Influence of 17β-estradiol on the synthesis of reduced neurosteroids in the brain (in vivo) and in glioma cells (in vitro): Possible relevance to mental disorders in women

Brain Research

Volumn 1020, Issue 1-2, 2004, Pages 167-172

  Maayan, Rachel ^a   Fisch, Benjamin ^b   Galdor, Moran ^a   Kaplan, Boris ^b   Shinnar, Nili ^a   Kinor, Noa ^c   Zeldich, Ella ^c   Valevski, Avi ^d   Weizman, Abraham ^a,d  

^a TEL AVIV UNIVERSITY   (Israel)

^b RABIN MEDICAL CENTER   (Israel)

^c BAR ILAN UNIVERSITY   (Israel)

^d GEHA MENTAL HEALTH CENTER   (Israel)

Author keywords

5 Reductase; Allopregnanolone; Endocrine and autonomic regulation; Estradiol; GABAA receptor; Neuroendocrine regulation: other; Neurosteroids; Progesterone

Indexed keywords

20ALPHA DIHYDROPROGESTERONE; ESTRADIOL; NEUROSTEROID; PROGESTERONE; STEROID 5ALPHA REDUCTASE; TETRAHYDROPROGESTERONE; ELTANOLONE; ENZYME INHIBITOR; HORMONE; MESSENGER RNA;

ANIMAL BEHAVIOR; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ESTROGEN BLOOD LEVEL; FEMALE; GLIOMA CELL; MENTAL DISEASE; NONHUMAN; PREGNANCY; PREMENSTRUAL SYNDROME; PRIORITY JOURNAL; RAT; STEROIDOGENESIS; ANALYSIS OF VARIANCE; ANIMAL; BIOSYNTHESIS; BRAIN CORTEX; CELL CULTURE; DRUG EFFECT; GENETICS; GLIOMA; HUMAN; HYPOTHALAMUS; METABOLISM; MOOD DISORDER; MOUSE; NERVE CELL; OXIDATION REDUCTION REACTION; PATHOPHYSIOLOGY; PHYSIOLOGY;

20-ALPHA-DIHYDROPROGESTERONE; ANALYSIS OF VARIANCE; ANIMALS; CEREBRAL CORTEX; ENZYME INHIBITORS; ESTRADIOL; FEMALE; GLIOMA; HORMONES; HUMANS; HYPOTHALAMUS; MICE; MOOD DISORDERS; NEURONS; OXIDATION-REDUCTION; PREGNANOLONE; PROGESTERONE; RATS; RNA, MESSENGER; TESTOSTERONE 5-ALPHA-REDUCTASE; TUMOR CELLS, CULTURED;

EID: 4143121067     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2004.06.025     Document Type: Article

References (49)

