Analysis of vascular endothelial growth factor (VEGF) and a receptor subtype (KDR/flk-1) in the liver of rats exposed to riddelliine: A potential role in the development of hemangiosarcoma

Experimental and Toxicologic Pathology

Volumn 55, Issue 6, 2004, Pages 455-465

  Moyer, C ^a   Allen, D ^a   Basabe, A ^a   Maronpot, R R ^b   Nyska, A ^b  

^a A Charles River Company   (United States)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Cytotoxicity; Endothelium; Hemangiosarcoma; Immunohistochemistry; In situ hybridization; KDR flk 1; Pyrrolizidine alkaloid; Vascular endothelial growth factor; VEGFR 2

Indexed keywords

MESSENGER RNA; PLANT EXTRACT; PYRROLIZIDINE ALKALOID; RIDDELLINE; TYROSINE; UNCLASSIFIED DRUG; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 2;

ANGIOSARCOMA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE DUCT; CARCINOGENESIS; CELL FUNCTION; CELL HYPERPLASIA; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; ENZYME SYNTHESIS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; LIVER CELL; LIVER LEVEL; LIVER SARCOMA; MALE; NONHUMAN; PROTEIN SYNTHESIS; QUALITATIVE ANALYSIS; RAT;

ANIMALIA;

EID: 4143086208     PISSN: 09402993     EISSN: None     Source Type: Journal    
DOI: 10.1078/0940-2993-00344     Document Type: Article

References (34)

