Influence of L-isoleucine and pantothenate auxotrophy for L-valine formation in Corynebacterium glutamicum revisited by metabolome analyses

Bioprocess and Biosystems Engineering

Volumn 31, Issue 3, 2008, Pages 217-225

  Bartek, Tobias ^a   Makus, Pia ^a   Klein, Bianca ^a   Lang, Siegmund ^b   Oldiges, Marco ^a  

^a FORSCHUNGSZENTRUM JÜLICH   (Germany)

^b TECHNICAL UNIVERSITY OF BRAUNSCHWEIG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BIOMASS; CARBON; CELL CULTURE; CONCENTRATION (PROCESS); METABOLISM;

CORYNEBACTERIUM GLUTAMICUM; METABOLOME ANALYSES;

BACTERIA;

ALANINE; CARBOXYLIC ACID; ISOLEUCINE; PANTOTHENIC ACID; PYRUVIC ACID; VALINE;

ARTICLE; AUXOTROPHY; BIOMASS; CONTROLLED STUDY; CORYNEBACTERIUM GLUTAMICUM; DRY WEIGHT; GLYCOLYSIS; NONHUMAN; PRIORITY JOURNAL; SUPPLEMENTATION;

BIOMASS; BIOTECHNOLOGY; CHROMATOGRAPHY, LIQUID; CORYNEBACTERIUM GLUTAMICUM; CYTOPLASM; GLYCOLYSIS; ISOLEUCINE; MASS SPECTROMETRY; METABOLISM; MODELS, CHEMICAL; PANTOTHENIC ACID; PYRUVATES; TIME FACTORS; TRICARBOXYLIC ACIDS; VALINE;

CORYNEBACTERIUM GLUTAMICUM;

EID: 41049089236     PISSN: 16157591     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00449-008-0202-z     Document Type: Article

References (42)

