issue 3, 2008, Pages

  Ramnath, Raina Devi ^a   Sun, Jia ^a   Adhikari, Sharmila ^a   Zhi, Liang ^a   Bhatia, Madhav ^a,b  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Activator protein 1; c Jun NH2 terminal kinase; Extracellular signal regulated kinase; Mitogen activated protein kinase kinase kinase 1; Nuclear factor B; Protein kinse C

Indexed keywords

2 BENZHYDRYL 3 (2 METHOXYBENZYLAMINO) 1 AZABICYCLO[2.2.2]OCTANE; CHEMOKINE; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 2; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE 1; MONOCYTE CHEMOTACTIC PROTEIN 1; PROTEIN KINASE C DELTA; PROTEIN KINASE C DELTA INHIBITOR; PROTEIN KINASE C INHIBITOR; RNA; ROTTLERIN; STRESS ACTIVATED PROTEIN KINASE; SUBSTANCE P; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG;

ACINAR CELL; ACUTE PANCREATITIS; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME MECHANISM; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN INDUCTION; PROTEIN PROTEIN INTERACTION; RECEPTOR AFFINITY; SIGNAL TRANSDUCTION;

ACETOPHENONES; ANIMALS; BENZOPYRANS; BIPHENYL COMPOUNDS; CHEMOKINE CCL2; CHEMOKINE CCL3; CHEMOKINE CXCL2; CHEMOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE KINASE KINASE 1; MAP KINASE KINASE KINASES; MICE; NF-KAPPA B; PANCREAS, EXOCRINE; PHOSPHORYLATION; PROTEIN KINASE C-DELTA; PROTEIN KINASE INHIBITORS; RECEPTORS, NEUROKININ-1; SIGNAL TRANSDUCTION; SUBSTANCE P; TIME FACTORS; TRANSCRIPTION FACTOR AP-1;

EID: 41549102879     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00360.2007     Document Type: Article

References (56)

