Common variants of the TCF7L2 gene are associated with increased risk of type 2 diabetes mellitus in a UK-resident South Asian population

BMC Medical Genetics

Volumn 9, Issue , 2008, Pages

  Rees, Simon D ^a   Bellary, Srikanth ^a,b   Britten, Abigail C ^a   O'Hare, J Paul ^c   Kumar, Sudhesh ^c   Barnett, Anthony H ^a,b   Kelly, M Ann ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b UNIVERSITY HOSPITALS BIRMINGHAM NHS FOUNDATION TRUST   (United Kingdom)

^c UNIVERSITY OF WARWICK   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR 7 LIKE 2; T CELL FACTOR 4; T CELL FACTOR PROTEIN; UNCLASSIFIED DRUG;

ADULT; AGED; ALLELE; ARTICLE; ASIAN; CONTROLLED STUDY; FEMALE; GENE LINKAGE DISEQUILIBRIUM; GENOTYPE; HOMOZYGOSITY; HUMAN; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PATHOGENESIS; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; UNITED KINGDOM; BLOOD; CHI SQUARE DISTRIBUTION; COHORT ANALYSIS; ETHNOLOGY; GENETIC PREDISPOSITION; GENETIC VARIABILITY; GENETICS; MIDDLE AGED; PAKISTAN; RISK;

ADULT; ALLELES; CHI-SQUARE DISTRIBUTION; COHORT STUDIES; DIABETES MELLITUS, TYPE 2; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; GREAT BRITAIN; HUMANS; LINKAGE DISEQUILIBRIUM; MALE; MIDDLE AGED; ODDS RATIO; PAKISTAN; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS; TCF TRANSCRIPTION FACTORS; VARIATION (GENETICS);

EID: 41449109466     PISSN: None     EISSN: 14712350     Source Type: Journal    
DOI: 10.1186/1471-2350-9-8     Document Type: Article

References (22)

