Electron transfer in flavocytochrome P450 BM3: Kinetics of flavin reduction and oxidation, the role of cysteine 999, and relationships with mammalian cytochrome P450 reductase

Biochemistry

Volumn 42, Issue 36, 2003, Pages 10809-10821

  Roitel, Olivier ^a   Scrutton, Nigel S ^a   Munro, Andrew W ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

STEADY-STATE KINETICS;

BINDING ENERGY; CHARGE TRANSFER; MUTAGENESIS; REACTION KINETICS; THERMODYNAMICS;

ENZYME KINETICS;

CYSTEINE; CYTOCHROME P450 REDUCTASE; FLAVINE ADENINE NUCLEOTIDE; FLAVINE MONONUCLEOTIDE; LACTATE DEHYDROGENASE (CYTOCHROME); QUERCETIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

ARTICLE; BINDING SITE; CATALYSIS; COMPLEX FORMATION; ELECTRON TRANSPORT; ENZYME KINETICS; ENZYME LOCALIZATION; OXIDATION REDUCTION REACTION; POTENTIOMETRY; PRIORITY JOURNAL; STEADY STATE; THERMODYNAMICS; TRANSPORT KINETICS;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; BACTERIAL PROTEINS; BINDING SITES; CYSTEINE; CYTOCHROME P-450 ENZYME SYSTEM; ESCHERICHIA COLI PROTEINS; FLAVIN-ADENINE DINUCLEOTIDE; FLAVINS; HUMANS; KINETICS; MIXED FUNCTION OXYGENASES; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NADP; NADPH-FERRIHEMOPROTEIN REDUCTASE; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SPECTROPHOTOMETRY;

MAMMALIA;

EID: 0042819974     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi034562h     Document Type: Article

References (41)

