메뉴 건너뛰기




Volumn 20, Issue 5, 2007, Pages 552-561

Fascin overexpression in intraductal papillary mucinous neoplasms (adenomas, borderline neoplasms, and carcinomas) of the pancreas, correlated with increased histological grade

Author keywords

Fascin; Immunohistochemistry; Intraductal papillary mucinous neoplasm; Laser microdissection; Phenotypic subclassification; Realtime RT PCR

Indexed keywords

FASCIN;

EID: 34247328661     PISSN: 08933952     EISSN: 15300285     Source Type: Journal    
DOI: 10.1038/modpathol.3800763     Document Type: Article
Times cited : (52)

References (46)
  • 1
    • 0000491695 scopus 로고
    • Four cases of 'mucin producing' cancer of the pancreas on specific findings of the papilla of Vater (Abstract)
    • Ohhashi K, Murakami Y, Takekoshi T, et al. Four cases of 'mucin producing' cancer of the pancreas on specific findings of the papilla of Vater (Abstract). Prog Diagn Endosc 1982;20:348-351.
    • (1982) Prog Diagn Endosc , vol.20 , pp. 348-351
    • Ohhashi, K.1    Murakami, Y.2    Takekoshi, T.3
  • 4
    • 18644383374 scopus 로고    scopus 로고
    • The dichotomy in the preinvasive neoplasia to invasive carcinoma sequence in the pancreas: Differential expression of MUC1 and MUC2 supports the existence of two separate pathways of carcinogenesis
    • Adsay NV, Merati K, Andea A, et al. The dichotomy in the preinvasive neoplasia to invasive carcinoma sequence in the pancreas: differential expression of MUC1 and MUC2 supports the existence of two separate pathways of carcinogenesis. Mod Pathol 2002;15:1087-1095.
    • (2002) Mod Pathol , vol.15 , pp. 1087-1095
    • Adsay, N.V.1    Merati, K.2    Andea, A.3
  • 5
    • 0035020633 scopus 로고    scopus 로고
    • Pancreatic intraepithelial neoplasia: A new nomenclature and classification system for pancreatic duct lesions
    • Hruban RH, Adsay NV, Albores-Saavedra J, et al. Pancreatic intraepithelial neoplasia: a new nomenclature and classification system for pancreatic duct lesions. Am J Surg Pathol 2001;25:579-586.
    • (2001) Am J Surg Pathol , vol.25 , pp. 579-586
    • Hruban, R.H.1    Adsay, N.V.2    Albores-Saavedra, J.3
  • 6
    • 3242744313 scopus 로고    scopus 로고
    • An illustrated consensus on the classification of pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasms
    • Hruban RH, Takaori K, Klimstra DS, et al. An illustrated consensus on the classification of pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasms. Am J Surg Pathol 2004;28:977-987.
    • (2004) Am J Surg Pathol , vol.28 , pp. 977-987
    • Hruban, R.H.1    Takaori, K.2    Klimstra, D.S.3
  • 7
    • 0036142203 scopus 로고    scopus 로고
    • Intraductal papillary-mucinous neoplasms of the pancreas: An analysis of in situ and invasive carcinomas in 28 patients
    • Adsay NV, Conlon KC, Zee SY, et al. Intraductal papillary-mucinous neoplasms of the pancreas: an analysis of in situ and invasive carcinomas in 28 patients. Cancer 2002;94:62-77.
    • (2002) Cancer , vol.94 , pp. 62-77
    • Adsay, N.V.1    Conlon, K.C.2    Zee, S.Y.3
  • 8
    • 3042801238 scopus 로고    scopus 로고
    • Pathologically and biologically distinct types of epithelium in intraductal papillary mucinous neoplasms: Delineation of an 'intestinal' pathway of carcinogenesis in the pancreas
    • Adsay NV, Merati K, Basturk O, et al. Pathologically and biologically distinct types of epithelium in intraductal papillary mucinous neoplasms: delineation of an 'intestinal' pathway of carcinogenesis in the pancreas. Am J Surg Pathol 2004;28:839-848.
