Modulation of cardiac function by A-kinase anchoring proteins

Current Opinion in Pharmacology

Volumn 8, Issue 2, 2008, Pages 166-173

  Diviani, Dario ^a  

^a UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE ANCHORING PROTEIN; PEPTIDE;

DRUG TARGETING; ENZYME SPECIFICITY; ENZYME SUBSTRATE; HEART CONTRACTION; HEART FAILURE; HEART FUNCTION; HEART HYPERTROPHY; HEART MUSCLE CELL; HEART MUSCLE POTENTIAL; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; REVIEW; SIGNAL TRANSDUCTION;

A KINASE ANCHOR PROTEINS; ACTION POTENTIALS; ANIMALS; CALCIUM; CARDIOMEGALY; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DRUG DELIVERY SYSTEMS; HEART FAILURE; HUMANS; MYOCARDIAL CONTRACTION; SIGNAL TRANSDUCTION;

EID: 40649095214     PISSN: 14714892     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coph.2007.11.001     Document Type: Review

References (50)

1. Francis S.H., and Corbin J.D. Structure and function of cyclic nuleotide-dependent protein kinases. Ann Rev Physiol 56 (1994) 237-272
2. Smith F.D., Langeberg L.K., and Scott J.D. The where's and when's of kinase anchoring. Trends Biochem Sci 31 (2006) 316-323
3. Beene D.L., and Scott J.D. A-kinase anchoring proteins take shape. Curr Opin Cell Biol 19 (2007) 192-198
4. Gold M.G., Lygren B., Dokurno P., Hoshi N., McConnachie G., Tasken K., Carlson C.R., Scott J.D., and Barford D. Molecular basis of AKAP specificity for PKA regulatory subunits. Mol Cell 24 (2006) 383-395
5. Kinderman F.S., Kim C., von Daake S., Ma Y., Pham B.Q., Spraggon G., Xuong N.H., Jennings P.A., and Taylor S.S. A dynamic mechanism for AKAP binding to RII isoforms of cAMP-dependent protein kinase. Mol Cell 24 (2006) 397-408. These studies were published in parallel and provide the first X-ray crystal structure of the interacting surface between PKA and the PKA-binding domain of an AKAP.
6. Fink M.A., Zakhary D.R., Mackey J.A., Desnoyer R.W., Apperson-Hansen C., Damron D.S., and Bond M. AKAP-mediated targeting of protein kinase A regulates contractility in cardiac myocytes. Circ Res 88 (2001) 291-297
7. Ruehr M.L., Russell M.A., and Bond M. A-kinase anchoring protein targeting of protein kinase A in the heart. J Mol Cell Cardiol 37 (2004) 653-665
8. Bers D.M. Cardiac excitation-contraction coupling. Nature 415 (2002) 198-205
9. Fraser I.D., Tavalin S.J., Lester L.B., Langeberg L.K., Westphal A.M., Dean R.A., Marrion N.V., and Scott J.D. A novel lipid-anchored A-kinase Anchoring Protein facilitates cAMP- responsive membrane events. EMBO J 17 (1998) 2261-2272
10. Gray P.C., Johnson B.D., Westenbroek R.E., Hays L.G., Yates J.R., Scheuer T., Catterall W.A., and Murphy B.J. Primary structure and function of an A kinase anchoring protein associated with calcium channels. Neuron 20 (1998) 1017-1026
11. 2+ channel and modulates its function. J Biol Chem 277 (2002) 4079-4087
12. Hulme J.T., Westenbroek R.E., Scheuer T., and Catterall W.A. Phosphorylation of serine 1928 in the distal C-terminal domain of cardiac CaV1.2 channels during beta1-adrenergic regulation. Proc Natl Acad Sci U S A 103 (2006) 16574-16579
13. Kapiloff M.S., Schillace R.V., Westphal A.M., and Scott J.D. mAKAP: An A-kinase anchoring protein targeted to the nuclear membrane of differentiated myocytes. J Cell Sci 112 (1999) 2725-2736
14. Marx S.O., Reiken S., Hisamatsu Y., Jayaraman T., Burkhoff D., Rosemblit N., and Marks A.R. PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts. Cell 101 (2000) 365-376
15. Henn V., Edemir B., Stefan E., Wiesner B., Lorenz D., Theilig F., Schmitt R., Vossebein L., Tamma G., Beyermann M., et al. Identification of a novel A-kinase anchoring protein 18 isoform and evidence for its role in the vasopressin-induced aquaporin-2 shuttle in renal principal cells. J Biol Chem 279 (2004) 26654-26665
16. 2+ reuptake.
17. MacLennan D.H., and Kranias E.G. Phospholamban: a crucial regulator of cardiac contractility. Nat Rev Mol Cell Biol 4 (2003) 566-577
