Regulation of acetate metabolism in Corynebacterium glutamicum: Transcriptional control of the isocitrate lyase and malate synthase genes

Archives of Microbiology

Volumn 168, Issue 4, 1997, Pages 262-269

  Wendisch, Volker F ^a   Spies, Marion ^a   Reinscheid, Dieter J ^a,b   Schnicke, Stephanie ^a   Sahm, Hermann ^a   Eikmanns, Bernhard J ^a  

^a FORSCHUNGSZENTRUM JÜLICH   (Germany)

^b TECHNICAL UNIVERSITY OF BRAUNSCHWEIG   (Germany)

Author keywords

Acetate kinase; Acetate metabolism; Acetyl CoA; Acetyl phosphate; Corynebacterium glutamicum; Isocitrate lyase; Malate synthase; Phosphotransacetylase

Indexed keywords

ACETIC ACID; ISOCITRATE LYASE; MALATE SYNTHASE;

ARTICLE; BACTERIAL METABOLISM; CONTROLLED STUDY; CORYNEBACTERIUM GLUTAMICUM; CULTURE MEDIUM; ENZYME ACTIVITY; GENETIC REGULATION; GENETIC TRANSCRIPTION; NONHUMAN; PLASMID; PRIORITY JOURNAL;

ACETATE KINASE; ACETATES; ACETYL COENZYME A; ARTIFICIAL GENE FUSION; BLOTTING, NORTHERN; CLONING, MOLECULAR; CORYNEBACTERIUM; GENE EXPRESSION REGULATION, BACTERIAL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUCOSE; GLUTAMIC ACID; ISOCITRATE LYASE; LACTATES; MALATE SYNTHASE; PHOSPHATE ACETYLTRANSFERASE; PLASMIDS; RESTRICTION MAPPING; SUCCINIC ACID; TRANSCRIPTION, GENETIC; TRANSFORMATION, GENETIC;

BACTERIA (MICROORGANISMS); CORYNEBACTERIUM GLUTAMICUM; FELIS CATUS;

EID: 0030760457     PISSN: 03028933     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002030050497     Document Type: Article

References (48)