1. Alessi DR, Cuenda A, Cohen P, Dudley DT, Saltiel AR. PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J Biol Chem 270: 27489-27494, 1995.
2. Bennett BL, Sasaki DT, Murray BW, O'Leary EC, Sakata ST, Xu W, Leisten JC, Motiwala A, Pierce S, Satoh Y, Bhagwat SS, Manning AM, Anderson DW. SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase. Proc Natl Acad Sci USA 98: 13681-13686, 2001.
3. Bhatia M, Brady M, Kang YK, Costello E, Newton DJ, Christmas SE, Neoptolemos JP, Slavin J. MCP-1 but not CINC synthesis is increased in rat pancreatic acini in response to cerulean hyperstimulation. Am J Physiol Gastrointest Liver Physiol 282: G77-G85, 2002.
4. Bhatia M, Brady M, Shokuhi S, Christmas S, Neoptolemos JP, Slavin J. Inflammatory mediators in acute pancreatitis. J Pathol 190: 117-125, 2000.
5. Bhatia M, Proudfoot AE, Wells TN, Christmas S, Neoptolemos JP, Slavin J. Treatment with Met-RANTES reduces lung injury in caerulein-induced pancreatitis. Br J Surg 90: 698-704, 2003.
6. Bhatia M, Ramnath RD, Chevali L, Guglielmotti A. Treatment with bindarit, a blocker of MCP-1 synthesis, protects mice against acute pancreatitis. Am J Physiol Gastrointest Liver Physiol 288: G1259-G1265, 2005.
7. Bhatia M, Saluja AK, Hofbauer B, Frossard JL, Lee HS, Castagliuolo I, Wang CC, Gerard N, Pothoulakis C, Steer ML. Role of substance P and the neurokinin 1 receptor in acute pancreatitis and pancreatitis-associated lung injury. Proc Natl Acad Sci USA 95: 4760-4765, 1998.
8. Bhatia M, Saluja AK, Hofbauer B, Lee HS, Frossard JL, Lu B, Gerard C, Steer ML. Neutral endopeptidase (NEP) plays an anti-inflammatory role in acute pancreatitis and pancreatitis-associated lung injury (Abstract). Pancreas 15: 428, 1997.
9. Bhatia M, Slavin J, Cao Y, Basbaum AI, Neoptolemos JP. Preprotachykinin-A gene deletion protects mice against acute pancreatitis and associated lung injury. Am J Physiol Gastrointest Liver Physiol 284: G830-G836, 2003.
10. Bonecchi R, Polentarutti N, Luini W, Borsatti A, Bernasconi S, Locati M, Power C, Proudfoot A, Wells TN, Mackay C, Mantovani A, Sozzani S. Up-regulation of CCR1 and CCR3 and induction of chemotaxis to CC chemokines by IFN-gamma in human neutrophils. J Immunol 162: 474-479, 1999.
11. Bowden JJ, Garland AM, Baluk P, Lefevre P, Grady EF, Vigna SR, Bunnett NW, McDonald DM. Direct observation of substance P-induced internalization of neurokinin 1 (NK1) receptors at sites of inflammation. Proc Natl Acad Sci USA 91: 8964-8968, 1994.
12. Castagliuolo I, Valenick L, Liu J, Pothoulakis C. Epidermal growth factor receptor transactivation mediates substance P-induced mitogenic responses in U-373 MG cells. J Biol Chem 275: 26545-26550, 2000.
13. Chen L, Hahn H, Wu G, Chen CH, Liron T, Schechtman D, Cavallaro G, Banci L, Guo Y, Bolli R, Dorn GWII, Mochly-Rosen D. Opposing cardioprotective actions and parallel hypertrophic effects of delta PKC and epsilon PKC. Proc Natl Acad Sci USA 98: 11114-11119, 2001.
14. Christian C, Gilbert M, Payan DG. Stimulation of transcriptional regulatory activity by substance P. Neuroimmunomodulation 1: 159-164, 1994.
15. Dempsey EC, Newton AC, Mochly-Rosen D, Fields AP, Reyland ME, Insel PA, Messing RO. Protein kinase C isozymes and the regulation of diverse cell responses. Am J Physiol Lung Cell Mol Physiol 279: L429-L438, 2000.
16. Dudley DT, Pang L, Decker SJ, Bridges AJ, Saltiel AR. A synthetic inhibitor of the mitogen-activated protein kinase cascade. Proc Natl Acad Sci USA 92: 7686-7689, 1995.
17. Garrington TP, Johnson GL. Organization and regulation of mitogen-activated protein kinase signaling pathways. Curr Opin Cell Biol 11: 211-218, 1999.
