메뉴 건너뛰기




Volumn 18, Issue 2, 2008, Pages 123-131

Myostatin inhibition: A potential performance enhancement strategy?

Author keywords

Doping in sports; Gene doping; Gene transfer techniques; Genetic enhancement; Muscle development; Myostatin

Indexed keywords

MYOSTATIN; TRANSFORMING GROWTH FACTOR BETA;

EID: 41149131358     PISSN: 09057188     EISSN: 16000838     Source Type: Journal    
DOI: 10.1111/j.1600-0838.2007.00759.x     Document Type: Article
Times cited : (51)

References (68)
  • 2
    • 25444490622 scopus 로고    scopus 로고
    • Knockdown of the Dnmt1s transcript using small interfering RNA in primary murine and bovine fibroblast cells
    • Adams AM, Pratt SL, Stice SL. Knockdown of the Dnmt1s transcript using small interfering RNA in primary murine and bovine fibroblast cells. Mol Reprod Dev 2005 : 72 : 311 319.
    • (2005) Mol Reprod Dev , vol.72 , pp. 311-319
    • Adams, A.M.1    Pratt, S.L.2    Stice, S.L.3
  • 4
    • 27744596872 scopus 로고    scopus 로고
    • Doping in the recombinant era: Strategies and counterstrategies
    • Azzazy HM, Mansour MM, Christenson RH. Doping in the recombinant era: strategies and counterstrategies. Clin Biochem 2005 : 38 : 959 965.
    • (2005) Clin Biochem , vol.38 , pp. 959-965
    • Azzazy, H.M.1    Mansour, M.M.2    Christenson, R.H.3
  • 5
    • 34548723321 scopus 로고    scopus 로고
    • Potential use of gene transfer in athletic performance enhancement
    • Baoutina A, Alexander IE, Rasko JE, Emslie KR. Potential use of gene transfer in athletic performance enhancement. Mol Ther 2007 : 15 : 1751 1766.
    • (2007) Mol Ther , vol.15 , pp. 1751-1766
    • Baoutina, A.1    Alexander, I.E.2    Rasko, J.E.3    Emslie, K.R.4
  • 6
    • 41149132445 scopus 로고    scopus 로고
    • BBCNews. (last accessed August 2007).
    • BBCNews. Drugs test denies Lazutina gold. 2002 (last accessed August 2007).
    • (2002) Drugs Test Denies Lazutina Gold
  • 9
    • 34547887987 scopus 로고    scopus 로고
    • Gene doping: Will athletes go for the ultimate high?
    • Brownlee C. Gene doping: will athletes go for the ultimate high? Science News On-line 2004 : 166 : 280.
    • (2004) Science News On-line , vol.166 , pp. 280
    • Brownlee, C.1
  • 11
    • 0037146606 scopus 로고    scopus 로고
    • Breakthrough of the year. Small RNAs make big splash
    • Couzin J. Breakthrough of the year. Small RNAs make big splash. Science 2002 : 298 : 2296 2297.
    • (2002) Science , vol.298 , pp. 2296-2297
    • Couzin, J.1
  • 12
    • 0033387710 scopus 로고    scopus 로고
    • Frequent sequence variation in the human myostatin (GDF8) gene as a marker for analysis of muscle-related phenotypes
    • Ferrell RE, Conte V, Lawrence EC, Roth SM, Hagberg JM, Hurley BF. Frequent sequence variation in the human myostatin (GDF8) gene as a marker for analysis of muscle-related phenotypes. Genomics 1999 : 62 : 203 207.
    • (1999) Genomics , vol.62 , pp. 203-207
    • Ferrell, R.E.1    Conte, V.2    Lawrence, E.C.3    Roth, S.M.4    Hagberg, J.M.5    Hurley, B.F.6
  • 13
    • 33646567450 scopus 로고    scopus 로고
    • Developmental roles of the BMP1/TLD metalloproteinases
    • Ge G, Greenspan DS. Developmental roles of the BMP1/TLD metalloproteinases. Birth Defects Res C Embryo Today 2006 : 78 : 47 68.
