Effect of pressure stress applied to the airway on cough-reflex sensitivity in guinea pigs

American Journal of Respiratory and Critical Care Medicine

Volumn 177, Issue 6, 2008, Pages 585-592

  Hara, Johsuke ^a,b   Fujimura, Masaki ^a   Ueda, Akihito ^a   Myou, Shigeharu ^a   Oribe, Yoshitaka ^a,c   Ohkura, Noriyuki ^a   Kita, Toshiyuki ^a,d   Yasui, Masahide ^a   Kasahara, Kazuo ^a  

^a KANAZAWA UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCE   (Japan)

^b ISHIKAWA PREFECTURAL CENTRAL HOSPITAL   (Japan)

^c Keiju Medical Center   (Japan)

^d NATIONAL HOSPITAL ORGANIZATION KANAZAWA MEDICAL CENTER   (Japan)

Author keywords

Cough; Cough reflex sensitivity; Hydroxyurea; Negative mechanical pressure stress; Neutrophilic airway inflammation

Indexed keywords

CAPSAICIN; HYDROXYUREA; SUBSTANCE P; ENZYME INHIBITOR; IRRITANT AGENT;

AIRWAY PRESSURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ARTIFICIAL VENTILATION; CONTROLLED STUDY; COUGHING; GUINEA PIG; LUNG LAVAGE; MALE; NEUTROPHIL; NEUTROPHIL COUNT; NONHUMAN; PRIORITY JOURNAL; REFLEX; STRESS; ANIMAL; BIOMECHANICS; BRONCHOSPASM; CHEMICALLY INDUCED DISORDER; CYTOLOGY; DISEASE MODEL; IMMUNOLOGY; INFLAMMATION; INHALATION TEST; METHODOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY;

ANIMALS; BIOMECHANICS; BRONCHIAL PROVOCATION TESTS; BRONCHOALVEOLAR LAVAGE FLUID; BRONCHOCONSTRICTION; CAPSAICIN; COUGH; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; GUINEA PIGS; HYDROXYUREA; INFLAMMATION; IRRITANTS; MALE; NEUTROPHILS; REFLEX; RESPIRATION, ARTIFICIAL;

EID: 40949107811     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.200703-457OC     Document Type: Article

References (39)

