IL-1β, but not BMP-7 leads to a dramatic change in the gene expression pattern of human adult articular chondrocytes-Portraying the gene expression pattern in two donors

Cytokine

Volumn 36, Issue 1-2, 2006, Pages 90-99

  Saas, J ^a   Haag, J ^b   Rueger, D ^c   Chubinskaya, S ^d   Sohler, F ^e   Zimmer, R ^e   Bartnik, E ^a   Aigner, T ^b  

^a SANOFI AVENTIS DEUTSCHLAND GMBH   (Germany)

^b UNIVERSITY OF LEIPZIG   (Germany)

^c Stryker Orthopaedics   (United States)

^d RUSH MEDICAL COLLEGE   (United States)

^e UNIVERSITY OF MUNICH   (Germany)

Author keywords

Anabolism; Cartilage; Catabolism; Cell signaling; Osteogenic protein

Indexed keywords

AGGRECAN; ALGINIC ACID; COLLAGEN TYPE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; OSTEOGENIC PROTEIN 1; SMAD PROTEIN; STRESS ACTIVATED PROTEIN KINASE; BONE MORPHOGENETIC PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; ARTICULAR CARTILAGE; BIOINFORMATICS; BIOSTATISTICS; BIOSYNTHESIS; CARTILAGE CELL; CATABOLISM; CELL CULTURE; CULTURE MEDIUM; DATA ANALYSIS SOFTWARE; DEVICE; DOWN REGULATION; EVALUATION; GENE EXPRESSION PROFILING; GENE REPRESSION; GENETIC ANALYSIS; HUMAN; HUMAN CELL; NORMAL HUMAN; NUCLEOTIDE SEQUENCE; OSTEOARTHRITIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UNINDEXED SEQUENCE; AGED; AUTOPSY; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; MALE; METABOLISM; MIDDLE AGED;

AGED; AUTOPSY; BONE MORPHOGENETIC PROTEINS; CARTILAGE, ARTICULAR; CELLS, CULTURED; CHONDROCYTES; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMANS; INTERLEUKIN-1BETA; MALE; MIDDLE AGED; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA;

EID: 33845995862     PISSN: 10434666     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cyto.2006.10.005     Document Type: Article

References (35)