    • (2006) Birth Defects Res C Embryo Today , vol.78 , pp. 47-68
    • Ge, G.1    Greenspan, D.S.2
  • 14
    • 15944400651 scopus 로고    scopus 로고
    • Towards safe, non-viral therapeutic gene expression in humans
    • Glover DJ, Lipps HJ, Jans DA. Towards safe, non-viral therapeutic gene expression in humans. Nat Rev Genet 2005 : 6 : 299 310.
    • (2005) Nat Rev Genet , vol.6 , pp. 299-310
    • Glover, D.J.1    Lipps, H.J.2    Jans, D.A.3
  • 16
    • 0024119330 scopus 로고
    • Pulmonary function values and growth in Belgian white and blue double-muscled cattle
    • Gustin P, Bakima M, Art T, Lekeux P, Lomba F, van de Woestijne KP. Pulmonary function values and growth in Belgian white and blue double-muscled cattle. Res Vet Sci 1988a : 45 : 405 410.
    • (1988) Res Vet Sci , vol.45 , pp. 405-410
    • Gustin, P.1    Bakima, M.2    Art, T.3    Lekeux, P.4    Lomba, F.5    Van De Woestijne, K.P.6
  • 17
    • 0024258986 scopus 로고
    • Cardio-pulmonary function values in double-muscled cattle during muscular exercise
    • Gustin P, Dhem AR, Lomba F, Lekeux P. Cardio-pulmonary function values in double-muscled cattle during muscular exercise. Vet Res Commun 1988b : 12 : 407 416.
    • (1988) Vet Res Commun , vol.12 , pp. 407-416
    • Gustin, P.1    Dhem, A.R.2    Lomba, F.3    Lekeux, P.4
  • 19
    • 0015609532 scopus 로고
    • Effects of stress on cattle with hereditary muscular hypertrophy
    • Holmes JH, Ashmore CR, Robinson DW. Effects of stress on cattle with hereditary muscular hypertrophy. J Anim Sci 1973 : 36 : 684 694.
    • (1973) J Anim Sci , vol.36 , pp. 684-694
    • Holmes, J.H.1    Ashmore, C.R.2    Robinson, D.W.3
  • 20
    • 41149153581 scopus 로고    scopus 로고
    • Mighty mice hold key to muscle-wasting disease. NewScientist, 2005, (last accessed August 2007).
    • Hooper R. Mighty mice hold key to muscle-wasting disease. NewScientist, 2005, (last accessed August 2007).
    • Hooper, R.1
  • 22
    • 33745854176 scopus 로고    scopus 로고
    • Myostatin regulation of muscle development: Molecular basis, natural mutations, physiopathological aspects
    • Joulia-Ekaza D, Cabello G. Myostatin regulation of muscle development: molecular basis, natural mutations, physiopathological aspects. Exp Cell Res 2006 : 312 : 2401 2414.
    • (2006) Exp Cell Res , vol.312 , pp. 2401-2414
    • Joulia-Ekaza, D.1    Cabello, G.2
  • 23
    • 32944454941 scopus 로고    scopus 로고
    • Design of noninflammatory synthetic siRNA mediating potent gene silencing in vivo
    • Judge AD, Bola G, Lee AC, MacLachlan I. Design of noninflammatory synthetic siRNA mediating potent gene silencing in vivo. Mol Ther 2006 : 13 : 494 505.
    • (2006) Mol Ther , vol.13 , pp. 494-505
    • Judge, A.D.1    Bola, G.2    Lee, A.C.3    MacLachlan, I.4
  • 24
    • 22344454846 scopus 로고    scopus 로고
    • Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA
    • Judge AD, Sood V, Shaw JR, Fang D, McClintock K, MacLachlan I. Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA. Nat Biotechnol 2005 : 23 : 457 462.