18. Gerard C, Frossard JL, Bhatia M, Saluja A, Gerard NP, Lu B, Steer M. Targeted disruption of the beta-chemokine receptor CCR1 protects against pancreatitis-associated lung injury. J Clin Invest 100: 2022-2027, 1997.
19. Grady T, Liang P, Ernst SA, Logsdon CD. Chemokine gene expression in rat pancreatic acinar cells is an early event associated with acute pancreatitis. Gastroenterology 113: 1966-1975, 1997.
20. Grady T, Mah'Moud M, Otani T, Rhee S, Lerch MM, Gorelick FS. Zymogen proteolysis within the pancreatic acinar cell is associated with cellular injury. Am J Physiol Gastrointest Liver Physiol 275: G1010-G1017, 1998.
21. Gschwendt M. Protein kinase C delta. Eur J Biochem 259: 555-564, 1999.
22. Hug H, Sarre TF. Protein kinase C isoenzymes: divergence in signal transduction? Biochem J 291: 329-343, 1993.
23. Jedrzkiewicz S, Nakamura H, Silverman ES, Luster AD, Mansharamani N, In KH, Tamura G, Lilly CM. IL-1 induces eotaxin gene transcription in A549 airway epithelial cells through NF-κB. Am J Physiol Lung Cell Mol Physiol 279: L1058-L1065, 2000.
24. Jensen RT, Jones SW, Lu YA, Xu JC, Folkers K, Gardner JD. Interaction of substance P antagonists with substance P receptors on dispersed pancreatic acini. Biochim Biophys Acta 804: 181-191, 1984.
25. Karin M. Inflammation-activated protein kinases as targets for drug development. Proc Am Thorac Soc 2: 386-390, 2005.
26. Kim YH, Lim JH, Lee TJ, Park JW, Kwon TK. Expression of cyclin D3 through Sp1 sites by histone deacetylase inhibitors is mediated with protein kinase C-delta (PKC-delta) signal pathway. J Cell Biochem 101: 987-995, 2007.
27. Konishi H, Tanaka M, Takemura Y, Matsuzaki H, Ono Y, Kikkawa U, Nishizuka Y. Activation of protein kinase C by tyrosine phosphorylation in response to H2O2. Proc Natl Acad Sci USA 94: 11233-11237, 1997.
28. Kontny E, Kurowska M, Szczepanska K, Maslinski W. Rottlerin, a PKC isozyme-selective inhibitor, affects signaling events and cytokine production in human monocytes. J Leukoc Biol 67: 249-258, 2000.
29. Koon HW, Zhao D, Na X, Moyer MP, Pothoulakis C. Metalloproteinases and transforming growth factor-alpha mediate substance P-induced mitogenactivated protein kinase activation and proliferation in human colonocytes. J Biol Chem 279: 45519-45527, 2004.
30. Koon HW, Zhao D, Zhan Y, Simeonidis S, Moyer MP, Pothoulakis C. Substance P-stimulated interleukin-8 expression in human colonic epithelial cells involves protein kinase C activation. J Pharmacol Exp Ther 314: 1393-1400, 2005.
31. 2+-MAPK/ERK pathways. J Neurochem 87: 508-521, 2003.
32. Liu JF, Crepin M, Liu JM, Barritault D, Ledoux D. FGF-2 and TPA induce matrix metalloproteinase-9 secretion in MCF-7 cells through PKC activation of the Ras/ERK pathway. Biochem Biophys Res Commun 293: 1174-1182, 2002.
33. Liu WS, Heckman CA. The sevenfold way of PKC regulation. Cell Signal 10: 529-542, 1998.
34. Luo W, Sharif TR, Sharif M. Substance P-induced mitogenesis in human astrocytoma cells correlates with activation of the mitogen-activated protein kinase signaling pathway. Cancer Res 56: 4983-4991, 1996.
35. Maa J, Grady EF, Yoshimi SK, Drasin TE, Kim EH, Hutter MM, Bunnett NW, Kirkwood KS. Substance P is a determinant of lethality in diet-induced hemorrhagic pancreatitis in mice. Surgery 128: 232-239, 2000.
36. Newton AC. Protein kinase C: structure, function, and regulation. J Biol Chem 270: 28495-28498, 1995.
37. Newton AC, Johnson JE. Protein kinase C: a paradigm for regulation of protein function by two membrane-targeting modules. Biochim Biophys Acta 1376: 155-172, 1998.
38. Parekh D, Ziegler W, Yonezawa K, Hara K, Parker PJ. Mammalian TOR controls one of two kinase pathways acting upon nPKCdelta and nPKCepsilon. J Biol Chem 274: 34758-34764, 1999.
