Effects of Statin Treatment on Serum Sex Steroids Levels and Autonomic and Erectile Function

Urology

Volumn 71, Issue 4, 2008, Pages 703-707

  Doǧru, M Tolga ^a   Başar, M Murad ^a   Şimşek, Ali ^a   Yuvanç, Ercan ^a   Güneri, Mahmut ^a   Ebinç, Haksun ^a   Batislam, Ertan ^a  

^a KIRIKKALE UNIVERSITY   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

ATORVASTATIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LIPID; SEX HORMONE;

ADULT; ARTICLE; CONTROLLED STUDY; DIAGNOSTIC PROCEDURE; DYSPEPSIA; ELECTROENCEPHALOGRAM; ERECTILE DYSFUNCTION; FOLLOW UP; HEART RATE VARIABILITY; HOLTER MONITORING; HUMAN; HYPERLIPIDEMIA; LIBIDO; MAJOR CLINICAL STUDY; MALE; NAUSEA; PARASYMPATHETIC GANGLION; PENIS ERECTION; PHYSICAL EXAMINATION; PRIORITY JOURNAL; QUESTIONNAIRE; SCORING SYSTEM; STATISTICAL SIGNIFICANCE; TREATMENT DURATION;

ADULT; AUTONOMIC NERVOUS SYSTEM; FOLLOW-UP STUDIES; GONADAL STEROID HORMONES; HEART RATE; HEPTANOIC ACIDS; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; HYPERLIPIDEMIAS; LIBIDO; LIPIDS; MALE; MIDDLE AGED; PENILE ERECTION; PYRROLES;

EID: 41149091861     PISSN: 00904295     EISSN: 15279995     Source Type: Journal    
DOI: 10.1016/j.urology.2007.11.059     Document Type: Article

References (30)

