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Volumn 22, Issue 2, 2008, Pages 101-112

Recombinant human growth hormone: Rationale for use in the treatment of HIV-associated lipodystrophy

Author keywords

HIV associated lipodystrophy syndrome, treatment; Somatropin, therapeutic use

Indexed keywords

HUMAN GROWTH HORMONE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; METFORMIN; PROTEINASE INHIBITOR; STAVUDINE; ZIDOVUDINE;

EID: 41049093322     PISSN: 11738804     EISSN: None     Source Type: Journal    
DOI: 10.2165/00063030-200822020-00003     Document Type: Review
Times cited : (16)

References (112)
  • 1
    • 0032493043 scopus 로고    scopus 로고
    • A syndrome of peripheral lipodystrophy, hyperlipidaemia and insulin resistance in patients receiving HIV protease inhibitors
    • Carr A, Samaras K, Burton S, et al. A syndrome of peripheral lipodystrophy, hyperlipidaemia and insulin resistance in patients receiving HIV protease inhibitors. AIDS 1998; 12: F51-8
    • (1998) AIDS , vol.12
    • Carr, A.1    Samaras, K.2    Burton, S.3
  • 2
    • 0033391005 scopus 로고    scopus 로고
    • A syndrome of peripheral fat wasting (lipodystrophy) in patients receiving long-term nucleoside analogue therapy
    • Saint-Marc T, Partisani M, Poizot-Martin I, et al. A syndrome of peripheral fat wasting (lipodystrophy) in patients receiving long-term nucleoside analogue therapy. AIDS 1999; 13: 1659-67
    • (1999) AIDS , vol.13 , pp. 1659-1667
    • Saint-Marc, T.1    Partisani, M.2    Poizot-Martin, I.3
  • 3
    • 3242740785 scopus 로고    scopus 로고
    • Markedly diminished lipolysis and partial restoration of glucose metabolism, without changes in fat distribution after extended discontinuation of protease inhibitors in severe lipodystrophic human immunodeficient virus-1-infected patients
    • van der Valk M, Allick G, Weverling GJ, et al. Markedly diminished lipolysis and partial restoration of glucose metabolism, without changes in fat distribution after extended discontinuation of protease inhibitors in severe lipodystrophic human immunodeficient virus-1-infected patients. J Clin Endocrinol Metab 2004; 89 (7): 3554-60
    • (2004) J Clin Endocrinol Metab , vol.89 , Issue.7 , pp. 3554-3560
    • van der Valk, M.1    Allick, G.2    Weverling, G.J.3
  • 5
    • 30744466427 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha is associated with insulin-mediated suppression of free fatty acids and net lipid oxidation in HIV-infected patients with lipodystrophy
    • Haugaard SB, Andersen O, Pedersen SB, et al. Tumor necrosis factor alpha is associated with insulin-mediated suppression of free fatty acids and net lipid oxidation in HIV-infected patients with lipodystrophy. Metabolism 2006; 55 (2): 175-82
    • (2006) Metabolism , vol.55 , Issue.2 , pp. 175-182
    • Haugaard, S.B.1    Andersen, O.2    Pedersen, S.B.3
  • 6
    • 0344513984 scopus 로고    scopus 로고
    • Metabolic complications associated with HIV protease inhibitor therapy
    • Nolan D. Metabolic complications associated with HIV protease inhibitor therapy. Drugs 2003; 63: 2555-74
    • (2003) Drugs , vol.63 , pp. 2555-2574
    • Nolan, D.1
  • 7
    • 0032798685 scopus 로고    scopus 로고
    • Syndrome of body fat redistribution in HIV-1-infected patients: Relationships to cortisol and catecholamines
    • Renard E, Fabre J, Paris F, et al. Syndrome of body fat redistribution in HIV-1-infected patients: relationships to cortisol and catecholamines. Clin Endocrinol (Oxf) 1999; 51: 223-30
    • (1999) Clin Endocrinol (Oxf) , vol.51 , pp. 223-230
    • Renard, E.1    Fabre, J.2    Paris, F.3
  • 8
    • 0035090230 scopus 로고    scopus 로고
    • Assessment of growth hormone dynamics in human immunodeficiency virus-related lipodystrophy
    • Rietschel P, Hadigan C, Corcoran C, et al. Assessment of growth hormone dynamics in human immunodeficiency virus-related lipodystrophy. J Clin Endocrinol Metab 2001; 86: 504-10
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 504-510
    • Rietschel, P.1    Hadigan, C.2    Corcoran, C.3
  • 9
    • 12244251427 scopus 로고    scopus 로고
    • Growth hormone (GH) responses to GH-releasing hormone-arginine testing in human immunodeficiency virus lipodystrophy
    • Koutkia P, Canavan B, Breu J, et al. Growth hormone (GH) responses to GH-releasing hormone-arginine testing in human immunodeficiency virus lipodystrophy. J Clin Endocrinol Metab 2005; 90 (1): 32-8
    • (2005) J Clin Endocrinol Metab , vol.90 , Issue.1 , pp. 32-38
    • Koutkia, P.1    Canavan, B.2    Breu, J.3
  • 10
    • 1942440983 scopus 로고    scopus 로고
    • Adults with partial growth hormone deficiency have an adverse body composition
    • Murray RD, Adams JE, Shalet SM. Adults with partial growth hormone deficiency have an adverse body composition. J Clin Endocrinol Metab 2004; 89: 1586-91
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 1586-1591
    • Murray, R.D.1    Adams, J.E.2    Shalet, S.M.3
  • 11
    • 13244275093 scopus 로고    scopus 로고
    • One year of GH replacement therapy with a fixed low-dose regimen improves body composition, bone mineral density and lipid profile of GH-deficient adults
    • Boguszewski CL, Meister LH, Zaminelli DC, et al. One year of GH replacement therapy with a fixed low-dose regimen improves body composition, bone mineral density and lipid profile of GH-deficient adults. Eur J Endocrinol 2005; 152: 67-75
    • (2005) Eur J Endocrinol , vol.152 , pp. 67-75
    • Boguszewski, C.L.1    Meister, L.H.2    Zaminelli, D.C.3
  • 12
    • 0037303554 scopus 로고    scopus 로고
    • Intramyocellular lipid accumulation and reduced whole body lipid oxidation in HIV lipodystrophy
    • Feb;
    • Luzi L, Perseghin G, Tambussi G, et al. Intramyocellular lipid accumulation and reduced whole body lipid oxidation in HIV lipodystrophy. Am J Physiol Endocrinol Metab 2003 Feb; 284 (2): E274-80
    • (2003) Am J Physiol Endocrinol Metab , vol.284 , Issue.2
    • Luzi, L.1    Perseghin, G.2    Tambussi, G.3
  • 13
    • 29644432811 scopus 로고    scopus 로고
    • GH treatment reduces trunkal adiposity in HIV-infected patients with lipodystrophy: A randomized placebo-controlled study