18. Fraser I., Cong M., Kim J., Rollins E., Daaka Y., Lefkowitz R., and Scott J. Assembly of an AKAP/beta2-adrenergic receptor signaling complex facilitates receptor phosphorylation and signaling. Curr Biol 10 (2000) 409-412
19. Cong M., Perry S.J., Lin F.T., Fraser I.D., Hu L.A., Chen W., Pitcher J.A., Scott J.D., and Lefkowitz R.J. Regulation of membrane targeting of the G protein-coupled receptor kinase 2 by protein kinase A and its anchoring protein AKAP79. J Biol Chem 22 (2001) 22
20. Lin F., Wang H., and Malbon C.C. Gravin-mediated formation of signaling complexes in beta 2-adrenergic receptor desensitization and resensitization. J Biol Chem 275 (2000) 19025-19034
21. Wang H., Tao J., Shumay E., and Malbon C.C. G-protein-coupled receptor-associated A-kinase anchoring proteins: AKAP79 and AKAP250 (gravin). Eur J Cell Biol 85 (2006) 643-650
22. Gardner L.A., Tavalin S.J., Goehring A.S., Scott J.D., and Bahouth S.W. AKAP79-mediated targeting of the cyclic AMP-dependent protein kinase to the beta1-adrenergic receptor promotes recycling and functional resensitization of the receptor. J Biol Chem 281 (2006) 33537-33553
23. Gardner L.A., Naren A.P., and Bahouth S.W. Assembly of an SAP97-AKAP79-cAMP-dependent protein kinase scaffold at the type 1 PSD-95/DLG/ZO1 motif of the human beta(1)-adrenergic receptor generates a receptosome involved in receptor recycling and networking. J Biol Chem 282 (2007) 5085-5099
24. Nerbonne J.M., and Kass R.S. Molecular physiology of cardiac repolarization. Phys Rev 85 (2005) 1205-1253
25. Marx S.O., Kurokawa J., Reiken S., Motoike H., D'Armiento J., Marks A.R., and Kass R.S. Requirement of a macromolecular signaling complex for beta adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel. Science 295 (2002) 496-499
26. Fodstad H., Swan H., Laitinen P., Piippo K., Paavonen K., Viitasalo M., Toivonen L., and Kontula K. Four potassium channel mutations account for 73% of the genetic spectrum underlying long-QT syndrome (LQTS) and provide evidence for a strong founder effect in Finland. Ann Med 36 Suppl. 1 (2004) 53-63
27. Kurokawa J., Motoike H.K., Rao J., and Kass R.S. Regulatory actions of the A-kinase anchoring protein Yotiao on a heart potassium channel downstream of PKA phosphorylation. Proc Natl Acad Sci U S A 101 (2004) 16374-16378
28. Chen L., Kurokawa J., and Kass R.S. Phosphorylation of the A-kinase-anchoring protein Yotiao contributes to protein kinase A regulation of a heart potassium channel. J Biol Chem 280 (2005) 31347-31352
29. Frey N., Katus H.A., Olson E.N., and Hill J.A. Hypertrophy of the heart: a new therapeutic target?. Circulation 109 (2004) 1580-1589
30. Pare G.C., Easlick J.L., Mislow J.M., McNally E.M., and Kapiloff M.S. Nesprin-1alpha contributes to the targeting of mAKAP to the cardiac myocyte nuclear envelope. Exp Cell Res 303 (2005) 388-399
31. Pare G.C., Bauman A.L., McHenry M., Michel J.J., Dodge-Kafka K.L., and Kapiloff M.S. The mAKAP complex participates in the induction of cardiac myocyte hypertrophy by adrenergic receptor signaling. J Cell Sci 118 (2005) 5637-5646
32. Dodge-Kafka K.L., Soughayer J., Pare G.C., Carlisle Michel J.J., Langeberg L.K., Kapiloff M.S., and Scott J.D. The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways. Nature 437 (2005) 574-578. This study describes the new findings that mAKAP organizes a cAMP responsive multiprotein complex that mediates the spatial and temporal regulation of PKA and Epac1 in cardiomyocytes. It also provides the first description for the implication of an AKAP in cardiomyocyte hypertrophy.
33. Kapiloff M.S., Jackson N., and Airhart N. mAKAP and the ryanodine receptor are part of a multi-component signaling complex on the cardiomyocyte nuclear envelope. J Cell Sci 114 (2001) 3167-3176
34. Dodge-Kafka K.L., and Kapiloff M.S. The mAKAP signaling complex: integration of cAMP, calcium, and MAP kinase signaling pathways. Eur J Cell Biol 85 (2006) 593-602