    • (2005) Nat Biotechnol , vol.23 , pp. 457-462
    • Judge, A.D.1    Sood, V.2    Shaw, J.R.3    Fang, D.4    McClintock, K.5    MacLachlan, I.6
  • 25
    • 0036906832 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors: From target to clinical trials
    • Kelly WK, O'Connor OA, Marks PA. Histone deacetylase inhibitors: from target to clinical trials. Expert Opin Investig Drugs 2002 : 11 : 1695 1713.
    • (2002) Expert Opin Investig Drugs , vol.11 , pp. 1695-1713
    • Kelly, W.K.1    O'Connor, O.A.2    Marks, P.A.3
  • 26
    • 0034520425 scopus 로고    scopus 로고
    • Myostatin and insulin-like growth factor-I and -II expression in the muscle of rats exposed to the microgravity environment of the NeuroLab space shuttle flight
    • Lalani R, Bhasin S, Byhower F, Tarnuzzer R, Grant M, Shen R, Asa S, Ezzat S, Gonzalez-Cadavid NF. Myostatin and insulin-like growth factor-I and -II expression in the muscle of rats exposed to the microgravity environment of the NeuroLab space shuttle flight. J Endocrinol 2000 : 167 : 417 428.
    • (2000) J Endocrinol , vol.167 , pp. 417-428
    • Lalani, R.1    Bhasin, S.2    Byhower, F.3    Tarnuzzer, R.4    Grant, M.5    Shen, R.6    Asa, S.7    Ezzat, S.8    Gonzalez-Cadavid, N.F.9
  • 27
    • 38349145459 scopus 로고    scopus 로고
    • Quadrupling muscle mass in mice by Targeting TGF-ss signaling pathways
    • Lee SJ. Quadrupling muscle mass in mice by Targeting TGF-ss signaling pathways. PLoS One 2007 : 2 : e789.
    • (2007) PLoS One , vol.2
    • Lee, S.J.1
  • 28
    • 0035979253 scopus 로고    scopus 로고
    • Regulation of myostatin activity and muscle growth
    • Lee SJ, McPherron AC. Regulation of myostatin activity and muscle growth. Proc Natl Acad Sci USA 2001 : 98 : 9306 9311.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 9306-9311
    • Lee, S.J.1    McPherron, A.C.2
  • 32
    • 2942724589 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors: Development as cancer therapy
    • discussion 281-268.
    • Marks PA, Richon VM, Kelly WK, Chiao JH, Miller T. Histone deacetylase inhibitors: development as cancer therapy. Novartis Found Symp 2004 : 259 : 269 281 discussion 281-268.
    • (2004) Novartis Found Symp , vol.259 , pp. 269-281
    • Marks, P.A.1    Richon, V.M.2    Kelly, W.K.3    Chiao, J.H.4    Miller, T.5
  • 33
    • 14644435182 scopus 로고    scopus 로고
    • The growth factor myostatin, a key regulator in skeletal muscle growth and homeostasis
    • Matsakas A, Diel P. The growth factor myostatin, a key regulator in skeletal muscle growth and homeostasis. Int J Sports Med 2005 : 26 : 83 89.
    • (2005) Int J Sports Med , vol.26 , pp. 83-89
    • Matsakas, A.1    Diel, P.2
  • 34
    • 0028918915 scopus 로고
    • Multiple defects and perinatal death in mice deficient in follistatin
    • Matzuk MM, Lu N, Vogel H, Sellheyer K, Roop DR, Bradley A. Multiple defects and perinatal death in mice deficient in follistatin. Nature 1995 : 374 : 360 363.
    • (1995) Nature , vol.374 , pp. 360-363
    • Matzuk, M.M.1    Lu, N.2    Vogel, H.3    Sellheyer, K.4    Roop, D.R.5    Bradley, A.6
  • 35
    • 0141768237 scopus 로고    scopus 로고
    • Myostatin negatively regulates satellite cell activation and self-renewal
    • McCroskery S, Thomas M, Maxwell L, Sharma M, Kambadur R. Myostatin negatively regulates satellite cell activation and self-renewal. J Cell Biol 2003 : 162 : 1135 1147.
