Cognitive MR spectroscopy of anterior cingulate cortex in ADHD: Elevated choline signal correlates with slowed hit reaction times

Journal of Psychiatric Research

Volumn 42, Issue 7, 2008, Pages 587-595

  Colla, Michael ^a,b   Ende, Gabriele ^b   Alm, Barbara ^b   Deuschle, Michael ^b   Heuser, Isabella ^a   Kronenberg, Golo ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b CENTRAL INSTITUTE OF MENTAL HEALTH   (Germany)

Author keywords

Adult ADHD; Anterior cingulate gyrus; Attention; Cognitive magnetic resonance spectroscopy; CPT

Indexed keywords

CHOLINE; CREATINE; N ACETYLASPARTIC ACID;

ADULT; ARTICLE; ATTENTION; ATTENTION DEFICIT DISORDER; CINGULATE GYRUS; CLINICAL ARTICLE; CLINICAL ASSESSMENT; COGNITION; CONTROLLED STUDY; FEMALE; HUMAN; INTELLIGENCE QUOTIENT; MALE; NEUROPSYCHOLOGICAL TEST; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; REACTION TIME; TASK PERFORMANCE;

ADULT; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; CEREBRAL CORTEX; CHOLINE; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; FEMALE; GYRUS CINGULI; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; REACTION TIME; SEVERITY OF ILLNESS INDEX; SIGNAL PROCESSING, COMPUTER-ASSISTED;

EID: 40849140762     PISSN: 00223956     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpsychires.2007.06.006     Document Type: Article

References (68)