1. Feldman H., Goldmein I., Harzichristou D., et al. Impotence and its medical and psychosocial correlates: results of the Massachusetts Male Aging Study. J Urol 151 (1994) 54-61
2. Seftel A.D., Sun P., and Swindle R. The prevalence of hypertension, hyperlipidemia, diabetes mellitus and depression in men with erectile dysfunction. J Urol 171 (2004) 2341-2345
3. Braun M., Wassmer G., Klotz T., et al. Epidemiology of erectile dysfunction: results of the "Cologne Male Survey. " Int J Impot Res 12 (2000) 305-311
4. Roumeguere T.H., Wespes E., Carpentier Y., et al. Erectile dysfunction is associated with a high prevalence of hyperlipidemia and coronary heart disease risk. Eur Urol 44 (2003) 355-359
5. Kim J.H., Klyachkin M.L., Svendsen E., et al. Experimental hypercholesterolemia in rabbits induces cavernosal atherosclerosis with endothelial and smooth muscle cell dysfunction. J Urol 151 (1994) 198-205
6. Puddu P., Puddu G.M., and Muscari A. HMG-CoA reductase inhibitors: is the endothelium the main target?. Cardiology 95 (2001) 9-13
7. Jarvisalo M.J., Toikka J.O., Vasankari T., et al. HMG CoA reductase inhibitors are related to improved systemic endothelial function in coronary artery disease. Atherosclerosis 147 (1999) 237-242
8. Keidar S., Aviram M., Maor I., et al. Pravastatin inhibits cellular cholesterol synthesis and increases low density lipoprotein receptor activity in macrophages: in vitro and in vivo studies. Br J Clin Pharmacol 38 (1994) 513-519
9. Welzig C.M., Shin D.G., Park H.J., et al. Lipid lowering by pravastatin increases parasympathetic modulation of heart rate Gα2, a possible molecular marker for parasympathetic responsiveness. Circulation 108 (2003) 2743-2746
10. Riahi S., Christensen J.H., Toft E., et al. HMG-CoA reductase inhibitors improve heart rate variability in patients with a previous myocardial infarction. Pharmacol Res 45 (2002) 479-483
11. Saltzman E.A., Guay A.T., and Jacobson J. Improvement in erectile function in men with organic erectile dysfunction by correction of elevated cholesterol levels: a clinical observation. J Urol 172 (2004) 255-258
12. Carvajal A., Macias D., Sainz M., et al. HMG CoA reductase inhibitors and impotence: two case series from the Spanish and French drug monitoring systems. Drug Saf 29 (2006) 143-149
13. de Graaf L., Brouwers A.H., and Diemont W.L. Is decreased libido associated with the use of HMG-CoA-reductase inhibitors?. Br J Clin Pharmacol 58 (2004) 326-328
14. Ormiston T., Wolkowitz O.M., Reus V.I., et al. Hormonal changes with cholesterol reduction: a double-blind pilot study. J Clin Pharm Ther 29 (2004) 71-73
15. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology: Heart rate variability: standards of measurement, physiological interpretation and clinical use. Circulation 93 (1996) 1043-1065
16. Ghanem H., and Posrt H. Etiology and risk factors of erectile dysfunction. In: Porst H., and Buvat J. (Eds). Standard Practice in Sexual Medicine (2006), Blackwell Publishing, Boston 49-58
17. Wei M., Macera C.A., Davis D.R., et al. Total cholesterol and high density lipoprotein cholesterol as important predictors of erectile dysfunction. Am J Epidemiol 140 (1994) 930-937
18. Nehra A., Azadzoi K.M., Moreland R.B., et al. Cavernosal expandability is an erectile tissue mechanical property which predicts trabecular histology in an animal model of vasculogenic erectile dysfunction. J Urol 159 (1998) 2229-2236
19. Treasure C.B., Klein J.L., Weintraub W.S., et al. Beneficial effects of cholesterol-lowering therapy on the coronary endothelium in patients with coronary artery disease. N Engl J Med 332 (1995) 481-487
20. Libby P., Aikawa M., Kinlay S., et al. Lipid lowering improves endothelial functions. Int J Cardiol 30 (2000) S3-S10
21. Lavie P., Shlitner A., and Nave R. Cardiac autonomic function during sleep in psychogenic and organic erectile dysfunction. J Sleep Res 8 (1999) 135-142
22. Kupari M., Virolainen J., Koskinen P., et al. Short-term heart rate variability and factors modifying the risk of coronary artery disease in a population sample. Am J Cardiol 72 (1993) 897-903
23. Ferini-Strambi L., Zucconi M., Rigatti P., et al. Male impotence: a possible beta-adrenergic dysfunction in some patients. Eur Urol 21 (1992) 332-334
24. Acharya U.R., Kannatathal N., Sing O.W., et al. Heart rate analysis in normal subjects of various age group. Biomed Eng Online 20 (2004) 24
25. Junemann K.P., Aufenanger J., Konrad T., et al. The effect of impaired lipid metabolism on the smooth muscle cells of rabbits. Urol Res 19 (1991) 271-275
26. Bonaa K.H., and Arnesen E. Association between heart rate and atherogenic blood lipid fractions in a population: the Tromso study. Circulation 86 (1992) 394-405
27. Krakoff L.R., Dziedzic S., Mann S.J., et al. Plasma epinephrine concentration in healthy men: correlation with systolic pressure and rate-pressure product. J Am Coll Cardiol 5 2 Pt 1 (1985) 352-356
28. Borghi C., Prandin M.G., Costa F.V., et al. Use of statins and blood pressure control in treated hypertensive patients with hypercholesterolemia. J Cardiovasc Pharmacol 35 (2000) 549-555
29. Masumoto A., Hirooka Y., Hironaga K., et al. Effect of pravastatin on endothelial function in patients with coronary artery disease (cholesterol-independent effect of pravastatin). Am J Cardiol 88 (2001) 1291-1294
30. Bohm M., Herrmann W., Wassmann S., et al. Does statin therapy influence steroid hormone synthesis?. Z Kardiol 93 (2004) 43-48