1. Blasco R, Cardenas J, Castillo F (1991) Regulation of isocitrate lyase in Rhodobacter capsulatus E1F1. Curr Microbiol 22:73-76
2. Boynton ZL, Bennett GN, Rudolph FB (1994) Intracellular concentrations of coenzyme A and its derivatives from Clostridium acetobutylicum ATCC 824 and their roles in enzyme regulation. Appl Environ Microbiol 60:39-44
3. Brown TDK, Jones-Mortimer MC, Kornberg HL (1977) The enzymatic interconversion of acetate and acetyl-coenzyme A in Escherichia coli. J Gen Microbiol 102:327-336
4. Chohnan S, Furukawa H, Fujio T, Nishihara H, Takamura Y (1997) Changes in the size and composition of intracellular pools of nonesterified coenzyme A and coenzyme A thioesters in aerobic and facultatively anaerobic bacteria. Appl Environ Microbiol 63:553-560
5. Chung T, Klumpp DJ, LaPorte DC (1988) Glyoxylate bypass operon of Escherichia coli: cloning and determination of the functional map. J Bacteriol 170:386-392
6. Clark DP, Cronan JE Jr (1996) Two-carbon compounds and fatty acids as carbon sources. In: Neidhardt FC, Curtiss R, Ingraham JL, Lin ECC, Low KB, Magasanik B, Reznikoff WS, Riley M, Schaechter M, Umbarger HE (eds) Escherichia coli and Salmonella typhimurium: cellular and molecular biology, vol 1. American Society for Microbiology, Washington, DC, pp 343-357
7. Cronan JE Jr (1997) In vivo evidence that acyl coenzyme A regulates DNA binding by the Escherichia coli FadR global transcription factor. J Bacteriol 179:1819-1823
8. Cronan JE Jr, LaPorte D (1996) Tricarboxylic acid cycle and glyoxylate bypass. In: Neidhardt FC, Curtiss R, Ingraham JL, Lin ECC, Low KB, Magasanik B, Reznikoff WS, Riley M, Schaechter M, Umbarger HE (eds) Escherichia coli and Salmonella typhimurium: cellular and molecular biology, vol 1. American Society for Microbiology, Washington, DC, pp 206-216
9. Dixon GH, Kornberg HL (1959) Assay methods for key enzymes of the glyoxylate cycle. Biochem J 72:3P
10. Dominguez H, Nezondet C, Lindley ND, Cocaign M (1993) Modified carbon flux during oxygen-limited growth of C. glutamicum and the consequences for amino acid overproduction. Biotechnol Lett 15:449-454
11. Ebbighausen H, Weil B, Krämer R (1991) Carrier-mediated acetate uptake in Corynebacterium glutamicum. Arch Microbiol 155:505-510
12. Eikmanns BJ, Kleinertz E, Liebl W, Sahm H (1991a) A family of Corynebacterium glutamicum/Escherichia coli shuttle vectors for cloning, controlled gene expression, and promoter probing. Gene 102:93-98
13. Eikmanns BJ, Metzger M, Reinscheid D, Kircher M, Sahm H (1991b) Amplification of three threonine biosynthesis genes in Corynebacterium glutamicum and its influence on carbon flux in different strains. Appl Microbiol Biotechnol 34:617-622
14. Eikmanns BJ, Thum-Schmitz N, Eggeling L, Lüdtke KU, Sahm H (1994) Nucleotide sequence, expression and transcriptional analysis of the Corynebacterium glutamicum gltA gene encoding citrate synthase. Microbiology 140:1817-1828
15. Eikmanns BJ, Rittmann D, Sahm H (1995) Cloning, sequence analysis, expression, and inactivation of the Corynebacterium glutamicum icd gene encoding isocitrate dehydrogenase and biochemical characterization of the enzyme. J Bacteriol 177:774-782
16. Feng J, Atkinson MR, McCleary W, Stock JB, Wanner BL, Ninfa AJ (1992) Role of phosphorylated metabolic intermediates in the regulation of glutamine synthetase synthesis in Escherichia coli. J Bacteriol 174:6061-6070
17. Gornall AG, Bardawill CJ, David MM (1949). Determination of serum proteins by means of the Biuret reaction. J Biol Chem 177:751-766
18. Grupe H, Gottschalk G (1992) Physiological events in Clostridium acetobutylicum during shift from acidogenesis to solventogenesis in continuous culture and presentation of a model for shift induction. Appl Environ Microbiol 58:3896-3902
19. Gui L, Sunnarborg A, LaPorte DC (1996) Regulated expression of a repressor protein: FadR activates icIR. J Bacteriol 178:4704-4709
20. Gutmann M, Hoischen C, Krämer R (1992) Carrier-mediated glutamate secretion by Corynebacterium glutamicum under biotin limitation. Biochim Biophys Acta 1112:115-123
21. Hanahan D (1985) Studies on transformation of Escherichia coli with plasmids. J Mol Biol 166:557-580
22. Henry MF, Cronan JE Jr (1991) Escherichia coli transcription factor that both activates fatty acid synthesis and represses fatty acid degradation. J Mol Biol 222:843-849
23. Henry MF, Cronan JE Jr (1992) A new mechanism of transcriptional regulation: release of an activator triggered by a small molecule binding. Cell 70:671-679
24. Hillier S, Charnetzky WT (1981) Glyoxylate bypass enzymes in Yersinia species and multiple forms of isocitrate lyase in Yersinia pestis. J Bacteriol 145:452-458