    • Luzi L, Meneghini E, Oggionni S, et al. GH treatment reduces trunkal adiposity in HIV-infected patients with lipodystrophy: a randomized placebo-controlled study. Eur J Endocrinol 2005; 153 (6): 781-9
    • (2005) Eur J Endocrinol , vol.153 , Issue.6 , pp. 781-789
    • Luzi, L.1    Meneghini, E.2    Oggionni, S.3
  • 14
    • 33747390119 scopus 로고    scopus 로고
    • Physiologic growth hormone replacement improves fasting lipid kinetics in patients with HIV lipodystrophy syndrome
    • D'Amico S, Shi J, Sekhar RV, et al. Physiologic growth hormone replacement improves fasting lipid kinetics in patients with HIV lipodystrophy syndrome. Am J Clin Nutr 2006; 84 (1): 204-11
    • (2006) Am J Clin Nutr , vol.84 , Issue.1 , pp. 204-211
    • D'Amico, S.1    Shi, J.2    Sekhar, R.V.3
  • 15
    • 33747743048 scopus 로고    scopus 로고
    • Comparison of body composition assessment methods in patients with human immunodeficiency virus-associated wasting receiving growth hormone
    • Esposito GJ, Thomas SG, Kingdon L, et al. Comparison of body composition assessment methods in patients with human immunodeficiency virus-associated wasting receiving growth hormone. J Clin Endocrinol Metab 2006; 91 (8): 2952-9
    • (2006) J Clin Endocrinol Metab , vol.91 , Issue.8 , pp. 2952-2959
    • Esposito, G.J.1    Thomas, S.G.2    Kingdon, L.3
  • 16
    • 4344630453 scopus 로고    scopus 로고
    • Low-dose growth hormone and human immunodeficiency virus-associated lipodystrophy syndrome: A pilot study
    • Andersen O, Haugaard SB, Flyvbjerg A, et al. Low-dose growth hormone and human immunodeficiency virus-associated lipodystrophy syndrome: a pilot study. Eur J Clin Invest 2004; 34 (8): 561-8
    • (2004) Eur J Clin Invest , vol.34 , Issue.8 , pp. 561-568
    • Andersen, O.1    Haugaard, S.B.2    Flyvbjerg, A.3
  • 17
    • 1442324033 scopus 로고    scopus 로고
    • Serostim in Adipose Redistribution Syndrome Study Group. Effects of growth hormone on abnormal visceral adipose tissue accumulation and dyslipidemia in HIV-infected patients
    • Kotler DP, Muurahainen N, Grunfeld C, et al. Serostim in Adipose Redistribution Syndrome Study Group. Effects of growth hormone on abnormal visceral adipose tissue accumulation and dyslipidemia in HIV-infected patients. J Acquir Immune Defic Syndr 2004; 35: 239-52
    • (2004) J Acquir Immune Defic Syndr , vol.35 , pp. 239-252
    • Kotler, D.P.1    Muurahainen, N.2    Grunfeld, C.3
  • 18
    • 1242338975 scopus 로고    scopus 로고
    • Pharmacologic therapy for HIV-associated lipodystrophy
    • Benavides S, Nahata MC. Pharmacologic therapy for HIV-associated lipodystrophy. Ann Pharmacother 2004; 38: 448-57
    • (2004) Ann Pharmacother , vol.38 , pp. 448-457
    • Benavides, S.1    Nahata, M.C.2
  • 19
    • 12144287338 scopus 로고    scopus 로고
    • Effects of exercise training and metformin on body composition and cardiovascular indices in HIV-infected patients
    • Driscoll SD, Meininger GE, Lareau MT, et al. Effects of exercise training and metformin on body composition and cardiovascular indices in HIV-infected patients. AIDS 2004; 18: 465-73
    • (2004) AIDS , vol.18 , pp. 465-473
    • Driscoll, S.D.1    Meininger, G.E.2    Lareau, M.T.3
  • 20
    • 0346732369 scopus 로고    scopus 로고
    • Exercise training benefits growth hormone (GH)-deficient adults in the absence or presence of GH treatment
    • Thomas SG, Esposito JG, Ezzat S. Exercise training benefits growth hormone (GH)-deficient adults in the absence or presence of GH treatment. J Clin Endocrinol Metab 2003; 88: 5737-8
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 5737-5738
    • Thomas, S.G.1    Esposito, J.G.2    Ezzat, S.3
  • 21
    • 0345737274 scopus 로고    scopus 로고
    • Exercise, hormones, and body temperature regulation and action of GH during exercise
    • Jorgensen JO, Krag M, Kanaley J, et al. Exercise, hormones, and body temperature regulation and action of GH during exercise. J Endocrinol Invest 2003; 26: 838-42
    • (2003) J Endocrinol Invest , vol.26 , pp. 838-842
    • Jorgensen, J.O.1    Krag, M.2    Kanaley, J.3
  • 22
    • 0346732369 scopus 로고    scopus 로고
    • Exercise training benefits growth hormone (GH)-deficient adults in the absence or presence of GH treatment
    • Thomas SG, Esposito JG, Ezzat S. Exercise training benefits growth hormone (GH)-deficient adults in the absence or presence of GH treatment. J Clin Endocrinol Metab 2003; 88 (12): 5734-8
    • (2003) J Clin Endocrinol Metab , vol.88 , Issue.12 , pp. 5734-5738
    • Thomas, S.G.1    Esposito, J.G.2    Ezzat, S.3
  • 23
    • 0026598960 scopus 로고
    • Human growth hormone and extracellular domain of its receptor: Crystal structure of the complex
    • de Vos AM, Ultsch M, Kossiakoff AA. Human growth hormone and extracellular domain of its receptor: crystal structure of the complex. Science 1992; 255: 306-12
    • (1992) Science , vol.255 , pp. 306-312
    • de Vos, A.M.1    Ultsch, M.2    Kossiakoff, A.A.3
  • 24
    • 0035176107 scopus 로고    scopus 로고
    • Growth hormone signalling and its regulation: Preventing too much of a good thing
    • Frank SJ. Growth hormone signalling and its regulation: preventing too much of a good thing. Growth Horm IGF Res 2001; 11: 201-12
    • (2001) Growth Horm IGF Res , vol.11 , pp. 201-212
    • Frank, S.J.1
  • 25
    • 0023635603 scopus 로고
    • Growth hormone receptor and serum binding protein: Purification, cloning and expression
    • Leung DW, Spencer SA, Cachianes G, et al. Growth hormone receptor and serum binding protein: purification, cloning and expression. Nature 1987; 330: 537-43
    • (1987) Nature , vol.330 , pp. 537-543
    • Leung, D.W.1    Spencer, S.A.2    Cachianes, G.3
  • 26
    • 0022631588 scopus 로고
    • A specific growth hormone-binding protein in human plasma: Initial characterization
    • Baumann G, Stolar MW, Amburn K, et al. A specific growth hormone-binding protein in human plasma: initial characterization. J Clin Endocrinol Metab 1986; 62: 134-41
    • (1986) J Clin Endocrinol Metab , vol.62 , pp. 134-141
    • Baumann, G.1    Stolar, M.W.2    Amburn, K.3
  • 27
    • 0029958128 scopus 로고    scopus 로고
    • Mechanism of signaling by growth hormone receptor
    • Argetsinger LS, Carter-Su C. Mechanism of signaling by growth hormone receptor. Physiol Rev 1996; 76 (4): 1089-107