1. ARBISER JL, LARSSON H, CLAESSON-WELSH L, et al.: Over-expression of VEGF 121 in immortalized endothelial cells causes conversion to slowly growing angiosarcoma and high level expression of the VEGF receptors VEGFR-1 and VEGFR-2 in vivo. Am J Pathol 2000; 156: 1469-1476.
2. BROWN, LF, TOGNAZZI, K, DVORAK, HF, et al.: Strong expression of kinase insert domain-containing receptor, a vascular permeability factor/vascular endothelial growth factor receptor in AIDS-associated Kaposi's sarcoma and cutaneous angiosarcoma. Am J Pathol 1996; 148: 1065-1074.
3. CARMELIET P: VEGF gene therapy: stimulating angiogenesis or angioma-genesis? Nat Med 2000; 6: 1102-1103.
4. CHAN PC, HASEMAN JK, PREJEAN JD, et al.: Toxicity and carcinogenicity of riddelliine in rats and mice. Toxicol Lett 2003; 144: 295-311.
5. CHAN PC, MAHLER J, BUCHER JR, et al.: Toxicity and carcinogenicity of riddelliine following 13 weeks of treatment to rats and mice. Toxicon 1994; 32: 891-908.
6. CLAFFEY KP, BROWN LF, DEL AGUILA LF, et al.: Expression of vascular permeability factor/vascular endothelial growth factor by melanoma cells increases tumor growth, angiogenesis, and experimental metastasis. Cancer Res 1996; 56: 172-181.
7. COPPLE BL, BANES A, GANEY PE, et al.: Endothelial cell injury and fibrin deposition in rat liver after monocrotaline exposure. Toxicol Sci 2002; 65: 309-318.
8. DOUGHER M, TERMAN BI: Autophosphorylation of KDR in the kinase domain is required for maximal VEGF-stimulated kinase activity and receptor internalization. Oncogene 1999; 18: 1619-1627.
9. DAYANIR V, MEYER RD, LASHKARI K, et al.: Identification of tyrosine residues in vascular endothelial growth factor receptor-2/flk-1 involved in activation of phosphatidylinositol 3-kinase and cell proliferation. J Biol Chem 2001; 276: 17686-17692.
10. EVANS JG, BRIAN GL: The digestive system. II: The hepatobioliary system. In Target Organ Pathology (Hoosen J, Turton JA, eds.), pp. 61-97. Taylor & Francis, London 1997.
11. FURNUS CC, INDA AM, ANDRINI LB, et al.: Chronobiology of the proliferative events related to angiogenesis in mice liver regeneration after partial hepatectomy. Cell Biol Int 2003; 27: 383-386.
12. GERBER HP, McMURTREY A, KOWALSKI J, et al.: Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol-3- kinase/Akt signal transduction pathway: requirement for flk-1/kdr activation. J Biol Chem 1998; 273: 30336-30343.
13. GILLE H, KOWALSKI J, LI B, et al.: Analysis of biological effects and signaling properties of Flt-1 (VEGFR-1) and KDR (VEGFR-2). A reassessment using novel receptor-specific vascular endothelial growth factor mutants. J Biol Chem 2001; 276: 3222-3230.
14. HATVA E, BOHLING T, JAASKELAINEN J, et al.: Vascular growth factors and receptors in capillary hemangioblastomas and hemangiopericytomas. Am J Path 1996; 148: 763-775.
15. HERMAN JR, DETHLOFF LA, McGUIRE EJ, et al.: Rodent carcinogenicity with the thiazolidinedione antidiabetic agent troglitazone. Tox Sci 2002; 68: 226-236.
16. Hsu SM, RAINE L: Protein A, avidin and biotin in immunohistochemistry. J Histochem Cytochem 1981; 29: 1349-1353.
17. LALICH JL, JOHNSON WD, RACZNIAK TJ, et al.: Fibrin thrombosis in monocrotaline pyrrole-induced cor pulmonale in rats. Arch Pathol Lab Med 1997; 101: 69-73.
18. LEE RJ, SPRINGER ML, BLANCO-BOSE WE, et al.: VEGF gene delivery to myocardium: deleterious effects of unregulated expression. Circulation 2000; 102: 898-901.
19. MILLAUER B, WIZIGMANN-VOOS S, SCHNURCH H, et al.: High affinity VEGF binding and developmental expression suggest flk-1 as a major regulator of vasculogenesis and angiogenesis. Cell 1993; 72: 835-846.
20. MIRSALIS JC, STEINMETZ KL, BLAZAK WF, et al.: Evaluation of the potential of riddelliine to induce unscheduled DNA synthesis, S-phase synthesis, or micronuclei following in vivo treatment with multiple doses. Environ. Mol. Mutagen. 1993; 21: 265-271.
21. MOCHIDA S, ISHIKAWA K, TOSHIMA K, et al.: The mechanisms of hepatic sinusoidal endothelial cell regeneration: a possible communication system associated with vascular endothelial growth factor in liver cells. J Gastroenterol Hepatol 1998; 13 Suppl: S1-5.
22. MOLYNEUX RJ, JOHNSON AE, ROITMAN JN, et al.: Chemistry of toxic range plants. Determination of pyrrolizidine alkaloid content and composition in Senecio species by nuclear magnetic resonance spectroscopy. J Agric Food Chem 1979; 27: 494-499.
23. MOLYNEUX RJ, JOHNSON AE, OLSEN JD, et al.: Toxicity of pyrrolizidine alkaloids from Riddell groundsel (Senecio riddellii) to cattle. Am J Vet Res 1991; 52: 146-151.
24. NATIONAL TOXICOLOGY PROGRAM: Toxicology and Carcinogenesis Studies of Riddelliine (CAS No. 23246-96-0) in F344/N Rats and B6C3F1 Mice (Gavage Studies). Board Draft, Technical Report 508, Public Health Service, U.S. Dept. of Health and Human Services, Bethesda, MD, 2001.
25. NYSKA A, MOOMAW CR, FOLEY JF, et al.: The hepatic endothelial carcinogen riddelliine induces endothelial apoptosis, mitosis, S phase, p53, and hepatocytic vascular endothelial growth factor expression after short-term exposure. Toxicol. Appl Pharmacol 2002; 183: 153-164.
26. ORTEGA N, HUTCHINGS H: Signal relays in the VEGF system. Front Biosci 1999; 4: 141-152.
27. PLATE KH, BREIER G, MILLAUER B, et al.: Up-regulation of vascular endothelial growth factor and its cognate receptors in a rat glioma model of tumor angiogenesis. Cancer Res 1993; 53: 5822-5827.
28. REINDEL JF, ROTH RA: The effects of monocrotaline pyrrole on cultured bovine pulmonary artery endothelial and smooth muscle cells. Am J Pathol 1991; 138: 707-719.
29. ROSMORDUC O, WENDUM D, CORPECHOT C, et al.: Hepatocellular hypoxia-induced vascular endothelial growth factor expression and angiogenesis in experimental biliary cirrhosis. Am J Pathol 1999; 155: 1065-1073.
30. STRAUME O, AKSLEN LA: Expression of vascular endothelial growth factor, its receptors (flt-1, kdr) and TSP-1 related to microvessel density and patient outcome in vertical growth phase melanomas. Am J Path 2001; 159: 223-235.
31. WILLIAMS L, CHOU MW, YAN J, et al.: Toxicokinetics of riddelliine, a carcinogenic pyrrolizidine alkaloid, and metabolites in rats and mice. Toxicol Appl Pharmacol 2002; 182: 98-104.
32. YANG YC, YAN J, DOERGE DR, et al.: Metabolic activation of the tumorigenic pyrrolizidine alkaloid, riddelliine, leading to DNA adduct formation in vivo. Chem Res Toxicol 2001; 14: 101-109.
33. ZENG H, DVORAK HF, MUKHOPADHYAY D: Vascular permeability factor (VPF)/vascular endothelial growth factor (VEGF) receptor-1 down-modulates VPF/VEGF receptor-2-mediated endothelial cell proliferation, but not migration, through phosphatidylinositol 3-kinase-dependent pathways. J Biol Chem 2001a; 276: 26969-26979.
34. ZENG H, SANYAL S, MUKHOPADHYAY D: Tyrosine residues 951 and 1059 of vascular endothelial growth factor receptor-2 (KDR) are essential for vascular permeability factor/vascular endothelial growth factor-induced endothelium migration and proliferation, respectively. J Biol Chem 2001b; 276: 32714-32719.