pagP Is Required for Resistance to Antibody-Mediated Complement Lysis during Bordetella bronchiseptica Respiratory Infection

Infection and Immunity

Volumn 72, Issue 5, 2004, Pages 2837-2842

  Pilione, Mylisa R ^a   Pishko, Elizabeth J ^a   Preston, Andrew ^b   Maskell, Duncan J ^c   Harvill, Eric T ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

^b UNIVERSITY OF GUELPH   (Canada)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; LIPID A; PALMITOYLTRANSFERASE; TRANSFERASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBIOTIC RESISTANCE; ANTIBODY TITER; ANTIGEN ANTIBODY COMPLEX; ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; BORDETELLA BRONCHISEPTICA; CONTROLLED STUDY; GENE FUNCTION; GENE MUTATION; HOST RESISTANCE; HOST SUSCEPTIBILITY; IMMUNE RESPONSE; IMMUNOPATHOLOGY; INFECTION SENSITIVITY; MOUSE; NONHUMAN; PAGP GENE; PALMITOYLATION; PRIORITY JOURNAL; RESPIRATORY TRACT INFECTION;

ANIMALS; ANTIBODIES, BACTERIAL; ANTIBODY-DEPENDENT CELL CYTOTOXICITY; B-LYMPHOCYTES; BORDETELLA BRONCHISEPTICA; BORDETELLA INFECTIONS; COMPLEMENT C3; GENES, BACTERIAL; IGA DEFICIENCY; IMMUNOGLOBULIN A; LUNG; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MUTATION; RECEPTORS, IGG; RESPIRATORY TRACT INFECTIONS;

EID: 2142646466     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.72.5.2837-2842.2004     Document Type: Article

References (21)

1. Backhed, F., S. Normark, E. K. Schweda, S. Oscarson, and A. Richter-Dahlfors. 2003. Structural requirements for TLR4-mediated LPS signalling: a biological role for LPS modifications. Microbes Infect. 5:1057-1063.
2. Bengoechea, J. A., K. Brandenhurg, M. D. Arraiza, U. Seydel, M. Skurnik. and I. Moriyón. 2003. Pathogenic Yersinia enterocolitica strains increase the outer membrane permeability in response to environmental stimuli by modulating lipopolysaccharide fluidity and lipid A structure. Infect. Immun. 71:2014-2021.
3. Burns, V. C., E. J. Pishko, A. Preston, D. J. Maskell, and E. T. Harvill. 2003. Role of Bordetella O antigen in respiratory tract infection. Infect. Immun. 71:86-94.
4. Cotter, P. A., and J. F. Miller. 1994. BvgAS-mediated signal transduction: analysis of phase-locked regulatory mutants of Bordetella bronchiseptica in a rabbit model. Infect. Immun. 62:3381-3390.
5. Erridge, C., E. Bennetl-Guerrero, and I. R. Poxton. 2002. Structure and function of lipopolysaccharides. Microbes Infect. 4:837-851.
6. Guo, L., K. B. Lim, C. M. Poduje, M. Daniel, J. S. Gunn, M. Hackett, and S. I. Miller. 1998. Lipid A acylation and bacterial resistance against vertebrate antimicrobial peptides. Cell 95:189-198.
7. Hajjar, A. M., R. K. Ernst, J. H. Tsai, C. B. Wilson, and S. I. Miller. 2002. Human Toll-like receptor 4 recognizes host-specific LPS modifications. Nat. Immunol. 3:354-359.
8. Harvill, E. T., P. A. Cotter, and J. F. Miller. 1999. Pregenomic comparative analysis between Bordetella bronchiseptica RB50 and Bordetella pertussis Tohama I in murine models of respiratory tract infection. Infect. Immun. 67:6109-6118.
9. Harvill, E. T., A. Preston, P. A. Cotter, A. G. Allen, D. J. Maskell, and J. F. Miller. 2000. Multiple roles for Bordetella lipopolysaccharide molecules during respiratory tract infection. Infect. Immun. 68:6720-6729.
10. Heininger, U., K. Stehr, S. Schmitt-Grobe, C. Lorenz, R. Rost, P. D. Christenson, M. Uberall, and J. D. Cherry. 1994. Clinical characteristics of illness caused by Bordetella parapertussis compared with illness caused by Bordetella pertussis. Pediatr. Infect. Dis. J. 13:306-309.
11. Kirimanjeswara, G. S., P. B. Mann, and E. T. Harvill. 2003. Role of antibodies in immunity to Bordetella infections. Infect. Immun. 71:1719-1724.
12. Mattoo, S., A. K. Foreman-Wykert, P. A. Cotter, and J. F. Miller. 2001. Mechanisms of Bordetella pathogenesis. Front. Biosci. 6:E168-E186.
13. Mey, A., D. Ponard, M. Colomb, G. Normier, H. Binz, and J. P. Revillard. 1994. Acylation of the lipid A region of a Klebsiella pneumoniae LPS controls the alternative pathway activation of human complement. Mol. Immunol. 31:1239-1246.
14. Musser, J. M., E. L. Hewlett, M. S. Peppler, and R. K. Selander. 1986. Genetic diversity and relationships in populations of Bordetella spp. J. Bacteriol. 166:230-237.
15. Pishko, E. J., G. S. Kirimanjeswara, M. R. Pilione, L. Gopinathan, M. J. Kennett, and E. T. Harvill. 2004. Antibody-mediated bacterial clearance from the lower respiratory tract of mice requires complement component C3. Eur. J. Immunol. 34:184-193.
16. Preston, A., and D. J. Maskell. 2002. Molecular genetics and role in infection of environmentally regulated lipopolysaccharide expression. Int. J. Med. Microbiol. 292:7-15.
17. Preston, A., E. Maxim, E. Toland, E. J. Pishko, E. T. Harvill, M. Caroff, and D. J. Maskell. 2003. Bordetella bronchiseptica PagP is a Bvg-regulated lipid A palmitoyl transferase that is required for persistent colonization of the mouse respiratory tract. Mol. Microbiol. 48:725-736.
18. Robey, M., W. O'Connell, and N. P. Cianciotto. 2001. Identification of Legionella pneumophila rcp, a pagP-like gene that confers resistance to cationic antimicrobial peptides and promotes intracellular infection. Infect. Immun. 69:4276-4286.
19. Sandberg, A. L., and A. G. Osler. 1971. Dual pathways of complement interaction with guinea pig immunoglobulins. J. Immunol. 107:1268-1273.
20. Starner, T. D., W. E. Swords, M. A. Apicella, and P. B. McCray, Jr. 2002. Susceptibility of nontypeable Haemophilus influenzae to human β-defensins is influenced by lipooligosaccharide acylation. Infect. Immun. 70:5287-5289.
21. Wiese, A., P. Grunewald, K. J. Schaper, and U. Seydel. 2001. Influence of acyl chain fluidity on the lipopolysaccharide-induced activation of complement. J. Endotoxin Res. 7:147-155.