    • (1996) Physiol Rev , vol.76 , Issue.4 , pp. 1089-1107
    • Argetsinger, L.S.1    Carter-Su, C.2
  • 28
    • 0029786991 scopus 로고    scopus 로고
    • Growth hormone promotes the association of transcription factor STAT5 with the growth hormone receptor
    • Xu BC, Wang X, Darus CJ, et al. Growth hormone promotes the association of transcription factor STAT5 with the growth hormone receptor. J Biol Chem 1996; 271 (33): 19768-73
    • (1996) J Biol Chem , vol.271 , Issue.33 , pp. 19768-19773
    • Xu, B.C.1    Wang, X.2    Darus, C.J.3
  • 29
    • 0030839112 scopus 로고    scopus 로고
    • A new protein containing an SH2 domain that inhibits JAK kinases
    • Endo TA, Masuhara M, Yokouchi M, et al. A new protein containing an SH2 domain that inhibits JAK kinases. Nature 1997; 387 (6636): 921-4
    • (1997) Nature , vol.387 , Issue.6636 , pp. 921-924
    • Endo, T.A.1    Masuhara, M.2    Yokouchi, M.3
  • 30
    • 20144380439 scopus 로고    scopus 로고
    • SOCS2 negatively regulates growth hormone action in vitro and in vivo
    • Greenhalgh CJ, Rico-Bautista E, Lorentzon M, et al. SOCS2 negatively regulates growth hormone action in vitro and in vivo. J Clin Invest 2005; 115 (2): 397-406
    • (2005) J Clin Invest , vol.115 , Issue.2 , pp. 397-406
    • Greenhalgh, C.J.1    Rico-Bautista, E.2    Lorentzon, M.3
  • 31
    • 26944493862 scopus 로고    scopus 로고
    • Model for growth hormone receptor activation based on subunit rotation within a receptor dimer
    • Brown RJ, Adams JJ, Pelekanos RA, et al. Model for growth hormone receptor activation based on subunit rotation within a receptor dimer. Nat Struct Mol Biol 2005; 12: 814-21
    • (2005) Nat Struct Mol Biol , vol.12 , pp. 814-821
    • Brown, R.J.1    Adams, J.J.2    Pelekanos, R.A.3
  • 32
    • 0034124975 scopus 로고    scopus 로고
    • Role of the tyrosine kinase JAK2 in signal transduction by growth hormone
    • Carter-Su C, Rui L, Herrington J. Role of the tyrosine kinase JAK2 in signal transduction by growth hormone. Pediatr Nephrol 2000; 14 (7): 550-7
    • (2000) Pediatr Nephrol , vol.14 , Issue.7 , pp. 550-557
    • Carter-Su, C.1    Rui, L.2    Herrington, J.3
  • 33
    • 0028154380 scopus 로고
    • Growth hormone treatment of obese women for 5 wk: Effect on body composition and adipose tissue LPL activity
    • Richelsen B, Pedersen SB, Borglum JD, et al. Growth hormone treatment of obese women for 5 wk: effect on body composition and adipose tissue LPL activity. Am J Physiol 1994; 266: E211-6
    • (1994) Am J Physiol , vol.266
    • Richelsen, B.1    Pedersen, S.B.2    Borglum, J.D.3
  • 34
    • 0034289895 scopus 로고    scopus 로고
    • The mechanism of effect of growth hormone on preadipocyte and adipocyte function
    • Nam SY, Lobie PE. The mechanism of effect of growth hormone on preadipocyte and adipocyte function. Obes Rev 2000; 1 (2): 73-86
    • (2000) Obes Rev , vol.1 , Issue.2 , pp. 73-86
    • Nam, S.Y.1    Lobie, P.E.2
  • 35
    • 33645500068 scopus 로고    scopus 로고
    • Lipodystrophy: Lessons in lipid and energy metabolism
    • Simha V, Garg A. Lipodystrophy: lessons in lipid and energy metabolism. Curr Opin Lipidol 2006; 17 (2): 162-9
    • (2006) Curr Opin Lipidol , vol.17 , Issue.2 , pp. 162-169
    • Simha, V.1    Garg, A.2
  • 36
    • 33746253894 scopus 로고    scopus 로고
    • Metabolic consequences of lipodystrophy in mouse models
    • Reue K, Phan J. Metabolic consequences of lipodystrophy in mouse models. Curr Opin Clin Nutr Metab Care 2006; 9 (4): 436-41
    • (2006) Curr Opin Clin Nutr Metab Care , vol.9 , Issue.4 , pp. 436-441
    • Reue, K.1    Phan, J.2
  • 37
    • 0034330702 scopus 로고    scopus 로고
    • HIV lipodystrophy: A review
    • Kravcik S. HIV lipodystrophy: a review. HIV Clin Trial 2000; 1 (3): 37-50
    • (2000) HIV Clin Trial , vol.1 , Issue.3 , pp. 37-50
    • Kravcik, S.1
  • 39
    • 0035941778 scopus 로고    scopus 로고
    • Risk of lipodystrophy in HIV-1 infected patients treated with protease inhibitors: A prospective cohort study
    • Martinez E, Mocroft A, Garcia-Viejo MA, et al. Risk of lipodystrophy in HIV-1 infected patients treated with protease inhibitors: a prospective cohort study. Lancet 2001; 357: 592-8
    • (2001) Lancet , vol.357 , pp. 592-598
    • Martinez, E.1    Mocroft, A.2    Garcia-Viejo, M.A.3
  • 40
    • 0344406674 scopus 로고    scopus 로고
    • Increased lipodystrophy is associated with increased exposure to highly active antiretroviral therapy in HIV-infected children
    • Viganò A, Mora S, Testolin C, et al. Increased lipodystrophy is associated with increased exposure to highly active antiretroviral therapy in HIV-infected children. J Acquir Immune Defic Syndr 2003; 32: 482-9
    • (2003) J Acquir Immune Defic Syndr , vol.32 , pp. 482-489
    • Viganò, A.1    Mora, S.2    Testolin, C.3
  • 41
    • 0034005969 scopus 로고    scopus 로고
    • Hyperlipidemia and insulin resistance are induced by protease inhibitors independent of changes in body composition in patients with HIV infection
    • Mulligan K, Grunfeld C, Tai VW, et al. Hyperlipidemia and insulin resistance are induced by protease inhibitors independent of changes in body composition in patients with HIV infection. J Acquir Immune Defic Syndr 2000; 23: 35-43
    • (2000) J Acquir Immune Defic Syndr , vol.23 , pp. 35-43
    • Mulligan, K.1    Grunfeld, C.2    Tai, V.W.3
  • 42
    • 0034008520 scopus 로고    scopus 로고
    • A syndrome of lipoatrophy, lactic acidaemia and liver dysfunction associated with HIV nucleoside analogue therapy: Contribution to protease inhibitor-related lipodystrophy syndrome
    • Carr A, Miller J, Law M, et al. A syndrome of lipoatrophy, lactic acidaemia and liver dysfunction associated with HIV nucleoside analogue therapy: contribution to protease inhibitor-related lipodystrophy syndrome. AIDS 2000; 14: F25-32
    • (2000) AIDS , vol.14
    • Carr, A.1    Miller, J.2    Law, M.3
  • 43
    • 0033924871 scopus 로고    scopus 로고
    • Contribution of nucleoside analogue reverse transcriptase inhibitors to subcutaneous fat wasting in patients with HIV infection
    • Mallal SA, John M, Moore CB, et al. Contribution of nucleoside analogue reverse transcriptase inhibitors to subcutaneous fat wasting in patients with HIV infection. AIDS 2000; 14: 1309-61
