Hormonal changes with cholesterol reduction: A double-blind pilot study

Journal of Clinical Pharmacy and Therapeutics

Volumn 29, Issue 1, 2004, Pages 71-73

  Ormiston, T ^a,b   Wolkowitz, O M ^c   Reus, V I ^c   Johnson, R ^c   Manfredi, F ^c  

^a SANTA CLARA VALLEY MEDICAL CENTER   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cholesterol; Dopamine; Homovanillic acid; Serotonin; Suicide

Indexed keywords

5 HYDROXYINDOLEACETIC ACID; ATORVASTATIN; CHOLESTEROL; DOPAMINE; HOMOVANILLIC ACID; HORMONE; HYDROCORTISONE; HYPOCHOLESTEROLEMIC AGENT; MEVINOLIN; PLACEBO; PREGNENOLONE; SEROTONIN; TESTOSTERONE;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CLINICAL OBSERVATION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FEMALE; HORMONE BLOOD LEVEL; HUMAN; MALE; MEASUREMENT; PILOT STUDY; REDUCTION;

ADULT; AGED; AGED, 80 AND OVER; CHOLESTEROL; DOUBLE-BLIND METHOD; FEMALE; HEPTANOIC ACIDS; HORMONES; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; HYPERLIPIDEMIAS; LOVASTATIN; MALE; MIDDLE AGED; PYRROLES;

EID: 1342267639     PISSN: 02694727     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2710.2003.00540.x     Document Type: Article

References (22)

1. Muldoon M, Manuck S, Mathews K (1990) Lowering cholesterol concentrations and mortality: a quantitative review of primary prevention trials. BMJ, 201, 309-314.
2. Lindberg G, Rastam L, Gullberg B, Eklund G (1992) Low serum cholesterol concentration and short term mortality from injuries in men and women. BMJ, 305, 277-279.
3. Cummings P, Psaty B (1994) The association between cholesterol and death from injury. Annals of Internal Medicine, 120, 848-855.
4. Golomb BA (1998) Cholesterol and violence: is there a connection? Annals of Internal Medicine, 128, 478-487.
5. Muldoon MF, Manuck SB, Mendelsohn AB, Kaplan JR, Belle SH (2001) Cholesterol reduction and non-illness mortality: meta-analysis of randomized clinical trials. BMJ, 322, 11-15.
6. Ormiston T, Wolkowitz O, Reus V, Manfredi F (2003) Behavioral implications of lowering cholesterol: a double-blinded pilot study. Psychosomatics, 44, 412-414.
7. Suarez E (1999) Relations of trait depression and anxiety to low lipid and lipoprotein concentrations in healthy young adult women. Psychosomatic Medicine, 61, 273-279.
8. Horsten M, Wamala S, Vingerhoets A, Orth-Gomer K (1997) Depressive symptoms, social support, and lipid profile in healthy middle-aged women. Psychosomatic Medicine, 59, 521-528.
9. Kaplan JR, Manruk S (1990) The effects of fat and cholesterol on aggressive behavior in monkeys. Psychosomatic Medicine, 52, 226-227.
10. Kaplan JR, Shively CA, Fontenot MB et al. (1994) Demonstration of an association among dietary cholesterol, central serotonergic activity and social behavior in monkeys. Psychosomatic Medicine, 56, 479-484.
11. Wells AS, Read NW, Laugharne JD, Ahluwalia NS (1998) Alterations in mood after changing to a low fat diet. British Journal of Nutrition, 79, 23-30.
12. Alvarez JC, Cremniter D, Lesieur P et al. (1999) Low blood cholesterol and low platelet serotonin levels in violent suicide attempters. Biological Psychiatry, 45, 1066-1069.
13. Kunugi H, Takei N, Aoki H, Nankop S (1997) Low serum cholesterol in suicide attempters. Biological Psychiatry, 41, 196-200.
14. Garland M, Hickey D, Corvin A, Golden J, Cunningham S, Walsh N (2000) Total serum cholesterol in relation to psychological correlates in parasuicide. British Journal of Psychiatry, 177, 77-83.
15. Faust J, Goldstein J, Brown M (1977) Receptor mediated uptake of low-density lipoprotein and utilization of cholesterol for steroid synthesis in cultured mouse adrenal cells. Journal of Biological Chemistry, 252, 4861-4871.
16. Rohr U (2002) The impact of testosterone imbalance on depression and women's health. Maturitas, 41(Suppl. 1), 25-46.
17. Bhagwagar Z, Whale R, Cowen P (2002) State and trait abnormalities in serotonin function in major depression. British Journal of Psychiatry, 180, 24-28.
18. Pitchot W, Herrera C, Ansseau M (2001) HPA axis dysfunction in major depression: relationship to 5-HT (1A) receptor activity. Neuropsychobiology, 44, 74-77.
19. Espejo EF, Minano FJ (1999) Pre-frontocorrical dopamine depletion induces anti-depressant-like effects in rats and alters the profile of desipramine during Porsolt's test. Neuroscience, 88, 609-615.
20. Ohmari T, Arora RC, Meltzer HY (1992) Serotenergic measures in suicide brains: the concentration of 5-HIAA, HVA, and tryptophan in frontal cortex of suicide victims. Biological Psychiatry, 32, 57-71.
21. Bacopoulos N, Hattox S, Roth R (1979) 3,4-Dihydroxyphenylacetic acid and homovanillic acid in rat plasm: possible indicators of central dopaminergic activity. European Journal of Pharmacology, 56, 225-236.
22. Sternberg D, Heninger G, Roth R (1983) Plasma homovanillic acid as an index of brain dopamine metabolism: enhancement with debrisoquin. Life Sciences, 32, 2447-2452.