Inhibition of β-TrCP function potentiates UVB-induced apoptosis in hTERT-immortalized normal human keratinocytes

Photochemistry and Photobiology

Volumn 84, Issue 2, 2008, Pages 376-381

  Bhatia, Neehar ^a   Demmer, Tara A ^a   Spiegelman, Vladimir S ^a  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA TRANSDUCIN REPEAT CONTAINING PROTEIN; TELOMERASE; TERT PROTEIN, HUMAN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL LINE; CYTOLOGY; DRUG ANTAGONISM; HUMAN; KERATINOCYTE; METABOLISM; RADIATION EXPOSURE; ULTRAVIOLET RADIATION;

APOPTOSIS; BETA-TRANSDUCIN REPEAT-CONTAINING PROTEINS; CELL LINE, TRANSFORMED; HUMANS; KERATINOCYTES; TELOMERASE; ULTRAVIOLET RAYS;

EUKARYOTA;

EID: 41049095847     PISSN: 00318655     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1751-1097.2007.00272.x     Document Type: Article

References (39)

1. Stewart, S. A. R. A. Weinberg (2006) Telomeres: Cancer to human aging. Annu. Rev. Cell Dev. Biol. 22, 531 557.
2. Stewart, S. A. R. A. Weinberg (2000) Telomerase and human tumorigenesis. Semin. Cancer Biol. 10, 399 406.
3. Allen-Hoffmann, B. L., S. J. Schlosser, C. A. Ivarie, C. A. Sattler, L. F. Meisner S. L. O'Connior (2000) Normal growth and differentiation in a spontaneously immortalized near-diploid human keratinocyte cell line, NIKS. J. Invest. Dermatol. 114, 444 455.
4. Baden, H. P., J. Kubilus, J. C. Kvedar, M. L. Steinberg S. R. Wolman (1987) Isolation and characterization of a spontaneously arising long-lived line of human keratinocytes (NM 1). In Vitro Cell Dev. Biol. 23, 205 213.
5. Boukamp, P., R. T. Petrussevska, D. Breitkreutz, J. Hornung, A. Markham N. E. Fusenig (1988) Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line. J. Cell Biol. 106, 761 771.
6. Rice, R. H., K. E. Steinmann, L. A. deGraffenried, Q. Qin, N. Taylor R. Schlegel (1993) Elevation of cell cycle control proteins during spontaneous immortalization of human keratinocytes. Mol. Biol. Cell 4, 185 194.
7. Bharti, A. C. B. B. Aggarwal (2002) Nuclear factor-κB and cancer: Its role in prevention and therapy. Biochem. Pharmacol. 64, 883 888.
8. Mayo, M. W. A. S. Baldwin (2000) The transcription factor NF-κB: Control of oncogenesis and cancer therapy resistance. Biochim. Biophys. Acta 1470, M55 62.
9. Karin, M. Y. Ben-Neriah (2000) Phosphorylation meets ubiquitination: The control of NF-[kappa]B activity. Annu. Rev. Immunol. 18, 621 663.
10. O'Connor, S., S. Markovina S. Miyamoto (2005) Evidence for a phosphorylation-independent role for Ser 32 and 36 in proteasome inhibitor-resistant (PIR) IκBα degradation in B cells. Exp. Cell Res. 307, 15 25.
11. O'Connor, S., S. D. Shumway, I. J. Amanna, C. E. Hayes S. Miyamoto (2004) Regulation of constitutive p50/c-Rel activity via proteasome inhibitor-resistant IκBα degradation in B cells. Mol. Cell Biol. 24, 4895 4908.
12. Wu, Z. H. S. Miyamoto (2007) Many faces of NF-κB signaling induced by genotoxic stress. J. Mol. Med. ???, ???.
13. Bubici, C., S. Papa, K. Dean G. Franzoso (2006) Mutual cross-talk between reactive oxygen species and nuclear factor-κB: Molecular basis and biological significance. Oncogene 25, 6731 6748.
14. Melnikova, V. O. H. N. Ananthaswamy (2005) Cellular and molecular events leading to the development of skin cancer. Mutat. Res. 571, 91 106.
15. Tobin, D., M. van Hogerlinden R. Toftgard (1998) UVB-induced association of tumor necrosis factor (TNF) receptor 1/TNF receptor-associated factor-2 mediates activation of Rel proteins. Proc. Natl Acad. Sci. USA 95, 565 569.
16. van Hogerlinden, M., B. L. Rozell, L. Ahrlund-Richter R. Toftgard (1999) Squamous cell carcinomas and increased apoptosis in skin with inhibited Rel/nuclear factor-κB signaling. Cancer Res. 59, 3299 3303.
17. Fuchs, S. Y. (2002) The role of ubiquitin-proteasome pathway in oncogenic signaling. Cancer Biol. Ther. 1, 337 341.
18. Fuchs, S. Y., V. S. Spiegelman K. G. Kumar (2004) The many faces of β-TrCP E3 ubiquitin ligases: Reflections in the magic mirror of cancer. Oncogene 23, 2028 2036.
19. Deshaies, R. J. (1999) SCF and Cullin/Ring H2-based ubiquitin ligases. Annu. Rev. Cell Dev. Biol. 15, 435 467.
20. Maniatis, T. (1999) A ubiquitin ligase complex essential for the NF-κB, Wnt/Wingless, and Hedgehog signaling pathways. Genes Dev. 13, 505 510.