    • (2000) AIDS , vol.14 , pp. 1309-1361
    • Mallal, S.A.1    John, M.2    Moore, C.B.3
  • 44
    • 0033963686 scopus 로고    scopus 로고
    • Effect of ritonavir on lipids and post heparin lipase activities in normal subjects
    • Purnell JQ, Zambon A, Knopp RH, et al. Effect of ritonavir on lipids and post heparin lipase activities in normal subjects. AIDS 2000; 14: 51-7
    • (2000) AIDS , vol.14 , pp. 51-57
    • Purnell, J.Q.1    Zambon, A.2    Knopp, R.H.3
  • 45
    • 0035902493 scopus 로고    scopus 로고
    • Use of human immunodeficiency virus-1 protease inhibitors is associated with atherogenic lipoprotein changes and endothelial dysfunction
    • Stein JH, Klein MA, Bellehumeur JL, et al. Use of human immunodeficiency virus-1 protease inhibitors is associated with atherogenic lipoprotein changes and endothelial dysfunction. Circulation 2001; 104: 257-62
    • (2001) Circulation , vol.104 , pp. 257-262
    • Stein, J.H.1    Klein, M.A.2    Bellehumeur, J.L.3
  • 46
    • 0033798242 scopus 로고    scopus 로고
    • HIV-1 protease inhibitors induce an increase of triglyceride level in HIV-infected men without modification of insulin sensitivity: A longitudinal study
    • Petit JM, Duong M, Duvillard L, et al. HIV-1 protease inhibitors induce an increase of triglyceride level in HIV-infected men without modification of insulin sensitivity: a longitudinal study. Horm Metab Res 2000; 32: 367-72
    • (2000) Horm Metab Res , vol.32 , pp. 367-372
    • Petit, J.M.1    Duong, M.2    Duvillard, L.3
  • 47
    • 0345151837 scopus 로고    scopus 로고
    • Atherogenic dyslipidemia in HIV-infected individuals treated with protease inhibitors
    • Periard D, Telenti A, Sudre P, et al. Atherogenic dyslipidemia in HIV-infected individuals treated with protease inhibitors. Circulation 1999; 100 (7): 700-5
    • (1999) Circulation , vol.100 , Issue.7 , pp. 700-705
    • Periard, D.1    Telenti, A.2    Sudre, P.3
  • 48
    • 0035143780 scopus 로고    scopus 로고
    • Apoprotein C-III and E-containing lipoprotein particles are markedly increased in HIV-infected patients treated with protease inhibitors: Association with the development of lipodystrophy
    • Bonnet E, Ruidavets JB, Tuech J, et al. Apoprotein C-III and E-containing lipoprotein particles are markedly increased in HIV-infected patients treated with protease inhibitors: association with the development of lipodystrophy. J Clin Endocrinol Metab 2001; 86 (1): 296-302
    • (2001) J Clin Endocrinol Metab , vol.86 , Issue.1 , pp. 296-302
    • Bonnet, E.1    Ruidavets, J.B.2    Tuech, J.3
  • 49
    • 0035895648 scopus 로고    scopus 로고
    • Low lipolytic enzyme activity in patients with severe hypertriglyceridemia on highly active antiretroviral therapy
    • Baril L, Beucler I, Valantin MA. Low lipolytic enzyme activity in patients with severe hypertriglyceridemia on highly active antiretroviral therapy. AIDS 2001; 15 (3): 415-7
    • (2001) AIDS , vol.15 , Issue.3 , pp. 415-417
    • Baril, L.1    Beucler, I.2    Valantin, M.A.3
  • 50
    • 2342596292 scopus 로고    scopus 로고
    • HIV-related lipodystrophy and related factors
    • Tershakovec AM, Frank I, Rader D. HIV-related lipodystrophy and related factors. Atherosclerosis 2004; 174 (1): 1-10
    • (2004) Atherosclerosis , vol.174 , Issue.1 , pp. 1-10
    • Tershakovec, A.M.1    Frank, I.2    Rader, D.3
  • 51
    • 0035134609 scopus 로고    scopus 로고
    • Metabolic abnormalities and cardiovascular disease risk factors in adults with human immunodeficiency virus infection and lipodystrophy
    • Hadigan C, Meigs JB, Corcoran C, et al. Metabolic abnormalities and cardiovascular disease risk factors in adults with human immunodeficiency virus infection and lipodystrophy. Clin Infect Dis 2001; 32: 130-9
    • (2001) Clin Infect Dis , vol.32 , pp. 130-139
    • Hadigan, C.1    Meigs, J.B.2    Corcoran, C.3
  • 52
    • 0034617191 scopus 로고    scopus 로고
    • The mechanism of insulin resistance caused by HIV protease inhibitor therapy
    • Murata H, Hruz PW, Mueckler M. The mechanism of insulin resistance caused by HIV protease inhibitor therapy. J Biol Chem 2000; 275: 20251-4
    • (2000) J Biol Chem , vol.275 , pp. 20251-20254
    • Murata, H.1    Hruz, P.W.2    Mueckler, M.3
  • 53
    • 0030093408 scopus 로고    scopus 로고
    • Over-expression of GLUT4 selectively in adipose tissue in transgenic mice: Implication for nutrient partitioning
    • Gnudi L, Shepherd PR, Kahn BB. Over-expression of GLUT4 selectively in adipose tissue in transgenic mice: implication for nutrient partitioning. Proc Nutr Soc 1996; 55: 191-9
    • (1996) Proc Nutr Soc , vol.55 , pp. 191-199
    • Gnudi, L.1    Shepherd, P.R.2    Kahn, B.B.3
  • 54
    • 0029148426 scopus 로고
    • Cardiac and adipose tissue abnormalities but not diabetes in mice deficient in GLUT 4
    • Katz EB, Stenbit AE, Hatton K, et al. Cardiac and adipose tissue abnormalities but not diabetes in mice deficient in GLUT 4. Nature 1995; 377: 151-5
    • (1995) Nature , vol.377 , pp. 151-155
    • Katz, E.B.1    Stenbit, A.E.2    Hatton, K.3
  • 55
    • 0030756249 scopus 로고    scopus 로고
    • Muscle-specific transgenic complementation of GLUT4-deficient mice
    • Tsao TS, Stenbit AE, Li J, et al. Muscle-specific transgenic complementation of GLUT4-deficient mice. J Clin Invest 1997; 100: 671-7
    • (1997) J Clin Invest , vol.100 , pp. 671-677
    • Tsao, T.S.1    Stenbit, A.E.2    Li, J.3
  • 56
    • 0034458011 scopus 로고    scopus 로고
    • Insulin-like growth factor I and growth hormone (GH) treatment in GH-deficient humans: Differential effects on protein, glucose, lipid, and calcium metabolism
    • Mauras N, O'Brien KO, Welch S, et al. Insulin-like growth factor I and growth hormone (GH) treatment in GH-deficient humans: differential effects on protein, glucose, lipid, and calcium metabolism. J Clin Endocrinol Metab 2000; 85: 1686-94
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 1686-1694
    • Mauras, N.1    O'Brien, K.O.2    Welch, S.3
  • 57
    • 0036185014 scopus 로고    scopus 로고
    • Regulation of human growth hormone secretion and its disorders