1. Sahm H, Eggeling L, de Graaf AA (2000) Pathway analysis and metabolic engineering in Corynebacterium glutamicum. Biol Chem 381:899-910
2. Lee SY, Lee DY, Kim TY (2005) Systems biotechnology for strain improvement. Trends Biotechnol 23:349-358
3. Mashego MR, Rumbold K, De Mey M, Vandamme E, Soetaert W, Heijnen JJ (2007) Microbial metabolomics: past, present and future methodologies. Biotechnol Lett 29:1-16
4. Oldiges M, Lütz S, Pflug S, Schroer K, Stein N, Wiendahl C (2007) Metabolomics: current state and evolving methodologies and tools. Appl Microbiol Biotechnol 76:495-511
5. Wendisch VF, Bott M, Kalinowski J, Oldiges M, Wiechert W (2006) Emerging Corynebacterium glutamicum systems biology. J Biotechnol 124:74-92
6. Magnus JB, Hollwedel D, Oldiges M, Takors R (2006) Monitoring and modeling of the reaction dynamics in the valine/leucine synthesis pathway in Corynebacterium glutamicum. Biotechnol Prog 22:1071-1083
7. Eggeling L, Pfefferle W, Sahm H (2001) Amino acids. In: Ratledge C, Bjoern K (eds) Basic biotechnology. Cambridge University Press, Cambridge, pp 281-303
8. Leyval D, Uy D, Delaunay S, Goergen JL, Engasser JM (2003) Characterisation of the enzyme activities involved in the valine biosynthetic pathway in a valine-producing strain of Corynebacterium glutamicum. J Biotechnol 104:241-252
9. Hüser AT, Chassagnole C, Lindle ND, Merkamm M, Guyonvarch A, Elisakova V, Patek M, Kalinowski J, Brune I, Pühler A, Tauch A (2005) Rational design of a Corynebacterium glutamicum pantothenate production strain and its characterization by metabolic flux analysis and genome-wide transcriptional profiling. Appl Environ Microbiol 71:3255-3268
10. Radmacher E, Vaitsikova A, Burger U, Krumbach K, Sahm H, Eggeling L (2002) Linking central metabolism with increased pathway flux: l-valine accumulation by Corynebacterium glutamicum. Appl Environ Microbiol 68:2246-2250
11. Leonardi R, Zhang YM, Rock CO, Jackowski S (2005) Coenzyme A: back in action. Prog Lipid Res 44:125-153
12. Cocaign-Bousquet M, Lindley ND (1995) Pyruvate overflow and carbon flux within the central metabolic pathways of Corynebacterium glutamicum during growth on lactate. Enzyme Microb Technol 17:260-267
13. Elisakova V, Patek M, Holatko J, Nesvera JN, Leyval D, Goergen JL, Delaunay S (2005) Feedback-resistant acetohydroxy acid synthase increases valine production in Corynebacterium glutamicum. Appl Environ Microbiol 71:207-213
14. Sambrook J, Russel DW (2001) Molecular cloning, 3rd edn. Cold Spring Harbor Laboratory Press, Cold Spring Harbor
15. Brik-Ternbach M, Bollman C, Wandrey C, Takors R (2005) Application of model discriminating experimental design for modeling and development of a fermentative fed-batch l-valine production process. Biotechnol Bioeng 91:356-368
16. Zelic B, Vasic-Racki D, Wandrey C, Takors R (2004) Modeling of the pyruvate production with Escherichia coli in a fed-batch bioreactor. Bioprocess Biosyst Eng 26:249-258
17. Luo B, Groenke K, Takors R, Wandrey C, Oldiges M (2007) Simultaneous determination of multiple intracellular metabolites in glycolysis, pentose phosphate pathway and tricarboxylic acid cycle by liquid chromatography-mass spectrometry. J Chromatogr A 1147:153-164
18. de Koning W, van Dam K (1992) A method for the determination of changes of glycolytic metabolites in yeast on a subsecond time scale using extraction at neutral ph. Anal Biochem 204:118-123
19. Rönsch H, Krämer R, Morbach S (2003) Impact of osmotic stress on volume regulation, cytoplasmic solute composition and lysine production in Corynebacterium glutamicum MH20-22B. J Biotechnol 104:87-97
20. Ruklisha M, Paegle L, Denina I (2007) l-valine biosynthesis during batch and fed-batch cultivations of Corynebacterium glutamicum: Relationship between changes in bacterial growth rate and intracellular metabolism. Process Biochem 42:634-640
21. Marx A, de Graaf AA, Wiechert W, Eggeling L, Sahm H (1996) Determination of the fluxes in the central metabolism of Corynebacterium glutamicum by nuclear magnetic resonance spectroscopy combined with metabolite balancing. Biotechnol Bioeng 49:111-129
22. Vadali RV, Bennett GN, San KY (2004) Cofactor engineering of intracellular CoA/acetyl-CoA and its effect on metabolic flux redistribution in Escherichia coli. Metab Eng 6:133-139
23. Begley TP, Kinsland C, Strauss E (2001) The biosynthesis of coenzyme A in bacteria. In: Litwack G, Begley TP (eds) Vitamins and hormones-advances in research and applications, vol 61. Academic Press, San Diego, pp 157-171
24. Schreiner ME, Fiur D, Holatkoj J, Patek M, Eikmanns BJ (2005) E1 enzyme of the pyruvate dehydrogenase complex in Corynebactetium glutamicum: molecular analysis of the gene and phylogenetic aspects. J Bacteriol 187:6005-6018
25. Bott M (2007) Offering surprises: TCA cycle regulation in Corynebacterium glutamicum. Trends Microbiol 15:417-425
26. Jackowski S, Rock CO (1986) Consequences of reduced intracellular coenzyme A content in Escherichia coli. J Bacteriol 166:866-871
27. Takayama K, Wang C, Besra GS (2005) Pathway to synthesis and processing of mycolic acids in Mycobacterium tuberculosis. Clin Microbiol Rev 18:81-101
28. Inui M, Murakami S, Okino S, Kawaguchi H, Vertes AA, Yukawa H (2004) Metabolic analysis of Corynebacterium glutamicum during lactate and succinate productions under oxygen deprivation conditions. J Mol Microbiol Biotechnol 7:182-196
29. Tarmy EM, Kaplan NO (1968) Kinetics of Escherichia coli B d-lactate dehydrogenase and evidence for pyruvate-controlled change in conformation. J Biol Chem 243:2587-2596
30. Schreiner ME, Eikmanns BJ (2005) Pyruvate:quinone oxidoreductase from Corynebacterium glutamicum: purification and biochemical characterization. J Bacteriol 187:862-871
31. Gerstmeir R, Wendisch VF, Schnicke S, Ruan H, Farwick M, Reinscheid D, Eikmanns BJ (2003) Acetate metabolism and its regulation in Corynebacterium glutamicum. J Biotechnol 104:99-122
32. Wendisch VF, Spies M, Reinscheid DJ, Schnicke S, Sahm H, Eikmanns BJ (1997) Regulation of acetate metabolism in Corynebacterium glutamicum: transcriptional control of the isocitrate lyase and malate synthase genes. Arch Microbiol 168:262-269
33. Richter H, Vlad D, Unden G (2001) Significance of pantothenate for glucose fermentation by Oenococcus oeni and for suppression of the erythritol and acetate production. Arch Microbiol 175:26-31
34. An GH, Song KB, Sinskey AJ (1999) Redirection of carbon flux to lysine in a recombinant of Corynebacterium lactofermentum ATCC 21799 by limited supply of pantothenate. J Biosci Bioeng 88:168-172
35. Marienhagen J, Kennerknecht N, Sahm H, Eggeling L (2005) Functional analysis of all aminotransferase proteins inferred from the genome sequence of Corynebacterium glutamicum. J Bacteriol 187:7639-7646
36. Atkinson DE, Walton GM (1967) Adenosine triphosphate conservation in metabolic regulation-rat liver citrate cleavage enzyme. J Biol Chem 242:3239-3241
37. Wittmann C, Krömer JO, Kiefer P, Binz T, Heinzle E (2004) Impact of the cold shock phenomenon on quantification of intracellular metabolites in bacteria. Anal Biochem 327:135-139
38. Leder IG (1972) Interrelated effects of cold shock and osmotic pressure on permeability of Escherichia coli membrane to permease accumulated substrates. J Bacteriol 11:211-219
39. Andersen KB, Meyenburg KV (1977) Charges of nicotinamide adenine-nucleotides and adenylate energy-charge as regulatory parameters of metabolism in Escherichia coli. J Biol Chem 252:4151-4156
40. Bolten CJ, Kiefer P, Letisse F, Portais JC, Wittmann C (2007) Sampling for metabolome analysis of microorganisms. Anal Chem 79:3843-3849
41. Shiio I, Ujigawa-Takeda K (1980) Presence and regulation of α-ketoglutarate dehydrogenase complex in a glutamate-producing bacterium, Brevibacterium flavum. Agric Biol Chem 44:1897-1904
42. Blombach B, Schreiner ME, Holatko J, Bartek T, Oldiges M, Eikmanns BJ (2007) (l)-Valine production with pyruvate dehydrogenase complex-deficient Corynebacterium glutamicum. Appl Environ Microbiol 73:2079-2084