1. Attali G., Weizman A., Gil-Ad I., Rehavi M. Opposite modulatory effects of ovarian hormones on rat brain dopamine and serotonin transporters. Brain Res. 756:1997;151-159
2. Baulieu E.E. Neurosteroids: a new function in the brain. Biol. Cell. 71:1991;3-10
3. Bicikova M., Dibbelt L., Hill M., Hampl R., Starka L. Allopregnanolone in women with premenstrual syndrome. Horm. Metab. Res. 30:1998;227-230
4. A receptor. Brain Res. 561:1991;157-161
5. A receptors. J. Neuroendocrinol. 7:1995;171-177
6. Bixo M., Backstrom T. Regional distribution of progesterone and 5α-pregnane-3, 20-dione in rat brain during progesterone-induced "anesthesia" Psychoneuroendocrinology. 15:1990;159-162
7. Bixo M., Backstrom T., Winblad B., Selstane G., Andersson A. Comparison between pre-and postovulatory distribution of estradiol and progesterone in the brain of the PHSG-treated rat. Acta Physiol. Scand. 128:1986;241-246
8. Bloch M., Schmidt P.P., Danaceau M., Murphy J., Nieman L., Rubinow D.R. Effects of gonadal steroids in women with a history of postpartum depression. Am. J. Psychiatry. 157:2000;924-930
9. Brann D.W., Hendry L.B., Mahesh V.B. Emerging diversities in the mechanism of action of steroid hormones. J. Steroid Biochem. Mol. Biol. 52:1995;113-133
10. Brot M.D., Akwa Y., Prudy R.H., Koob G.F., Britton K.T. The anxiolytic-like effects of the neurosteroid allopregnanolone: interaction with GABA(A) receptors. Eur. J. Pharmacol. 325(1):1997;1-7
11. Cheng Y.J., Karavalas H.J. Conversion of progesterone to 5α-pregnane-3, 20-dione and 3α-hydroxy-5α-pregnane-20-one by rat medial basal hypothalami and the effect of estradiol and stage of estrous cycle on the conversion. Endocrinology. 93:1973;1157-1162
12. Chowen J.A., Azcoitia I., Cardona-Gomez G.P., Garcia-Segura M.G. Sex steroids and the brain. J. Endocrinol. Metab. Pediat. 13:2000;1045-1066
13. Compagnone N.A., Mellon S.H. Neurosteroids: biosynthesis and function of these novel neuromodulators. Front. Neuroendocrinol. 21:2000;1-56
14. Concas A., Mostallino M.C., Porcu P., Follesa P., Barbaccia M.L., Trabuccki M., Purdy R.H., Grisenti P., Biggio G. Role of brain allopregnanolone in the plasticity of γ-aminobutyric acid type A receptor in rat brain during pregnancy and after delivery. Proc. Natl. Acad. Sci. U. S. A. 95:1998;13284-13289
15. Corpechot C., Young J., Calvel M., Wehrey C., Veltz J.N., Touyer G., Mouren M., Prasad V.V.K., Banner C., Sjovall J., Baulieu E.E., Robel P. Neurosteroids: 3α-hydroxy-5α-pregnane-20-one and its precursors in the brain, plasma and steroidogenic glands of male and female rats. Endocrinology. 133:1993;1003-1009
16. Epperson C.N., Haga K., Mason G.G., Sellers E., Gueorguieud R., Thang W., Weiss E., Rothmark L., Krystal J.J. Cortical-gamma-aminobutyric acid levels across the menstrual cycle in healthy women and those with premenstrual dysphoric disorder. Arch. Gen. Psychiatry. 59:2002;851-858
17. Finn D., Gee K.W. The influence of estrus cycle on neurosteroid potency at the gamma-aminobutyric acid A receptor complex. J. Pharmacol. Exp. Ther. 265:1993;1374-1379
18. Galea L.A., Wide.J.K., Barr A.M. Estradiol alleviates depressive-like symptoms in a novel animal model of post-partum depression. Behav. Brain Res. 122:2001;1-9
19. Gindler S.S., Straneva P.A., Light K.C., Pedersen C.A., Morrow A.L. Allopregnanolone levels and reactivity to mental stress in premenstrual dysphoric disorder. Biol. Psychiatry. 49:2001;788-797
20. Griffin L.D., Mellon S.H. Selective serotonin reuptake inhibitors directly alter activity of neurosteroidogenic enzymes. Proc. Natl. Acad. Sci. U. S. A. 96:1999;13512-13517
21. Griffin L.D., Conrad S.C., Mellon S.H. Current perspectives on the role of neurosteroids in PMS and depression. Int. Rev. Neurobiol. 46:2001;479-492
22. Guidotti A., Costa E. Can the antidysphoric and anxiolytic profiles of selective serotonin reuptake inhibitors be related to their ability to increase 5-alpha-tetradroprogesterone (allopregnaxolone) availability? Biol. Psychiatry. 44:1998;865-873
23. Halbreich U., Kahn L.S. Role of estrogen in the aetiology and treatment of mood disorders. CNS Drugs. 15:2001;797-817
24. Harrison N.L., Simmonds M.A. Modulation of the GABA receptor complex by a steroid anaesthetic. Brain Res. 323:1984;287-292
25. Herbison A.E. Physiological roles for the neurosteroid allopregnanolone in the modulation of brain function during pregnancy and parturition. Prog. Brain Res. 133:2001;39-47
26. Joffe H., Cohen S. Estrogen, serotonin, and mood disturbance: where is the therapeutic bridge? Biol. Psychiatry. 44:1998;798-811
