Immunity in the absence of CD28 and CD137 (4-1BB) molecules

Immunology and Cell Biology

Volumn 81, Issue 3, 2003, Pages 176-184

  Vinay, Dass S ^a   Wolisi, Godwin O ^b   Yu, Kang Y ^b   Choi, Beom K ^c   Kwon, Byoung S ^a,c  

^a LA State University Eye Center   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c University of Ulsan   (South Korea)

Author keywords

4 1BB; CD28; Costimulation

Indexed keywords

ALLERGEN; CD137 ANTIGEN; CD28 ANTIGEN; CD3 ANTIGEN; CONCANAVALIN A; IMMUNOGLOBULIN A; IMMUNOGLOBULIN CLASS; IMMUNOGLOBULIN G2A; IMMUNOGLOBULIN G2B; INTERLEUKIN 2; T LYMPHOCYTE ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN DETECTION; ANTIGEN SPECIFICITY; ARTICLE; CELL PROLIFERATION; CELL SPECIFICITY; CELL VIABILITY; CONTACT SENSITIVITY; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; EAR; FEMALE; FERTILITY; GENE MUTATION; GENE REARRANGEMENT; IMMUNE DEFICIENCY; IMMUNITY; IMMUNOREGULATION; MOUSE; NONHUMAN; PHENOTYPE; SPLEEN; T LYMPHOCYTE; THICKNESS; THYMUS; VESICULAR STOMATITIS VIRUS; VIRUS NEUTRALIZATION; VIRUS PLAQUE; VIRUS STRAIN; WILD TYPE;

ANIMALS; ANTIBODY FORMATION; ANTIGENS, CD; ANTIGENS, CD137; ANTIGENS, CD28; DERMATITIS, CONTACT; FEMALE; IMMUNITY, CELLULAR; IMMUNOGLOBULIN CLASS SWITCHING; INTERLEUKIN-2; LYMPHOCYTE ACTIVATION; LYMPHOCYTE CULTURE TEST, MIXED; MICE; MICE, MUTANT STRAINS; RECEPTORS, NERVE GROWTH FACTOR; RECEPTORS, TUMOR NECROSIS FACTOR; T-LYMPHOCYTES;

ANIMALIA; VESICULAR STOMATITIS VIRUS;

EID: 0037680240     PISSN: 08189641     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1440-1711.2003.01153.x     Document Type: Article

References (52)

