Modeling the in Vitro 20S Proteasome Activity: The Effect of PA28-αβ and of the Sequence and Length of Polypeptides on the Degradation Kinetics

Journal of Molecular Biology

Volumn 377, Issue 5, 2008, Pages 1607-1617

  Mishto, Michele ^a   Luciani, Fabio ^b   Holzhütter, Hermann Georg ^c   Bellavista, Elena ^a   Santoro, Aurelia ^a   Textoris Taube, Kathrin ^c   Franceschi, Claudio ^a   Kloetzel, Peter M ^c   Zaikin, Alexey ^d  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

^c HUMBOLDT UNIVERSITY   (Germany)

^d UNIVERSITY OF ESSEX   (United Kingdom)

Author keywords

digestion kinetics; mathematical modeling; MHC class I antigen; prediction algorithm; proteasome degradation

Indexed keywords

POLYPEPTIDE; PROTEASOME;

AMINO ACID SEQUENCE; ARTICLE; COMPLEX FORMATION; COMPUTER MODEL; DEGRADATION KINETICS; ENZYME ACTIVITY; ENZYME SUBUNIT; IN VITRO STUDY; PRIORITY JOURNAL;

EID: 40849140603     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2008.01.086     Document Type: Article

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