    • Kato Y, Murakami Y, Sohmiya M, et al. Regulation of human growth hormone secretion and its disorders. Inter Med 2002; 41 (1): 7-13
    • (2002) Inter Med , vol.41 , Issue.1 , pp. 7-13
    • Kato, Y.1    Murakami, Y.2    Sohmiya, M.3
  • 58
    • 0043231590 scopus 로고    scopus 로고
    • Effects of growth hormone administration in human obesity
    • Shadid S, Jensen MD. Effects of growth hormone administration in human obesity. Obes Res 2003; 11: 170-5
    • (2003) Obes Res , vol.11 , pp. 170-175
    • Shadid, S.1    Jensen, M.D.2
  • 59
    • 33745192515 scopus 로고    scopus 로고
    • Visceral obesity, impaired glucose tolerance, metabolic syndrome, and growth hormone therapy
    • Attallah H, Friedlander AL, Hoffman AR. Visceral obesity, impaired glucose tolerance, metabolic syndrome, and growth hormone therapy. Growth Horm IGF Res 2006; 16 Suppl. A: S62-7
    • (2006) Growth Horm IGF Res , vol.16 , Issue.SUPPL. A
    • Attallah, H.1    Friedlander, A.L.2    Hoffman, A.R.3
  • 60
    • 0031057076 scopus 로고    scopus 로고
    • Growth hormone treatment of abdominally obese men reduces abdominal fat mass, improves glucose and lipoprotein metabolism, and reduces diastolic blood pressure
    • Johannsson G, Mårin P, Lönn L, et al. Growth hormone treatment of abdominally obese men reduces abdominal fat mass, improves glucose and lipoprotein metabolism, and reduces diastolic blood pressure. J Clin Endocrinol Metab 1997; 82 (3): 727-34
    • (1997) J Clin Endocrinol Metab , vol.82 , Issue.3 , pp. 727-734
    • Johannsson, G.1    Mårin, P.2    Lönn, L.3
  • 61
    • 15944394754 scopus 로고    scopus 로고
    • Growth hormone treatment reduces abdominal visceral fat in postmenopausal women with abdominal obesity: A 12-month placebo-controlled trial
    • Franco C, Brandberg J, Lönn L, et al. Growth hormone treatment reduces abdominal visceral fat in postmenopausal women with abdominal obesity: a 12-month placebo-controlled trial. J Clin Endocrinol Metab 2005; 90 (3): 1466-74
    • (2005) J Clin Endocrinol Metab , vol.90 , Issue.3 , pp. 1466-1474
    • Franco, C.1    Brandberg, J.2    Lönn, L.3
  • 62
    • 0031792510 scopus 로고    scopus 로고
    • Consensus guidelines for the diagnosis and treatment of adults with growth hormone deficiency: summary statement of the Growth Hormone Research Society workshop on adult growth hormone deficiency. J Clin Endocrinol Metab 1998; 98 (2): 379-81
    • Consensus guidelines for the diagnosis and treatment of adults with growth hormone deficiency: summary statement of the Growth Hormone Research Society workshop on adult growth hormone deficiency. J Clin Endocrinol Metab 1998; 98 (2): 379-81
  • 63
    • 2142673373 scopus 로고    scopus 로고
    • Growth hormone deficiency in adulthood and the effects of growth hormone replacement: A review
    • Carroll PV, Christ ER, Bengtsson B-Å, et al. Growth hormone deficiency in adulthood and the effects of growth hormone replacement: a review. J Clin Endocrinol Metab 1998; 83: 382-95
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 382-395
    • Carroll, P.V.1    Christ, E.R.2    Bengtsson, B.-Å.3
  • 64
    • 0028344205 scopus 로고
    • Reduced bone mineral density in patients with adult onset growth hormone deficiency
    • Holmes SJ, Economou G, Whitehouse RW, et al. Reduced bone mineral density in patients with adult onset growth hormone deficiency. J Clin Endocrinol Metab 1994; 78: 669-74
    • (1994) J Clin Endocrinol Metab , vol.78 , pp. 669-674
    • Holmes, S.J.1    Economou, G.2    Whitehouse, R.W.3
  • 65
    • 0026528825 scopus 로고
    • Myocardial dysfunction in treated adult hypopituitarism: A possible explanation for increased cardiovascular mortality
    • Shahi M, Beshyah SA, Hackett D, et al. Myocardial dysfunction in treated adult hypopituitarism: a possible explanation for increased cardiovascular mortality. Br Heart J 1992; 67: 92-6
    • (1992) Br Heart J , vol.67 , pp. 92-96
    • Shahi, M.1    Beshyah, S.A.2    Hackett, D.3
  • 66
    • 0025333249 scopus 로고
    • Premature mortality due to cardiovascular disease in hypopituitarism
    • Rosen T, Bengtsson B-Å. Premature mortality due to cardiovascular disease in hypopituitarism. Lancet 1990; 336: 285-8
    • (1990) Lancet , vol.336 , pp. 285-288
    • Rosen, T.1    Bengtsson, B.-Å.2
  • 67
    • 0002071662 scopus 로고    scopus 로고
    • Cardiovascular disease and risk factors in adults with hypopituitarism
    • Beshyah SA, Johnston DG. Cardiovascular disease and risk factors in adults with hypopituitarism. Clin Endocrinol 1999; 50 (1): 1-15
    • (1999) Clin Endocrinol , vol.50 , Issue.1 , pp. 1-15
    • Beshyah, S.A.1    Johnston, D.G.2
  • 68
    • 33744956573 scopus 로고    scopus 로고
    • Lack of evidence of premature atherosclerosis in untreated severe isolated growth hormone (GH) deficiency due to a GH-releasing hormone receptor mutation
    • Menezes Oliveira JL, Marques-Santos C, Barreto-Filho JA, et al. Lack of evidence of premature atherosclerosis in untreated severe isolated growth hormone (GH) deficiency due to a GH-releasing hormone receptor mutation. J Clin Endocrinol Metab 2006; 91 (6): 2093-9
    • (2006) J Clin Endocrinol Metab , vol.91 , Issue.6 , pp. 2093-2099
    • Menezes Oliveira, J.L.1    Marques-Santos, C.2    Barreto-Filho, J.A.3
  • 69
    • 0029548928 scopus 로고
    • Growth hormone-deficient adults are insulin resistant
    • Johansson JO, Fowelin J, Landin K, et al. Growth hormone-deficient adults are insulin resistant. Metab Clin Exp 1995; 44: 1126-9
    • (1995) Metab Clin Exp , vol.44 , pp. 1126-1129
    • Johansson, J.O.1    Fowelin, J.2    Landin, K.3
  • 70
    • 9044222881 scopus 로고    scopus 로고
    • Insulin resistance in growth hormone-deficient adults: Defects in glucose utilization and glycogen synthase activity
    • Hew FL, Koschmann M, Christopher M, et al. Insulin resistance in growth hormone-deficient adults: defects in glucose utilization and glycogen synthase activity. J Clin Endocrinol Metab 1996; 81: 555-64
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 555-564
    • Hew, F.L.1    Koschmann, M.2    Christopher, M.3
  • 71
    • 0028079626 scopus 로고
    • Serum lipid levels in growth hormone-deficient men
    • De Boer H, Blok GJ, Voerman HJ, et al. Serum lipid levels in growth hormone-deficient men. Metab Clin Exp 1994; 43: 199-203