1. Flechtenmacher J., Huch K., Thonar E.J.M.A., Mollenhauer J., Davies S.R., Schmid T., et al. Recombinant human osteogenic protein 1 is a potent stimulator of the synthesis of cartilage proteoglycans and collagens by human articular chondrocytes. Arthritis Rheum 39 (1996) 1896-1904
2. Chubinskaya S., Merrihew C., Cs-Szabó G., Mollenhauer J., McCartney J., Rueger D.C., et al. Human articular chondrocytes express osteogenic protein-1. J Histochem Cytochem 48 (2000) 239-250
3. Martel-Pelletier J., Di Battista J.A., Lajeunesse D., and Pelletier J.P. IGF/IGFBP axis in cartilage and bone in osteoarthritis pathogenesis. Inflamm Res 47 (1998) 90-100
4. Tyler J.A. Insulin-like growth factor I can decrease degradation and promote synthesis of proteoglycan in cartilage exposed to cytokines. Biochem J 260 (1989) 543-548
5. Lories R.J., and Luyten F.P. Bone morphogenetic protein signaling in joint homeostasis and disease. Cytokine Growth Factor Rev 16 (2005) 287-298
6. Goldring M.B. Osteoarthritis and cartilage: the role of cytokines. Curr Rheumatol Rep 2 (2000) 459-465
7. Westacott C.I., and Sharif M. Cytokines in osteoarthritis: mediators or markers of joint destruction?. Semin Arthritis Rheum 25 (1996) 254-272
8. Firestein G.S., and Manning A.M. Signal transduction and transcription factors in rheumatic disease. Arthritis Rheum 42 (1999) 609-621
9. Lefebvre V., Peeters-Joris C., and Vaes G. Modulation by interleukin 1 and tumor necrosis factor a of production of collagenase, tissue inhibitor of metalloproteinases and collagen types in differentiated and dedifferentiated articular chondrocytes. Biochim Biophys Acta 1052 (1990) 366-378
10. Tyler J.A. Articular cartilage cultured with catabolin (pig interleukin 1) synthesizes decreased number of normal proteoglycan molecules. Biochem J 227 (1985) 869-878
11. Mankin H.J., Dorfman H., Lippiello L., and Zarins A. Biochemical and metabolic abnormalities in articular cartilage from osteoarthritic human hips. J Bone Joint Surg 53-A (1971) 523-537
12. Cs-Szabó G., Roughley P.J., Plaas A.H.K., and Glant T.T. Large and small proteoglycans of osteoarthritic and rheumatoid articular cartilage. Arthritis Rheum 38 (1995) 660-668
13. Aigner T., Bertling W., Stoss H., Weseloh G., and von der Mark K. Independent expression of fibril-forming collagens I, II, and III in chondrocytes of human osteoarthritic cartilage. J Clin Invest 91 (1993) 829-837
14. Aigner T., Zien A., Gehrsitz A., Gebhard P.M., and McKenna L.A. Anabolic and catabolic gene expression pattern analysis in normal versus osteoarthritic cartilage using complementary DNA-array technology. Arthritis Rheum 44 (2001) 2777-2789
15. Finger F., Schörle C.M., Zien A., Gebhard P.M., Goldring M.B., and Aigner T. Molecular phenotyping of human chondrocyte cell lines T/C-28a2, T/C-28a4, C-28/I2. Arthritis Rheum 48 (2003) 3395-3403
16. R Development Core Team. R: a language and environment for statistical computing. Vienna, Austria: R Foundation for Statistical Computing, 2005.
17. Takahashi N., Rieneck K., van der Kraan P.M., Van Beuningen H.M., Vitters E.L., Bendtzen K., et al. Elucidation of IL-1/TGF-beta interactions in mouse chondrocyte cell line by genome-wide gene expression. Osteoarthritis Cartilage 13 (2005) 426-438
18. Bau B., Gebhard P.M., Haag J., Knorr T., Bartnik E., and Aigner T. Relative messenger RNA expression profiling of collagenases and aggrecanases in human articular chondrocytes in vivo and in vitro. Arthritis Rheum 46 (2002) 2648-2657
19. Mitchell P.G., Magna H.A., Reeves L.M., Lopresti-Morrow L.L., Yocum S.A., Rosner P.J., et al. Cloning, expression, and type II collagenolytic activity of matrix metalloproteinase-13 from human osteoarthritic cartilage. J Clin Invest 97 (1996) 761-768
20. Stephenson M.L., Goldring M.B., Birkhead J.R., Krane M., Rahmsdorf H.J., and Angel P. Stimulation of procollagenase synthesis parallels increases in cellular procollagenase mRNA in human articular chondrocytes exposed to recombinant interleukin 1β or phorbol ester. Biochem Biophys Res Commun 144-2 (1987) 583-590
21. Mengshol J.A., Vincenti M.P., Coon C.I., Barchowsky A., and Brinckerhoff C.E. Interleukin-1 induction of collagenase 3 (matrix metalloproteinase 13) gene expression in chondrocytes requires p38, c-Jun N-terminal kinase, and nuclear factor kappaB: differential regulation of collagenase 1 and collagenase 3. Arthritis Rheum 43 (2000) 801-811
22. Nguyen Q., Mort J.S., and Roughley P.J. Preferential mRNA expression of prostromelysin relative to procollagenase and in situ localization in human articular cartilage. J Clin Invest 89 (1992) 1189-1197
23. Reboul P., Pelletier J.P., Tardif G., Cloutier J.-M., and Martel-Pelletier J. The new collagenase, collagenase-3, is expressed and synthesized by human chondrocytes but not by synoviocytes. J Clin Invest 97 (1996) 2011-2019
24. Tortorella M.D., Malfait A., Deccico C., Arner E., and Nagase H. The role of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) in a model of cartilage degradation. Osteoarthritis Cartilage 9 (2001) 539-552
25. Fan Z., Chubinskaya S., Rueger D., Bau B., Haag J., and Aigner T. Regulation of anabolic and catabolic gene expression in normal and osteoarthritic adult human articular chondrocytes by osteogenic protein-1. Clin Exp Rheumatol 22 (2004) 103-106
26. Bachner D., Ahrens M., Schroder D., Hoffmann A., Lauber J., Betat N., et al. Bmp-2 downstream targets in mesenchymal development identified by subtractive cloning from recombinant mesenchymal progenitors (C3H10T). Dev Dyn 213 (1998) 398-411
27. DeLise A.M., Fischer L., and Tuan R.S. Cellular interactions and signaling in cartilage development. Osteoarthritis Cartilage 8 (2000) 309-334
28. Soeder S., Hakimiyan A., Rueger D., Kuettner K., Aigner T., and Chubinskaya S. Antisense inhibition of osteogenic protein-1 disturbs human articular cartilage integrity. Arthritis Rheum 52 (2005) 468-478
29. Shi Y., and Massague J. Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell 113 (2003) 685-700
30. Bau B., Haag J., Schmid E., Kaiser M., Gebhard P.M., and Aigner T. Bone morphogenetic protein-mediating receptor-associated Smads as well as common Smad are expressed in human articular chondrocytes, but not upregulated or downregulated in osteoarthritic cartilage. J Bone Miner Res 17 12 (2002) 2141-2150
31. Kaiser M., Haag J., Söder S., Bau B., and Aigner T. BMP- and TGFβ-inhibitory Smads 6 and 7 are expressed in human adult normal and osteoarthritic cartilage in vivo and differentially regulated in vitro by Il-1β. Arthritis Rheum 11 (2004) 3535-3540
32. Schaeffer H.J., and Weber M.J. Mitogen-activated protein kinases: specific messages from ubiquitous messengers. Mol Cell Biol 19 (1999) 2435-2444
33. Renard P., and Raes M. The proinflammatory transcription factor NFkappaB: a potential target for novel therapeutical strategies. Cell Biol Toxicol 15 (1999) 341-344
34. Fan Z., Bau B., Yang H., and Aigner T. Il-beta induction of Il-6 and LIF in normal articular human chondrocytes involves the ERK, p38 and NFkB signaling pathways. Cytokine 28 (2004) 17-24
35. Saklatvala J., Dean J., and Finch A. Protein kinase cascades in intracellular signalling by interleukin-I and tumour necrosis factor. Biochem Soc Symp 64 (1999) 63-77