1. Mueller DL, Jenkins MK, Schwartz RH. Clonal expansion versus functional clonal inactivation: a costimulatory signalling pathway determines the out come of T cell antigen receptor occupancy. Annu. Rev. Immunol. 1989; 7: 445-80.
2. June CH, Bluestone JA, Nadler LM, Thompson CB. The B7 and CD28 receptor families. Immunol. Today 1994; 15: 321-31.
3. Bluestone JA. New perspectives of CD28-B7-mediated T cell costimulation. Immunity 1995; 2: 555-9.
4. King CL, Stupi RJ, Craighead N, June CH, Thyphronitis G. CD28 activation promotes Th2 subset differentiation by human CD4+ cells. Eur. J. Immunol. 1997; 25: 587-5.
5. Palme EM, van Seventer GA. Human T helper cell differentiation is regulated by the combined action of cytokines and accessory cell-dependent costimulatory signals. J. Immunol. 1997; 158: 2654-2.
6. Linsley PS, Wallace PM, Johnson J et al. Immunosuppression in vivo by a soluble form of the CTLA-4 T cell activation molecule. Science 1992; 257: 792-5.
7. Tan P, Anasetti C, Hansen JA et al. Induction of alloantigen-specific hyporesponsiveness in human T lymphocytes by blocking interaction of CD28 with its natural ligand B7/BB1. J. Exp. Med. 1993; 177: 165-3.
8. Saha B, Harlan DM, Lee KP, June CH, Abe R. Protection against lethal toxic shock by targeted disruption of the CD28 gene. J. Exp. Med. 1996; 183: 2675-80.
9. Tada Y, Nagasawa K, Ho A et al. CD28-deficent mice are highly resistant to collagen-induced arthritis. J. Immunol. 1998; 162: 203-8.
10. Palmer LD, Saha B, Hodes RJ, Abe R. The role of CD28 costimulation in immune-mediated responses against mouse mammary tumor viruses. J. Immunol. 1996; 156: 2112-18.
11. Mittrucker HW, Shahnian A, Bouchard D, Kundig TM, Mak TW. Induction of unresponsiveness and impaired T cell expansion by staphylococcal enterotoxin B in CD28-deficient mice. J. Exp. Med. 1996; 183: 2481-8.
12. Lenschow DJ, Walunas TL, Bluestone JA. CD28/B7 system of T cell costimulation. Annu. Rev. Immunol. 1996; 14: 233-8.
13. Gause WC, Chen SJ, Greenwald RJ et al. CD28 dependence of T cell differentiation to IL-4 production varies with the particular type-2 immune response. J. Immunol. 1997; 158: 4082-7.
14. Kawai K, Shahnian A, Mak TW, Ohashi PS. Skin allograft rejection in CD28-deficient mice. Transplantation 1996; 61: 352-5.
15. Saoulli K, Lee SY, Cannons JL et al. CD28-independent, TRAF2-dependent costimulation of resting T cells by 4-1BB ligand. J. Exp. Med. 1988; 187: 1849-62.
16. Watts TH, DeBenedette MA. T cell costimulatory molecules other than CD28. Curr. Opin. Immunol. 1999; 11: 286-3.
17. Vinay DS, Kwon BS. Role of 4-1BB in immune regulation. Sem. Immunol. 1998; 10: 481-9.
18. Langstein J, Michel J, Fritsche J, Kreutz M, Andreesen R, Schwarz H. CD137 (ILA/4-1BB), a member of TNF receptor family induces monocyte activation via bidirectional signaling. J. Immunol. 1998; 160: 2488-4.
19. Michel J, Langstein J, Hofstadter F, Schwarz H. A soluble form of CD137 (ILA/4-1BB), a member of TNF receptor family, is released by activated lymphocytes and is detectable in sera of patients with rheumatoid arthritis. Eur. J. Immunol. 1998; 28: 290-5.
20. Pinto A, Aldinucci D, Gloghini A et al. The role of eosinophils in the pathobiology of Hodgkin's disease. Ann. Oncol. 1997; 8: 89-96.
21. Wang S, Kim YJ, Bick C, Kim SH, Kwon BS. The potential roles of 4-1BB costimulation in HIV type I infection. AIDS Res. Hum. Retrovirus 1998; 14: 223-31.
22. Kwon BS, Weissman SM. cDNA sequences of two inducible T-cell genes. Proc. Natl Acad. Sci. USA 1989; 86: 1963-7.
23. Kwon BS, Kozak CA, Kim KK, Pickard RT. Genomic organization and chromosomal localization of the T-cell antigen 4-1BB. J. Immunol. 1994; 152: 2256-62.
24. Melero I, Johnston JV, Shufford WW, Mittler RS, Chen L. NK 1.1 cells express 4-1BB (CDw137) co-stimulatory molecule and are required for tumor immunity elicited by anti-4-1BB monoclonal antibodies. Cell. Imrnunol. 1998; 190: 167-72.
25. DeBenedette MA, Chu NR, Pollok KE et al. Role of 4-1BB ligand in costimulation of T lymphocyte growth and its upregulation on M12 B lymphomas by cAMP. J. Exp. Med. 1995; 181: 985-92.
