Positron emission tomography and target-controlled infusion for precise modulation of brain drug concentration

Nuclear Medicine and Biology

Volumn 35, Issue 3, 2008, Pages 299-303

  Eriksson, Olof ^a,b   Josephsson, Ray ^c   Långstrom, Bengt ^a   Bergström, Mats ^b  

^a Uppsala Imanet AB   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

^c NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Brain distribution; CCIP; Flumazenil; PET; TCI

Indexed keywords

FLUMAZENIL; FLUMAZENIL C 11; RADIOISOTOPE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG BRAIN LEVEL; DRUG DISTRIBUTION; INFUSION PUMP; MALE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; RAT;

ANESTHETICS; ANIMALS; BRAIN; BRAIN CHEMISTRY; CALIBRATION; CARBON RADIOISOTOPES; DRUG THERAPY, COMPUTER-ASSISTED; FLUMAZENIL; INFUSION PUMPS; MALE; MODELS, BIOLOGICAL; POSITRON-EMISSION TOMOGRAPHY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-A; TISSUE DISTRIBUTION;

EID: 40749122166     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nucmedbio.2007.12.003     Document Type: Article

References (26)

1. Van Poucke G.E., Bravo L.J., and Shafer S.L. Target controlled infusions: targeting the effect site while limiting peak plasma concentration. IEEE Trans Biomed Eng 51 11 (2004) 1869-1875
2. Guarracino F., Lapolla F., Cariello C., Danella A., Doroni L., and Baldassarri R. Target controlled infusion: TCI. Minerva Anestesiol 71 6 (2005) 335-337 [Review]
3. Absalom A., and Kenny G.N. Current and future applications of target-controlled infusions. Drugs Today (Barc) 35 11 (1999) 823-834
4. Dyck J.B., Maze M., Haack C., Azarnoff D.L., Vuorilehto L., and Shafer S.L. Computer-controlled infusion of intravenous dexmedetomidine hydrochloride in adult human volunteers. Anesthesiology 78 5 (1993) 821-828
5. Fiset P., Paus T., Daloze T., Plourde G., Meuret P., and Bonhomme V. Brain mechanisms of propofol-induced loss of consciousness in humans: a positron emission tomographic study. J Neurosci 19 13 (1999) 5506-5513
6. Gustafsson L.L., Ebling W.F., Osaki E., Harapat S., Stanski D.R., and Shafer S.L. Plasma concentration clamping in the rat using a computer-controlled infusion pump. Pharm Res 9 6 (1992) 800-807
7. Hacker S.O., White C.E., and Black I.H. A comparison of target-controlled infusion versus volatile inhalant anesthesia for heart rate, respiratory rate, and recovery time in a rat model. Contemp Top Lab Anim Sci 44 5 (2005) 7-12
8. Yamakage M., Iwasaki S., Jeong S.W., Ishiyama S.I., and Namiki A. Comparative study between propofol in a long-chain triglyceride and propofol in a medium/long-chain triglyceride during sedation with target-controlled infusion. Anaesth Intensive Care 33 3 (2005) 351-355
9. Breslin D.S., Mirakhur R.K., Reid J.E., and Kyle A. Manual versus target-controlled infusions of propofol. Anaesthesia 59 11 (2004) 1059-1063
10. Russell D., Wilkes M.P., Hunter S.C., Glen J.B., Hutton P., and Kenny G.N. Manual compared with target-controlled infusion of propofol. Br J Anaesth 75 5 (1995) 562-566
11. Kucken A.M., Teissere J.A., Seffinga-Clark J., Wagner D.A., and Czajkowski C. Structural requirements for imidazobenzodiazepine binding to GABA(A) receptors. Mol Pharmacol 63 2 (2003) 289-296
12. Haefely W., and Hunkeler W. The story of flumazenil. Eur J Anaesthesiol Suppl 2 (1988) 3-13
13. Bergström M., and Långström B. Pharmacokinetic studies with PET. In: Rudin M. (Ed). Progress in drug research vol. 62 (2005), Basel, Birkhäuser Verlag 281-317
14. Wall A., Kågedal M., Bergstrom M., Jacobsson E., Nilsson D., and Antoni G. Distribution of zolmitriptan into the CNS in healthy volunteers: a positron emission tomography study. Drugs R&D 6 3 (2005) 139-147
15. 18F]cyclofoxy and positron emission tomography. J Cereb Blood Flow Metab 13 (1993) 24-42
16. 11C]raclopride binding with continuous infusion. J Cereb Blood Flow Metab 17 (1997) 437-447
17. Carson R.E. PET physiological measurements using constant infusion. Nucl Med Biol 27 (2000) 657-660
18. 11C]dihydrotetrabenazine (DTBZ) and positron emission tomography. J Cereb Blood Flow Metab 17 9 (1997) 919-931
19. Samson Y., Hantraye P., Baron J.C., Soussaline F., Comar D., and Maziere M. Kinetics and displacement of Ro-15-1788, a benzodiazepine antagonist, studied in human brain in vivo by positron emission tomography. Eur Pharmacol 110 (1985) 247-251
20. Alkire M.T., and Haier R.J. Correlating in vivo anaesthetic effects with ex vivo receptor density data supports a GABAergic mechanism of action for propofol, but not for isoflurane. Br J Anaesth 86 5 (2001) 618-626
21. Liao M., Sonner J.M., Jurd R., Rudolph U., Borghese C.M., and Harris R.A. Beta3-containing gamma-aminobutyric acidA receptors are not major targets for the amnesic and immobilizing actions of isoflurane. Anesth Analg 101 2 (2005) 412-418
22. Zhang Y., Sonner J.M., Eger II E.I., Stabernack C.R., Laster M.J., and Raines D.E. Gamma-aminobutyric acidA receptors do not mediate the immobility produced by isoflurane. Anesth Analg 99 1 (2004) 85-90
23. Hentschke H., Schwarz C., and Antkowiak B. Neocortex is the major target of sedative concentrations of volatile anaesthetics: strong depression of firing rates and increase of GABAA receptor-mediated inhibition. Eur J Neurosci 21 1 (2005) 93-102
24. Jenkins A., Greenblatt E.P., Faulkner H.J., Bertaccini E., Light A., and Lin A. Evidence for a common binding cavity for three general anesthetics within the GABAA receptor. J Neurosci 21 6 (2001) RC136
25. Syvänen S., Blomqvist G., Sprycha M., Höglund U., Roman M., and Eriksson O. Duration and degree of cyclosporin induced P-glycoprotein inhibition in the rat blood-brain barrier can be studied with PET. Neuroimage 32 (2006) 1134-1141
26. Hantraye P., Brouillet E., Fukuda H., Chavoix C., Guibert B., and Dodd R.H. Benzodiazepine receptors studied in living primates by positron emission tomography: antagonist interactions. Eur J Pharmacol 153 (1988) 25-32