3-O-Deacylation of Lipid A by PagL, a PhoP/PhoQ-regulated Deacylase of Salmonella typhimurium, Modulates Signaling through Toll-like Receptor 4

Journal of Biological Chemistry

Volumn 279, Issue 19, 2004, Pages 20044-20048

  Kawasaki, Kiyoshi ^a   Ernst, Robert K ^a   Miller, Samuel I ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL ACTIVATION; ENZYMES; ESCHERICHIA COLI; GENES; LIPIDS; MASS SPECTROMETRY; POLYSACCHARIDES; THIN LAYER CHROMATOGRAPHY;

GENE PRODUCT; INFECTION; RECEPTORS;

BIOCHEMISTRY;

GENE PRODUCT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPID A; LIPOPOLYSACCHARIDE; PROTEIN PAGL; PROTEIN PAGP; PROTEIN PHOP PHOQ; TOLL LIKE RECEPTOR 4; TRANSFERASE; UNCLASSIFIED DRUG; VIRULENCE FACTOR;

ANIMAL CELL; ARTICLE; BACTERIAL VIRULENCE; CONTROLLED STUDY; DEACYLATION; ESCHERICHIA COLI; HOST RESISTANCE; HUMAN; HUMAN CELL; MASS SPECTROMETRY; MOUSE; NONHUMAN; PALMITOYLATION; PRIORITY JOURNAL; REPORTER GENE; SALMONELLA TYPHIMURIUM; SALMONELLOSIS; SIGNAL TRANSDUCTION; THIN LAYER CHROMATOGRAPHY;

ACYLTRANSFERASES; ANIMALS; BACTERIAL PROTEINS; CARBOXYLIC ESTER HYDROLASES; CHROMATOGRAPHY, THIN LAYER; DOSE-RESPONSE RELATIONSHIP, DRUG; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; HUMANS; LIPID A; MASS SPECTROMETRY; MEMBRANE GLYCOPROTEINS; MICE; MODELS, CHEMICAL; NF-KAPPA B; PLASMIDS; RECEPTORS, CELL SURFACE; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4; TOLL-LIKE RECEPTORS;

ANIMALIA; BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; NEGIBACTERIA; SALMONELLA TYPHIMURIUM;

EID: 2442544458     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M401275200     Document Type: Article

References (33)

