Single nucleotide polymorphisms in inflammation-related genes and mortality in a community-based cohort in Washington County, Maryland

American Journal of Epidemiology

Volumn 167, Issue 7, 2008, Pages 807-813

  Gallicchio, Lisa ^a,b   Chang, Howard ^b   Christo, Dana K ^b   Thuita, Lucy ^b   Huang, Han Yao ^b   Strickland, Paul ^b   Ruczinski, Ingo ^b   Hoffman, Sandra C ^b   Helzlsouer, Kathy J ^a,b  

^a MERCY MEDICAL CENTER   (United States)

^b JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

C reactive protein; Cohort studies; Inflammation; Mortality; Neoplasms; Polymorphism, genetic

Indexed keywords

C REACTIVE PROTEIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GAMMA INTERFERON; LYMPHOTOXIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; TUMOR NECROSIS FACTOR ALPHA;

COHORT ANALYSIS; DATA SET; DNA; ENZYME ACTIVITY; GENE; GENOTYPE; MOLECULAR ANALYSIS; MORTALITY; PROTEIN; SERUM; TUMOR;

ADULT; AGED; ARTICLE; BLOOD SAMPLING; CAUSE OF DEATH; COHORT ANALYSIS; CONTROLLED STUDY; CORRELATION ANALYSIS; DNA EXTRACTION; FEMALE; FOLLOW UP; GENOTYPE; HUMAN; INFLAMMATION; MAJOR CLINICAL STUDY; MALE; MORTALITY; OUTCOME ASSESSMENT; PROTEIN BLOOD LEVEL; SINGLE NUCLEOTIDE POLYMORPHISM; UNITED STATES;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; C-REACTIVE PROTEIN; CARDIOVASCULAR DISEASES; CHILD; CHILD, PRESCHOOL; FEMALE; GENOTYPE; HUMANS; INFLAMMATION; LOGISTIC MODELS; MALE; MARYLAND; MIDDLE AGED; MORTALITY; POLYMORPHISM, SINGLE NUCLEOTIDE; QUESTIONNAIRES;

NORTH AMERICA; UNITED STATES; WASHINGTON [UNITED STATES];

EID: 41349119584     PISSN: 00029262     EISSN: 14766256     Source Type: Journal    
DOI: 10.1093/aje/kwm378     Document Type: Article

References (37)

