Chemically modified oligonucleotides with efficient RNase H response

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 7, 2008, Pages 2296-2300

  Vester, Birte ^a   Boel, Anne Marie ^a   Lobedanz, Sune ^a   Babu, B Ravindra ^a   Raunkjær, Michael ^a   Lindegaard, Dorthe ^a   Raunak, ^a   Hrdlicka, Patrick J ^b   Højland, Torben ^a   Sharma, Pawan K ^a,c   Kumar, Surender ^a   Nielsen, Poul ^a   Wengel, Jesper ^a  

^a UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^b UNIVERSITY OF IDAHO   (United States)

^c KURUKSHETRA UNIVERSITY   (India)

Author keywords

Antisense oligonucleotide; Antisense technology; Modified nucleotide; Modified oligonucleotide; RNase H cleavage

Indexed keywords

ANTISENSE OLIGODEOXYNUCLEOTIDE; COMPLEMENTARY RNA; DNA; OLIGONUCLEOTIDE; RIBONUCLEASE H; RNA;

ARTICLE; CHEMICAL MODIFICATION; CORRELATION ANALYSIS; DNA RNA HYBRIDIZATION; PROTEIN STRUCTURE; RNA CLEAVAGE; THERMOSTABILITY;

BASE SEQUENCE; BINDING SITES; DNA; NUCLEIC ACID CONFORMATION; OLIGONUCLEOTIDES; RIBONUCLEASE H; RNA; SUBSTRATE SPECIFICITY;

EID: 41149136850     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.03.004     Document Type: Article

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