Association of functional haem oxygenase-1 gene promoter polymorphism with polycystic kidney disease and IgA nephropathy

Nephrology Dialysis Transplantation

Volumn 23, Issue 2, 2008, Pages 608-611

  Courtney, Aisling E ^a,b,c   McNamee, Peter T ^b   Heggarty, Shirley ^a   Middleton, Derek ^c   Maxwell, A Peter ^a,b  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^b Regional Nephrology Unit

^c BELFAST CITY HOSPITAL   (United Kingdom)

Author keywords

Gene polymorphism; Haem oxygenase 1; IgA nephropathy; Polycystic kidney disease; Progression of kidney disease

Indexed keywords

HEME OXYGENASE 1;

ALLELE; ARTICLE; CHRONIC KIDNEY DISEASE; CONTROLLED STUDY; FEMALE; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; IMMUNOGLOBULIN A NEPHROPATHY; KIDNEY POLYCYSTIC DISEASE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROMOTER REGION; RENAL REPLACEMENT THERAPY;

FEMALE; GLOMERULONEPHRITIS, IGA; HEME OXYGENASE-1; HUMANS; KIDNEY FAILURE, CHRONIC; MALE; MIDDLE AGED; POLYCYSTIC KIDNEY DISEASES; POLYMORPHISM, GENETIC; PROMOTER REGIONS (GENETICS);

EID: 40849104187     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfm736     Document Type: Article

References (25)

1. Tenhunen R, Marver HS, Schmid R. The enzymatic conversion of heme to bilirubin by microsomal heme oxygenase. Proc Natl Acad Sci U S A 1968; 61: 748-755
2. Exner M, Minar E, Wagner O et al. The role of heme oxygenase-1 promoter polymorphisms in human disease. Free Radic Biol Med 2004; 37: 1097-1104
3. Otterbein LE, Bach FH, Alam J et al. Carbon monoxide has antiinflammatory effects involving the mitogen-activated protein kinase pathway. Nat Med 2000; 6: 422-428
4. Peyton KJ, Reyna SV, Chapman GB et al. Heme oxygenase-1-derived carbon monoxide is an autocrine inhibitor of vascular smooth muscle cell growth. Blood 2002; 99: 4443-8
5. Brouard S, Otterbein LE, Anrather J et al. Carbon monoxide generated by heme oxygenase 1 suppresses endothelial cell apoptosis. J Exp Med 2000; 192: 1015-1026
6. Pae HO, Oh GS, Choi BM et al. Carbon monoxide produced by heme oxygenase-1 suppresses T cell proliferation via inhibition of IL-2 production. J Immunol 2004; 172: 4744-4751
7. Llesuy SF, Tomaro ML. Heme oxygenase and oxidative stress. Evidence of involvement of bilirubin as physiological protector against oxidative damage. Biochim Biophys Acta 1994; 1223: 9-14
8. Balla G, Jacob HS, Balla J et al. Ferritin: a cytoprotective antioxidant strategem of endothelium. J Biol Chem 1992; 267: 18148-18153
9. Kanakiriya SK, Croatt AJ, Haggard JJ et al. Heme: a novel inducer of MCP-1 through HO-dependent and HO-independent mechanisms. Am J Physiol Renal Physiol 2003; 284: F546-F554
10. Inguaggiato P, Gonzalez-Michaca L, Croatt AJ et al. Cellular overexpression of heme oxygenase-1 up-regulates p21 and confers resistance to apoptosis. Kidney Int 2001; 60: 2181-2191
11. Woo J, Iyer S, Cornejo MC et al. Stress protein-induced immunosuppression: inhibition of cellular immune effector functions following overexpression of haem oxygenase (HSP 32). Transpl Immunol 1998; 6: 84-93
12. Maser RL, Vassmer D, Magenheimer BS et al. Oxidant stress and reduced antioxidant enzyme protection in polycystic kidney disease. J Am Soc Nephrol 2002; 13: 991-999
13. Kawada N, Moriyama T, Ando A et al. Increased oxidative stress in mouse kidneys with unilateral ureteral obstruction. Kidney Int 1999; 56: 1004-1013
14. Mosley K, Wembridge DE, Cattell V et al. Heme oxygenase is induced in nephrotoxic nephritis and hemin, a stimulator of heme oxygenase synthesis, ameliorates disease. Kidney Int 1998; 53: 672-678
15. Haugen E, Nath KA. The involvement of oxidative stress in the progression of renal injury. Blood Purif 1999; 17: 58-65
16. Haugen EN, Croatt AJ, Nath KA. Angiotensin II induces renal oxidant stress in vivo and heme oxygenase-1 in vivo and in vitro. Kidney Int 2000; 58: 144-152
17. Sikorski EM, Hock T, Hill-Kapturczak N et al. The story so far: molecular regulation of the heme oxygenase-1 gene in renal injury. Am J Physiol Renal Physiol 2004; 286: F425-F441
18. Courtney AE, McNamee PT, Middleton D et al. Association of functional heme oxygenase-1 gene promoter polymorphism with renal transplantation outcomes. Am J Transplant 2007; 7: 908-913
19. Nath KA, Haggard JJ, Croatt AJ et al. The indispensability of heme oxygenase-1 in protecting against acute heme protein-induced toxicity in vivo. Am J Pathol 2000; 156: 1527-1535
20. Shimizu H, Takahashi T, Suzuki T et al. Protective effect of heme oxygenase induction in ischemic acute renal failure. Crit Care Med 2000; 28: 809-817
21. Rosenberg ME, Smith LJ, Correa-Rotter R et al. The paradox of the renin-angiotensin system in chronic renal disease. Kidney Int 1994; 45: 403-410
22. Paterson AD, Magistroni R, He N et al. Progressive loss of renal function is an age-dependent heritable trait in type 1 autosomal dominant polycystic kidney disease. J Am Soc Nephrol 2005; 16: 755-762
23. Fain PR, McFann KK, Taylor MR et al. Modifier genes play a significant role in the phenotypic expression of PKD1. Kidney Int 2005; 67: 1256-1267
24. Torres VE, Harris PC, Pirson Y. Autosomal dominant polycystic kidney disease. Lancet 2007; 369: 1287-1301
25. Barratt J, Feehally J, Smith AC. Pathogenesis of IgA nephropathy. Semin Nephrol 2004; 24: 197-217