21. Guardavaccaro, D., Y. Kudo, J. Boulaire, M. Barchi, L. Busino, M. Donzelli, F. Margottin-Goguet, P. K. Jackson, L. Yamasaki M. Pagano (2003) Control of Meiotic and Mitotic Progression by the F Box Protein beta-Trcpl In Vivo. Dev. Cell 4, 799 812.
22. Bour, S., C. Perrin, H. Akari K. Strebel (2001) The human immunodeficiency virus type 1 Vpu protein inhibits NF-κB activation by interfering with beta TrCP-mediated degradation of IκB. J. Biol. Chem. 276, 15920 15928.
23. Saitoh, T. M. Katoh (2001) Expression profiles of βTRCPl and βTRCP2, and mutation analysis of βTRCP2 in gastric cancer. Int. J. Oncol. 18, 959 964.
24. Spiegelman, V. S., W. Tang, A. M. Chan, M. Igarashi, S. A. Aaronson, D. A. Sassoon, M. Katoh, T. J. Slaga S. Y. Fuchs (2002) Induction of homologue of Slimb ubiquitin ligase receptor by mitogen signaling. J. Biol. Chem. 277, 36624 36630.
25. Belaidouni, N., M. Peuchmaur, C. Perret, A. Florentin, R. Benarous C. Besnard- Guerin (2005) Overexpression of human β TrCPl deleted of its F box induces tumorigenesis in transgenic mice. Oncogene 24, 2271 2276.
26. Kudo, Y., D. Guardavaccaro, P. G. Santamaria, R. Koyama-Nasu, E. Latres, R. Bronson, L. Yamasaki M. Pagano (2004) Role of F-box protein betaTrcpl in mammary gland development and tumorigenesis. Mol. Cell. Biol. 24, 8184 8194.
27. Bhatia, N., J. R. Herter, T. J. Slaga, S. Y. Fuchs V. S. Spiegelman (2002) Mouse homologue of HOS (mHOS) is overexpressed in skin tumors and implicated in constitutive activation of NF-κB. Oncogene 21, 1501 1509.
28. Counter, C. M., W. C. Hahn, W. Wei, S. D. Caddie, R. L. Beijersbergen, P. M. Lansdorp, J. M. Sedivy R. A. Weinberg (1998) Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization. Proc. Natl Acad. Sci. USA 95, 14723 14728.
29. Pincelli, C., C. Sevignani, R. Manfredini, A. Grande, F. Fantini, L. Bracci-Laudiero, L. Aloe, S. Ferrari, A. Cossarizza A. Giannetti (1994) Expression and function of nerve growth factor and nerve growth factor receptor on cultured keratinocytes. J. Invest. Dermatol. 103, 13 18.
30. Baden, H. P., J. Kubilus, S. R. Wolman, M. L. Steinberg, S. B. Phillips J. C. Kvedar (1987) NM1 keratinocyte line is cytogenetically and biologically stable and exhibits a unique structural protein. J. Invest. Dermatol. 89, 574 579.
31. Bryan, D., C. J. Sexton, D. Williams, I. M. Leigh I. A. McKay (1995) Oral keratinocytes immortalized with the early region of human papillomavirus type 16 show elevated expression of interleukin 6, which acts as an autocrine growth factor for the derived T103C cell line. Cell Growth Differ. 6, 1245 1250.
32. Dickson, M. A., W. C. Hahn, Y. Ino, V. Ronfard, J. Y. Wu, R. A. Weinberg, D. N. Louis, F. P. Li J. G. Rheinwald (2000) Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics. Mol. Cell. Biol. 20, 1436 1447.
33. Haga, K., S. Ohno, T. Yugawa, M. Narisawa-Saito, M. Fujita, M. Sakamoto, D. A. Galloway T. Kiyono (2007) Efficient immortalization of primary human cells by p16INK4a-specific short hairpin RNA or Bmi-1, combined with introduction of hTERT. Cancer Sci. 98, 147 154.
34. Spiegelman, V. S., P. Stavropoulos, E. Latres, M. Pagano, Z. Ronai, T. J. Slaga S. Y. Fuchs (2001) Induction of beta-transducin repeat-containing protein by JNK signaling and its role in the activation of NF-κB. J. Biol. Chem. 276, 27152 27158.
35. Spiegelman, V. S., T. J. Slaga, M. Pagano, T. Minamoto, Z. Ronai S. Y. Fuchs (2000) Wnt/beta-catenin signaling induces the expression and activity of βTrCP ubiquitin ligase receptor. Mol. Cell 5, 877 882.
36. Karin, M., Y. Cao, F. R. Greten Z. W. Li (2002) NF-κB in cancer: from innocent bystander to major culprit. Nat. Rev. Cancer 2, 301 310.
37. Han, Y., S. Weinman, L Boldogh, R. K. Walker A. R. Brasier (1999) Tumor necrosis factor-alpha-inducible IκBα proteolysis mediated by cytosolic m-calpain, A mechanism parallel to the ubiquitin-proteasome pathway for nuclear factor-kappab activation. J. Biol. Chem. 274, 787 794.
38. Pianetti, S., M. Arsura, R. Romieu-Mourez, R. J. Coffey G. E. Sonenshein (2001) Her-2/neu overexpression induces NF-κB via a PI3-kinase/Akt pathway involving calpain-mediated degradation of IκB-α that can be inhibited by the tumor suppressor PTEN. Oncogene 20, 1287 1299.
39. Solan, N. J., H. Miyoshi, E. M. Carmona, G. D. Bren C. V. Paya (2002) RelB cellular regulation and transcriptional activity are regulated by p100. J. Biol. Chem. 277, 1405 1418.