Human uroporphyrinogen III synthase: NMR-based mapping of the active site

Proteins: Structure, Function and Genetics

Volumn 71, Issue 2, 2008, Pages 855-873

  Cunha, Luis ^a,b   Kuti, Miklos ^a   Bishop, David F ^a   Mezei, Mihaly ^a   Zeng, Lei ^a   Zhou, Ming Ming ^a   Desnick, Robert J ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PORTO   (Portugal)

Author keywords

Chemical shift perturbation; Enzyme complex; Heme biosynthesis; Molecular docking; Porphyria; Resonance assignments

Indexed keywords

ENZYME INHIBITOR; HEME; HOLOENZYME; PORPHOBILINOGEN DEAMINASE; UROPORPHYRINOGEN DECARBOXYLASE; UROPORPHYRINOGEN III SYNTHASE;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMICAL LABELING; COMPETITIVE INHIBITION; COMPLEX FORMATION; COMPUTER MODEL; CRYSTAL STRUCTURE; CYTOSOL; ENZYME ACTIVE SITE; ENZYME ANALYSIS; ENZYME INHIBITION; ENZYME PURIFICATION; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; HEME SYNTHESIS; NITROGEN NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTON NUCLEAR MAGNETIC RESONANCE;

AMINO ACID SEQUENCE; BINDING SITES; CARBON ISOTOPES; COMPUTER SIMULATION; HUMANS; HYDROXYMETHYLBILANE SYNTHASE; KINETICS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NITROGEN ISOTOPES; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; RECOMBINANT PROTEINS; THERMODYNAMICS; UROPORPHYRINOGEN DECARBOXYLASE; UROPORPHYRINOGEN III SYNTHETASE; UROPORPHYRINOGENS;

EID: 41149169307     PISSN: 08873585     EISSN: 10970134     Source Type: Journal    
DOI: 10.1002/prot.21755     Document Type: Article

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