1. Alexander M.P., Stuss D.T., Picton T., Shallice T., and Gillingham S. Regional frontal injuries cause distinct impairments in cognitive control. Neurology 68 18 (2007) 1515-1523
2. Barch D.M., Braver T.S., Sabb F.W., and Noll D.C. Anterior cingulate and the monitoring of response conflict: evidence from an fMRI study of overt verb generation. Journal of Cogntion and Neuroscience 12 2 (2000) 298-309
3. Barker P.B., Breiter S.N., Soher B.J., Chatham J.C., Forder J.R., Samphilipo M.A., et al. Quantitative proton spectroscopy of canine brain: in vivo and in vitro correlations. Magnetic Resonance in Medicine 32 2 (1994) 157-163
4. Barkley R.A., and Biederman J. Toward a broader definition of the age-of-onset criterion for attention-deficit hyperactivity disorder. Journal of the American Academy of Child and Adolescent Psychiatry 36 (1997) 1204-1210
5. Bartzokis G. Acetylcholinesterase inhibitors may improve myelin integrity. Biological Psychiatry 2006 [Epub ahead of print].
6. Benedict R.H., Lockwood A.H., Shucard J.L., Shucard D.W., Wack D., and Murphy B.W. Functional neuroimaging of attention in the auditory modality. Neuroreport 9 1 (1998) 121-126
7. Botvinick M.M., Braver T.S., Barch D.M., Carter C.S., and Cohen J.D. Conflict monitoring and cognitive control. Psychological Review 108 (2001) 624-652
8. Boulanger Y., Labelle M., and Khiat A. Role of phospholipase A(2) on the variations of the choline signal intensity observed by 1H magnetic resonance spectroscopy in brain diseases. Brain Research Brain Research Reviews 33 2-3 (2000) 380-389
9. Braus D.F., Ende G., Weber-Fahr W., Demirakca T., Tost H., and Henn F.A. Functioning and neuronal viability of the anterior cingulate neurons following antipsychotic treatment: MR-spectroscopic imaging in chronic schizophrenia. European Neuropsychopharmacology 12 2 (2002) 145-152
10. Bush G., Frazier J.A., Rauch S.L., Seidman L.J., Whalen P.J., Jenike M.A., et al. Anterior cingulate cortex dysfunction in attention-deficit/hyperactivity disorder revealed by fMRI and the counting stroop. Biological Psychiatry 45 12 (1999) 1542-1552
11. Carter C.S., Macdonald A.M., Botvinick M., Ross L.L., Stenger V.A., Noll D., et al. Parsing executive processes: strategic vs. evaluative functions of the anterior cingulate cortex. Proceedings of the National Academy of Sciences USA 97 4 (2000) 1944-1948
12. Casey B.J., Trainor R., Giedd J., Vauss Y., Vaituzis C.K., Hamburger S., et al. The role of the anterior cingulate in automatic and controlled processes: a developmental neuroanatomical study. Developmental Psychobiology 30 1 (1997) 61-69
13. Castellanos F.X., Lee P.P., Sharp W., Jeffries N.O., Greenstein D.K., Clasen L.S., et al. Developmental trajectories of brain volume abnormalities in children and adolescents with attention-deficit/hyperactivity disorder. JAMA 288 14 (2002) 1740-1748
14. Chang L., Ernst T., Tornatore C., Aronow H., Melchor R., Walot I., et al. Metabolite abnormalities in progressive multifocal leucoencephalopathy by proton magnetic resonance spectroscopy. Neurology 48 4 (1997) 836-845
15. Colla M., Ende G., Bohrer M., Deuschle M., Kronenberg G., Henn F.A., et al. MR spectroscopy in Alzheimer's disease: gender differences in probabilistic learning capacity. Neurobiology of Aging 24 4 (2003) 545-552
16. Conners C.K., Sitarenios G., Parker J.D., and Epstein J.N. The revised Conners' Parent Rating Scale (CPRS-R): factor structure, reliability, and criterion validity. Journal of Abnormal Child Psychology 26 4 (1998) 257-268
17. Cornblatt B., and Keilp J. Impaired attention, genetics and the pathophysiology of schizophrenia. Schizophrenia Bulletin 20 (1994) 31-46
18. Cornblatt B.A., Lenzenweger M.F., and Erlenmeyer-Kimling L. The continuous performance test, identical pairs version: II. Contrasting attentional profiles in schizophrenic and depressed patients. Psychiatry Research 29 (1989) 65-85
19. Cornblatt B.A., Risch N.J., Faris G., Friedman D., and Erlenmeyer-Kimling L. The continuous performance test, identical pairs version (CPT-IP): I. New findings about sustained attention in normal families. Psychiatry Research 26 (1988) 223-238
20. Curko Kera E.A., Marks D.J., Berwid O.G., Santra A., and Halperin J.M. Self-report and objective measures of ADHD-related behaviors in parents of preschool children at risk for ADHD. CNS Spectrums 9 9 (2004) 661-666
21. Dreher J., and Berman K.F. Fractionating the neural substrate of cognitive control processes. Proceedings of the National Academy of Sciences USA 99 (2002) 14595-14600
22. DuPaul G., Power T., Anastopoulos A., and Reid R. ADHD Rating Scale IV: checklists, norms, and clinical interpretation (1998), Guilford Press, New York
