In the lipodystrophy associated with highly active antiretroviral therapy, pseudo-Cushing's syndrome is associated with increased regeneration of cortisol by 11β-hydroxysteroid dehydrogenase type 1 in adipose tissue

Diabetologia

Volumn 47, Issue 10, 2004, Pages 1668-1671

  Sutinen, J ^a   Kannisto, K ^b   Korsheninnikova, E ^c   Nyman, T ^c   Ehrenborg, E ^b   Andrew, R ^d   Wake, D J ^d   Hamsten, A ^b   Walker, B R ^d   Yki Jarvinen H ^a,b  

^a UNIVERSITY OF HELSINKI   (Finland)

^b KAROLINSKA INSTITUTE   (Sweden)

^c MINERVA FOUNDATION INSTITUTE FOR MEDICAL RESEARCH   (Finland)

^d UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

11 Hydroxysteroid dehydrogenase type 1; Adipose tissue; Antiretroviral therapy; Cortisol; Glucocorticoid; HIV; Lipodystrophy; PCR; Real time

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; ANGIOTENSINOGEN; HYDROCORTISONE; MESSENGER RNA;

ADIPOSE TISSUE; ADULT; ARTICLE; CELL REGENERATION; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; CUSHINGOID SYNDROME; DISEASE ASSOCIATION; FEMALE; GAS CHROMATOGRAPHY; GENE EXPRESSION; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LIPODYSTROPHY; MALE; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE IMAGING; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1; ADIPOSE TISSUE; ADULT; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; CUSHING SYNDROME; FEMALE; HIV INFECTIONS; HUMANS; HYDROCORTISONE; LIPODYSTROPHY; MALE; RNA, MESSENGER;

EID: 19944417900     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-004-1508-2     Document Type: Article

References (10)

1. Carr A, Cooper DA (2000) Adverse effects of antiretroviral therapy. Lancet 356:1423-1430
2. Miller KK, Daly PA, Sentochnik D et al. (1998) Pseudo-Cushing's syndrome in human immunodeficiency virus-infected patients. Clin Infect Dis 27:68-72
3. Seckl JR, Walker BR (2001) Minireview: 11beta-hydroxysteroid dehydrogenase type 1 - a tissue-specific amplifier of glucocorticoid action. Endocrinology 142:1371-1376
4. Stulnig TM, Waldhäusl W (2004) 11β-Hydroxysteroid dehydrogenase type 1 in obesity and type 2 diabetes. Diabetologia 47:1-11
5. Masuzaki H, Paterson J, Shinyama H et al. (2001) A transgenic model of visceral obesity and the metabolic syndrome. Science 294:2166-2170
6. Kotelevtsev Y, Holmes MC, Burchell A et al. (1997) 11beta-Hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity or stress. Proc Natl Acad Sci USA 94:14924-14929
7. Tomlinson JW, Moore J, Cooper MS et al. (2001) Regulation of expression of 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue: tissue-specific induction by cytokines. Endocrinology 142:1982-1989
8. Kannisto K, Sutinen J, Korsheninnikova E et al. (2003) Expression of adipogenic transcription factors, peroxisome proliferator-activated receptor gamma co-activator 1, IL-6 and CD45 in subcutaneous adipose tissue in lipodystrophy associated with highly active antiretroviral therapy. AIDS 17:1753-1762
9. Yki-Järvinen H, Sutinen J, Silveira A et al. (2003) Regulation of plasma PAI-1 concentrations in HAART-associated lipodystrophy during rosiglitazone therapy. Arterioscler Thromb Vasc Biol 23:688-694
10. Wake DJ, Rask E, Livingstone DE, Soderberg S, Olsson T, Walker BR (2003) Local and systemic impact of transcriptional up-regulation of 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue in human obesity. J Clin Endocrinol Metab 88:3983-3988