1. Munro, A. W., and Lindsay, J. G. (1996) Mol. Microbiol. 20, 1115-1125.
2. Iyanagi, T., and Mason, H. S. (1973) Biochemistry 12, 2297-2308.
3. Wang, M., Roberts, D. L., Paschke, R., Shea, T. M., Masters, B. S. S., and Kim, J.-J. P. (1997) Proc. Natl. Acad. Sci. U.S.A. 94, 8411-8416.
4. Narhi, L. O., and Fulco, A. J. (1987) J. Biol. Chem. 262, 6683-6690.
5. Narhi, L. O., Wen, L. P., and Fulco, A. J. (1988) Mol. Cell. Biochem. 79, 63-71.
6. Noble, M. A., Miles, C. S., Chapman, S. K., Lysek, D. A., Mackay, A. C., Reid, G. A., Hanzlik, R. P., and Munro, A. W. (1999) Biochem. J. 339, 371-379.
7. Ravichandran, K. G., Boddupalli, S. S., Hasemann, C. A., Peterson, J. A., and Deisenhofer, J. (1993) Science 261,731-736.
8. Li, H. Y., and Poulos, T. L. (1997) Nat. Struct. Biol. 4, 140-146.
9. Ost, T. W. B., Miles, C. S., Munro, A. W., Murdoch, l., Reid, G. A., and Chapman, S. K. (2001) Biochemistry 40, 13421-13429.
10. Leclerc, D., Wilson, A., Dumas, R., Gafuik, C., Song, D., Watkins, D., Heng, H. H., Rommens, J. M., Scherer, S. W., Rosenblatt, D. S., and Gravel, R. A. (1998) Proc. Natl. Acad. Sci. U.S.A. 95, 3059-3064.
11. Griffith, O. W., and Stuehr, D. J. (1995) Annu. Rev. Physiol. 57, 707-736.
12. Paine, M. J. I., Garner, A. P., Powell, D., Sibbald, J., Sales, M., Pratt, N., Smith, T., Tew, D. G., and Wolf, C. R. (2000) J. Biol. Chem. 275, 1471-1478.
13. Munro, A. W., Noble, M. A., Robledo, L., Daff, S., and Chapman, S. K. (2001) Biochemistry 40, 1956-1963.
14. Iyanagi, T., Makino, N., and Mason, H. S. (1974) Biochemistry 13, 1701-1710.
15. Daff, S. N., Chapman, S. K., Turner, K. L., Holt, R. A., Govindaraj, S., Poulos, T. L., and Munro, A. W. (1997) Biochemistry 36, 13816-13823.
16. Wolthers, K., Basran, J., Munro, A. W., and Scrutton, N. S. (2003) Biochemistry 42, 3911-3920.
17. Finn, R. D., Basran, J., Roitel, O., Wolf, C. R., Munro, A. W., Paine, M. J. I., and Scrutton, N. S. (2003) Eur. J. Biochem. 270, 1164-1175.
18. Munro, A. W., Daff, S., Coggins, J. R., Lindsay, J. G., and Chapman, S. K. (1996) Eun J. Biochem. 239, 403-409.
19. Guengerich, F. P., and Johnson, W. W. (1997) Biochemistry 36, 14741-14750
20. Gutierrez, A., Lian, L.-Y., Wolf, C. R., Scrutton, N. S., and Roberts, G. C. K. (2001) Biochemistry 40, 1964-1975.
21. Shen, A. L., Sem, D. S., and Kasper, C. B. (1999) J. Biol. Chem. 274, 5391-5398.
22. Govindaraj, S., and Poulos, T. L. (1997) J. Biol. Chem. 272, 7915-7921.
23. Miles, J. S., Munro, A. W., Rospendowski, B, N., Smith, W. E., McKnight, J., and Thomson, A. J. (1992) Biochem. J, 288, 503-509.
24. Daff, S., Sharp, R. E., Short, D. M. Bell, C., White, P., Manson, F. D. C., Reid, G. A., and Chapman, S. K. (1996) Biochemistry 35, 6351-6357.
25. Dutton, P. L. (1978) Methods Enymol. 54, 411-435.
26. Murataliev, M. B., and Feyereisen, R. (1997) Biochemistry 36, 8401-8412.
27. Lee, H. J., Basran, J., and Scrutton, N. S. (1998) Biochemistry 37, 15503-15512.
28. Knight, K., and Scrutton, N. S. (2002) Biochern. J. 367, 19-30.
29. McLean, K. J., Scrutton, N. S., and Munro, A. W. (2003) Biochem. J. 372, 317-327.
30. Gutierrez, A., Paine, M., Wolf, C. R., Scrutton, N. S., and Roberts, G. C. K. (2002) Biochemistry 41, 4626-4637.
31. Stuehr, D. J. (1999) Biochim. Biophys. Acta 1411, 217-230.
32. Munro, A. W., Leys, D. G., McLean, K. J., Marshall, K. R., Ost, T. W. B., Daft, S., Miles, C. S., Chapman, S. K., Lysek, D. A., Moser, C. C., Page, C. C., and Dutton, P. L. (2002) Trends Biochem. Sci. 27, 250-257.
33. Lee, T.-R., Hsu, H.-P., and Shaw, G.-C. (2001) J. Biochem. 130, 569-574.
34. Ralstonia metallidurans homepage at the DOE microbial genomes web site: http://www.jgi.doe.gov/JGI_microbial/html/ralstonia/ralston_homepage.html.
35. Noble, M. A., Munro, A. W., Rivers, S. L., Robledo, L., Daff, S.N, Yellowlees, L. J., Shimizu, T., Sagami, I., Guillemette, J. G., and Chapman, S. K. (1999) Biochemistry 38, 16413-16418.
36. Murataliev, M. B., and Feyereisen, R. (2000) Biochemistry 39, 12699-12707.
37. Murataliev, M. B., and Feyereisen, R. (2000) Biochemistry 39, 5066-5074.
38. Sem, D. S., and Kasper, C. B. (1993) Biochemistry 32, 11539- 11547.
39. Sem, D. S., and Kasper, C. B. (1993) Biochemistry 32, 11548-11558.
40. Hubbard, P. A., Shen, A. L., Paschke, R., Kasper, C. B., and Kim, J.-J. P. (2001) J. Biol. Chem. 276, 29163-29170.
41. Bhattacharyya, A. K., Lipka, J. J., Waskell, L., and Tollin, G. (1991) Biochemistry 30, 259-265.