1. Beutler, B., and Rietschel, E. T. (2003) Nat. Rev. Immunol. 3, 169-176
2. O'Brien, A. D., Rosenstreich, D. L., Scher, I., Campbell, G. H., MacDermott, R. P., and Formal, S. B. (1980) J. Immunol. 124, 20-24
3. Cross, A. S., Sadoff, J. C., Kelly, N., Bernton, E., and Gemski, P. (1989) J. Exp. Med. 169, 2021-2027
4. Poltorak, A., He, X., Smirnova, I., Liu, M.-Y., Huffel, C. V., Du, X., Birdwell, D., Alejos, E., Silva, M., Galanos, C., Freudenberg, M., Ricciardi-Castagnoil, P., Layton, B., and Beutler, B. (1998) Science 282, 2085-2088
5. Qureshi, S. T., Lariviere, L., Leveque, G., Clermont, S., Moore, K. J., Gros, P., and Malo, D. (1999) J. Exp. Med. 189, 615-625
6. Hoshino, K., Takeuchi, O., Kawai, T., Sanjo, H., Ogawa, T., Takeda, Y., Takeda, K., and Akira, S. (1999) J. Immunol. 162, 3749-3752
7. Shimazu, R., Akashi, S., Ogata, H., Nagai, Y., Fukudome, K., Miyake, K., and Kimoto, M. (1999) J. Exp. Med. 189, 1777-1782
8. Nagai, Y., Akashi, S., Nagafuku, M., Ogata, M., Iwakura, Y., Akira, S., Kitamura, T., Kosugi, A., Kimoto, M., and Miyake, K. (2002) Nat. Immunol. 3, 667-672
9. Akashi, S., Saitoh, S.-i., Wakabayashi, Y., Kikuchi, T., Takamura, N., Nagai, Y., Kusumoto, Y., Fukase, K., Kusumoto, S., Adachi, Y., Kosugi, A., and Miyake, K. (2003) J. Exp. Med. 198, 1035-1042
10. Visintin, A., Latz, E., Monks, B. G., Espevik, T., and Golenbock, D. T. (2003) J. Biol. Chem. 278, 48313-48320
11. Raetz, C. R. H., and Whitfield, C. (2002) Annu. Rev. Biochem. 71, 635-700
12. Guo, L., Lim, K. B., Gunn, J. S., Bainbridge, B., Darveau, R. P., Hackett, M., and Miller, S. I. (1997) Science 276, 250-253
13. Miller, S. I., Kukral, A. M., and Mekalanos, J. J. (1989) Proc. Natl. Acad. Sci. U. S. A. 86, 5054-5058
14. Hohmann, E. L., Oletta, C. A., Killeen, K. P., and Miller, S. I. (1996) J. Infect. Dis. 173, 1408-1414
15. Scherer, C. A., and Miller, S. I. (2001) in Principles of Bacterial Pathogenesis (Groisman, E. A., eds) pp. 265-333, Academic Press, San Diego, CA
16. Bader, M. W., Navarre, W. W., Shiau, W., Nikaido, H., Frye, J. G., McClelland, M., Fang, F. C., and Miller, S. I. (2003) Mol. Microbiol. 50, 219-230
17. Trent, M. S., Pabich, W., Raetz, C. R. H., and Miller, S. I. (2001) J. Biol. Chem. 276, 9083-9092
18. Guo, L., Lim, K. B., Poduje, C. M., Daniel, M., Gunn, J. S., Hackett, M., and Miller, S. I. (1998) Cell 95, 189-198
19. Bishop, R. E., Gibbons, H. S., Guina, T., Trent, M. S., Miller, S. I., and Raetz, C. R. H. (2000) EMBO J. 19, 5071-5080
20. Tanamoto, K.-i., and Azumi, S. (2000) J. Immunol. 164, 3149-3156
21. Guzman, L.-M., Belin, D., Carson, M. J., and Beckwith, J. (1995) J. Bacteriol. 177, 4121-4130
22. Zhou, Z., Lin, S., Cotter, R. J., and Raetz, C. R. H. (1999) J. Biol. Chem. 274, 18503-18514
23. Que, N. L., Lin, S., Cotter, R. J., and Raetz, C. R. H. (2000) J. Biol. Chem. 275, 28006-28016
24. Rouser, G., Siakotos, A. N., and Fleischer, S. (1966) Lipids 1, 85-86
25. Kawasaki, K., Akashi, S., Shimazu, R., Yoshida, T. Miyake, K., and Nishijima, M. (2000) J. Biol. Chem. 275, 2251-2254
26. Gomi, K., Kawasaki, K., Kawai, Y., Shiozaki, M., and Nishijima, M. (2002) J. Immunol. 168, 2939-2943
27. Mizushima, S., and Nagata, S. (1990) Nucleic Acids Res. 18, 5322
28. Akashi, S., Nagai, Y., Ogata, H., Oikawa, M., Fukase, K., Kusumoto, S., Kawasaki, K., Nishijima, M., Hayashi, S., Kimoto, M., and Miyake, K. (2001) Int. Immunol. 13, 1595-1599
29. Fujita, T., Nolan, G. P., Liou, H.-C., Scott, M. L., and Baltimore, D. (1993) Genes Dev. 7, 1354-1363
30. Kawasaki, K., Gomi, K., and Nishijima, M. (2001) J. Immunol. 166, 11-14
31. Hajjar A. M., Ernst, R. K., Tsai, J. H., Wilson, C. B., and Miller, S. I. (2002) Nat. Immunol. 3, 354-359
32. Stover, A. G., da Silva Correia, J., Evans, J. T., Cluff, C. W., Elliott, M. W., Jeffery, E. W., Johnson, D. A., Lacy, M. J., Baldridge, J. R., Probst, P., Ulevitch, R. J., Persing, D. H., and Hershberg, R. M. (2004) J. Biol. Chem. 279, 4440-4449
33. Yi, E. C., and Hackett, M. (2000) Analyst 125, 651-656