39. Parry GC, Mackman N. A set of inducible genes expressed by activated human monocytic and endothelial cells contain kappa B-like sites that specifically bind c-Rel-p65 heterodimers. J Biol Chem 269: 20823-20825, 1994.
40. Patto RJ, Vinayek R, Jensen RT, Gardner JD. Carbachol does not down-regulate substance P receptors in pancreatic acini. Pancreas 7: 447-452, 1992.
41. Ramnath RD, Bhatia M. Substance P treatment stimulates chemokine synthesis in pancreatic acinar cells via the activation of NF-κB. Am J Physiol Gastrointest Liver Physiol 291: G1113-G1119, 2006.
42. Ramnath RD, Sun J, Adhikari S, Bhatia M. Effect of MAP kinases on chemokine synthesis induced by substance P in mouse pancreatic acinar cells. J Cell Mol Med 11: 1326-1341, 2007.
43. Raraty M, Ward J, Erdemli G, Vaillant C, Neoptolemos JP, Sutton R, Petersen OH. Calcium-dependent enzyme activation and vacuole formation in the apical granular region of pancreatic acinar cells. Proc Natl Acad Sci USA 97: 13126-13131, 2000.
44. Ron D, Kazanietz MG. New insights into the regulation of protein kinase C and novel phorbol ester receptors. FASEB J 13: 1658-1676, 1999.
45. Satoh A, Gukovskaya AS, Nieto JM, Cheng JH, Gukovsky I, Reeve JR Jr, Shimosegawa T, Pandol SJ. PKC-δ and -ε regulate NF-κB activation induced by cholecystokinin and TNF-α in pancreatic acinar cells. Am J Physiol Gastrointest Liver Physiol 287: G582-G591, 2004.
46. Satoh A, Gukovskaya AS, Reeve JR Jr, Shimosegawa T, Pandol SJ. Ethanol sensitizes NF-κB activation in pancreatic acinar cells through effects on protein kinase C-ε. Am J Physiol Gastrointest Liver Physiol 291: G432-G438, 2006.
47. Shin M, Yan C, Boyd D. An inhibitor of c-jun aminoterminal kinase (SP600125) represses c-Jun activation, DNA-binding and PMA-inducible 92-kDa type IV collagenase expression. Biochim Biophys Acta 1589: 311-316, 2002.
48. Sjodin L, Gylfe E. A selective and potent antagonist of substance P receptors on pancreatic acinar cells. Biochem Int 27: 145-153, 1992.
49. Smyth DC, Kerr C, Richards CD. Oncostatin M-induced IL-6 expression in murine fibroblasts requires the activation of protein kinase Cdelta. J Immunol 177: 8740-8747, 2006.
50. Soltoff SP, Toker A. Carbachol, substance P, and phorbol ester promote the tyrosine phosphorylation of protein kinase C delta in salivary gland epithelial cells. J Biol Chem 270: 13490-13495, 1995.
51. Tan M, Xu X, Ohba M, Ogawa W, Cui MZ. Thrombin rapidly induces protein kinase D phosphorylation, and protein kinase C delta mediates the activation. J Biol Chem 278: 2824-2828, 2003.
52. Thurgston G, Baluk P, Hirata A, McDonald DM. Permeability-related changes revealed at endothelial cell borders in inflamed venules by lectin binding. Am J Physiol Heart Circ Physiol 271: H2547-H2562, 1996.
53. Williams JA. Regulation of pancreatic acinar cell function. Curr Opin Gastroenterol 22: 498-504, 2006.
54. Yang BM, Demaine AG, Kingsnorth A. Chemokines MCP-1 and RANTES in isolated rat pancreatic acinar cells treated with CCK and ethanol in vitro. Pancreas 21: 22-31, 2000.
55. Yang CM, Hsiao LD, Chien CS, Lin CC, Luo SF, Wang CC. Substance P-induced activation of p42/44 mitogen-activated protein kinase associated with cell proliferation in human tracheal smooth muscle cells. Cell Signal 14: 913-923, 2002.
56. 2+- and protein kinase C-dependent signaling pathway for nuclear factor-kappaB activation, inducible nitric-oxide synthase expression, and tumor necrosis factor-alpha production in lipopolysaccharide-stimulated rat peritoneal macrophages. J Biol Chem 281: 31337-31347, 2006.