Sensitivity to a neurosteroid is increased during addition of progestagen to postmenopausal hormone replacement therapy

Neuroendocrinology

Volumn 73, Issue 6, 2001, Pages 397-407

  Wihlbäck, Anna Carin ^a   Sundström Poromaa, Inger ^a   Nyberg, Sigrid ^a   Bäckström, Torbjörn ^a  

^a UMEÅ UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Clinical neuroendocrinology; Gonadal steroids; Hormone replacement therapy; Menopause; Mood; Neuroactive steroids; Saccadic eye velocity; Sedation

Indexed keywords

ELTANOLONE; ESTRADIOL; GESTAGEN; MEDROXYPROGESTERONE ACETATE; NEUROSTEROID; NORETHISTERONE ACETATE; PLACEBO;

ADULT; ARTICLE; CLIMACTERIUM; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; FEMALE; HORMONE RESPONSE; HORMONE SENSITIVITY; HUMAN; LATENT PERIOD; PHARMACODYNAMICS; POSTMENOPAUSE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SACCADIC EYE MOVEMENT; SEDATION;

AFFECT; CLIMACTERIC; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; ESTRADIOL; ESTROGEN REPLACEMENT THERAPY; FEMALE; HUMANS; MEDROXYPROGESTERONE 17-ACETATE; MIDDLE AGED; NORETHINDRONE; PLACEBOS; POSTMENOPAUSE; PREGNANOLONE; PROGESTINS; SACCADES;

EID: 0034935715     PISSN: 00283835     EISSN: None     Source Type: Journal    
DOI: 10.1159/000054658     Document Type: Article

References (60)

1. Effect on bone mass after eight years of hormonal replacement therapy
2. Estrogen replacement therapy and coronary heart disease: A quantitative assessment of the epidemiologic evidence
3. Estrogen deficiency and risk of Alzheimer's disease in women
4. Effects of hormonal replacement therapy on the postural balance among postmenopausal women
5. Estrogen effects on cognition in menopausal women
6. Drug related negative side-effects is a common reason for poor compliance in hormone replacement therapy
7. Cyclical mood changes as in the premenstrual tension syndrome during sequential estrogen-progestagen postmenopausal replacement treatment
8. The effect of norethisterone in postmenopausal women on oestrogen therapy: A model for the premenstrual syndrome
9. Progesterone intolerance and compliance with hormone replacement therapy in menopausal women
10. A meta-analysis of the effect of hormone replacement therapy upon depressed mood
11. Negative mood changes during hormone replacement therapy: A comparison between two progestogens
12. Neuroactive steroids
13. Pregnanolone emulsion: A preliminary pharmacokinetic and pharmacodynamic study of a new intravenous anaesthetic agent
14. The effect of progesterone and its metabolites on the interictal epileptiform discharge in the cat's cerebral cortex
15. Anxiolytic activity of the progesterone metabolite 5α-pregnan-3α-ol-20-one
16. Orally administered progesterone enhances sensitivity to triazolam in postmenopausal women
17. Reduced benzodiazepine sensitivity in patients with premenstrual syndrome, a pilot study
18. Relationship between the anestetic and gestagenic action and estrus behaviour-inducing activity of different progestins
19. A-ring reduced derivatives of two synthetic progestins induce anxiolytic effects in ovariectomized rats
20. Benzodiazepine sensitivity in normal human subjects
21. Pharmacology of saccadic eye movements in man. 1. Effects of the benzodiazepine receptor ligands midazolam and flumenazil
22. Further properties of the human saccadic system: Eye movements and correction saccades with and without visual fixation points
23. The pharmacology of saccadic eye movements
24. Patients with premenstrual syndrome have reduced sensitivity to midazolam compared to control subjects
25. Patients with premenstrual syndrome have a different sensitivity to a neuroactive steroid during the menstrual cycle compared to control subjects
26. Utility of a new procedure for diagnosing mental disorders in primary care
27. Treatment of premenstrual syndrome with gonadotropin-releasing hormone agonist in a low dose regimen
28. Effect of benzodiazepines upon saccadic eye movements in man
29. A microcomputer system to assess CNS depression from the analysis of the dynamics of saccadic eye movements
30. An IBM-based system for the generation, collection and analysis of saccadic and smooth pursuit eye movements
31. Quantitative measurement of saccade amplitude, duration, and velocity
32. Benzodiazepine pharmacodynamics: Utility of eye movement measures
33. Thyrotropin-releasing hormone selectively reverse lorazepam-induced sedation but not slowing of saccadic eye movements
34. Effects of diphenhydramine on human eye movements
35. A receptor stimulation during the oestrus cycle of the rat
36. Ovarian endocrine status modulates the anxiolytic potency of diazepam and the efficacy of gamma-aminobutyric acid-benzodiazepine receptor-mediated chloride ion transport
37. A receptor function
38. A receptors in specific brain regions by ovarian hormones
39. A-receptor sensitivity in maternal brain: An antecedent of post-partum blues?
40. Acute effects of triazolam in women: Relationships with progesterone, estradiol and allopregnanolone
41. Influence of endogenous progesterone on alprazolam pharmacodynamics
42. Effects of triazolam at three phases of the menstrual cycle
43. 4 subunit suppression prevents withdrawal properties of an endogenous steroid
44. Progesterone withdrawal. I. Pro-convulsant effects
45. Citalopram increases pregnanolone sensitivity in patients with premenstrual syndrome: An open trial
46. A-receptors
47. Effect of progesterone and its 5alpha and 5beta metabolites on symptoms of premenstrual syndrome according to route of administration
48. Ineffectiveness of progesterone suppository treatment for premenstrual syndrome
49. Premenstrual syndrome: A double-blind controlled trial of progesterone and placebo
50. A double-blind placebo-controlled trial of progesterone vaginal suppositories in the treatment of premenstrual syndrome
51. Progesterone treatment of premenstrual tension - A double blind study
52. Progesterone and the premenstrual syndrome: A double blind crossover trial
53. Neurosteroids and reward: Allopregnanolone conditioned place aversion in rats
54. Circulating levels of allopregnanolone in humans: Gender, age and endocrine influences
55. Effects of antidepressant treatment on neuroactive steroids in major depression
56. Estrogen improves psychological function in asymptomatic postmenopausal women
57. Oestrogen therapy and the menopausal syndrome
58. Estrogen replacement in perimenopause-related depression: A preliminary report
59. Estrogen replacement and response to fluoxetine in a multicenter geriatric depression trial: Fluoxetine Collaborative Study Group
60. Lack of efficacy of estrogen supplementation to imipramine in resistant female depressives