A functional nuclear localization signal in insulin-like growth factor binding protein-6 mediates its nuclear import

Endocrinology

Volumn 149, Issue 3, 2008, Pages 1214-1226

  Iosef, Cristiana ^a,b   Gkourasas, Theofanis ^a   Jia, Christina Y H ^a   Li, Shawn S C ^a,b   Han, Victor K M ^a,b  

^a WESTERN UNIVERSITY   (Canada)

^b CHILDREN S HEALTH RESEARCH INSTITUTE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; GLYCINE; KARYOPHERIN ALPHA; KARYOPHERIN BETA; LYSINE; PROLINE; SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN BINDING PROTEIN 5; SOMATOMEDIN BINDING PROTEIN 6;

APOPTOSIS; ARTICLE; CELL FUNCTION; CONTROLLED STUDY; HUMAN; HUMAN CELL; NUCLEAR IMPORT; NUCLEAR LOCALIZATION SIGNAL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; RHABDOMYOSARCOMA; WILD TYPE;

ACTIVE TRANSPORT, CELL NUCLEUS; ADENOSINE TRIPHOSPHATE; ALPHA KARYOPHERINS; AMINO ACID SEQUENCE; BETA KARYOPHERINS; CELL LINE; CELL NUCLEUS; HUMANS; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 3; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 5; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 6; KIDNEY; MOLECULAR SEQUENCE DATA; NUCLEAR LOCALIZATION SIGNALS; RHABDOMYOSARCOMA; TUMOR CELLS, CULTURED;

EID: 40849142339     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2007-0959     Document Type: Article

References (52)