    • (2003) J Cell Biol , vol.162 , pp. 1135-1147
    • McCroskery, S.1    Thomas, M.2    Maxwell, L.3    Sharma, M.4    Kambadur, R.5
  • 36
    • 2942748216 scopus 로고    scopus 로고
    • Powerful genes - Myostatin regulation of human muscle mass
    • McNally EM. Powerful genes - myostatin regulation of human muscle mass. N Engl J Med 2004 : 350 : 2642 2644.
    • (2004) N Engl J Med , vol.350 , pp. 2642-2644
    • McNally, E.M.1
  • 37
    • 0031010050 scopus 로고    scopus 로고
    • Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member
    • McPherron AC, Lawler AM, Lee SJ. Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member. Nature 1997 : 387 : 83 90.
    • (1997) Nature , vol.387 , pp. 83-90
    • McPherron, A.C.1    Lawler, A.M.2    Lee, S.J.3
  • 38
    • 0030840359 scopus 로고    scopus 로고
    • Double muscling in cattle due to mutations in the myostatin gene
    • McPherron AC, Lee SJ. Double muscling in cattle due to mutations in the myostatin gene. Proc Natl Acad Sci USA 1997 : 94 : 12457 12461.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 12457-12461
    • McPherron, A.C.1    Lee, S.J.2
  • 41
    • 0642309352 scopus 로고    scopus 로고
    • Sulfated polysaccharides of brown seaweed Cystoseira canariensis bind to serum myostatin protein
    • Ramazanov Z, Jimenez del Rio M, Ziegenfuss T. Sulfated polysaccharides of brown seaweed Cystoseira canariensis bind to serum myostatin protein. Acta Physiol Pharmacol Bulg 2003 : 27 : 101 106.
    • (2003) Acta Physiol Pharmacol Bulg , vol.27 , pp. 101-106
    • Ramazanov, Z.1    Jimenez Del Rio, M.2    Ziegenfuss, T.3
  • 42
    • 33745813868 scopus 로고    scopus 로고
    • Myogenic gene expression at rest and after a bout of resistance exercise in young (18-30 yr) and old (80-89 yr) women
    • Raue U, Slivka D, Jemiolo B, Hollon C, Trappe S. Myogenic gene expression at rest and after a bout of resistance exercise in young (18-30 yr) and old (80-89 yr) women. J Appl Physiol 2006 : 101 : 53 59.
    • (2006) J Appl Physiol , vol.101 , pp. 53-59
    • Raue, U.1    Slivka, D.2    Jemiolo, B.3    Hollon, C.4    Trappe, S.5
  • 43
    • 27744524408 scopus 로고    scopus 로고
    • Effects of the compact mutant myostatin allele Mstn (Cmpt-dl1Abc) introgressed into a high growth mouse line on skeletal muscle cellularity
    • Rehfeldt C, Ott G, Gerrard DE, Varga L, Schlote W, Williams JL, Renne U, Bunger L. Effects of the compact mutant myostatin allele Mstn (Cmpt-dl1Abc) introgressed into a high growth mouse line on skeletal muscle cellularity. J Muscle Res Cell Motility 2005 : 26 : 103 112.
    • (2005) J Muscle Res Cell Motility , vol.26 , pp. 103-112
    • Rehfeldt, C.1    Ott, G.2    Gerrard, D.E.3    Varga, L.4    Schlote, W.5    Williams, J.L.6    Renne, U.7    Bunger, L.8
  • 44
    • 0038505243 scopus 로고    scopus 로고
    • Myostatin gene expression is reduced in humans with heavy-resistance strength training: A brief communication
    • Roth SM, Martel GF, Ferrell RE, Metter EJ, Hurley BF, Rogers MA. Myostatin gene expression is reduced in humans with heavy-resistance strength training: a brief communication. Exp Biol Med (Maywood) 2003 : 228 : 706 709.