26. Pollok KE, Kim YJ, Zhou Z et al. The inducible T cell antigen 4-1BB: analysis of expression and function. J. Immunol. 1993; 150: 771-81.
27. Kim YJ, Kim SH, Mantel P, Kwon BS. Human 4-1BB regulates CD28 costimulates to promote Th1 cell responses. Eur. J. Immunol. 1998; 28: 881-90.
28. Kwon BS, Hurtado JC, Lee ZH et al. Immune responses in 4-1BB (CD137) -deficient mice. J. Immunol. 2002; 168: 5483-90.
29. Lucas PJ, Negishi I, Nakayama K, Fields LE, Loh DY. Naive CD28-deficient T cells can initiate but not sustain an in vitro antigen-specific immune response. J. Immunol. 1995; 154: 5757-68.
30. -/- mice: thymic positive selection is biased toward the helper phenotype. J. Immunol. 1995; 155: 3727-33.
31. 51Cr-labelled allogeneic target cells in vitro: inhibition by isoantibody and by drugs. Immunology 1968; 14: 18196.
32. Tang A, Judge TA, Nickoloff BJ, Turka LA. Suppression of murine allergic contact dermatitis by CTLA4-Ig. Tolerance induction of Th2 responses requires additional blockade of CD40-ligand. J. Immunol. 1996; 157: 117-25.
33. Maizels N, Bothwell A. The T cell independent immune response to the hapten NP uses a large repertoire of heavy chain genes. Cell 1985; 43: 715-20.
34. Mongini PKH, Stein KE, Paul WE. T cell regulation of IgG subclass antibody production in response to T-independent antigens. J. Exp. Med. 1981; 153: 1-12.
35. Hurtado JC, Kim SH, Pollok KE, Lee ZH, Kown BS. Potential role of 4-1BB in T cell activation: comparison with the costimulatory molecule CD28. J. Immunol. 1995; 155: 3360-7.
36. Schwarz H, Blanco FJ, von Kempis J, Valbracht J, Lotz M. ILA, member of the human nerve growth factor/tumor necrosis factor receptor family, regulates T-lymphocyte proliferation and survival. Blood 1996; 87: 2839-45.
37. Shahnian A, Pfeffer K, Lee KP et al. Differential T cell costimulatory requirements in CD28-deficient mice. Science 1993; 261: 609-12.
38. Ferguson SE, Han S, Kelsoe G, Thompson CB. CD28 is required for germinal center formation. J. Immunol. 1996; 156: 4576-81.
39. Kundig TM, Shahnian A, Kawai K et al. Duration of TcR stimulation determines costimulatory requirement of T cells. Immunity 1996; 5: 41-52.
40. Ruedl C, Kopf M, Bachmann MF. CD8+ T cells mediate CD40-independent maturation of dendritic cells in vivo. J. Exp. Med. 1999; 189: 1875-84.
41. Takahashi C, Mittler RS, Vella AT. 4-1BB is a bona-fide CD8 T cell survival signal. J. Immunol. 1999; 162: 5037-40.
42. Leist TP, Cobbol SP, Waldman H, Aguet M, Zinkernagel RM. Functional analysis of T lymphocyte subsets in antiviral host defense. J. Immunol. 1987; 138: 2278-81.
43. Oxenius A, Campbell KA, Maliszewski CR et al. CD40-CD40 ligand interactions are critical in T-B cooperation but not for other antiviral CD4+ T cell-functions. J. Exp. Med. 1996; 183: 2209-18.
44. Banner R, Hijmans W, Haaijman JJ. The bone marrow: the major source of serum immunoglobulins, but still a neglected site of antibody formation. Clin. Exp. Immunol. 1981; 46: 1-8.
45. Katz DH, Benacerraf B. The regulatory influence activated T cells on B cell responses to antigens. Adv. Immunol. 1972; 15: 1-94.
46. Asherson GL, Ptak W. Contact and delayed type hypersensitivity in the mouse. Immunology 1968; 15: 405-16.
47. Cher DJ, Mosmann TR. Two types of routine helper T cell clones. II. Delayed-type hypersenisitivity is mediated by Th1 clones. J. Immunol. 1987; 138: 3688-94.
48. Muller KM, Jaunin F, Masouye I, Saurat JH, Hauser C. Th2 cells mediate IL-4-dependent local tissue inflammation. J. Immunol. 1993; 150: 5576-84.
49. Enk AH, Katz SI. Early molecular events in the induction phase of contact sensitivity. Proc. Natl Acad. Sci. USA 1992; 89: 1398-02.
50. -/- mice. J. Immunol. 1996; 157: 4822-9.
51. Shanafelt MC, Soderberg C, Allsup A, Adelman D, Peltz G, Lahesmaa R. Costimulatory signals can selectively modulate cytokine production by subsets of CD4+ T cells. J. Immunol. 1995; 154: 1684-90.
52. Lucas PJ, Negishi I, Nakayama K, Fields LE, Loh DY. Naïve CD28-deficient T cells can initiate but not sustain an in vitro antigen-specific immune response. J. Immunol. 1995; 154: 5757-68.