    • (2004) Am J Surg Pathol , vol.28 , pp. 839-848
    • Adsay, N.V.1    Merati, K.2    Basturk, O.3
  • 9
    • 0030886967 scopus 로고    scopus 로고
    • Intraductal papillary tumors and mucinous cystic tumors of the pancreas: Clinicopathologic study of 38 cases
    • Fukushima N, Mukai K, Kanai Y, et al. Intraductal papillary tumors and mucinous cystic tumors of the pancreas: clinicopathologic study of 38 cases. Hum Pathol 1997;28:1010-1017.
    • (1997) Hum Pathol , vol.28 , pp. 1010-1017
    • Fukushima, N.1    Mukai, K.2    Kanai, Y.3
  • 10
    • 0036262152 scopus 로고    scopus 로고
    • New classification of pancreatic intraductal papillarymucinous tumour by mucin expression: Its relationship with potential for malignancy
    • Nakamura A, Horinouchi M, Goto M, et al. New classification of pancreatic intraductal papillarymucinous tumour by mucin expression: its relationship with potential for malignancy. J Pathol 2002;197:201-210.
    • (2002) J Pathol , vol.197 , pp. 201-210
    • Nakamura, A.1    Horinouchi, M.2    Goto, M.3
  • 11
    • 0032829578 scopus 로고    scopus 로고
    • Gene expression of gastric type mucin (MUC5AC) in pancreatic tumors: Its relationship with the biological behavior of the tumor
    • Yonezawa S, Horinouchi M, Osako M, et al. Gene expression of gastric type mucin (MUC5AC) in pancreatic tumors: its relationship with the biological behavior of the tumor. Pathol Int 1999;49:45-54.
    • (1999) Pathol Int , vol.49 , pp. 45-54
    • Yonezawa, S.1    Horinouchi, M.2    Osako, M.3
  • 12
    • 0036036341 scopus 로고    scopus 로고
    • The expression of several types of mucin is related to the biological behavior of pancreatic neoplasms
    • Yonezawa S, Nakamura A, Horinouchi M, et al. The expression of several types of mucin is related to the biological behavior of pancreatic neoplasms. J Hepatobiliary Pancreat Surg 2002;9:328-341.
    • (2002) J Hepatobiliary Pancreat Surg , vol.9 , pp. 328-341
    • Yonezawa, S.1    Nakamura, A.2    Horinouchi, M.3
  • 13
    • 15144354735 scopus 로고    scopus 로고
    • MUC-1 mucin expression in invasive areas of intraductal papillary mucinous tumors of the pancreas
    • Yonezawa S, Taira M, Osako M, et al. MUC-1 mucin expression in invasive areas of intraductal papillary mucinous tumors of the pancreas. Pathol Int 1998;48:319-322.
    • (1998) Pathol Int , vol.48 , pp. 319-322
    • Yonezawa, S.1    Taira, M.2    Osako, M.3
  • 14
    • 28444458875 scopus 로고    scopus 로고
    • Classification of types of intraductal papillary-mucinous neoplasm of the pancreas: A consensus study
    • Furukawa T, Kloppel G, Volkan Adsay N, et al. Classification of types of intraductal papillary-mucinous neoplasm of the pancreas: a consensus study. Virchows Arch 2005;447:794-799.
    • (2005) Virchows Arch , vol.447 , pp. 794-799
    • Furukawa, T.1    Kloppel, G.2    Volkan Adsay, N.3
  • 15
    • 4444285120 scopus 로고    scopus 로고
    • Roles of fascin in cell adhesion and motility
    • Adams JC. Roles of fascin in cell adhesion and motility. Curr Opin Cell Biol 2004;16:590-596.
    • (2004) Curr Opin Cell Biol , vol.16 , pp. 590-596
    • Adams, J.C.1
  • 16
    • 21844439742 scopus 로고    scopus 로고
    • Roles of fascin in human carcinoma motility and signaling: Prospects for a novel biomarker?