27. Lofgren M., Backstrom R., Joelsson I. Decrease in serum concentration of 5α-pregnane-3,20 dione prior to spontaneous labor. Acta Obstet. Gynecol. Scand. 67:1998;467-470
28. Luisi S., Petroglia F., Benedeto C., Nappi R.E., Bernard F., Fadalti M., Reis F.M., Luisi M., Genazzani A.R. Serum allopregnanolone level in pregnant women: changes during pregnancy at delivery and in hypertensive patients. J. Clin. Endocrinol. Metab. 84:2000;2429-2433
29. Maggi A., Perez J. Estrogen-induced up-regulation of gamma-aminobutyric acid receptors in the CNS of rodents. J. Neurochem. 47:1986;1793-1797
30. A receptor mechanism of action and physiological significance. Prog. Neurobiol. 38:1992;379-395
31. Majewska M.D., Harrison N.L., Schwartz R.D., Barker J.L., Paul S.M. Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor. Science. 232:1986;1004-1007
32. A receptors during gestation by tetrahydroprogesterone. Eur. J. Pharmacol. 174:1989;43-47
33. A receptor sensitivity in maternal brain: an antecedent of post-partum "blues" Brain Res. 482:1989;397-401
34. Martini L., Celloti F., Melcangi R.C. Testosterone and progesterone metabolism in the central nervous system: cellular localization and mechanism of control of the enzymes involved. Cell. Mol. Neurobiol. 16:1996;271-282
35. Maurice T., Urani A., Phan V.-L., Romieu P. The interaction between neuroactive steroids and σ1 receptor function: behavioral consequences and therapeutic opportunities. Brain Res. Rev. 37:2001;116-132
36. McCauley L.D., Gee K.W. Influence of the estrus cycle on the discrimination of apparent neuroactive steroid site subtypes on the gamma-aminobutyric acid A receptor complex in the rat. J. Pharmacol. Exp. Ther. 275:1995;1412-1417
37. Melcangi R.C., Celloti F., Martini L. Progesterone 5 alpha-reduction in neural and different types of glial cell cultures: type 1 and 2 astrocytes and oligodendrocytes. Brain Res. 639:1994;202-206
38. Melcangi R.C., Cavarretta I., Magnaghi V., Ballabio M., Martini L., Motta M. Crosstalk between normal and tumoral brain cells. Endocrine. 8:1998;65-71
39. Mellon S.H. Special article. Neurosteroid biochemistry: modes of action and clinical relevance. J. Clin. Endocrinol. Metab. 78:1994;1003-1008
40. Mensah-Nyagan A.G., Do-Rego J.L., Luu-The V., Pelletier G., Vaudry H. Neurosteroids: expression of steroidogenic enzymes and regulation of steroid biosynthesis in the central nervous system. Pharmacol. Rev. 51:1999;63-81
41. Moritaa K., Tsuruob Y., Ishimurab K., Herc S., Belle R.A., Wonge D.L. Influence of serum-free culture conditions on steroid 5-reductase mRNA expression in rat C6 glioma cells. Brain Res. 830:1999;179-182
42. Pearlstein T.B., Halbreich U., Batzar E.D., Brown C.S., Endicott J., Frank E., Freeman E.W., Harrison W.M., Haskett R.F., Stout A.L., Yonkers K.A. Psychosocial functioning in women with premenstrual dysphoric disorder before and treatment with sertraline or placebo. J. Clin. Psychiatry. 61:2000;101-109
43. Putnam C.D., Brann D.W., Kolbeck R.C., Mahesh V.B. Inhibition of uterine contractility by progesterone and progesterone metabolites: mediation by progesterone and gamma amino butyric acid A receptor system. Biol. Reprod. 45:1991;266-272
44. Romeo E., Strokle A., Spalletta G., Michele F., Hermann B., Holsboer R., Pasini A., Rupprecht R. Effect of antidepressant treatment on neuroactive steroids in major depression. Am. J. Psychiatry. 155:1998;910-913
45. Schmidt P.J., Nieman L.K., Danaceau M.A., Adams L.F., Rubinow D.R. Differential behavioral effects of gonadal steroids in women with and without premenstrual syndrome. N. Engl. J. Med. 228:1998;209-216
46. Uzunov D.P., Cooper T.B., Costa E., Guidotti A. Fluoxetine-elicited changes in brain neurosteroid content measured by negative ion mass fragmentography. Proc. Natl. Acad. Sci. U. S. A. 93:1996;12599-12604
47. Uzunova V., Skeline Y., Davis J.M., Rasmusson A., Uzunov D.P., Costa E., Guidotti A. Increase in the cerebrospinal fluid content of neurosteroids in patients with unipolar major depression who are receiving fluoxetine or fluvoxamine. Proc. Natl. Acad. Sci. U. S. A. 95:1998;3239-3244
48. Wang M., Seipple L., Purdy R.H., Backstrom T. Relationship between symptom severity and steroid variation in women with premenstrual syndrome: study on serum pregnenolone, pregnenolone sulfate 5α-pregnane-3, 20-dione and 3α-hydroxy-5α-pregnane-20-one. J. Clin. Endocrinol. Metab. 81:1996;1076-1082
49. Wihlback A.C., Sunstrom-Poromaa I., Nyberg S., Backstrom T. Sensitivity to a neurosteroid is increased during addition of progestagen to postmenopausal hormone replacement therapy. Neuroendocrinology. 73:2001;397-407