Effects of exercise on adipokines and the metabolic syndrome

Current Diabetes Reports

Volumn 8, Issue 1, 2008, Pages 7-11

  You, Tongjian ^a   Nicklas, Barbara J ^b  

^a UNIVERSITY AT BUFFALO   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ADIPOCYTOKINE; ADIPONECTIN; C REACTIVE PROTEIN; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA;

AEROBIC EXERCISE; ANTIINFLAMMATORY ACTIVITY; CLINICAL TRIAL; CYTOKINE PRODUCTION; DISEASE ASSOCIATION; GLUCOSE BLOOD LEVEL; HUMAN; LOW CALORY DIET; METABOLIC SYNDROME X; OBESITY; PHYSICAL ACTIVITY; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN SECRETION; REVIEW; RISK FACTOR; TREATMENT OUTCOME;

ADIPOKINES; CALORIC RESTRICTION; DIET; EXERCISE; HUMANS; METABOLIC SYNDROME X;

EID: 40749128967     PISSN: 15344827     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11892-008-0003-4     Document Type: Review

References (47)

1. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III) [no authors listed]. JAMA 2001, 285:2486-2497.
2. Kip KE, Marroquin OC, Kelley DE, et al.: Clinical importance of obesity versus the metabolic syndrome in cardiovascular risk in women: a report from the Women's Ischemia Syndrome Evaluation (WISE) study. Circulation 2004, 109:706-713.
3. Kershaw EE, Flier JS: Adipose tissue as an endocrine organ. J Clin Endocrinol Metab 2004, 89:2548-2556.
4. Reilly MP, Rader DJ: The metabolic syndrome: more than the sum of its parts? Circulation 2003, 108:1546-1551.
5. Haffner SM, Valdez RA, Hazuda HP, et al.: Prospective analysis of the insulin-resistauce syndrome (syndrome X). Diabetes 1992, 41:715-722.
6. Meigs JB, Nathan DM, Wilson PW, et al.: Metabolic risk factors worsen continuously across the spectrum of nondiabetic glucose tolerance. The Framingham Offspring Study. Ann Intern Med 1998, 128:524-533.
7. Park YW, Zhu S, Palaniappan L, et al.: The metabolic syndrome: prevalence and associated risk factor findings in the US population from the Third National Health and Nutrition Examination Survey, 1988-1994. Arch Intern Med 2003, 163:427-436.
8. Bahia L, Aguiar LG, Villela N, et al.: Relationship between adipokines, inflammation, and vascular reactivity in lean controls and obese subjects with metabolic syndrome. Clinics 2006, 61:433-440.
9. Choi KM, Ryu OH, Lee KW, et al.: Serum adiponectin, interleukin-10 levels and inflammatory markers in the metabolic syndrome. Diabetes Res Clin Pract 2007, 75:235-240.
10. You T, Nicklas BJ, Ding J, et al.: The metabolic syndrome is associated with adipokines in older adults across a wide range of adiposity. J Gerontol A Biol Sci Med Sci 2007, in press.
11. Gabay C, Kushner I: Acute-phase proteins and other systemic responses to inflammation. N Engl J Med 1999, 340:448-454.
12. Feingold KR, Grunfeld C: Role of cytokines in inducing hyperlipidemia. Diabetes 1992, 41(suppl 2):97-101.
13. Halse R, Pearson SL, McCormack JG, et al.: Effects of tumor necrosis factor-alpha on insulin action in cultured human muscle cells. Diabetes 2001, 50:1102-1109.
14. Ouchi N, Walsh K: Adiponectin as an anti-inflammatory factor. Clin Chim Acta 2007, 380:24-30.
15. Wolf AM, Wolf D, Rumpold H, et al.: Adiponectin induces the anti-inflammatory cytokines IL-10 and IL-1RA in human leukocytes. Biochem Biophys Res Commun 2004, 323:630-635.
16. Trujillo ME, Scherer PE: Adiponectin: journey from an adipocyte secretory protein to biomarker of the metabolic syndrome. J Intern Med 2005, 257:167-175.
17. Ridker PM, Buring JE, Cook NR, Rifai N: C-reactive protein, the metabolic syadrome, and risk of incident cardiovascular events: an 8-year follow-up of 14,719 initially healthy American women. Circulation 2003, 107:391-397.
18. Kritchevsky SB, Cesari M, Pahor M: Inflammatory markers and cardiovascular health in older adults. Cardiovasc Res 2005, 66:265-275.
19. Weisberg SP, McCann D, Desai M, et al.: Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 2003, 112:1796-1808.
20. Hotamisligil GS, Arner P, Caro JF, et al.: Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. J Clin Invest 1995, 95:2409-2415.
21. Berk ES, Kovera AJ, Boozer CN, et al.: Adiponectin levels during low- and high-fat eucaloric diets in lean and obese women. Obes Res 2005, 13:1566-1571.
22. Ghanim H, Aljada A, Hofmeyer D, et al.: Circulating mononuclear cells in the obese are in a proinflammatory state. Circulation 2004, 110:1564-1571.
23. Colbert LH, Visser M, Simonsick EM, et al.: Physical activity, exercise, and inflammatory markers in older adults: findings from the Health, Aging and Body Composition Study. J Am Geriatr Soc 2004, 52:1098-1104.
24. Pischon T, Hankinson SE, Hotamisligil GS, et al.: Leisure-time physical activity and reduced plasma levels of obesity-related inflammatory markers. Obes Res 2003, 11:1055-1064.