    • Hashimoto Y, Skacel M, Adams JC. Roles of fascin in human carcinoma motility and signaling: prospects for a novel biomarker? Int J Biochem Cell Biol 2005;37:1787-1804.
    • (2005) Int J Biochem Cell Biol , vol.37 , pp. 1787-1804
    • Hashimoto, Y.1    Skacel, M.2    Adams, J.C.3
  • 17
    • 0036010596 scopus 로고    scopus 로고
    • Fascins, and their roles in cell structure and function
    • Kureishy N, Sapountzi V, Prag S, et al. Fascins, and their roles in cell structure and function. Bioessays 2002;24:350-361.
    • (2002) Bioessays , vol.24 , pp. 350-361
    • Kureishy, N.1    Sapountzi, V.2    Prag, S.3
  • 18
    • 10744221447 scopus 로고    scopus 로고
    • Independent value of fascin immunoreactivity for predicting lymph node metastases in typical and atypical pulmonary carcinoids
    • Pelosi G, Pasini F, Fraggetta F, et al. Independent value of fascin immunoreactivity for predicting lymph node metastases in typical and atypical pulmonary carcinoids. Lung Cancer 2003;42:203-213.
    • (2003) Lung Cancer , vol.42 , pp. 203-213
    • Pelosi, G.1    Pasini, F.2    Fraggetta, F.3
  • 19
    • 0037463236 scopus 로고    scopus 로고
    • Independent prognostic value of fascin immunoreactivity in stage I nonsmall cell lung cancer
    • Pelosi G, Pastorino U, Pasini F, et al. Independent prognostic value of fascin immunoreactivity in stage I nonsmall cell lung cancer. Br J Cancer 2003;88:537-547.
    • (2003) Br J Cancer , vol.88 , pp. 537-547
    • Pelosi, G.1    Pastorino, U.2    Pasini, F.3
  • 20
    • 0034609766 scopus 로고    scopus 로고
    • C-erbB-2/ HER-2 upregulates fascin, an actin-bundling protein associated with cell motility, in human breast cancer cell lines
    • Grothey A, Hashizume R, Ji H, et al. C-erbB-2/ HER-2 upregulates fascin, an actin-bundling protein associated with cell motility, in human breast cancer cell lines. Oncogene 2000;19:4864-4875.
    • (2000) Oncogene , vol.19 , pp. 4864-4875
    • Grothey, A.1    Hashizume, R.2    Ji, H.3
  • 21
    • 0033826484 scopus 로고    scopus 로고
    • Fascin, an actin-bundling protein associated with cell motility, is upregulated in hormone receptor negative breast cancer
    • Grothey A, Hashizume R, Sahin AA, et al. Fascin, an actin-bundling protein associated with cell motility, is upregulated in hormone receptor negative breast cancer. Br J Cancer 2000;83:870-873.
    • (2000) Br J Cancer , vol.83 , pp. 870-873
    • Grothey, A.1    Hashizume, R.2    Sahin, A.A.3
  • 22
    • 33645072444 scopus 로고    scopus 로고
    • Prognostic significance of basal-like phenotype and fascin expression in node-negative invasive breast carcinomas
    • Rodriguez-Pinilla SM, Sarrio D, Honrado E, et al. Prognostic significance of basal-like phenotype and fascin expression in node-negative invasive breast carcinomas. Clin Cancer Res 2006;12:1533-1539.
    • (2006) Clin Cancer Res , vol.12 , pp. 1533-1539
    • Rodriguez-Pinilla, S.M.1    Sarrio, D.2    Honrado, E.3
  • 23
    • 11344285907 scopus 로고    scopus 로고
    • The expression of fascin, an actin-bundling motility protein, correlates with hormone receptor-negative breast cancer and a more aggressive clinical course
    • Yoder BJ, Tso E, Skacel M, et al. The expression of fascin, an actin-bundling motility protein, correlates with hormone receptor-negative breast cancer and a more aggressive clinical course. Clin Cancer Res 2005;11:186-192.