    • (1994) Metab Clin Exp , vol.43 , pp. 199-203
    • De Boer, H.1    Blok, G.J.2    Voerman, H.J.3
  • 72
    • 33646402056 scopus 로고    scopus 로고
    • Evaluation and treatment of adult growth hormone deficiency: An Endocrine Society clinical practice guideline
    • Molitch ME, Clemmons DR, Malozowski S, et al. Evaluation and treatment of adult growth hormone deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2006; 91 (5): 1621-34
    • (2006) J Clin Endocrinol Metab , vol.91 , Issue.5 , pp. 1621-1634
    • Molitch, M.E.1    Clemmons, D.R.2    Malozowski, S.3
  • 73
    • 0038301176 scopus 로고    scopus 로고
    • Long-term experience with GH replacement therapy: Efficacy and safety
    • Monson JP. Long-term experience with GH replacement therapy: efficacy and safety. Eur J Endocrinol 2003; 148 Suppl. 2: S9-14
    • (2003) Eur J Endocrinol , vol.148 , Issue.SUPPL. 2
    • Monson, J.P.1
  • 74
    • 33645744658 scopus 로고    scopus 로고
    • Effect of short-term therapy with recombinant human growth hormone (GH) on metabolic parameters and preclinical atherosclerotic markers in hypopituitary patients with growth hormone deficiency
    • Benedini S, Dalle Carbonare L, Albiger N, et al. Effect of short-term therapy with recombinant human growth hormone (GH) on metabolic parameters and preclinical atherosclerotic markers in hypopituitary patients with growth hormone deficiency. Horm Metab Res 2006; 38 (1): 16-21
    • (2006) Horm Metab Res , vol.38 , Issue.1 , pp. 16-21
    • Benedini, S.1    Dalle Carbonare, L.2    Albiger, N.3
  • 75
    • 33745218966 scopus 로고    scopus 로고
    • Beginning to end: Cardiovascular implications of growth hormone (GH) deficiency and GH therapy
    • Colao A, Di Somma C, Savanellia MC, et al. Beginning to end: cardiovascular implications of growth hormone (GH) deficiency and GH therapy. Growth Horm IGF Res 2006; 16 Suppl.: 41-8
    • (2006) Growth Horm IGF Res , vol.16 , Issue.SUPPL. , pp. 41-48
    • Colao, A.1    Di Somma, C.2    Savanellia, M.C.3
  • 76
    • 0033811902 scopus 로고    scopus 로고
    • A nine-month, placebo-controlled study of the effects of growth hormone treatment on lipoproteins and LDL size in abdominally obese men
    • Svensson J, Bengtsson B-Å, Taskinen MR, et al. A nine-month, placebo-controlled study of the effects of growth hormone treatment on lipoproteins and LDL size in abdominally obese men. Growth Horm IGF Res 2000; 10 (3): 118-26
    • (2000) Growth Horm IGF Res , vol.10 , Issue.3 , pp. 118-126
    • Svensson, J.1    Bengtsson, B.-Å.2    Taskinen, M.R.3
  • 77
    • 15944428211 scopus 로고    scopus 로고
    • Growth hormone and cardiovascular risk factors
    • Gola M, Bonadonna S, Doga M, et al. Growth hormone and cardiovascular risk factors. J Clin Endocrinol Metab 2005; 90 (3): 1864-70
    • (2005) J Clin Endocrinol Metab , vol.90 , Issue.3 , pp. 1864-1870
    • Gola, M.1    Bonadonna, S.2    Doga, M.3
  • 78
    • 0034890263 scopus 로고    scopus 로고
    • Optimizing gh therapy in adults and children
    • Aug;
    • Drake WM, Howell SJ, Monson JP, et al. Optimizing gh therapy in adults and children. Endocr Rev 2001 Aug; 22 (4): 425-50
    • (2001) Endocr Rev , vol.22 , Issue.4 , pp. 425-450
    • Drake, W.M.1    Howell, S.J.2    Monson, J.P.3
  • 79
    • 4644224748 scopus 로고    scopus 로고
    • Evidence for a link between IGF-I and cancer
    • Jenkins PJ, Bustin SA. Evidence for a link between IGF-I and cancer. Eur J Endocrinol 2004; 151 Suppl. 1: S17-22
    • (2004) Eur J Endocrinol , vol.151 , Issue.SUPPL. 1
    • Jenkins, P.J.1    Bustin, S.A.2
  • 80
    • 0034797758 scopus 로고    scopus 로고
    • Paradoxical elevations in serum IGF II and IGF binding protein-2 in acromegaly: Insights into the regulation of these peptides
    • Renehan AG, Toogood AA, Ryder WD, et al. Paradoxical elevations in serum IGF II and IGF binding protein-2 in acromegaly: insights into the regulation of these peptides. Clin Endocrinol (Oxf) 2001; 55 (4): 469-75
    • (2001) Clin Endocrinol (Oxf) , vol.55 , Issue.4 , pp. 469-475
    • Renehan, A.G.1    Toogood, A.A.2    Ryder, W.D.3
  • 81
    • 0030659547 scopus 로고    scopus 로고
    • Risk of leukemia in children treated with human growth hormone: Review and reanalysis
    • Allen DB, Rundle AC, Graves DA, et al. Risk of leukemia in children treated with human growth hormone: review and reanalysis. J Pediatr 1997; 131: S32-6
    • (1997) J Pediatr , vol.131
    • Allen, D.B.1    Rundle, A.C.2    Graves, D.A.3
  • 82
    • 0000006365 scopus 로고    scopus 로고
    • Adverse events during growth hormone treatment: 10 years experience in KIGS, a pharmacoepidemiological study
    • Ranke MB, editor, Leipzig: Johann Ambrosius Barth Verlag
    • Wilton P. Adverse events during growth hormone treatment: 10 years experience in KIGS, a pharmacoepidemiological study. In: Ranke MB, editor. Growth hormone therapy in KIGS: 10 years experience. Leipzig: Johann Ambrosius Barth Verlag, 1999
    • (1999) Growth hormone therapy in KIGS: 10 years experience
    • Wilton, P.1
  • 83
    • 0030723307 scopus 로고    scopus 로고
    • Growth hormone therapy and malignancy
    • Shalet SM, Brennan BM, Reddingius RE. Growth hormone therapy and malignancy. Horm Res 1997; 48 Suppl. 4: 29-32
    • (1997) Horm Res , vol.48 , Issue.SUPPL. 4 , pp. 29-32
    • Shalet, S.M.1    Brennan, B.M.2    Reddingius, R.E.3
  • 84
    • 3543099135 scopus 로고    scopus 로고
    • Safety of growth hormone replacement therapy in adults
    • Jul;
    • Gibney J, Johannsson G. Safety of growth hormone replacement therapy in adults. Expert Opin Drug Saf 2004 Jul; 3 (4): 305-16
    • (2004) Expert Opin Drug Saf , vol.3 , Issue.4 , pp. 305-316
    • Gibney, J.1    Johannsson, G.2
  • 85
    • 33748756346 scopus 로고    scopus 로고
    • Growth hormone treatment and risk of second neoplasms in the childhood cancer survivor
    • Ergun-Longmire B, Mertens AC, Mitby P, et al. Growth hormone treatment and risk of second neoplasms in the childhood cancer survivor. J Clin Endocrinol Metab 2006; 91 (9): 3494-8
    • (2006) J Clin Endocrinol Metab , vol.91 , Issue.9 , pp. 3494-3498
    • Ergun-Longmire, B.1    Mertens, A.C.2    Mitby, P.3
  • 86
    • 0029968709 scopus 로고    scopus 로고