    • (2003) Exp Biol Med (Maywood) , vol.228 , pp. 706-709
    • Roth, S.M.1    Martel, G.F.2    Ferrell, R.E.3    Metter, E.J.4    Hurley, B.F.5    Rogers, M.A.6
  • 46
    • 33646244749 scopus 로고    scopus 로고
    • Gene doping in sports: The science and ethics of genetically modified athletes
    • Schneider AJ, Friedmann T. Gene doping in sports: the science and ethics of genetically modified athletes. Adv Genet 2006 : 51 : 1 110.
    • (2006) Adv Genet , vol.51 , pp. 1-110
    • Schneider, A.J.1    Friedmann, T.2
  • 48
    • 0034867295 scopus 로고    scopus 로고
    • Polymorphic variation in the human myostatin (GDF-8) gene and association with strength measures in the women's health and aging study II cohort
    • Seibert MJ, Xue QL, Fried LP, Walston JD. Polymorphic variation in the human myostatin (GDF-8) gene and association with strength measures in the women's health and aging study II cohort. J Am Geriatr Soc 2001 : 49 : 1093 1096.
    • (2001) J Am Geriatr Soc , vol.49 , pp. 1093-1096
    • Seibert, M.J.1    Xue, Q.L.2    Fried, L.P.3    Walston, J.D.4
  • 49
    • 41149140037 scopus 로고    scopus 로고
    • Extract of marine plant Cystoseira canariensis (Cystocan), supplemented with whey protein and creatine, enhance muscle creatine content and protein synthesis in healthy, sedentary males participating in a resistance-training program. (last accessed August 2007).
    • Seifulla R, Abidoff M, Miguel Jimenez del Rio M, Ziegenfuss T, Krendal F. Extract of marine plant Cystoseira canariensis (Cystocan), supplemented with whey protein and creatine, enhance muscle creatine content and protein synthesis in healthy, sedentary males participating in a resistance-training program. 2005, (last accessed August 2007).
    • (2005)
    • Seifulla, R.1    Abidoff, M.2    Migueljimenezdelrio, M.3    Ziegenfuss, T.4    Krendal, F.5
  • 51
    • 41149122831 scopus 로고    scopus 로고
    • Researchers scent blood on trail of new cheats. Times Online, 2006.
    • Slot O. Researchers scent blood on trail of new cheats. Times Online, 2006.
    • Slot, O.1
  • 52
    • 34247269816 scopus 로고    scopus 로고
    • Therapeutic strategies for muscular dystrophy by myostatin inhibition
    • [in Japanese].
    • Sunada Y. Therapeutic strategies for muscular dystrophy by myostatin inhibition. Rinsho Shinkeigaku 2006 : 11 : 942 944 [in Japanese].
    • (2006) Rinsho Shinkeigaku , vol.11 , pp. 942-944
    • Sunada, Y.1
  • 53
    • 3142558011 scopus 로고    scopus 로고
    • Gene doping
    • Sweeney HL. Gene doping. Sci Am 2004 : 291 : 62 69.
    • (2004) Sci Am , vol.291 , pp. 62-69
    • Sweeney, H.L.1
  • 54
    • 34548291542 scopus 로고    scopus 로고
    • Myostatin DNA vaccine increases skeletal muscle mass and endurance in mice
    • Tang L, Yan Z, Wan Y, Han W, Zhang Y. Myostatin DNA vaccine increases skeletal muscle mass and endurance in mice. Muscle Nerve 2007 : 36 : 342 348.
    • (2007) Muscle Nerve , vol.36 , pp. 342-348
    • Tang, L.1    Yan, Z.2    Wan, Y.3    Han, W.4    Zhang, Y.5
  • 55
    • 18744396428 scopus 로고    scopus 로고
    • Myostatin, a negative regulator of muscle mass: Implications for muscle degenerative diseases
    • Tobin JF, Celeste AJ. Myostatin, a negative regulator of muscle mass: implications for muscle degenerative diseases. Curr Opin Pharmacol 2005 : 5 : 328 332.