    • (2005) Clin Cancer Res , vol.11 , pp. 186-192
    • Yoder, B.J.1    Tso, E.2    Skacel, M.3
  • 24
    • 20244381388 scopus 로고    scopus 로고
    • Prognostic significance of fascin overexpression in human esophageal squamous cell carcinoma
    • Hashimoto Y, Ito T, Inoue H, et al. Prognostic significance of fascin overexpression in human esophageal squamous cell carcinoma. Clin Cancer Res 2005;11:2597-2605.
    • (2005) Clin Cancer Res , vol.11 , pp. 2597-2605
    • Hashimoto, Y.1    Ito, T.2    Inoue, H.3
  • 25
    • 25844474348 scopus 로고    scopus 로고
    • Role of fascin in the proliferation and invasiveness of esophageal carcinoma cells
    • Xie JJ, Xu LY, Zhang HH, et al. Role of fascin in the proliferation and invasiveness of esophageal carcinoma cells. Biochem Biophys Res Commun 2005;337:355-362.
    • (2005) Biochem Biophys Res Commun , vol.337 , pp. 355-362
    • Xie, J.J.1    Xu, L.Y.2    Zhang, H.H.3
  • 26
    • 4444249228 scopus 로고    scopus 로고
    • The prognostic relevance of fascin expression in human gastric carcinoma
    • Hashimoto Y, Shimada Y, Kawamura J, et al. The prognostic relevance of fascin expression in human gastric carcinoma. Oncology 2004;67:262-270.
    • (2004) Oncology , vol.67 , pp. 262-270
    • Hashimoto, Y.1    Shimada, Y.2    Kawamura, J.3
  • 27
    • 0037221974 scopus 로고    scopus 로고
    • Fascin, an actin-bundling protein, modulates colonic epithelial cell invasiveness and differentiation in vitro
    • Jawhari AU, Buda A, Jenkins M, et al. Fascin, an actin-bundling protein, modulates colonic epithelial cell invasiveness and differentiation in vitro. Am J Pathol 2003;162:69-80.
    • (2003) Am J Pathol , vol.162 , pp. 69-80
    • Jawhari, A.U.1    Buda, A.2    Jenkins, M.3
  • 28
    • 10644285602 scopus 로고    scopus 로고
    • Differential expression profiling of human pancreatic adenocarcinoma and healthy pancreatic tissue
    • Lu Z, Hu L, Evers S, et al. Differential expression profiling of human pancreatic adenocarcinoma and healthy pancreatic tissue. Proteomics 2004;4:3975-3988.
    • (2004) Proteomics , vol.4 , pp. 3975-3988
    • Lu, Z.1    Hu, L.2    Evers, S.3
  • 29
    • 0141742113 scopus 로고    scopus 로고
    • Multicomponent analysis of the pancreatic adenocarcinoma progression model using a pancreatic intraepithelial neoplasia tissue microarray
    • Maitra A, Adsay NV, Argani P, et al. Multicomponent analysis of the pancreatic adenocarcinoma progression model using a pancreatic intraepithelial neoplasia tissue microarray. Mod Pathol 2003;16:902-912.
    • (2003) Mod Pathol , vol.16 , pp. 902-912
    • Maitra, A.1    Adsay, N.V.2    Argani, P.3
  • 30
    • 18444403112 scopus 로고    scopus 로고
    • Immunohistochemical validation of a novel epithelial and a novel stromal marker of pancreatic ductal adenocarcinoma identified by global expression microarrays: Sea urchin fascin homolog and heat shock protein 47
    • Maitra A, Iacobuzio-Donahue C, Rahman A, et al. Immunohistochemical validation of a novel epithelial and a novel stromal marker of pancreatic ductal adenocarcinoma identified by global expression microarrays: sea urchin fascin homolog and heat shock protein 47. Am J Clin Pathol 2002;118:52-59.
    • (2002) Am J Clin Pathol , vol.118 , pp. 52-59
    • Maitra, A.1    Iacobuzio-Donahue, C.2    Rahman, A.3
  • 31
    • 12144288836 scopus 로고    scopus 로고
    • Analysis of novel tumor markers in pancreatic and biliary carcinomas using tissue microarrays
    • Swierczynski SL, Maitra A, Abraham SC, et al. Analysis of novel tumor markers in pancreatic and biliary carcinomas using tissue microarrays. Hum Pathol 2004;35:357-366.
