The carbon monoxide-releasing molecule tricarbonyldichlororuthenium(II) dimer protects human osteoarthritic chondrocytes and cartilage from the catabolic actions of interleukin-1β

Journal of Pharmacology and Experimental Therapeutics

Volumn 325, Issue 1, 2008, Pages 56-61

  Megías, Javier ^a   Guillén, María Isabel ^a,b   Bru, Antonio ^c   Gomar, Francisco ^a   Alcaraz, María José ^a  

^a UNIVERSITY OF VALENCIA   (Spain)

^b UNIVERSIDAD CEU CARDENAL HERRERA   (Spain)

^c HOSPITAL GENERAL UNIVERSITARIO DE VALENCIA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

AGGRECAN; AGGRECANASE; CARBON MONOXIDE; COLLAGEN TYPE 2; COLLAGENASE 3; CYTOKINE; DISINTEGRIN; INTERLEUKIN 1BETA; INTERSTITIAL COLLAGENASE; MATRIX METALLOPROTEINASE; METALLOPROTEINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN ADAMTS 5; RUTHENIUM DERIVATIVE; STROMELYSIN; THROMBOSPONDIN; UNCLASSIFIED DRUG;

AGED; ARTICLE; CARTILAGE; CARTILAGE CELL; CARTILAGE DEGENERATION; CATABOLISM; CELL PROTECTION; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME SYNTHESIS; FEMALE; HOMEOSTASIS; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; OSTEOARTHRITIS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN SYNTHESIS;

AGED; AGGRECANS; CARBON MONOXIDE; CARTILAGE; CHONDROCYTES; COLLAGEN TYPE II; DOWN-REGULATION; FEMALE; HUMANS; INTERLEUKIN-1BETA; MALE; MATRIX METALLOPROTEINASES; ORGANOMETALLIC COMPOUNDS; OSTEOARTHRITIS; PROTECTIVE AGENTS;

EID: 41149151839     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.107.134650     Document Type: Article

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