1. Shimasaki S, Ling N 1991 Identification and molecular characterization of insulin-like growth factor binding proteins (IGFBP-1, -2, -3, -4, -5 and -6). Prog Growth Factor Res 3:243-266
2. Jones JI, Clemmons DR 1995 Insulin-like growth factors and their binding proteins. Endocr Rev 16:3-34
3. Han VK, Carter AM 2000 Spatial and temporal patterns of expression of messenger RNA for insulin-like growth factors and their binding proteins in the placenta of man and laboratory animals. Placenta 21:289-305
4. Janosi JB, Ramsland PA, Mott MR, Firth SM, Baxter RC, Delhanty PJ 1999 The acid-labile subunit of the serum insulin-like growth factor-binding protein complexes. Structural determination by molecular modeling and electron microscopy. J Biol Chem 274:23328-23332
5. Kelley KM, Oh Y, Garcosky SE, Gucev Z, Matsumoto T, Hwa V, Ng L, Simpson DM, Rosenfeld RG 1996 Insulin-like growth factor-binding proteins (IGFBPs) and their regulatory dynamics. Int J Biochem Cell Biol 28:619-637.
6. Clemmons DR 1999 Insulin-like growth factor binding proteins and their role in controlling IGF actions. Cytokine Growth Factor Rev 8:45-62
7. Martin JL, Coverly JL, Baxter RC 1994 Regulation of Immunoreactive insulin like growth factor binding protein-6 in normal and transformed fibroblast. J Biol Chem 269:11470-11477
8. Yan T, Wergedal J, Zhou Y, Mohan S, Baylink DJ, Strong DD 2001 Inhibition of human osteoblast marker gene expression by retinoids is mediated in part by insulin-like growth factor binding protein-6. Growth Horm IGF Res 11:368-377
9. Kim EJ, Kang YH, Schaffer BS, Bach LA, MacDonald RG, Park JH 2002 Inhibition of Caco-2 cell proliferation by all-trans retinoic acid: role of insulinlike growth factor binding protein-6. J Cell Physiol 190:92-100
10. Sueoka N, Lee HY, Walsh GL, Fang B, Ji L, Roth JA, LaPushin R, Hong WK, Cohen P, Kurie JM 2002 Am J Respir Cell Mol Biol 23:297-303
11. Grellier P, Berrebi D, Peuchmaur M, Babajko S 2002 The IGF system in neuroblastoma xenografts: focus on IGF-binding protein 6. J Endocrinol 172:467-476
12. Sueoka N, Lee HY, Wiehle S, Cristiano RJ, Fang B, Ji L, Roth JA, Hong WK, Cohen P, Kurie JM 2000 Insulin-like growth factor binding protein-6 activates programmed cell death in non-small cell lung cancer cells. Oncogene 19:4432-4436
13. Babajko S, Leneuve P, Loret C, Binoux M 1997 IGF-binding protein-6 is involved in growth inhibition in SH-SY5Y human neuroblastoma cells: its production is both IGF- and cell density-dependent. J Endocrinol 152:221-227
14. Hale K, Murray AW, Cosgrove LJ, Bach LA, Hartfield PJ 2000 Prevention of apoptosis by insulin-like growth factor (IGF)-I and IGF-II is differentially attenuated by IGF-binding proteins in PC12 cells. Neurosci Res Commun 27:75-83
15. Grellier P, de Galle B, Babajko S 1998 Expression of insulin-like growth factor (IGF) binding protein-6 complementary DNA alters neuroblastoma cell growth. Cancer Res 58:1670-1676
16. Sueoka N, Lee HY, Walsh GL, Fang B, Ji L, Roth JA, LaPushin R, Hong WK, Cohen P, Rosenfeld RG 1996 Insulin-like growth factor-binding proteins (IGFBPs) and their regulatory dynamics. Int J Biochem Cell Biol 28:619-637
17. Butt AJ, Firth SM, Baxter RC 1999 The IGF axis and programmed cell death. Cell Biol 77:256-262
18. Butt AJ, Firth SM, King MA, Baxter RC 2000 Insulin-like growth factor-binding protein-3 modulates expression of Bax and Bcl-2 and potentiates p53-independent radiation-induced apoptosis in human breast cancer cells. J Biol Chem 275 :39174-39181
19. Spagnoli A, Torello M, Nagalla SR, Horton WA, Pattee P, Hwa V, Chiarelli F, Roberts Jr CT, Rosenfeld RG 2002 Identification of STAT-1 as a molecular target of IGFBP-3 in the process of chondrogenesis. J Biol Chem 277:18860-18867
20. Taylor VL, Spencer EM 2001 Characterisation of insulin-like growth factor-binding protein-3 binding to a novel receptor on human platelet membranes. J Endocrinol 168:307-315
21. Liu B, Lee HY, Weinzimer SA, Powell DR, Clifford JL, Kurie JM, Cohen P 2000 Direct functional interactions between insulin-like growth factor-binding protein-3 and retinoid X receptor-α regulate transcriptional signaling and apoptosis. J Biol Chem 275:33607-33613
22. Baxter RC 2001 Inhibition of the insulin-like growth factor (IGF)-IGF-binding protein interaction. Horm Res 2:68-72
23. Rajah R, Valentinis B, Cohen P 1997 Insulin-like growth factor (IGF)-binding protein-3 induces apoptosis and mediates the effects of transforming growth factor-β1 on programmed cell death through a p53- and IGF-independent mechanism. J Biol Chem 272:12181-12188
24. Oh Y, Muller HL, Lamson G, Rosenfield RG 1993 Insulin-like growth factor (IGF)-independent action of IGF-binding protein-3 in Hs578T human breast cancer cells. J Biol Chem 268:14964-14971