25. Ischander M, Zaldivar F Jr, Eliakim A, et al.: Physical activity, growth, and inflammatory mediators in BMI-matched female adolescents. Med Sci Sports Exerc 2007, 39:1131-1138.
26. Mora S, Lee IM, Buring JE, Ridker PM: Association of physical activity and body mass index with novel and traditional cardiovascular biomarkers in women. JAMA 2006, 295:1412-1419.
27. Fischer CP, Berntsen A, Perstrup LB, et al.: Plasma levels of inteleukin-6 and C-reactive protein are associated with physical inactivity independent of obesity. Scand J Med Sci Sports 2006, 17:580-587.
28. Mattusch F, Dufaux B, Heine O, et al.: Reduction of the plasma concentration of C-reactive protein following nine months of endurance training. Int J Sports Med 2000, 21:21-24.
29. Straczkowski M, Kowalska I, Dzienis-Straczkowska S, et al.: Changes in tumor necrosis factor-alpha system and insulin sensitivity during an exercise training program in obese women with normal and impaired glucose tolerance. Eur J Endocrinol 2001, 145:273-280.
30. Adamopoulos S, Parissis J, Kroupis C, et al.: Physical training reduces peripheral markers of inflammation in patients with chronic heart failure. Eur Heart J 2001, 22:791-797.
31. Nassis GP, Papantakou K, Skenderi K, et al.: Aerobic exercise training improves insulin sensitivity without changes in body weight, body fat, adiponectin, and inflammatory markers in overweight and obese girls. Metabolism 2005, 54:1472-1479.
32. Polak J, Klimcakova E, Moro C, et al.: Effect of aerobic training on plasma levels and subcutaneous abdominal adipose tissue gene expression of adiponectin, leptin, interleukin 6, and tumor necrosis factor alpha in obese women. Metabolism 2006, 55:1375-1381.
33. Kondo T, Kobayashi I, Murakami M: Effect of exercise on circulating adipokine levels in obese young women. Endocr J 2006, 53:189-195.
34. Ring-Dimitriou S, Paulweber B, von Duvillard SP, et al.: The effect of physical activity and physical fitness ou plasma adiponectin in adults with predisposition to metabolic syndrome. Eur J Appl Physiol 2006, 98:472-481.
35. Fairey AS, Courneya KS, Field CJ, et al.: Effect of exercise training on C-reactive protein in postmenopausal breast cancer survivors: a randomized controlled trial. Brain Behav Immun 2005, 19:381-388.
36. Troseid M, Lappegard KT, Claudi T, et al.: Exercise reduces plasma levels of the chemokines MCP-1 and IL-8 in subjects with the metabolic syndrome. Eur Heart J 2004, 25:349-355.
37. Dandona P, Weinstock R, Thusu K, et al.: Tumor necrosis factor-alpha in sera of obese patients: fall with weight loss. J Clin Endocrinol Metab 1998, 83:2907-2910.
38. Gallistl S, Sudi KM, Aigner R, Borkenstein M: Changes in serum interleukin-6 concentrations in obese children and adolescents during a weight reduction program. Int J Obes Relat Metab Disord 2001, 25:1640-1643.
39. Monzillo LU, Hamdy O, Horton ES, et al.: Effect of lifestyle modification on adipokine levels in obese subjects with insulin resistance. Obes Res 2003, 11:1048-1054.
40. Esposito K, Pontillo A, Di Palo C, et al.: Effect of weight loss and lifestyle changes ou vascular inflammatory markers in obese women: a randomized trial. JAMA 2003, 289:1799-1804.
41. Villareal DT, Miller BV 3rd, Banks M, et al.: Effect of lifestyle intervention on metabolic coronary heart disease risk factors in obese older adults. Am J Clin Nutr 2006, 84:1317-1323.
42. You T, Berman DM, Ryan AS, Nicklas BJ: Effects of hypocaloric diet and exercise training on inflammation and adipocyte lipolysis in obese postmenopausal women. J Clin Endocrinol Metab 2004, 89:1739-1746.
43. Jae SY, Fernhall B, Heffernan KS, et al.: Effects of lifestyle modifications on C-reactive protein: contribution of weight loss and improved aerobic capacity. Metabolism 2006, 55:825-831.
44. Klimcakova E, Polak J, Moro C, et al.: Dynamic strength training improves insulin sensitivity without altering plasma levels and gene expression of adipokines in subcutaneous adipose tissue in obese men. J Clin Endocrinol Metab 2006, 91:5107-5112.
45. Bruun JM, Helge JW, Richelsen B, Stallknecht B: Diet and exercise reduce low-grade inflammation and macrophage infiltration in adipose tissue but not in skeletal muscle in severely obese subjects. Am J Physiol Endocrinol Metab 2006, 290:E961-E967.
46. Smith JK, Dykes R, Douglas JE, et al.: Long-term exercise and atherogenic activity of blood mononuclear cells in persons at risk of developing ischemic heart disease. JAMA 1999, 281:1722-1727.
47. Petersen AM, Pedersen BK: The anti-inflammatory effect of exercise. J Appl Physiol 2005, 98:1154-1162.