1. Salvioli S, Capri M, Valensin S, et al. Inflamm-aging, cytokines and aging: state of the art, new hypotheses on the role of mitochondria and new perspectives from systems biology. Curr Pharm Des 2006;12:3161-71.
2. Capri M, Salvioli S, Sevini F, et al. The genetics of human longevity. Ann N Y Acad Sci 2006;106:252-63.
3. Cesari M, Penninx BW, Newman AB, et al. Inflammatory markers and onset of cardiovascular events: results from the Health ABC Study. Circulation 2003;108:2317-22.
4. Vasan RS, Sullivan LM, Roubenoff R, et al. Inflammatory markers and risk of heart failure in elderly subjects without prior myocardial infarction: the Framingham Heart Study. Circulation 2003;107:1486-91.
5. Ridker PM, Rifai N, Stampfer MJ, et al. Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men. Circulation 2000;101:1767-72.
6. Ridker PM, Hennekens CH, Buring JE, et al. C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N Engl J Med 2000;342:836-43.
7. Volpato S, Guralnik JM, Ferrucci L, et al. Cardiovascular disease, interleukin-6, and risk of mortality in older women: the Women's Health and Aging Study. Circulation 2001;103:947-53.
8. Helzlsouer KJ, Erlinger TP, Platz EA. C-reactive protein levels and subsequent cancer outcomes: results from a prospective cohort study. Eur J Cancer 2006;42:704-7.
9. McSorley MA, Alberg AJ, Allen DS, et al. C-reactive protein concentrations and subsequent ovarian cancer risk. Obstet Gynecol 2007;109:933-41.
10. Solomon DH, Curhan GC, Rimm EB, et al. Cardiovascular risk factors in women with and without rheumatoid arthritis. Arthritis Rheum 2004;50:3444-9.
11. Wang Q, Hunt SC, Xu Q, et al. Association study of CRP gene polymorphisms with serum CRP level and cardiovascular risk in the NHLBI Family Heart Study. Am J Physiol Heart Circ Physiol 2006;291:H2752-7.
12. Brull DJ, Serrano N, Zito F, et al. Human CRP gene polymorphism influences CRP levels: implications for the prediction and pathogenesis of coronary heart disease. Arterioscler Thromb Vasc Biol 2003;23:2063-9.
13. Carlson CS, Aldred SF, Lee PK, et al. Polymorphisms within the C-reactive protein (CRP) promoter region are associated with plasma CRP levels. Am J Hum Genet 2005;77:64-77.
14. Kathiresan S, Larson MG, Vasan RS, et al. Contribution of clinical correlates and 13 C-reactive protein gene polymorphisms to interindividual variability in serum C-reactive protein level. Circulation 2006;113:1415-23.
15. Lange LA, Carlson CS, Hindorff LA, et al. Association of polymorphisms in the CRP gene with circulating C-reactive protein levels and cardiovascular events. JAMA 2006;296:2703-11.
16. Russell AI, Cunninghame Graham DS, Shepherd C, et al. Polymorphism at the C-reactive protein locus influences gene expression and predisposes to systemic lupus erythematosus. Hum Mol Genet 2004;13:137-47.
17. Suk HJ, Ridker PM, Cook NR, et al. Relation of polymorphism within the C-reactive protein gene and plasma CRP levels. Atherosclerosis 2005;178:139-45.
18. Szalai AJ, McCrory MA, Cooper GS, et al. Association between baseline levels of C-reactive protein (CRP) and a dinucleotide repeat polymorphism in the intron of the CRP gene. Genes Immun 2002;3:14-19.
19. Zee RY, Ridker PM. Polymorphism in the human C-reactive protein (CRP) gene, plasma concentrations of CRP, and the risk of future arterial thrombosis. Atherosclerosis 2002;162:217-19.
20. Miller DT, Zee RY, Suk DJ, et al. Association of common CRP gene variants with CRP levels and cardiovascular events. Ann Hum Genet 2005;69:623-38.
21. Crawford DC, Sanders CL, Qin X, et al. Genetic variation is associated with C-reactive protein levels in the Third National Health and Nutrition Examination Survey. Circulation 2006;114:2458-65.
22. Kardys I, Knetsch AM, Bleumink GS, et al. C-reactive protein and risk of heart failure. The Rotterdam Study. Am Heart J 2006;152:514-20.
23. Kovacs A, Green F, Hansson LO, et al. A novel common single nucleotide polymorphism in the promoter region of the C-reactive protein gene associated with the plasma concentration of C-reactive protein. Atherosclerosis 2005;178:193-8.
24. Obisesan TO, Leeuwenburgh C, Phillips T, et al. C-reactive protein genotypes affect baseline, but not exercise training-induced changes, in C-reactive protein levels. Arterioscler Thromb Vasc Biol 2004;24:1874-9.
25. Rea IM, Ross OA, Armstrong M, et al. Interleukin-6-gene C/G 174 polymorphism in nonagenarian and octogenarian subjects in the BELFAST Study. Reciprocal effects on IL-6, soluble IL-6 receptor and for IL-10 in serum and monocyte supernatants. Mech Ageing Dev 2003;124:555-61.
26. Lio D, Scola L, Crivello A, et al. Gender-specific association between -1082 IL-10 promoter polymorphism and longevity. Genes Immun 2002;3:30-3.
27. Bonafe M, Olivieri F, Cavallone L, et al. A gender-dependent genetic predisposition to produce high levels of IL-6 is detrimental for longevity. Eur J Immunol 2001;31:2357-61.
28. 915 polymorphism of transforming growth factor beta1 is associated with human longevity: a study in Italian centenarians. Aging Cell 2004;3:443-8.
29. Genkinger JM, Platz EA, Hoffman SC, et al. C47T polymorphism in manganese superoxide dismutase (MnSOD), antioxidant intake and survival. Mech Ageing Dev 2006;127:371-7.
30. Klintschar M, Neuhuber F. Evaluation of an alkaline lysis method for the extraction of DNA from whole blood and forensic stains for STR analysis. J Forensic Sci 2000;45:669-73.
31. Huang HY, Thuita L, Strickland P, et al. Frequencies of single nucleotide polymorphisms in genes regulating inflammatory responses in a community-based population. (Electronic article). BMC Genet 2007;8:7.
32. Rubin DB. Inference and missing data. Biometrika 1976;63:581-92.
33. Kooperberg C, Ruczinski I, LeBlanc ML, et al. Sequence analysis using logic regression. Genet Epidemiol 2001;21(suppl):S626-31.
34. Ruczinski I, Kooperberg C, LeBlanc ML. Logic regression. J Comput Graph Stat 2003;12:475-511.
35. De Martinis M, Franceschi C, Monti D, et al. Inflammation markers predicting frailty and mortality in the elderly. Exp Mol Pathol 2006;80:219-27.
36. Licastro F, Grimaldi LM, Bonafe M, et al. Interleukin-6 gene alleles affect the risk of Alzheimer's disease and levels of the cytokine in blood and brain. Neurobiol Aging 2003;24:921-6.
37. Franceschi C, Valensin S, Lescai F, et al. Neuroinflammation and the genetics of Alzheimer's disease: the search for a proinflammatory phenotype. Aging (Milano) 2001;13:163-70.