1. Choudry NB, Fuller RW. Sensitivity of the cough reflex in patients with chronic cough. Eur Respir J 1992;5:296-300.
2. Fujimura M, Kamio Y, Hashimoto T, Matsuda T. Cough receptor sensitivity and bronchial responsiveness in patients with only chronic nonproductive cough: in view of effect of bronchodilator therapy. J Asthma 1994;31:463-472.
3. Xiang A, Uchida Y, Nomura A, Iijima H, Dong F, Zhang MJ, Hasegawa S. Effects of airway inflammation on cough response in the guinea pig. J Appl Physiol 1998;85:1847-1854.
4. Liu Q, Fujimura M, Tachibana H, Myou S, Kasahara K, Yasui M. Characterization of increased cough sensitivity after antigen challenge in guinea pigs. Clin Exp Allergy 2001;31:474-484.
5. Widdicombe J. Neurophysiology of the cough reflex. Eur Respir J 1995;8:1193-1202.
6. Korpas J, Tomori Z. Cough and other respiratory reflexes. In: Herzog H, editor. Progress in respiration research. Basel, Switzerland: Karger; 1979. pp. 15-179.
7. Langlands J. The dynamics of cough in health and in chronic bronchitis. Thorax 1967;22:88-96.
8. Masaoka A. Tracheobronchomalacia. Journal of the Japan Society for Bronchology 1993;15:719-728.
9. Pederson OF, Thiessen B, Lyger S. Airway compliance and flow limitation during forced expiration in dogs. J Appl Physiol 1982;52:357-369.
10. Hayama N, Kondo T, Kobayashi I, Tazaki G, Eguchi K. Effects of bronchial intermittent constrictions on explosive flow during coughing in the dogs. Jpn J Physiol 2003;53:71-76.
11. Jatakanon A, Lalloon U, Lim S, Chung KF, Barnes PJ. Increased neutrophils and cytokines, TNF-a and IL-8, in induced sputum of nonasthmatic patients with chronic dry cough. Thorax 1999;54:234-237.
12. Chaudhuri R, McMahon A, Thomson L, Macleod K, McSharry C, Livingston E, Mckay A, Thomson N. Effect of inhaled corticosteroids on symptom severity and sputum mediator levels in chronic persistent cough. J Allergy Clin Immunol 2004;113:1063-1070.
13. Pizzichini E, Pizzichini MM, Clelland L. Induced sputum indices of inflammation in patients with chronic dry cough [abstract]. Eur Respir J 1997;10:183s.
14. Ventresca P, Nichol G, Barnes PJ, Chung KF. Inhaled fulosemide inhibits cough induced by low cholide content solutions and not by capsaicin. Am Rev Respir Dis 1990;142:143-146.
15. Niimi A, Torrego A, Nicholson AG, Cosio BG, Oates TB, Chung KF. Nature of airway inflammation and remodeling in chronic cough. J Allergy Clin Immunol 2005;116:565-570.
16. Ricard JD, Dreyfuss D, Saumon G. Production of inflammatory cytokines in ventilator-induced lung injury: a reappraisal. Am J Respir Crit Care Med 2001;163:1176-1180.
17. Held HD, Boettcher S, Hamann L, Uhlig S. Ventilation-induced chemokine and cytokine release is associated with activation of nuclear factor-kB and is blocked by steroids. Am J Respir Crit Care Med 2001;163:711-716.
18. Tremblay L, Valenza F, Ribeiro SP, Li J, Slutsky AS. Injurious ventilatory strategies increase cytokines and c-fos m-RNA expression in an isolated rat lung model. J Clin Invest 1997;99:944-952.
19. Oudin S, Pugin J. Role of MAP kinase activation in interleukin-8 production by human BEAS-2B bronchial epithelial cells submitted to cyclic stretch. Am J Respir Cell Mol Biol 2002;27:107-114.
20. Thomas RA, Norman JC, Huynh TT, Williams B, Bolton SJ, Wardlaw AJ. Mechanical stretch has contrasting effects on mediator release from bronchial epithelial cells, with a rho-kinase-dependent component to the mechanotransduction pathway. Respir Med 2006;100:1588-1597.
21. Lim LH, Wagner EM. Airway distension promotes leukocyte recruitment in rat tracheal circulation. Am J Respir Crit Care Med 2003;168:1068-1074.
22. Wagner EM, Jenkins J. Effects of airway distension on leukocyte recruitment in the mouse tracheal microvasculature. J Appl Physiol 2007;102:1528-1534.
23. Nightingale JA, Rogers DF, Barnes PJ. Effect of repeated sputum induction on cell counts in normal volunteers. Thorax 1998;53:87-90.
24. Thompson JE, Scypinski LA, Gordon T, Sheppard D. Hydroxyurea inhibits airway hyperresponsiveness in guinea pigs by a granulocyte-independent mechanism. Am Rev Respir Dis 1986;l34:1213-1218.
25. O'Byrne PM, Walters EH, Gold BD, Aizawa HA, Fabbri LM, Alpert SE, Nadel JA, Holtzman MJ. Neutrophil depletion inhibits airway hyperresponsiveness induced by ozone exposure. Am Rev Respir Dis 1984;130:214-219.
26. 2 toxicity in adult sheep. Am Rev Respir Dis 1992;145:13-18.
27. Dusser DJ, Jacoby DB, Djokic TD, Rubinstein I, Borson DB, Nadel JA. Virus induces airway hyperresponsiveness to tachykinins: role of neutral endopeptidase. J Appl Physiol 1989;67:1504-1511.
28. Jacoby DB, Tamaoki J, Borson DB, Nadel JA. Influenza infection causes airway hyperresponsiveness by decreasing enkephalinase. J Appl Physiol 1988;64:2653-2658.
29. Katayama N, Fujimura M, Ueda A, Kita T, Abo M, Tachibana H, Myou S, Kurashima K. Effect of carbocysteine of antigen-induced increases in cough sensitivity and bronchial responsiveness in guinea pigs. J Pharmacol Exp Ther 2001;297:975-980.
30. Sekizawa K, Jia Y, Ebihara T, Hirose Y, Hirayama Y, Sasaki H. Role of substance P in cough. Pulm Pharmacol 1996;9:323-328.
31. O'Connor TM, O'Connor J, O'Brien DI, Goode T, Bredin CP, Shanahan F. The role of substance P in inflammatory disease. J Cell Physiol 2004;201:167-180.
32. Advenier C, Lagente V, Boichot E. The role of tachykinin receptor antagonists in the prevention of bronchial hyperresponsiveness, airway inflammation and cough. Eur Respir J 1997;10:1892-1906.
33. Pizzichini MM, Pizzichini E, Parameswaran K, Clelland L, Efthimiadis A, Dolovich J, Hargreave FE. Nonasthmatic chronic cough: no effect of treatment with an inhaled corticosteroid in patients without sputum eosinophilia. Can Respir J 1999;6:323-330.
34. Jia Y, McLeod RL, Wang X, Parra LE, Egan RW, Hey JA. Anandamide induces cough in conscious guinea-pigs through VR1 receptors. Br J Pharmacol 2002;137:831-836.
35. Groneberg DA, Niimi A, Dinh QT, Cosio B, Hew M, Fischer A, Chung KF. Increased expression of transient receptor potential vanilloid-1 in airway nerves of chronic cough. Am J Respir Crit Care Med 2004;170:1276-1280.
36. Canning BJ. Anatomy and neurophysiology of the cough reflex: ACCP evidence-based clinical practice guidelines. Chest 2006;129:33-47.
37. Ho CY, Gu Q, Lin YS, Lee LY. Sensitivity of vagal afferent endings to chemical irritants in the rat lung. Respir Physiol 2001;127:113-124.
38. McAlexander MA, Myers AC, Undem BJ. Adaptation of guinea-pig vagal airway afferent neurones to mechanical stimulation. J Physiol 1999;521:239-247.
39. Pack AI, DeLaney RG. Response of pulmonary rapidly adapting receptors during lung inflation. J Appl Physiol 1983;55:955-963.