Human uroporphyrinogen-III synthase: Genomic organization, alternative promoters, and erythroid-specific expression

Genomics

Volumn 70, Issue 2, 2000, Pages 223-231

  Aizencang, Gerardo ^a   Solis, Constanza ^a   Bishop, David F ^a   Warner, Cecilia ^a   Desnick, Robert J ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEME; LUCIFERASE; TRANSCRIPTION FACTOR GATA 1; TRANSCRIPTION FACTOR NF E2; UROPORPHYRINOGEN III SYNTHASE;

5' UNTRANSLATED REGION; ARTICLE; CELL ACTIVITY; CELL DIFFERENTIATION; CONGENITAL ERYTHROPOIETIC PORPHYRIA; ENZYME ASSAY; ERYTHROID CELL; ERYTHROPOIESIS; GENE EXPRESSION REGULATION; GENE ISOLATION; GENETIC ORGANIZATION; HELA CELL; HOUSEKEEPING GENE; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; TISSUE SPECIFICITY;

EID: 0034548040     PISSN: 08887543     EISSN: None     Source Type: Journal    
DOI: 10.1006/geno.2000.6373     Document Type: Article

References (34)

1. Uroporphyrinogen III synthase. An alternative promoter controls erythroid-specific expression in the murine gene
2. Regional assignment of the human uroporphyrinogen III synthase (UROS) gene to chromosome 10q25.2 → q26.3
3. The mouse porphobilinogen deaminase gene. Structural organization, sequence, and transcriptional analysis
4. Two different genes encode delta-aminolevulinate synthase in humans: Nucleotide sequences of cDNAs for the housekeeping and erythroid genes
5. Genetic regulation of delta-aminolevulinate dehydratase during erythropoiesis
6. The gene encoding the second enzyme of the heme biosynthetic pathway, aminolevulinate dehydratase, has two transcriptional promoters
7. Organization and expression of eucaryotic split genes coding for proteins
8. Alternative transcription and splicing of the human porphobilinogen deaminase gene result either in tissue-specific or in housekeeping expression
9. Human erythroid 5-aminolevulinate synthase. Gene structure and species-specific differences in alternative RNA splicing
10. Coproporphyrinogen oxidase: Gene organization and description of a mutation leading to exon 6 skipping
11. Altered brain metabolism of iron as a cause of neurodegenerative diseases
12. Tissue-specific expression of porphobilinogen deaminase. Two isoenzymes from a single gene
13. Hemin control of heme biosynthesis and catabolism in a human leukemia cell line
14. Identification of a stage selector element in the human gamma-globin gene promoter that fosters preferential interaction with the 5' HS2 enhancer when in competition with the beta-promoter
15. Interaction of the CNC-bZIP factor TCF11/LCR-F1/Nrf1 with MafG: Binding-site selection and regulation of transcription
16. The porphyrias
17. Human delta-aminolevulinate dehydratase (ALAD) gene: Structure and alternative splicing of the erythroid and housekeeping mRNAs
18. Promoter elements and erythroid cell nuclear factors that regulate alpha-globin gene transcription in vitro
19. Pre- and postnatal ontogeny of aromatase cytochrome P450 messenger ribonucleic acid expression in the male rat brain studied by in situ hybridization
20. Uroporphyrinogen III cosynthase in bovine erythropoietic porphyria
21. Cis- and trans-acting elements involved in the regulation of the erythroid promoter of the human porphobilinogen deaminase gene
22. Uroporphyrinogen decarboxylase: Complete human gene sequence and molecular study of three families with hepatoerythropoietic porphyria
23. Characterization of hypersensitive sites, protein-binding motifs, and regulatory elements in both promoters of the mouse porphobilinogen deaminase gene
24. Structure of the gene for human uroporphyrinogen decarboxylase
25. Uroporphyrinogen III co-synthetase activity in asymptomatic carriers of congenital erythropoietic porphyria
26. Uroporphyrinogen III cosynthetase in human congenital erythropoietic porphyria
27. Structure of a mouse erythroid 5-aminolevulinate synthase gene and mapping of erythroid-specific DNAse I hypersensitive sites
28. The human protoporphyrinogen oxidase gene (PPOX): Organization and location to chromosome 1
29. Structure of the human ferrochelatase gene. Exon/intron gene organization and location of the gene to chromosome 18
30. Purification and properties of uroporphyrinogen III synthase from human erythrocytes
31. Human uroporphyrinogen III synthase: Molecular cloning, nucleotide sequence, and expression of a full-length cDNA
32. A single promoter directs both housekeeping and erythroid preferential expression of the human ferrochelatase gene
33. Uroporphyrinogen-III synthase: Molecular cloning, nucleotide sequence, expression of a mouse full-length cDNA, and its localization on mouse chromosome 7
34. Hydroxymethylbilane synthase: Complete genomic sequence and amplifiable polymorphisms in the human gene