Differences in brain chemistry in children and adolescents with attention deficit hyperactivity disorder with and without comorbid bipolar disorder: A proton magnetic resonance spectroscopy study

American Journal of Psychiatry

Volumn 163, Issue 2, 2006, Pages 316-318

  Moore, Constance M ^a   Biederman, Joseph ^b   Wozniak, Janet ^b   Mick, Eric ^b   Aleardi, Megan ^b   Wardrop, Megan ^b   Dougherty, Meghan ^b   Harpold, Terri ^b   Hammerness, Paul ^b   Randall, Edin ^b   Renshaw, Perry F ^b  

^a MCLEAN HOSPITAL   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CARBAMAZEPINE; DOPAMINE; GLUTAMIC ACID; GLUTAMINE; INOSITOL; LITHIUM; NEUROTRANSMITTER; PHOSPHATIDYLINOSITOL; PROTON; SEROTONIN; TRANQUILIZER; VALPROIC ACID; CREATINE; CREATINE PHOSPHATE; DIAGNOSTIC AGENT;

ADOLESCENT; ARTICLE; ATTENTION DEFICIT DISORDER; BIPOLAR DISORDER; BRAIN METABOLISM; CHILD; CHILD PSYCHIATRY; CINGULATE GYRUS; CLINICAL ARTICLE; COMORBIDITY; CONTROLLED STUDY; DRUG MECHANISM; FEMALE; HUMAN; MALE; NEUROCHEMISTRY; NEUROIMAGING; NEUROTRANSMISSION; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; AGE; BRAIN LEVEL; COMPARATIVE STUDY; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PATHOPHYSIOLOGY; PHYSIOLOGY; STATISTICS; TISSUE DISTRIBUTION;

ADOLESCENT; AGE FACTORS; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; BIPOLAR DISORDER; BRAIN CHEMISTRY; CHILD; COMORBIDITY; CREATINE; DOPAMINE; GLUTAMIC ACID; GLUTAMINE; GYRUS CINGULI; HUMANS; INOSITOL; MAGNETIC RESONANCE SPECTROSCOPY; PHOSPHOCREATINE; PROTONS; SEROTONIN; TISSUE DISTRIBUTION;

EID: 33644991424     PISSN: 0002953X     EISSN: None     Source Type: Journal    
DOI: 10.1176/appi.ajp.163.2.316     Document Type: Article

References (21)

1. Geller B, Fox LW, Clark KA: Rate and predictors of prepubertal bipolarity during follow-up of 6- to 12-year-old depressed children. J Am Acad Child Adolesc Psychiatry 1994; 33:461-468
2. Wozniak J, Biederman J, Richards JA: Diagnostic and therapeutic dilemmas in the management of pediatric-onset bipolar disorder. J Clin Psychiatry 2001; 62:10-15
3. Biederman J, Mick E, Faraone SV, Spencer T, Wilens TE, Wozniak J: Pediatric mania: a developmental subtype of bipolar disorder? Biol Psychiatry 2000; 48:458-466
4. Biederman J: Pediatric bipolar disorder coming of age. Biol Psychiatry 2003; 53:931-934
5. Moore CM, Breeze JL, Gruber SA, Babb SM, Frederick BB, Villafuerte RA, Stoll AL, Hennen J, Yurgelun-Todd DA, Cohen BM, Renshaw PF: Choline, myo-inositol and mood in bipolar disorder: a proton magnetic resonance spectroscopic imaging study of the anterior cingulate cortex. Bipolar Disord 2000; 2:207-216
6. Davanzo P, Thomas MA, Yue K, Oshiro T, Belin T, Strober M, McCracken J: Decreased anterior cingulate myo-inositol/creatine spectroscopy resonance with lithium treatment in children with bipolar disorder. Neuropsychopharmacology 2001; 24: 359-369
7. Davanzo P, Yue K, Thomas MA, Belin T, Mintz J, Venkatraman TN, Santoro E, Barnett S, McCracken J: Proton magnetic resonance spectroscopy of bipolar disorder versus intermittent explosive disorder in children and adolescents. Am J Psychiatry 2003; 160:1442-1452
8. Cecil KM, DelBello MP, Sellars MC, Strakowski SM: Proton magnetic resonance spectroscopy of the frontal lobe and cerebellar vermis in children with a mood disorder and a familial risk for bipolar disorders. J Child Adolesc Psychopharmacol 2003; 13:545-555
9. MacMaster FP, Carrey N, Sparkes S, Kusumakar V: Proton spectroscopy in medication-free pediatric attention-deficit/hyperactivity disorder. Biol Psychiatry 2003; 53:184-187
10. Courvoisie H, Hooper SR, Fine C, Kwock L, Castillo M: Neurometabolic functioning and neuropsychological correlates in children with ADHD-H: preliminary findings. J Neuropsychiatry Clin Neurosci 2004; 16:63-69
11. Chang K, Adleman NE, Dienes K, Simeonova DI, Menon V, Reiss A: Anomalous prefrontal-subcortical activation in familial pediatric bipolar disorder: a functional magnetic resonance imaging investigation. Arch Gen Psychiatry 2004; 61:781-792
12. Provencher SW: Automatic quantitation of localized in vivo 1H spectra with LCModel. NMR Biomed 2001; 14:260-264
13. Russell VA: Dopamine hypofunction possibly results from a defect in glutamate-stimulated release of dopamine in the nucleus accumbens shell of a rat model for attention deficit hyperactivity disorder - the spontaneously hypertensive rat. Neurosci Biobehav Rev 2003; 27:671-682
14. Ford RE, Greenhill L, Posner K: Stimulants, in Pediatric Psychopharmacology. Edited by Martin A, Scahill L, Charney DS, Leckman JF. New York, Oxford University Press, 2003, pp 255-263
15. Volkow ND, Swanson JM: Variables that affect the clinical use and abuse of methylphenidate in the treatment of ADHD. Am J Psychiatry 2003; 160:1909-1918
16. Volkow ND, Wang G-J, Fowler JS, Telang F, Maynard L, Logan J, Gatley SJ, Pappas N, Wong C, Vaska P, Zhu W, Swanson JM: Evidence that methylphenidate enhances the saliency of a mathematical task by increasing dopamine in the human brain. Am J Psychiatry 2004; 161:1173-1180
17. Gould TD, Quiroz JA, Singh J, Zarate CA, Manji HK: Emerging experimental therapeutics for bipolar disorder: insights from the molecular and cellular actions of current mood stabilizers. Mol Psychiatry 2004; 9:734-755
18. Harwood AJ, Agam G: Search for a common mechanism of mood stabilizers. Biochem Pharmacol 2003; 66:179-189
19. Strober M, DeAntonio M, Schmidt-Lackner S, Freeman R, Lampert C, Diamond J: Early childhood attention deficit hyperactivity disorder predicts poorer response to acute lithium therapy in adolescent mania. J Affect Disord 1998; 51:145-151
20. State RC, Frye MA, Altshuler LL, Strober M, DeAntonio M, Hwang S, Mintz J: Chart review of the impact of attention-deficit/hyperactivity disorder comorbidity on response to lithium or divalproex sodium in adolescent mania. J Clin Psychiatry 2004; 65:1057-1063
21. Popper CW: Pharmacologic alternatives to psychostimulants for the treatment of attention-deficit/hyperactivity disorder. Child Adolesc Psychiatr Clin N Am 2000; 9:605-646