Inhibition of the insulin-like growth factor (IGF)-IGF-binding protein interaction

Hormone Research

Volumn 55, Issue SUPPL. 2, 2001, Pages 68-72

  Baxter, Robert C ^a,b  

^a UNIVERSITY OF SYDNEY   (Australia)

^b ROYAL NORTH SHORE HOSPITAL   (Australia)

Author keywords

Association; Binding; Dissociation; Extraction; Insulin like growth factor binding proteins; Insulin like growth factors; Proteolysis

Indexed keywords

GLYCOSAMINOGLYCAN; PROTEIN SUBUNIT; SOMATOMEDIN; SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN BINDING PROTEIN 5;

BINDING AFFINITY; CIRCULATION; COMPLEX FORMATION; CONFERENCE PAPER; DISSOCIATION; EXTRAVASCULAR SPACE; HORMONE PROTEIN COMPLEX; HORMONE TRANSPORT; HUMAN; KINETICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DETERMINATION; PROTEIN LOCALIZATION; PROTEIN STABILITY; QUANTITATIVE ANALYSIS; REGULATORY MECHANISM; VALIDATION PROCESS;

ANIMALS; HUMANS; INSULIN-LIKE GROWTH FACTOR BINDING PROTEINS; KINETICS; SOMATOMEDINS;

EID: 0035742041     PISSN: 03010163     EISSN: None     Source Type: Journal    
DOI: 10.1159/000063479     Document Type: Conference Paper

References (33)

1. Insulin-like growth factor (IGF) binding proteins: Interactions with IGFs and intrinsic bioactivities
2. Structure of the IGF-binding domain of the insulin-like growth factor-binding protein-5 (IGFBP-5): Implications for IGF and IGF-I receptor interactions
3. Characterization of truncated insulin-like growth factor-binding protein-2 in human milk
4. Ligand-binding characteristics of recombinant amino-and carboxyl-terminal fragments of human insulin-like growth factor binding protein 3
5. Insulin-like growth factor binding proteins in serum and other biological fluids: Regulation and functions
6. r 140,000 growth hormone-dependent insulin-like growth factor binding protein complex: Determination by reconstitution and affinity labeling
7. Insulin-like growth factor (IGF)-binding protein 5 forms an alternative ternary complex with IGFs and the acid-labile subunit
8. Molecular distribution of insulin-like growth factor binding protein-5 in human serum
9. Circulating binding proteins for the insulin-like growth factors
10. Regulation of the insulin-like growth factors and their binding proteins by glucocorticoid and growth hormone in non-islet tumor hypoglycemia
11. Insulin-like growth factors I and II in healthy man. Estimations of half-lives and production rates
12. Transcapillary permeability and subendothelial distribution of endothelial and amniotic fluid insulin-like growth factor binding proteins in the rat heart
13. Regulation of IGF bioavailability by IGFBP proteases
14. Insulin-like growth factor-binding protein from human plasma. Purification and characterization
15. Structural differences between insulin and somatomedin C/insulin-like growth factor I receptors revealed by autoantibodies to the insulin receptor
16. Biosensor measurement of the interaction kinetics between insulin-like growth factors and their binding proteins
17. Biosensor measurement of the binding of insulin-like growth factors I and II and their analogues to the insulin-like growth factor binding protein 3
18. Differential regulation of insulin-like growth factor binding protein 3 protease activity in MCF-7 breast cancer cells by estrogen and transforming growth factor-b1
19. Insulin-like growth factor binding protein 3: Factors affecting binary and ternary complex formation
20. IGFBP-3 and IGFBP-5 association with endothelial cells: Role of C-terminal heparin binding domain
21. Structural determinants of ligand and cell-surface binding of insulin-like growth factor-binding protein 3
22. Glycosaminoglycans inhibit formation of the 140 kilodalton insulin-like growth factor-binding protein complex
23. Liberation of immunoreactive somatomedin-C from its binding proteins by proteolytic enzymes and heparin
24. Altered ligand specificity of proteolysed insulin-like growth factor binding protein-3
25. Structural determinants for binary and ternary complex formation between insulin-like growth factor I (IGF-I) and IGF binding protein 3
26. Inhibition of access of bound somatomedin to membrane receptor and immunobinding sites: A comparison of RRA and RIA of somatomedin in native and acid-ethanol-extracted serum
27. Radioimmunoassay for insulin-like growth factor I: Solutions to some potential problems and pitfalls
28. Radioimmunological determination of insulin-like growth factors I and II in normal subjects and in patients with growth disorders and extra-pancreatic tumor hypoglycemia
29. Production of insulin-like growth factor I and its binding protein by adult rat hepatocytes in primary culture
30. Development of a simple valid method for the complete removal of insulin-like growth factor (IGF)-binding proteins from IGFs in human serum and other biological fluids: Comparison with acid-ethanol treatment and C18 Sep-Pak separation
31. Radioimmunoassay of growth hormone-dependent insulin-like growth factor binding protein in human plasma
32. A specific radioimmunoassay for insulin-like growth factor II: The interference of IGF binding proteins can be blocked by excess IGF-I
33. Comparison of acid-ethanol extraction and acid gel filtration prior to IGF-I and IGF-II radioimmunoassays: Improvement of determinations in acid ethanol extracts by the use of truncated IGF-I as radioligand