25. Schmid C, Keller C, Gosteli-Peter M, Zapf J 1999 Mitogenic and antiapoptotic effects of insulin-like growth factor binding protein-6 in the human osteoblastic osteosarcoma cell line Saos-2/B-10. Biochem Biophys Res Commun 263:786-789
26. Gallicchio MA, Kneen M, Hall C, Scott AM, Bach LA 2001 Overexpression of insulin-like growth factor binding protein-6 inhibits rhabdomyosarcoma growth in vivo. Int J Cancer 94:645-651
27. Schedlich L, Le Page S, Firth SM, Briggs LJ, Jans DA, Baxter RC 2000 Nuclear import of Insulin-like growth factor binding protein-3 and -5 is mediated by importin-β subunit. J Biol Chem 275:23462-23470
28. Gorlich D, Vogel F, Mills AD, Hartmann E, Laskey RA 1995 Distinct functions for the two importin subunits in nuclear protein import. Nature 377:246-249
29. Gorlich D, Mattaj IW 1996 Nucleocytoplasmic transport. Science 271:1513-1518
30. Mattaj IW, Englmeier L 1998 Nucleocytoplasmic transport: the soluble phase. Ann Rev Biochem 67:265-306
31. Dingwall C, Laskey RA 1991 Nuclear targeting sequences - a consensus? Trends Biochem Sci 16:478-481
32. Kalderon D, Roberts BL, Richardson WD, Smith AE 1984 A short amino acid sequence able to specify nuclear location. Cell 39:499-509
33. Robbins J, Dilworth SM, Laskey RA, Dingwall C 1991 Two interdependent basic domains in nucleoplasmin nuclear targeting sequence: identification of a class of bipartite nuclear targeting sequence. Cell 64:615-623
34. Kohler M., Speck C, Christianensen M, Bischoff R, Prehn S, Haller H, Gorlich D, Hartmann E 2000 Evidence for distinct substrate specificities of importin-α family members in nuclear protein import. Mol Cell Biol 19:7782-7791
35. Cingolani G, Bednenko J, Gillespie MT, Gerace L 2002 Molecular basis for the recognition of a nonclassical nuclear localization signal by importin β. Mol Cell 10:1345-1353
36. Chook YM, Blobel G 2001 Karyopherins and nuclear import. Curr Opin Struct Biol 11:703-715
37. Catimel B, Teh T, Fontes MR, Jennings IG, Jans DA, Howlett GJ, Nice EC, Kobe B 2001 Biophysical characterization of interactions involving importin-α during nuclear import. J Biol Chem 276:34189-34198
38. Romanelli MG, Morandi C 2002 Importin-α binds to unusual nuclear localization signal in the heterogeneous ribonucleoprotein type I. Eur J Biochem 269:2727-2734
39. Tkizawa G C, Weiss K, Morgan D O 1999 Ran-independent nuclear import of cycline B1-cdc2 by importin-β. Proc Natl Acad Sci USA 96:7938-7943
40. Adam SA, Marr RS, Gerace L 1990 Nuclear protein import in permeabilized mammalian cells requires soluble cytoplasmic factors. J Cell Biol 111:807-816
41. Bradshaw SL, D'Ercole SJ, Han VKM 1999 Overexpression of insulin-like growth factor binding protein-2 in C6 glioma cells result in conditional alteration of cellular growth. Endocrinology 140:575-584
42. Li C, Iosef C, Jia, CY, Han VK, Li SS 2003 Dual functional roles for the X-linked lymphoproliferative syndrome gene product SAP/SH2D1A in signaling through the signaling lymphocyte activation molecule (SLAM) family of immune receptors. J Biol Chem 278:3852-3859
43. Jans DA, Briggs LJ, Gustin SE, Jans P, Ford S, Young IG 1997 The cytokine interleukin-5 (IL-5) effects cotransport of its receptor subunits to the nucleus in vitro. FEBS Lett 406:315-320
44. Kawano T, Fujita M, Sakamoto H 2000 Unique and redundant functions of SR proteins, a conserved family of splicing factors, in Caenorhabditis elegans development. Mech Dev 95:67-76
45. Buchberger A, Pabst O, Brand T, Seidl K, Arnold HH 1996 Chick NKx-2.3 represents a novel family member of vertebrate homologues to the Drosophila homeobox gene tinman: differential expression of cNKx-2.3 and cNKx-2.5 during heart and gut development. Mech Dev 56:151-163
46. Boudeau J, Kieloch A, Alessi DR, Stella A, Guanti G, Resta N 2003 Functional analysis of LKB1/STK11 mutants and two aberrant isoforms found in Peutz-Jeghers syndrome patients. Hum Mutat 21:172-178
47. Bertinato J Schild-Poulter C, Hache RJK 2000 Nuclear localization of Ku antigen is promoted independently by basic motifs in the Ku70 an Ku80 subunits. J of Cell Sci 114:89-99
48. Boulikas T 1994 Transcription factor binding sites in the matrix attachment region (MAR) of the chicken α-globin gene. J Cell Biochem 55:32-58
49. Bogerd HP, Benson RE, Truant R, Herold A, Phingbodhipakkiya M, Cullen BR 1999 Definition of a consensus transportin-specific nucleocytoplasmic transport signal. J Biol Chem 274:9771-9777
50. Siomi H, Dreyfuss G 1995 A nuclear localization domain in the hnRNP A1 protein. J Cell Biol 129:551-560
51. Miyamo Y, Hieda M, Harreman MT, Fukumoto F, Saiwaki T, Hodel AE, Corbett AH, Yoneda Y 2002 Importin-α can migrate into the nucleus of an importin-β and Ran-independent manner. EMBO J 21:5833-5842
52. Coverley JA, Martin JL, Baxter RC 2000 The effect of phosphorylation by casein kinase 2 on the activity of insulin-like growth factor-binding protein-3. Endocrinology 141:564-570