GF120918, a P-glycoprotein modulator, increases the concentration of unbound amprenavir in the central nervous system in rats

Antimicrobial Agents and Chemotherapy

Volumn 46, Issue 7, 2002, Pages 2284-2286

  Edwards, Jeffrey E ^a   Brouwer, Kenneth R ^a   McNamara, Patrick J ^a  

^a University of Kentucky   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPRENAVIR; ELACRIDAR; GLYCOPROTEIN P; PROTEINASE INHIBITOR; ACRIDINE DERIVATIVE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; CARBAMIC ACID DERIVATIVE; ISOQUINOLINE DERIVATIVE; SULFONAMIDE; TETRAHYDROISOQUINOLINE DERIVATIVE;

ANIMAL EXPERIMENT; ARTICLE; BLOOD BRAIN BARRIER; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DRUG DISTRIBUTION; EXTRACELLULAR FLUID; MALE; MICRODIALYSIS; NONHUMAN; PRIORITY JOURNAL; RAT; TISSUE DISTRIBUTION; BRAIN; DRUG ANTAGONISM; METABOLISM;

ACRIDINES; ANTI-HIV AGENTS; BLOOD-BRAIN BARRIER; BRAIN; HIV PROTEASE INHIBITORS; ISOQUINOLINES; MICRODIALYSIS; P-GLYCOPROTEIN; SULFONAMIDES; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; CARBAMATES; TETRAHYDROISOQUINOLINES;

EID: 0035984821     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.46.7.2284-2286.2002     Document Type: Article

References (18)

1. 4-Trimethylammonium antipyrine: A quaternary ammonium nonradionuclide marker for blood-brain barrier integrity during in vivo microdialysis
2. P-glycoproteins and multidrug resistance
3. Pharmacokinetics and distribution over the blood-brain barrier of zalcitabine (2′,3′-dideoxycytidine) and BEA005 (2′,3′-dideoxy-3′-hydroxymethylcytidine) in rats, studied by microdialysis
4. Methodological aspects of the use of a calibrator in in vivo microdialysis-further development of the retrodialysis method
5. Modulation effects of cyclosporine on etoposide pharmacokinetics and CNS distribution in the rat utilizing microdialysis
6. Pharmacological inhibition of P-glycoprotein transport enhances the distribution of HIV-1 protease inhibitors into brain and testes
7. Application of microdialysis in pharmacokinetic studies
8. The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors
9. HIV-1 protease inhibitors are substrates for the MDR1 multidrug transporter
10. Weak binding of VX-478 to human plasma proteins and implications for anti-human immunodeficiency virus therapy
11. Reservoirs for HIV-1: Mechanisms for viral persistence in the presence of antiviral immune responses and antiretroviral therapy
12. Role of P-glycoprotein on the CNS disposition of amprenavir (141W94), an HIV protease inhibitor
13. Human immunodeficiency virus protease inhibitors
14. HIV-associated dementia: New insights into disease pathogenesis and therapeutic interventions
15. The functional role of P-glycoprotein in the blood-brain barrier
16. Effect of the P-glycoprotein inhibitor, cyclosporin A, on the distribution of rhodamine-123 to the brain: An in vivo microdialysis study in freely moving rats
17. Zidovudine transport in the rabbit brain during intravenous and intracerebroventricular infusion
18. Microdialysis studies of the distribution of stavudine into the central nervous system in the freely-moving rat