    • Safety of recombinant deoxyribonucleic acid-derived growth hormone: The National Cooperative Growth Study experience
    • Blethen SL, Allen DB, Graves D, et al. Safety of recombinant deoxyribonucleic acid-derived growth hormone: the National Cooperative Growth Study experience. J Clin Endocrinol Metab 1996; 81: 1704-10
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 1704-1710
    • Blethen, S.L.1    Allen, D.B.2    Graves, D.3
  • 87
    • 0034685191 scopus 로고    scopus 로고
    • Incidence of diabetes mellitus and impaired glucose tolerance in children and adolescents receiving growth-hormone treatment
    • Cutfield WS, Wilton P, Bennmarker H, et al. Incidence of diabetes mellitus and impaired glucose tolerance in children and adolescents receiving growth-hormone treatment. Lancet 2000; 355: 610-3
    • (2000) Lancet , vol.355 , pp. 610-613
    • Cutfield, W.S.1    Wilton, P.2    Bennmarker, H.3
  • 89
    • 0024467665 scopus 로고
    • Carbohydrate metabolism on high dose growth hormone therapy in children treated for leukaemia
    • Crawford BA, Cowell CT, Greenacre P, et al. Carbohydrate metabolism on high dose growth hormone therapy in children treated for leukaemia. Aust Paediatr J 1989; 25: 236-40
    • (1989) Aust Paediatr J , vol.25 , pp. 236-240
    • Crawford, B.A.1    Cowell, C.T.2    Greenacre, P.3
  • 90
    • 0027484698 scopus 로고
    • Symptomatic non-insulin-dependent diabetes mellitus during therapy with recombinant human growth hormone
    • Botero D, Danon M, Brown RS. Symptomatic non-insulin-dependent diabetes mellitus during therapy with recombinant human growth hormone. J Pediatr 1993; 123: 590-2
    • (1993) J Pediatr , vol.123 , pp. 590-592
    • Botero, D.1    Danon, M.2    Brown, R.S.3
  • 91
    • 0036096692 scopus 로고    scopus 로고
    • Effects of seven years of GH-replacement therapy on insulin sensitivity in GH-deficient adults
    • Svensson J, Fowelin J, Landin K, et al. Effects of seven years of GH-replacement therapy on insulin sensitivity in GH-deficient adults. J Clin Endocrinol Metab 2002; 87: 2121-7
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 2121-2127
    • Svensson, J.1    Fowelin, J.2    Landin, K.3
  • 92
    • 0028826366 scopus 로고
    • Differential impact of age, sex steroid hormones, and obesity on basal versus pulsatile growth hormone secretion in men as assessed in an ultrasensitive chemiluminescence assay
    • Veldhuis JD, Liem AY, South S, et al. Differential impact of age, sex steroid hormones, and obesity on basal versus pulsatile growth hormone secretion in men as assessed in an ultrasensitive chemiluminescence assay. J Clin Endocrinol Metab 1995; 80: 3209-22
    • (1995) J Clin Endocrinol Metab , vol.80 , pp. 3209-3222
    • Veldhuis, J.D.1    Liem, A.Y.2    South, S.3
  • 93
    • 0025973802 scopus 로고
    • Dual defects in pulsatile growth hormone secretion and clearance subserve the hyposomatotropism of obesity in man
    • Veldhuis JD, Iranmanesh A, Ho KK, et al. Dual defects in pulsatile growth hormone secretion and clearance subserve the hyposomatotropism of obesity in man. J Clin Endocrinol Metab 1991; 72: 51-9
    • (1991) J Clin Endocrinol Metab , vol.72 , pp. 51-59
    • Veldhuis, J.D.1    Iranmanesh, A.2    Ho, K.K.3
  • 94
    • 0026716395 scopus 로고
    • Arginine potentiates but does not restore the blunted growth hormone response to growth-hormone releasing hormone in obesity
    • Ghigo E, Procopio M, Boffano GM, et al. Arginine potentiates but does not restore the blunted growth hormone response to growth-hormone releasing hormone in obesity. Metabolism 1992; 41: 560-3
    • (1992) Metabolism , vol.41 , pp. 560-563
    • Ghigo, E.1    Procopio, M.2    Boffano, G.M.3
  • 95
    • 0033040713 scopus 로고    scopus 로고
    • Effects of metformin on insulin resistance and central adiposity in patients receiving effective protease inhibitor therapy
    • Saint-Marc T, Touraine JL. Effects of metformin on insulin resistance and central adiposity in patients receiving effective protease inhibitor therapy. AIDS 1999; 2813 (8): 1000-2
    • (1999) AIDS , vol.2813 , Issue.8 , pp. 1000-1002
    • Saint-Marc, T.1    Touraine, J.L.2
  • 96
    • 17844368346 scopus 로고    scopus 로고
    • Effects of growth hormone-releasing hormone on bone turnover in human immunodeficiency virus-infected men with fat accumulation
    • Koutkia P, Canavan B, Breu J, et al. Effects of growth hormone-releasing hormone on bone turnover in human immunodeficiency virus-infected men with fat accumulation. J Clin Endocrinol Metab 2005; 90 (4): 2154-60
    • (2005) J Clin Endocrinol Metab , vol.90 , Issue.4 , pp. 2154-2160
    • Koutkia, P.1    Canavan, B.2    Breu, J.3
  • 97
    • 1442324033 scopus 로고    scopus 로고
    • Kotler DP, Muurahainen N, Grunfeld C, et al. Effects of growth hormone on abnormal visceral adipose tissue accumulation and dyslipidemia in HIV-infected patients. Serostim in Adipose Redistribution Syndrome Study Group. J Acquir Immune Defic Syndr 2004; 1;35 (3): 239-52
    • Kotler DP, Muurahainen N, Grunfeld C, et al. Effects of growth hormone on abnormal visceral adipose tissue accumulation and dyslipidemia in HIV-infected patients. Serostim in Adipose Redistribution Syndrome Study Group. J Acquir Immune Defic Syndr 2004; 1;35 (3): 239-52
  • 98
    • 11344256743 scopus 로고    scopus 로고
    • Different growth hormone sensitivity of target tissues and growth hormone response to glucose in HIV-infected patients with and without lipodystrophy
    • Andersen O, Haugaard SB, Hansen BR, et al. Different growth hormone sensitivity of target tissues and growth hormone response to glucose in HIV-infected patients with and without lipodystrophy. Scand J Infect Dis 2004; 36 (11-12): 832-9
    • (2004) Scand J Infect Dis , vol.36 , Issue.11-12 , pp. 832-839
    • Andersen, O.1    Haugaard, S.B.2    Hansen, B.R.3
  • 99
    • 9344265769 scopus 로고    scopus 로고
    • Insulin-like growth factors, insulin-like growth factor-binding proteins, insulin-like growth factor-binding protein-3 protease, and growth hormone-binding protein in lipodystrophic human immunodeficiency virus-infected patients