    • (2004) Hum Pathol , vol.35 , pp. 357-366
    • Swierczynski, S.L.1    Maitra, A.2    Abraham, S.C.3
  • 32
    • 16644366258 scopus 로고    scopus 로고
    • Gene expression profiling identifies markers of ampullary adenocarcinoma
    • Van Heek NT, Maitra A, Koopmann J, et al. Gene expression profiling identifies markers of ampullary adenocarcinoma. Cancer Biol Ther 2004;3:651-656.
    • (2004) Cancer Biol Ther , vol.3 , pp. 651-656
    • Van Heek, N.T.1    Maitra, A.2    Koopmann, J.3
  • 33
    • 0035135688 scopus 로고    scopus 로고
    • Increased expression of fascin, motility associated protein, in cell cultures derived from ovarian cancer and in borderline and carcinomatous ovarian tumors
    • Hu W, McCrea PD, Deavers M, et al. Increased expression of fascin, motility associated protein, in cell cultures derived from ovarian cancer and in borderline and carcinomatous ovarian tumors. Clin Exp Metastasis 2000;18:83-88.
    • (2000) Clin Exp Metastasis , vol.18 , pp. 83-88
    • Hu, W.1    McCrea, P.D.2    Deavers, M.3
  • 34
    • 23444460878 scopus 로고    scopus 로고
    • Fascin-1 expression in papillary and invasive urothelial carcinomas of the urinary bladder
    • Tong GX, Yee H, Chiriboga L, et al. Fascin-1 expression in papillary and invasive urothelial carcinomas of the urinary bladder. Hum Pathol 2005;36:741-746.
    • (2005) Hum Pathol , vol.36 , pp. 741-746
    • Tong, G.X.1    Yee, H.2    Chiriboga, L.3
  • 35
    • 0035990482 scopus 로고    scopus 로고
    • Actin-binding protein fascin expression in skin neoplasia
    • Goncharuk VN, Ross JS, Carlson JA. Actin-binding protein fascin expression in skin neoplasia. J Cutan Pathol 2002;29:430-438.
    • (2002) J Cutan Pathol , vol.29 , pp. 430-438
    • Goncharuk, V.N.1    Ross, J.S.2    Carlson, J.A.3
  • 36
    • 3142704586 scopus 로고    scopus 로고
    • A new molecular biology approach in morphology: Basic method and application of laser microdissection
    • Tachikawa T, Irie T. A new molecular biology approach in morphology: basic method and application of laser microdissection. Med Electron Microsc 2004;37:82-88.
    • (2004) Med Electron Microsc , vol.37 , pp. 82-88
    • Tachikawa, T.1    Irie, T.2
  • 37
    • 0023277545 scopus 로고
    • Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
    • Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987;162:156-159.
    • (1987) Anal Biochem , vol.162 , pp. 156-159
    • Chomczynski, P.1    Sacchi, N.2
  • 38
    • 0034698675 scopus 로고    scopus 로고
    • Stimulation of fascin spikes by thrombospondin-1 is mediated by the GTPases Rac and Cdc42
    • Adams JC, Schwartz MA. Stimulation of fascin spikes by thrombospondin-1 is mediated by the GTPases Rac and Cdc42. J Cell Biol 2000;150:807-822.
    • (2000) J Cell Biol , vol.150 , pp. 807-822
    • Adams, J.C.1    Schwartz, M.A.2
  • 39
    • 0031694209 scopus 로고    scopus 로고
    • Fascin, an actin-bundling protein, induces membrane protrusions and increases cell motility of epithelial cells
    • Yamashiro S, Yamakita Y, Ono S, et al. Fascin, an actin-bundling protein, induces membrane protrusions and increases cell motility of epithelial cells. Mol Biol Cell 1998;9:993-1006.
