A hydrocarbon ruler measures palmitate in the enzymatic acylation of endotoxin

EMBO Journal

Volumn 23, Issue 15, 2004, Pages 2931-2941

  Ahn, Victoria E ^a   Lo, Eileen I ^a   Engel, Christian K ^b,e   Chen, Lu ^b   Hwang, Peter M ^a   Kay, Lewis E ^a,c   Bishop, Russell E ^a,d   Privé, Gilbert G ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b PRINCESS MARGARET HOSPITAL   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d Aventis Pharma ^*  (Canada)

^e SANOFI AVENTIS DEUTSCHLAND GMBH   (Germany)

Author keywords

Crystal structure; Endotoxin; Lipid A; Phospholipids; Signal transduction

Indexed keywords

ACYLTRANSFERASE; CARBENE; DETERGENT; ENDOTOXIN; ENZYME; FATTY ACID AMIDASE; FATTY ACID DERIVATIVE; GLYCINE; HYDROCARBON; LIPID A; LIPOCALIN; MEMBRANE ACYLTRANSFERASE; MEMBRANE ENZYME; PAGP PROTEIN; PALMITIC ACID; PHOSPHOLIPID; PROTEIN; UNCLASSIFIED DRUG;

ACYLATION; ARTICLE; BACTERIAL OUTER MEMBRANE; BETA SHEET; CRYSTAL STRUCTURE; CRYSTALLIZATION; ENZYME ACTIVITY; EVOLUTION; GENE MUTATION; HYDROPHOBICITY; IMMUNE RESPONSE; MOLECULAR BIOLOGY; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE;

ACYLATION; ACYLTRANSFERASES; AMINO ACID SEQUENCE; BACTERIAL OUTER MEMBRANE PROTEINS; BINDING SITES; BIOLOGICAL TRANSPORT; CRYSTALLOGRAPHY, X-RAY; ENDOTOXINS; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; GENE EXPRESSION; HYDROCARBONS; LIGANDS; LIPID METABOLISM; LIPIDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PALMITATES; PROTEIN STRUCTURE, TERTIARY; SEQUENCE ALIGNMENT; STRUCTURAL HOMOLOGY, PROTEIN; SUBSTRATE SPECIFICITY;

BACTERIA (MICROORGANISMS); NEGIBACTERIA;

EID: 4143131241     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.emboj.7600320     Document Type: Article

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