    • (2005) Curr Opin Pharmacol , vol.5 , pp. 328-332
    • Tobin, J.F.1    Celeste, A.J.2
  • 56
    • 32944469015 scopus 로고    scopus 로고
    • The role of myostatin and bone morphogenetic proteins in muscular disorders
    • Tsuchida K. The role of myostatin and bone morphogenetic proteins in muscular disorders. Expert Opin Biol Ther 2006 : 6 : 147 154.
    • (2006) Expert Opin Biol Ther , vol.6 , pp. 147-154
    • Tsuchida, K.1
  • 57
    • 3042571406 scopus 로고    scopus 로고
    • Gene doping in sports
    • Unal M, Ozer Unal D. Gene doping in sports. Sports Med 2004 : 34 : 357 362.
    • (2004) Sports Med , vol.34 , pp. 357-362
    • Unal, M.1    Ozer Unal, D.2
  • 58
    • 27544453428 scopus 로고    scopus 로고
    • Muscle regeneration through myostatin inhibition
    • Wagner KR. Muscle regeneration through myostatin inhibition. Curr Opin Rheumatol 2005 : 17 : 720 724.
    • (2005) Curr Opin Rheumatol , vol.17 , pp. 720-724
    • Wagner, K.R.1
  • 59
    • 34447550642 scopus 로고    scopus 로고
    • Activin RIIB and Follistatin haplotype associations with muscle mass and strength in humans
    • Walsh S, Metter EJ, Ferrucci L, Roth SM. Activin RIIB and Follistatin haplotype associations with muscle mass and strength in humans. J Appl Physiol 2007 : 102 : 2142 2148.
    • (2007) J Appl Physiol , vol.102 , pp. 2142-2148
    • Walsh, S.1    Metter, E.J.2    Ferrucci, L.3    Roth, S.M.4
  • 63
    • 4344649468 scopus 로고    scopus 로고
    • Effects of an alleged myostatin-binding supplement and heavy resistance training on serum myostatin, muscle strength and mass, and body composition
    • Willoughby DS. Effects of an alleged myostatin-binding supplement and heavy resistance training on serum myostatin, muscle strength and mass, and body composition. Int J Sport Nutr Exerc Metab 2004 : 14 : 461 472.
    • (2004) Int J Sport Nutr Exerc Metab , vol.14 , pp. 461-472
    • Willoughby, D.S.1
  • 65
    • 0033205183 scopus 로고    scopus 로고
    • Plasma myostatin-immunoreactive protein is increased after prolonged bed rest with low-dose T3 administration
    • Zachwieja JJ, Smith SR, Sinha-Hikim I, Gonzalez-Cadavid N, Bhasin S. Plasma myostatin-immunoreactive protein is increased after prolonged bed rest with low-dose T3 administration. J Gravit Physiol 1999 : 6 : 11 15.
    • (1999) J Gravit Physiol , vol.6 , pp. 11-15
    • Zachwieja, J.J.1    Smith, S.R.2    Sinha-Hikim, I.3    Gonzalez-Cadavid, N.4    Bhasin, S.5
  • 66
    • 25844484021 scopus 로고    scopus 로고
    • Transgenic expression of myostatin propeptide prevents diet-induced obesity and insulin resistance
    • Zhao B, Wall RJ, Yang J. Transgenic expression of myostatin propeptide prevents diet-induced obesity and insulin resistance. Biochem Biophys Res Commun 2005 : 337 : 248 255.
    • (2005) Biochem Biophys Res Commun , vol.337 , pp. 248-255
    • Zhao, B.1    Wall, R.J.2    Yang, J.3
  • 67
    • 0034716993 scopus 로고    scopus 로고
    • Dominant negative myostatin produces hypertrophy without hyperplasia in muscle
    • Zhu X, Hadhazy M, Wehling M, Tidball JG, McNally EM. Dominant negative myostatin produces hypertrophy without hyperplasia in muscle. FEBS Lett 2000 : 474 : 71 75.
    • (2000) FEBS Lett , vol.474 , pp. 71-75
    • Zhu, X.1    Hadhazy, M.2    Wehling, M.3    Tidball, J.G.4    McNally, E.M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.