Critical role of amino acid 23 in mediating activity and specificity of vinckepain-2, a papain-family cysteine protease of rodent malaria parasites

Biochemical Journal

Volumn 368, Issue 1, 2002, Pages 273-281

  Singh, Ajay ^a   Shenai, Bhaskar R ^a   Choe, Youngchool ^b   Gut, Jiri ^a   Sijwali, Puran S ^a   Craik, Charles S ^b   Rosenthal, Philip J ^a  

^a SAN FRANCISCO GENERAL HOSPITAL   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Falcipain; Haemoglobin; Plasmodium; Proteinase

Indexed keywords

AMINO ACIDS; CATALYSIS; DRUG PRODUCTS; ENZYMES; ESCHERICHIA COLI; GENES; HEMOGLOBIN; HYDROLYSIS;

GENES ENCODING;

BIOCHEMISTRY;

ALANINE; AMINO ACID; CYSTEINE PROTEINASE; GLYCINE; HEMOGLOBIN; LEUCINE; PAPAIN; PEPTIDE; UNCLASSIFIED DRUG; VINCKEPAIN 2;

ACIDITY; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; CATALYSIS; DNA SEQUENCE; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME SPECIFICITY; ENZYME SUBSTRATE; ENZYME SUBSTRATE COMPLEX; MALARIA; NONHUMAN; NUCLEOTIDE SEQUENCE; PLASMODIUM VINCKEI; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN HYDROLYSIS; REDUCTION; SEQUENCE ANALYSIS; SOLUBILIZATION;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; BASE SEQUENCE; CYSTEINE ENDOPEPTIDASES; HELMINTH PROTEINS; MALARIA; MOLECULAR SEQUENCE DATA; MUTATION; PAPAIN; PEPTIDE LIBRARY; PLASMODIUM FALCIPARUM; PROTEIN FOLDING; PROTOZOAN PROTEINS; RECOMBINANT PROTEINS; RODENT DISEASES; RODENTIA; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY;

ANIMALIA; ESCHERICHIA COLI; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; PLASMODIUM VINCKEI; PRIMATES; PROTOZOA; RODENTIA;

EID: 0037113235     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20020753     Document Type: Article

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