35. Dodge K.L., Khouangsathiene S., Kapiloff M.S., Mouton R., Hill E.V., Houslay M.D., Langeberg L.K., and Scott J.D. mAKAP assembles a protein kinase A/PDE4 phosphodiesterase cAMP signaling module. EMBO J 20 (2001) 1921-1930
36. Nicol R.L., Frey N., Pearson G., Cobb M., Richardson J., and Olson E.N. Activated MEK5 induces serial assembly of sarcomeres and eccentric cardiac hypertrophy. EMBO J 20 (2001) 2757-2767
37. Diviani D., Soderling J., and Scott J.D. AKAP-Lbc anchors protein kinase A and nucleates Galpha 12-selective Rho-mediated stress fiber formation. J Biol Chem 276 (2001) 44247-44257
38. Klussmann E., Edemir B., Pepperle B., Tamma G., Henn V., Klauschenz E., Hundsrucker C., Maric K., and Rosenthal W. Ht31: the first protein kinase A anchoring protein to integrate protein kinase A and Rho signaling. FEBS Lett 507 (2001) 264-268
39. Sah V.P., Hoshijima M., Chien K.R., and Brown J.H. Rho is required for Galphaq and alpha1-adrenergic receptor signaling in cardiomyocytes. Dissociation of Ras and Rho pathways. J Biol Chem 271 (1996) 31185-31190
40. Appert-Collin A., Cotecchia S., Nenniger-Tosato M., Pedrazzini T., and Diviani D. The A- kinase anchoring protein (AKAP)-Lbc-signaling complex mediates alpha1 adrenergic receptor-induced cardiomyocyte hypertrophy. Proc Natl Acad Sci U S A 104 (2007) 10140-10145. This work describes the findings that AKAP-Lbc participates in a transduction pathway activated by the α1-AR that promotes cardiomyocyte hypertrophy. It also identifies AKAP-Lbc as the first Rho-GEF involved in cardiomyocyte hypertrophy.
41. Yanazume T., Hasegawa K., Wada H., Morimoto T., Abe M., Kawamura T., and Sasayama S. Rho/ROCK pathway contributes to the activation of extracellular signal-regulated kinase/GATA-4 during myocardial cell hypertrophy. J Biol Chem 277 (2002) 8618-8625
42. Morissette M.R., Sah V.P., Glembotski C.C., and Brown J.H. The Rho effector, PKN, regulates ANF gene transcription in cardiomyocytes through a serum response element. Am J Physiol Heart Circul Physiol 278 (2000) H1769-H1774
43. Maruyama Y., Nishida M., Sugimoto Y., Tanabe S., Turner J.H., Kozasa T., Wada T., Nagao T., and Kurose H. Galpha(12/13) mediates alpha(1)-adrenergic receptor-induced cardiac hypertrophy. Circ Res 91 (2002) 961-969
44. Diviani D., Abuin L., Cotecchia S., and Pansier L. Anchoring of both PKA and 14-3-3 inhibits the Rho-GEF activity of the AKAP-Lbc signaling complex. EMBO J 23 (2004) 2811-2820
45. Jin J., Smith F.D., Stark C., Wells C.D., Fawcett J.P., Kulkarni S., Metalnikov P., O'Donnell P., Taylor P., Taylor L., et al. Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. Curr Biol 14 (2004) 1436-1450
46. Baisamy L., Jurisch N., and Diviani D. Leucine zipper-mediated homo-oligomerization regulates the Rho-GEF activity of AKAP-Lbc. J Biol Chem 280 (2005) 15405-15412
47. Carnegie G.K., Smith F.D., McConnachie G., Langeberg L.K., and Scott J.D. AKAP-Lbc nucleates a protein kinase D activation scaffold. Mol Cell 15 (2004) 889-899. The authors provide evidence that AKAP-Lbc assembles a multiprotein complex that mediates the activation of protein kinase D in cardiomyocytes.
48. Vega R.B., Harrison B.C., Meadows E., Roberts C.R., Papst P.J., Olson E.N., and McKinsey T.A. Protein kinases C and D mediate agonist-dependent cardiac hypertrophy through nuclear export of histone deacetylase 5. Mol Cell Biol 24 (2004) 8374-8385
49. Harrison B.C., Kim M.S., van Rooij E., Plato C.F., Papst P.J., Vega R.B., McAnally J.A., Richardson J.A., Bassel-Duby R., Olson E.N., et al. Regulation of cardiac stress signaling by protein kinase D1. Mol Cell Biol 26 (2006) 3875-3888
50. Zakhary D.R., Fink M.A., Ruehr M.L., and Bond M. Selectivity and regulation of A-kinase anchoring proteins in the heart. The role of autophosphorylation of the type II regulatory subunit of cAMP-dependent protein kinase. J Biol Chem 275 (2000) 41389-41395