    • (1998) Mol Biol Cell , vol.9 , pp. 993-1006
    • Yamashiro, S.1    Yamakita, Y.2    Ono, S.3
  • 40
    • 0029776445 scopus 로고    scopus 로고
    • beta-Catenin associates with the actin-bundling protein fascin in a noncadherin complex
    • Tao YS, Edwards RA, Tubb B, et al. beta-Catenin associates with the actin-bundling protein fascin in a noncadherin complex. J Cell Biol 1996;134:1271-1281.
    • (1996) J Cell Biol , vol.134 , pp. 1271-1281
    • Tao, Y.S.1    Edwards, R.A.2    Tubb, B.3
  • 41
    • 0033605134 scopus 로고    scopus 로고
    • Glucocorticoid down-regulation of fascin protein expression is required for the steroid-induced formation of tight junctions and cell-cell interactions in rat mammary epithelial tumor cells
    • Wong V, Ching D, McCrea PD, et al. Glucocorticoid down-regulation of fascin protein expression is required for the steroid-induced formation of tight junctions and cell-cell interactions in rat mammary epithelial tumor cells. J Biol Chem 1999;274:5443-5453.
    • (1999) J Biol Chem , vol.274 , pp. 5443-5453
    • Wong, V.1    Ching, D.2    McCrea, P.D.3
  • 42
    • 0036107889 scopus 로고    scopus 로고
    • Discovery of novel tumor markers of pancreatic cancer using global gene expression technology
    • Iacobuzio-Donahue CA, Maitra A, Shen-Ong GL, et al. Discovery of novel tumor markers of pancreatic cancer using global gene expression technology. Am J Pathol 2002;160:1239-1249.
    • (2002) Am J Pathol , vol.160 , pp. 1239-1249
    • Iacobuzio-Donahue, C.A.1    Maitra, A.2    Shen-Ong, G.L.3
  • 43
    • 0036110390 scopus 로고    scopus 로고
    • Aberrant p16(INK4A) and DPC4/Smad4 expression in intraductal papillary mucinous tumours of the pancreas is associated with invasive ductal adenocarcinoma
    • Biankin AV, Biankin SA, Kench JG, et al. Aberrant p16(INK4A) and DPC4/Smad4 expression in intraductal papillary mucinous tumours of the pancreas is associated with invasive ductal adenocarcinoma. Gut 2002;50:861-868.
    • (2002) Gut , vol.50 , pp. 861-868
    • Biankin, A.V.1    Biankin, S.A.2    Kench, J.G.3
  • 44
    • 0036305839 scopus 로고    scopus 로고
    • Aberrant methylation of CpG islands in intraductal papillary mucinous neoplasms of the pancreas
    • Sato N, Ueki T, Fukushima N, et al. Aberrant methylation of CpG islands in intraductal papillary mucinous neoplasms of the pancreas. Gastroenterology 2002;123:365-372.
    • (2002) Gastroenterology , vol.123 , pp. 365-372
    • Sato, N.1    Ueki, T.2    Fukushima, N.3
  • 45
    • 0037385581 scopus 로고    scopus 로고
    • Progressive genomic alterations in intraductal papillary mucinous tumours of the pancreas and morphologically similar lesions of the pancreatic ducts
    • Soldini D, Gugger M, Burckhardt E, et al. Progressive genomic alterations in intraductal papillary mucinous tumours of the pancreas and morphologically similar lesions of the pancreatic ducts. J Pathol 2003;199:453-461.
    • (2003) J Pathol , vol.199 , pp. 453-461
    • Soldini, D.1    Gugger, M.2    Burckhardt, E.3
  • 46
    • 8944260415 scopus 로고    scopus 로고
    • Intraductal oncocytic papillary neoplasms of the pancreas
    • Adsay NV, Adair CF, Heffess CS, et al. Intraductal oncocytic papillary neoplasms of the pancreas. Am J Surg Pathol 1996;20:980-994
    • (1996) Am J Surg Pathol , vol.20 , pp. 980-994
    • Adsay, N.V.1    Adair, C.F.2    Heffess, C.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.