23. Ende G., Braus D.F., Walter S., Weber-Fahr W., Soher B., Maudsley A.A., et al. Effects of age, medication, and illness duration on N-acetyl-aspartate signal of the anterior cingulate region in schizophrenia. Schizophrenia Research 41 (2000) 389-395
24. Ende G., Laxer K.D., Knowlton R.C., Matson G.B., Schuff N., Fein G., et al. Temporal lobe epilepsy: bilateral hippocampal metabolite changes revealed at proton MR spectroscopic imaging. Radiology 202 (1997) 809-817
25. Epstein J.N., Erkanli A., Conners C.K., Klaric J., Costello J.E., and Angold A. Relations between continuous performance test performance measures and ADHD behaviors. Journal of Abnormal Child Psychology 31 5 (2003) 543-554
26. Fallgatter A.J., Ehlis A.C., Rosler M., Strik W.K., Blocher D., and Herrmann M.J. Diminished prefrontal brain function in adults with psychopathology in childhood related to attention deficit hyperactivity disorder. Biological Psychiatry 138 2 (2005) 157-169
27. Fan J., Flombaum J.I., McCandliss B.D., Thomas K.M., and Posner M.I. Cognitive and brain consequences of conflict. Neuroimage 18 1 (2003) 42-57
28. Faries D., Yalcin I., Harder D., and Heiligenstein J. Validation of the ADHD rating scale as a clinician administered and scored instrument. Journal of Attention Disorders 5 (2001) 107-115
29. Filipek P.A., Semrud-Clikeman M., Steingard R.J., Renshaw P.F., Kennedy D.N., and Biederman J. Volumetric MRI analysis comparing subjects having attention-deficit hyperactivity disorder with normal controls. Neurology 48 3 (1997) 589-601
30. Gualtieri C.T., and Johnson L.G. Efficient allocation of attentional resources in patients with ADHD: maturational changes from age 10 to 29. Journal of Attention Disorders 9 3 (2006) 534-542
31. Hesslinger B., Thiel T., Tebartz van Elst L., Hennig J., and Ebert D. Attention-deficit disorder in adults with or without hyperactivity: where is the difference? A study in humans using short echo (1)H-magnetic resonance spectroscopy. Neuroscience Letters 304 1-2 (2001) 117-119
32. Holdnack J.A., Moberg P.J., Arnold S.E., Gur R.C., and Gur R.E. Speed of processing and verbal learning deficits in adults diagnosed with attention deficit disorder. Neuropsychology and Behavioral Neurology 8 (1995) 282-292
33. Horn W. Leistungspruefsystem (1983), HansHuber Verlag, Bern
34. Jin Z., Zang Y.F., Zeng Y.W., Zhang L., and Wang Y.F. Striatal neuronal loss or dysfunction and choline rise in children with attention-deficit hyperactivity disorder: a 1H-magnetic resonance spectroscopy study. Neuroscience Letters 315 1-2 (2001) 45-48
35. Kerns J.G., Cohen J.D., MacDonald III A.W., Cho R.Y., Stenger V.A., and Carter C.S. Anterior cingulate conflict monitoring and adjustments in control. Science 303 (2004) 1023-1026
36. Laurent A., Saoud M., Bougerol T., d'Amato T., Anchisi A., Biloa-Tang M., et al. Attentional deficits in patients with schizophrenia and in their non-psychotic first degree relatives. Psychiatry Research 89 (1999) 147-159
37. Losier B.J., McGrath P.J., and Klein R.M. Error patterns on the continuous performance test in non-medicated and medicated samples of children with and without ADHD: a meta-analytic review. Journal of Child Psychology and Psychiatry 37 8 (1996) 971-987
38. MacDonald A.W., Cohen J.D., Stenger V.A., and Carter C.S. Dissociating the role of the dorsolateral prefrontal and anterior cingulate cortex in cognitive control. Science 288 (2000) 1835-1838
39. MacMaster F.P., Carrey N., Sparkes S., and Kusumakar V. Proton spectroscopy in medication-free pediatric attention-deficit/hyperactivity disorder. Biological Psychiatry 53 2 (2003) 184-187
40. Magno E., Foxe J.J., Molholm S., Robertson I.H., and Garavan H. The anterior cingulate and error avoidance. Journal of Neuroscience 26 18 (2006) 4769-4773
41. Margari L., Ventura P., Portoghese C., Presicci A., Buttiglione M., and Di Cuonzo F. Brain magnetic resonance spectroscopy in Sydenham's chorea and ADHD. Pediatric Neurology 34 6 (2006) 467-473
42. Maudsley A.A., Matson G.B., Hugg J.W., and Weiner M.W. Reduced phase encoding in spectroscopic imaging. Magnetic Resonance in Medicine 31 (1994) 645-651
43. Merz J., Lehrl S., Galster J.V., and Erzigkeit H. MWT-B - ein Intelligenzkurztest. Psychiatrie Neurologie Medizinische Psychologie (Leipzig) 27 (1975) 423-428
44. Michaelis T., Merboldt K.D., Bruhn H., Hanicke W., and Frahm J. Absolute concentrations of metabolites in the adult human brain in vivo: quantification of localized proton MR spectra. Radiology 187 (1993) 219-227
45. Moore C.M., Biederman J., Wozniak J., Mick E., Aleardi M., Wardrop M., et al. Differences in brain chemistry in children and adolescents with attention deficit hyperactivity disorder with and without comorbid bipolar disorder: a proton magnetic resonance spectroscopy study. Am J Psychiatry 163 2 (2006) 316-318
