Genotypic analysis of hydatidiform mole: An accurate and practical method of diagnosis

American Journal of Surgical Pathology

Volumn 32, Issue 3, 2008, Pages 445-451

  Bifulco, Carlo ^a   Johnson, Chaline ^a   Hao, Liming ^a   Kermalli, Husnain ^a   Bell, Susan ^a   Hui, Pei ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Genotyping diagnosis; Hydatidiform mole

Indexed keywords

DNA; PARAFFIN;

ADOLESCENT; ADULT; ALLELE; ARTICLE; CHORION VILLUS; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DNA EXTRACTION; ENDOMETRIUM; FEMALE; GENOTYPE; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; HYDATIDIFORM MOLE; MAJOR CLINICAL STUDY; MICRODISSECTION; MORPHOLOGY; POLYMERASE CHAIN REACTION;

ADOLESCENT; ADULT; FEMALE; GENOTYPE; HOMOZYGOTE; HUMANS; HYDATIDIFORM MOLE; IMMUNOHISTOCHEMISTRY; MIDDLE AGED; PLOIDIES; POLYMERASE CHAIN REACTION; PREGNANCY; UTERINE NEOPLASMS;

EID: 40849100429     PISSN: 01475185     EISSN: None     Source Type: Journal    
DOI: 10.1097/PAS.0b013e3181520034     Document Type: Article

References (27)

1. Abeln EC, Cornelisse CJ, Dreef EJ, et al. Molecular identification of a partial hydatidiform mole. Diagn Mol Pathol. 1997;6:58-63.
2. Barry TS, Kim PM, Treaba DO, et al. Use of p57kip2 and Ki-67 immunohistochemistry and interphase FISH in the diagnosis of hydatidiform mole: a unique algorithmic approach. Mod Pathol. 2007;20(suppl 2):189A.
3. Bell KA, Van Deerlin V, Addya K, et al. Molecular genetic testing from paraffin-embedded tissue distinguishes nonmolar hydropic abortion from hydatidiform mole. Mol Diagn. 1999;4:11-19.
4. Budowle B, Shea B, Niezgoda S, et al. CODIS STR loci data from 41 sample populations. J Forensic Sci. 2001;46:453-489.
5. Castrillon DH, Sun D, Weremowicz S, et al. Discrimination of complete hydatidiform mole from its mimics by immunohistochemistry of the paternally imprinted gene product p57KIP2. Am J Surg Pathol. 2001;25:1225-1230.
6. Chilosi M, Piazzola E, Lestani M, et al. Differential expression of p57kip2, a maternally imprinted cdk inhibitor, in normal human placenta and gestational trophoblastic disease. Lab Invest. 1998;78:269-276.
7. Cotton EA, Allsop RF, Guest JL, et al. Validation of the AMPFlSTR SGM plus system for use in forensic casework. Forensic Sci Int. 2000;112:151-161.
8. Darzynkiewicz Z, Robinson JP, Crissman HA. Methods in Cell Biology: Flow Cytometry. 2nd ed. USA: Academic Press Inc; 1994.
9. Fisher RA, Hodges MD, Rees HC, et al. The maternally transcribed gene p57(KIP2) (CDNK1C) is abnormally expressed in both androgenetic and biparental complete hydatidiform moles. Hum Mol Genet. 2002;11:3267-3272.
10. Fisher RA, Hodges MD, Newlands ES. Familial recurrent hydatidiform mole: a review. J Reprod Med. 2004;49:595-601.
11. Fukunaga M. Immunohistochemical characterization of p57Kip2 expression in tetraploid hydropic placentas. Arch Pathol Lab Med. 2004;128:897-900.
12. Fukuyama R, Takata M, Kudoh J, et al. DNA diagnosis of hydatidiform mole using the polymerase chain reaction. Hum Genet. 1991;87:216-218.
13. Genest D. Partial hydatidiform mole: clinicopathological features, differential diagnosis, ploidy and molecular studies, and gold standards for diagnosis. Int J Gynecol Pathol. 2001;20:315-322.
14. Hui P, Martel M, Parkash V. Gestational trophoblastic diseases: recent advances in histopathologic diagnosis and related genetic aspects. Adv Anat Pathol. 2005;12:116-125.
15. Kajii T, Ohama K. Androgenetic origin of hydatidiform mole. Nature. 1977;268:633-634.
16. Kihara M, Matsui H, Seki K, et al. Genetic origin and imprinting in hydatidiform moles. Comparison between DNA polymorphism analysis and immunoreactivity of p57KIP2. J Reprod Med. 2005;50:307-312.
17. Li HW, Tsao SW, Cheung AN. Current understandings of the molecular genetics of gestational trophoblastic diseases. Placenta. 2002;23:20-31.
18. McFadden DE, Pantzar JT. Placental pathology of triploidy. Hum Pathol. 1996;27:1018-1020.
19. Merchant SH, Amin MB, Viswanatha DS, et al. p57KIP2 immunohistochemistry in early molar pregnancies: emphasis on its complementary role in the differential diagnosis of hydropic abortuses. Hum Pathol. 2005;36:180-186.
20. Popiolek DA, Yee H, Mittal K, et al. Multiplex short tandem repeat DNA analysis confirms the accuracy of p57(KIP2) immunostaining in the diagnosis of complete hydatidiform mole. Hum Pathol. 2006;37:1426-1434.
21. Redline RW, Hassold T, Zaragoza MV. Prevalence of the partial molar phenotype in triploidy of maternal and paternal origin. Hum Pathol. 1998;29:505-511.
22. Romaguera RL, Rodriguez MM, Bruce JH, et al. Molar gestations and hydropic abortions differentiated by p57 immunostaining. Fetal Pediatr Pathol. 2004;23:181-190.
23. Sebire NJ, Rees HC, Peston D, et al. p57(KIP2) immunohistochemical staining of gestational trophoblastic tumours does not identify the type of the causative pregnancy. Histopathology. 2004;45:135-141.
24. Szulman A. Syndromes of hydatidiform moles, partial vs. complete. J Reprod Med. 1984;29:788-791.
25. Wersto RP, Liblit RL, Koss LG. Flow cytometric DNA analysis of human solid tumors: a review of the interpretation of DNA histograms. Hum Pathol. 1991;22:1085-1098.
26. Zaragoza MV, Keep D, Genest DR, et al. Early complete hydatidiform moles contain inner cell mass derivatives. Am J Med Genet. 1997;70:273-277.
27. Zaragoza MV, Surti U, Redline RW, et al. Parental origin and phenotype of triploidy in spontaneous abortions: predominance of diandry and association with the partial hydatidiform mole. Am J Hum Genet. 2000;66:1807-1820.