Innate immunity to intraphagosomal pathogens is mediated by Interferon Regulatory Factor 8 (IRF-8) that stimulates the expression of macrophage-specific Nramp1 through antagonizing repression by c-Myc

Journal of Biological Chemistry

Volumn 283, Issue 5, 2008, Pages 2724-2733

  Alter Koltunoff, Michal ^a   Goren, Sigal ^a   Nousbeck, Janna ^a   Feng, Carl G ^c   Sher, Alan ^c   Ozato, Keiko ^b   Azriel, Aviva ^a   Levi, Ben Zion ^a  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^b EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^c NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENE EXPRESSION; LAWS AND LEGISLATION; MACROPHAGES; OXYGEN; PATHOGENS; PROTEINS; TRANSCRIPTION FACTORS;

ACTIVATION STATES; ANTI-MICROBIAL; BONE MARROWS; DOMINANT GENES; EARLY STAGES; IMMUNE DEFENSES; INNATE IMMUNITIES; INTERFERON REGULATORY FACTORS; INTRACELLULAR PATHOGENS; LEISHMANIA; MOLECULAR BASES; MOUSE STRAINS; MYCOBACTERIUM BOVIS; MYELOID CELLS; PHAGOSOMES; PROTEIN INTERACTIONS; REACTIVE SPECIES; SALMONELLA ENTERICA SEROVAR TYPHIMURIUM; WILD TYPES;

TRANSCRIPTION;

INTERFERON CONSENSUS SEQUENCE BINDING PROTEIN; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 1; TRANSCRIPTION FACTOR; CATION TRANSPORT PROTEIN; DNA; INTERFERON REGULATORY FACTOR; MYC PROTEIN; MYC PROTEIN, MOUSE; NATURAL RESISTANCE-ASSOCIATED MACROPHAGE PROTEIN 1; ONCOPROTEIN; PRIMER DNA; PROTO ONCOGENE PROTEIN SPI 1; PROTO-ONCOGENE PROTEIN SPI-1; TRANSACTIVATOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE REPRESSION; INNATE IMMUNITY; MACROPHAGE; MOUSE; MYCOBACTERIUM BOVIS; NONHUMAN; ONCOGENE C MYC; PERITONEUM; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; SALMONELLA ENTERICA; SEROTYPE; WILD TYPE; ANIMAL; BINDING SITE; C57BL MOUSE; CELL LINE; GENETICS; IMMUNOLOGY; MACROPHAGE ACTIVATION; METABOLISM; MICROBIOLOGY; MOUSE MUTANT; NUCLEOTIDE SEQUENCE; PHAGOSOME; PROMOTER REGION; SALMONELLA TYPHIMURIUM;

CORYNEBACTERINEAE; MUS; MYCOBACTERIUM BOVIS; SALMONELLA; SALMONELLA ENTERICA SUBSP. ENTERICA SEROVAR TYPHIMURIUM;

ANIMALS; BASE SEQUENCE; BINDING SITES; CATION TRANSPORT PROTEINS; CELL LINE; DNA; DNA PRIMERS; IMMUNITY, NATURAL; INTERFERON REGULATORY FACTORS; MACROPHAGE ACTIVATION; MACROPHAGES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYCOBACTERIUM BOVIS; PHAGOSOMES; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MYC; SALMONELLA TYPHIMURIUM; TRANS-ACTIVATORS;

EID: 41449113593     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M707704200     Document Type: Article

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