1. Grant SF Thorleifsson G Reynisdottir I Benediktsson R Manolescu A Sainz J Helgason A Stefansson H Emilsson V Helgadottir A Styrkarsdottir U Magnusson KP Walters GB Palsdottir E Jonsdottir T Gudmundsdottir T Gylfason A Saemundsdottir J Wilensky RL Reilly MP Rader DJ Bagger Y Christiansen C Gudnason V Sigurdsson G Thorsteinsdottir U Gulcher JR Kong A Stefansson K Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes Nat Genet 2006, 38:320-323 10.1038/ ng1732 16415884
2. Zhang C Qi L Hunter DJ Meigs JB Manson JE van Dam RM Hu FB Variant of transcription factor 7-like 2 (TCF7L2) gene and the risk of type 2 diabetes in large cohorts of U.S. women and men Diabetes 2006, 55:2645-2648 10.2337/db06-0643 16936216
3. Wang J Kuusisto J Vanttinen M Kuulasmaa T Lindstrom J Tuomilehto J Uusitupa M Laakso M Variants of transcription factor 7-like 2 (TCF7L2) gene predict conversion to type 2 diabetes in the Finnish Diabetes Prevention Study and are associated with impaired glucose regulation and impaired insulin secretion Diabetologia 2007, 50:1192-1200 10.1007/ s00125-007-0656-6 17437080
4. van Vliet-Ostaptchouk JV Shiri-Sverdlov R Zhernakova A Strengman E van Haeften TW Hofker MH Wijmenga C Association of variants of transcription factor 7-like 2 (TCF7L2) with susceptibility to type 2 diabetes in the Dutch Breda cohort Diabetologia 2007, 50:59-62 10.1007/s00125-006-0477-z 17031610
5. Scott LJ Bonnycastle LL Willer CJ Sprau AG Jackson AU Narisu N Duren WL Chines PS Stringham HM Erdos MR Valle TT Tuomilehto J Bergman RN Mohlke KL Collins FS Boehnke M Association of transcription factor 7-like 2 (TCF7L2) variants with type 2 diabetes in a Finnish sample Diabetes 2006, 55:2649-2653 10.2337/db06-0341 16936217
6. Mayans S Lackovic K Lindgren P Ruikka K Agren A Eliasson M Holmberg D TCF7L2 polymorphisms are associated with type 2 diabetes in northern Sweden Eur J Hum Genet 2007, 15:342-346 10.1038/sj.ejhg.5201773 17245407
7. Humphries SE Gable D Cooper JA Ireland H Stephens JW Hurel SJ Li KW Palmen J Miller MA Cappuccio FP Elkeles R Godsland I Miller GJ Talmud PJ Common variants in the TCF7L2 gene and predisposition to type 2 diabetes in UK European Whites, Indian Asians and Afro-Caribbean men and women J Mol Med 2006, 84:1-10 10.1007/s00109-005-0725-6 17043802
8. Loos RJ Franks PW Francis RW Barroso I Gribble FM Savage DB Ong KK O'Rahilly S Wareham NJ TCF7L2 polymorphisms modulate proinsulin levels and {beta}-cell function in a British Europid population Diabetes 2007, 56:1943-1947 10.2337/db07-0055 17416797
9. Florez JC Jablonski KA Bayley N Pollin TI de Bakker PI Shuldiner AR Knowler WC Nathan DM Altshuler D TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program N Engl J Med 2006, 355:241-250 1762036 16855264 10.1056/NEJMoa062418
10. Damcott CM Pollin TI Reinhart LJ Ott SH Shen H Silver KD Mitchell BD Shuldiner AR Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in the Amish: Replication and evidence for a role in both insulin secretion and insulin resistance Diabetes 2006, 55:2654-2659 10.2337/db06-0338 16936218
11. Chandak GR Janipalli CS Bhaskar S Kulkarni SR Mohankrishna P Hattersley AT Frayling TM Yajnik CS Common variants in the TCF7L2 gene are strongly associated with type 2 diabetes mellitus in the Indian population Diabetologia 2007, 50:63-67 10.1007/s00125-006-0502-2 17093941
12. Florez JC The new type 2 diabetes gene TCF7L2 Curr Opin Clin Nutr Metab Care 2007, 10:391-396 10.1097/MCO.0b013e3281e2c9be 17563454
13. Cauchi S El Achhab Y Choquet H Christian D Krempler F Weitgasser R Nejjari C Patsch W Chikri M Meyre D Froguel P TCF7L2 is reproducibly associated with type 2 diabetes in various ethnic groups: A global meta-analysis Journal of Molecular Medicine 2007, 85:777-782 10.1007/ s00109-007-0203-4 17476472
14. Saxena R Gianniny L Burtt NP Lyssenko V Giuducci C Sjogren M Florez JC Almgren P Isomaa B Orho-Melander M Lindblad U Daly MJ Tuomi T Hirschhorn JN Ardlie KG Groop LC Altshuler D Common single nucleotide polymorphisms in TCF7L2 are reproducibly associated with type 2 diabetes and reduce the insulin response to glucose in nondiabetic individuals Diabetes 2006, 55:2890-2895 10.2337/db06-0381 17003358
15. Smith U TCF7L2 and type 2 diabetes-we WNT to know Diabetologia 2007. 50:5-7 10.1007/s00125-006-0521-z 17102948
16. Barnett AH Dixon AN Bellary S Hanif MW O'Hare JP Raymond NT Kumar S Type 2 diabetes and cardiovascular risk in the UK south Asian community Diabetologia 2006, 49:2234-2246 10.1007/s00125-006-0325-1 16847701
17. WHO Consultation Definition, Diagnosis and Classification of Diabetes Mellitus and its complications, Part 1: Diagnosis and Classification of Diabetes Mellitus Report of the WHO Consultation 1999 Geneva World Health Organisation
18. Barrett JC Fry B Maller J Daly MJ Haploview: Analysis and visualization of LD and haplotype maps Bioinformatics 2005, 21:263-265 10.1093/ bioinformatics/bth457 15297300
19. The International HapMap Consortium The International HapMap Project Nature 2003, 426:789-796 10.1038/nature02168 14685227
20. Cauchi S Meyre D Dina C Choquet H Samson C Gallina S Balkau B Charpentier G Pattou F Stetsyuk V Scharfmann R Staels B Fruhbeck G Froguel P Transcription factor TCF7L2 genetic study in the French population: Expression in human beta-cells and adipose tissue and strong association with type 2 diabetes Diabetes 2006, 55:2903-2908 10.2337/ db06-0474 17003360
21. Zhang R Zhu Z Zhu H Nguyen T Yao F Xia K Liang D Liu C SNP Cutter: A comprehensive tool for SNP PCR-RFLP assay design Nucleic Acids Res 2005, 33:W489-W492 1160119 15980518 10.1093/nar/gki358
22. Helgason A Palsson S Thorleifsson G Grant SF Emilsson V Gunnarsdottir S Adeyemo A Chen Y Chen G Reynisdottir I Benediktsson R Hinney A Hansen T Andersen G Borch-Johnsen K Jorgensen T Schafer H Faruque M Doumatey A Zhou J Wilensky RL Reilly MP Rader DJ Bagger Y Christiansen C Sigurdsson G Hebebrand J Pedersen O Thorsteinsdottir U Gulcher JR Kong A Rotimi C Stefansson K Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution Nat Genet 2007, 39:218-225 10.1038/ ng1960 17206141