    • Haugaard SB, Andersen O, Hansen BR, et al. Insulin-like growth factors, insulin-like growth factor-binding proteins, insulin-like growth factor-binding protein-3 protease, and growth hormone-binding protein in lipodystrophic human immunodeficiency virus-infected patients. Metabolism 2004; 53 (12): 1565-73
    • (2004) Metabolism , vol.53 , Issue.12 , pp. 1565-1573
    • Haugaard, S.B.1    Andersen, O.2    Hansen, B.R.3
  • 101
    • 19944417900 scopus 로고    scopus 로고
    • In the lipodystrophy associated with highly active antiretroviral therapy, pseudo-Cushing's syndrome is associated with increased regeneration of cortisol by 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue
    • Oct;
    • Sutinen J, Kannisto K, Korsheninnikova E, et al. In the lipodystrophy associated with highly active antiretroviral therapy, pseudo-Cushing's syndrome is associated with increased regeneration of cortisol by 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue. Diabetologia 2004 Oct; 47 (10): 1668-71
    • (2004) Diabetologia , vol.47 , Issue.10 , pp. 1668-1671
    • Sutinen, J.1    Kannisto, K.2    Korsheninnikova, E.3
  • 102
    • 0031762902 scopus 로고    scopus 로고
    • Immunohistochemical localization of type 1 11β-hydroxysteroid dehydrogenase in human tissues
    • Ricketts ML, Verhaeg JM, Bujalska I, et al. Immunohistochemical localization of type 1 11β-hydroxysteroid dehydrogenase in human tissues. J Clin Endocrinol Metab 1998; 83: 1325-35
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 1325-1335
    • Ricketts, M.L.1    Verhaeg, J.M.2    Bujalska, I.3
  • 103
    • 0033305631 scopus 로고    scopus 로고
    • Differentiation of adipose stromal cells: The roles of glucocorticoids and 11β-hydroxysteroid dehydrogenase
    • Bujalska IJ, Kumar S, Hewison M, et al. Differentiation of adipose stromal cells: the roles of glucocorticoids and 11β-hydroxysteroid dehydrogenase. Endocrinology 1999; 140: 3188-96
    • (1999) Endocrinology , vol.140 , pp. 3188-3196
    • Bujalska, I.J.1    Kumar, S.2    Hewison, M.3
  • 104
    • 0030936556 scopus 로고    scopus 로고
    • Does central obesity reflect "Cushing's disease of the omentum"?
    • Bujalska IJ, Kumar S, Stewart PM. Does central obesity reflect "Cushing's disease of the omentum"? Lancet 1997; 349: 1210-3
    • (1997) Lancet , vol.349 , pp. 1210-1213
    • Bujalska, I.J.1    Kumar, S.2    Stewart, P.M.3
  • 105
    • 0036882136 scopus 로고    scopus 로고
    • Expression of 11β-hydroxysteroid dehydrogenase type 1 in adipose tissue is not increased in human obesity
    • Tomlinson JW, Sinha B, Bujalska I, et al. Expression of 11β-hydroxysteroid dehydrogenase type 1 in adipose tissue is not increased in human obesity. J Clin Endocrinol Metab 2002; 87: 5630-563
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 5630-6563
    • Tomlinson, J.W.1    Sinha, B.2    Bujalska, I.3
  • 106
    • 33749578271 scopus 로고    scopus 로고
    • The impact of glucocorticoid replacement regimens on metabolic outcome and comorbidity in hypopituitary patients
    • Filipsson H, Monson JP, Koltowska-Häggström M, et al. The impact of glucocorticoid replacement regimens on metabolic outcome and comorbidity in hypopituitary patients. J Clin Endocrinol Metab 2006; 91 (10): 3954-61
    • (2006) J Clin Endocrinol Metab , vol.91 , Issue.10 , pp. 3954-3961
    • Filipsson, H.1    Monson, J.P.2    Koltowska-Häggström, M.3
  • 107
    • 0037405673 scopus 로고    scopus 로고
    • Preferential loss of omental-mesenteric fat during growth hormone therapy of HIV-associated lipodystrophy
    • He Q, Engelson ES, Albu JB, et al. Preferential loss of omental-mesenteric fat during growth hormone therapy of HIV-associated lipodystrophy. J Appl Physiol 2003; 94 (5): 2051-7
    • (2003) J Appl Physiol , vol.94 , Issue.5 , pp. 2051-2057
    • He, Q.1    Engelson, E.S.2    Albu, J.B.3
  • 108
    • 0038030838 scopus 로고    scopus 로고
    • Low-dose growth hormone inhibits 11 beta-hydroxysteroid dehydrogenase type 1 but has no effect upon fat mass in patients with simple obesity
    • Tomlinson JW, Crabtree N, Clark PM, et al. Low-dose growth hormone inhibits 11 beta-hydroxysteroid dehydrogenase type 1 but has no effect upon fat mass in patients with simple obesity. J Clin Endocrinol Metab 2003; 88 (5): 2113-8
    • (2003) J Clin Endocrinol Metab , vol.88 , Issue.5 , pp. 2113-2118
    • Tomlinson, J.W.1    Crabtree, N.2    Clark, P.M.3
  • 109
    • 0035687741 scopus 로고    scopus 로고
    • Growth hormone, insulin-like growth factor-I and the cortisol-cortisone shuttle
    • Stewart PM, Toogood AA, Tomlinson JW. Growth hormone, insulin-like growth factor-I and the cortisol-cortisone shuttle. Horm Res 2001; 56 Suppl. 1: 1-6
    • (2001) Horm Res , vol.56 , Issue.SUPPL. 1 , pp. 1-6
    • Stewart, P.M.1    Toogood, A.A.2    Tomlinson, J.W.3
  • 110
    • 41049097117 scopus 로고    scopus 로고
    • Effects of physical exercise in lipodystrophy HIV-related on metabolic parameters
    • in Italian; thesis, Mar
    • Lauriola V. Effects of physical exercise in lipodystrophy HIV-related on metabolic parameters [in Italian; thesis]. Milan: Faculty of Exercise Sciences, University of Study of Milan, 2007 Mar
    • (2007) Milan: Faculty of Exercise Sciences, University of Study of Milan
    • Lauriola, V.1
  • 111
    • 0034822021 scopus 로고    scopus 로고
    • Coronary risk in growth hormone deficient hypopituitary adults: Increased predicted risk is due largely to lipid profile abnormalities
    • Abdu TA, Neary R, Elhadd TA, et al. Coronary risk in growth hormone deficient hypopituitary adults: increased predicted risk is due largely to lipid profile abnormalities. Clin Endocrinol (Oxf) 2001; 55 (2): 209-16
    • (2001) Clin Endocrinol (Oxf) , vol.55 , Issue.2 , pp. 209-216
    • Abdu, T.A.1    Neary, R.2    Elhadd, T.A.3
  • 112
    • 33744540303 scopus 로고    scopus 로고
    • Growth factors, glucose and insulin kinetics after low dose growth hormone therapy in HIV-lipodystrophy
    • Haugaard SB, Andersen O, Flyvbjergd A, et al. Growth factors, glucose and insulin kinetics after low dose growth hormone therapy in HIV-lipodystrophy. J Infect 2006; 52 (6): 389-98
    • (2006) J Infect , vol.52 , Issue.6 , pp. 389-398
    • Haugaard, S.B.1    Andersen, O.2    Flyvbjergd, A.3


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