46. Mulert C., Gallinat J., Dorn H., Herrmann W.M., and Winterer G. The relationship between reaction time, error rate and anterior cingulate cortex activity. International Journal of Psychophysiology 47 2 (2003) 175-183
47. Murphy K., and Barkley R.A. Preliminary normative data on DSM IV criteria for adults. The ADHD Report 3 (1995) 6-7
48. Naito E., Kinomura S., Geyer S., Kawashima R., Roland P.E., and Zilles K. Fast reaction to different sensory modalities activates common fields in the motor areas, but the anterior cingulate cortex is involved in the speed of reaction. Journal of Neurophysiology 83 3 (2000) 1701-1709
49. Ochsner K.N., Kosslyn S.M., Cosgrove G.R., Cassem E.H., Price B.H., Nierenberg A.A., et al. Deficits in visual cognition and attention following bilateral anterior cingulotomy. Neuropsychologia 39 (2001) 219-230
50. O'Dougherty M., Nuechterlein K.H., and Drew B. Hyperactive and hypoxic children: signal detection, sustained attention, and behavior. Journal of Abnormal Psychology 93 2 (1984) 178-191
51. Overmeyer S., Bullmore E.T., Suckling J., Simmons A., Williams S.C., Santosh P.J., et al. Distributed grey and white matter deficits in hyperkinetic disorder: MRI evidence for anatomical abnormality in an attentional network. Psychological Medicine 31 8 (2001) 1425-1435
52. Paus T., Koski L., Caramanos Z., and Westbury C. Regional differences in the effects of task difficulty and motor output on blood flow response in the human anterior cingulate cortex: a review of 107 PET activation studies. Neuroreport 9 9 (1998) R37-R47
53. Perlov E, Philipsen A, Hesslinger B, Buechert M, Ahrendts J, Feige B, et al. Reduced cingulate glutamate/glutamine-to-creatine ratios in adult patients with attention deficit/hyperactivity disorder - a magnet resonance spectroscopy study. Journal of Psychiatric Research 2007. doi:10.1016/j.jpsychires.2006.12.007.
54. Posner M.I., DiGirolamo G.J., and Fernandez-Duque D. Brain mechanisms of cognitive skills. Consciousness and Cognition 6 2-3 (1997) 267-290
55. Ross A.J., and Sachdev P.S. Magnetic resonance spectroscopy in cognitive research. Brain Research Brain Research Reviews 44 2-3 (2004) 83-102
56. Ruiz-Cabello J., and Cohen J.S. Phospholipid metabolites as indicators of cancer cell function. NMR in Biomedicine 4 (1992) 109-116
57. Russell V.A., Oades R.D., Tannock R., Killeen P.R., Auerbach J.G., Johansen E.B., et al. Response variability in Attention-Deficit/Hyperactivity Disorder: a neuronal and glial energetics hypothesis. Behavioral and Brain Functions 2 (2006) 30
58. Sartorius A., Vollmayr B., Neumann-Haefelin C., Ende G., Hoehn M., and Henn F.A. Specific creatine rise in learned helplessness induced by electroconvulsive shock treatment. Neuroreport 14 17 (2003) 2199-2201
59. Soher B.J., Young K., Govindaraju V., and Maudsley A.A. Automated spectral analysis III: application to in vivo proton MR spectroscopy and spectroscopic imaging. Magnetic Resonance in Medicine 40 (1998) 822-831
60. Stanley J.A., Kipp H., Greisenegger E., MacMaster F.P., Panchalingam K., Pettegrew J.W., et al. Regionally specific alterations in membrane phospholipids in children with ADHD: an in vivo 31P spectroscopy study. Psychiatry Research 148 2-3 (2006) 217-221
61. Ward M.F., Wender P.H., and Reimherr F.W. The Wender Utah Rating Scale: an aid in the retrospective diagnosis of childhood attention deficit hyperactivity disorder. American Journal of Psychiatry 150 (1993) 885-890
62. Wasserstein J. Diagnostic issues for adolescents and adults with ADHD. Journal of Clinical Psychology 61 5 (2005) 535-547
63. Wender P.H., Wolf L.E., and Wasserstein J. Adults with ADHD. An overview. Annals of the New York Academy of Sciences 931 (2001) 1-16
64. Weissman D.H., Warner L.M., and Woldorff M.G. The neural mechanisms for minimizing cross-modal distraction. Journal of Neuroscience 24 48 (2004) 10941-10949
65. Wittchen H, Zaudig M, Frydrich T. Strukturiertes Klinisches Interview für DSM-IV (SKID-I und SKID-II) Achse I: Psychische Störungen/Achse II: Persönlichkeitsstörungen. Hogrefe 1997.
66. Young K., Govindaraju V., Soher B.J., and Maudsley A.A. Automated spectral analysis I: formation of a priori information by spectral simulation. Magnetic Resonance in Medicine 40 (1998) 812-815
67. Young K., Soher B.J., and Maudsley A.A. Automated spectral analysis II: application of wavelet shrinkage for characterization of non-parameterized signals. Magnetic Resonance in Medicine 40 (1998) 816-821
68. Zametkin A.J., Nordahl T.E., Gross M., King A.C., Semple W.E., Rumsey J., et al. Cerebral glucose metabolism in adults with hyperactivity of childhood onset. New England Journal of Medicine 323 (1990) 1361-1366