25. Huisman GW, Siegele DA, Zambrano MM, Kolter R (1996) Morphological and physiological changes during stationary phase. In: Neidhardt FC, Curtiss R, Ingraham JL, Lin ECC, Low KB, Magasanik B, Reznikoff WS, Riley M, Schaechter M, Umbarger HE (eds) Escherichia coli and Salmonella typhimurium: cellular and molecular biology, vol 2. American Society for Microbiology, Washington, DC. pp 1672-16
26. Kakuda H, Hosono K, Shiroishi K, Ichihara S (1994) Identification and characterization of the ackA (acetate kinase A)-pta (phosphotransacetylase) operon and complementation analysis of acetate utilization by an ackA-pta deletion mutant of Escherichia coli. J Biochem 116:916-922
27. Kinoshita S (1985) Glutamic acid bacteria. In: Demain AL, Solomon NA (eds) Biology of industrial microorganisms. Benjamin/Cummings, London, pp 115-142
28. Kinoshita S, Tanaka K (1972) Glutamic acid. In: Yamada K (ed) The microbial production of amino acids. Wiley, New York, pp 263-324
29. Kornberg HL (1966) Anaplerotic sequences and their role in metabolism. In: Campbell PN, Greville GP (eds) Essays in biochemistry, vol 2. Academic Press, New York, pp 1-31
30. LaPorte DC, Thorsness PE, Koshland DE Jr (1985) Compensatory phosphorylation of isocitrate dehydrogenase. a mechanism for adaptation to the intracellular environment. J Biol Chem 260:10563-10568
31. Maloy SR, Nunn WD (1982) Genetic regulation of the glyoxylate shunt in Escherichia coli K12. J Bacteriol 149:173-180
32. McCleary WR, Stock JB (1994) Acetyl-phosphate and the activation of two-component response regulators. J Biol Chem 269:31567-31572
33. McCleary WR, Stock JB, Ninfa AJ (1993) Is acetyl-phosphate a global signal in Escherichia coli? J Bacteriol 175:2793-2798
34. Meyer CL, Papoutsakis ET (1989) Increased levels of ATP and NADH are associated with increased solvent production in continuous cultures of Clostridium acetobutylicum. Appl Microbiol Biotechnol 30:450-459
35. Nachlas MM, Davidson MB, Goldberg JD, Seligman AM (1963) Colorimetric method for the measurement of isocitric dehydrogenase activity. J Lab Clin Med 62:148-158
36. Nesvera J, Patek M, Hochmannova J, Abrhamova Z, Becvarova V, Jelinkova M, Vohradsky J (1997) Plasmid pGA1 from Corynebacterium glutamicum codes for a gene product that positively influences plasmid copy number. J Bacteriol 179:1525-1532
37. Raman N, DiRusso CC (1995) Analysis of acyl coenzyme A binding to the transcription factor FadR and identification of amino acid residues in the carboxyterminus required for ligand binding. J Biol Chem 270:1092-1097
38. Reinscheid DJ, Eikmanns B, Sahm H (1994a) Characterization of the isocitrate lyase gene from Corynebacterium glutamicum and biochemical analysis of the enzyme. J Bacteriol 176:3474-3483
39. Reinscheid DJ, Eikmanns BJ, Sahm H (1994b) Malate synthase from Corynebacterium glutamicum: sequence analysis of the gene and biochemical characterization of the enzyme. Microbiology 140:3099-3108
40. Sambrook J, Fritsch EF, Maniatis J (1989) Molecular cloning. A laboratory manual. Cold Spring Harbor Laboratory. Cold Spring Harbor, NY
41. Shaw WV (1975) Chloramphenicol acetyltransferase from chloramphenicol-resistant bacteria. Methods Enzymol 43:737-755
42. Shiio I, Momose H, Oyama A (1969) Genetic and biochemical studies on bacterial formation of glutamate. 1. Relationship between isocitrate lyase. acetate kinase and phosphate acetyltransferase levels and glutamate production in Brevibacterium flavum. J Gen Appl Microbiol 15:27-40
43. Singh-Wissmann K, Ferry JG (1995) Transcriptional regulation of the phosphotransacetylase-encoding and acetate kinase-encoding genes (pta and ack) from Methanosarcina thermophila. J Bacteriol 177:1699-1702
44. Thauer RK, Jungermann K, Decker K (1977) Energy conservation in chemotrophic anaerobic bacteria. Bacteriol Rev 41:100-180
45. Vanderwinkel E, Liard P, Ramos F, Wiame JM (1963) Genetic control of the regulation of isocitritase and malate synthase in Escherichia coli K12. Biochem Biophys Res Commun 12:157-162
46. Van Dyk TK, LaRossa RA (1987) Involvement of ack-pta operon products in α-ketobutyrate metabolism by Salmonella typhimurium. Mol Gen Genet 207:435-440
47. Wanner BL, Wilmes-Riesenberg MR (1992) Involvement of phosphotransacetylase, acetate kinase, and acetyl-phosphate synthesis in control of the phosphate regulon in Escherichia coli J Bacteriol 174:2124-2130
48. Warren WA (1970) Catalysis of both oxidation and reduction of glyoxylate by pig heart lactate dehydrogenase isoenzyme I. J Biol Chem 245:1675-1681