Strategies to induce marked prolongation of secondary skin allograft survival in alloantigen-primed mice

American Journal of Transplantation

Volumn 8, Issue 4, 2008, Pages 761-772

  Minamimura, K ^a,b   Sato, K ^a   Yagita, H ^c   Tanaka, T ^d   Arii, S ^b   Maki, T ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^c JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d HYOGO COLLEGE OF MEDICINE   (Japan)

Author keywords

Allosensitization; Allotransplantation; Antilymphocyte antibodies; Experimental transplantation; Interleukin 15; Memory T cells; OX4; Skin allograft

Indexed keywords

ALLOANTIGEN; CD134 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; HERMES ANTIGEN; INTERLEUKIN 2 RECEPTOR BETA; RAPAMYCIN; T LYMPHOCYTE ANTIBODY;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CD4+ T LYMPHOCYTE; CELL PROLIFERATION; CELL STIMULATION; CONTROLLED STUDY; DRUG TOLERABILITY; GRAFT REJECTION; GRAFT SURVIVAL; MEMORY T LYMPHOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SENSITIZATION; SKIN ALLOGRAFT; SURVIVAL TIME; T CELL DEPLETION; TREATMENT RESPONSE;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; GRAFT REJECTION; GRAFT SURVIVAL; IMMUNOLOGIC MEMORY; ISOANTIBODIES; LYMPH NODES; MICE; MICE, INBRED DBA; MICE, INBRED STRAINS; MODELS, ANIMAL; SIROLIMUS; SKIN TRANSPLANTATION; T-LYMPHOCYTES; TRANSPLANTATION, HOMOLOGOUS;

EID: 40449142603     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/j.1600-6143.2007.02143.x     Document Type: Article

References (52)

1. Warrens AN, Lombardi G, Lechler RI. Presentation and recognition of major and minor histocompatibility antigens. Transplant Immunol 1994 2 : 103 107.
2. Auchincloss H Jr., Sultan H. Antigen processing and presentation in transplantation. Curr Opin Immunol 1996 8 : 681 687.
3. Maki T, Simpson M, Monaco AP. Development of suppressor T cells by antilymphocyte serum treatment in mice. Transplantation 1982 34 : 376 381.
4. Minamimura K, Gao W, Maki T. CD4+ regulatory T cells are spared from deletion by anti-lymphocyte serum (ALS), a polyclonal anti-T cell antibody. J. Immunol 2006 176 : 4125 4132.
5. Wu Z, Bensinger SJ, Zhang J et al. Homeostatic proliferation is a barrier to transplantation tolerance. Nat Med 2004 10 : 87 92.
6. Morris RE. Rapamycin: Antifungal, antitumor, antiproliferative and immunosuppressive macrolides. Transplant Rev 1992 6 : 39 50.
7. Sabatini DM, Erdjument-Bromage H, Lui M, Tempst P, Snyder SH. RAFT1: A mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs. Cell 1994 78 : 35 43.
8. + T cell help. J Immunol 2006 176 : 2316 2323.
9. Li Y, Li XC, Zeng XX, Wells AD, Turka LA, Strom TB. Blocking both signal 1 and signal 2 of T-cell activation prevents apoptosis of alloreactive T cells and induction of peripheral allograft tolerance. Nat Med 1999 5 : 1298 1302.
10. Bobbio SA, Wood ML, Monaco AP. Effect of Rapamycin on induction of unresponsiveness in ALS-treated, marrow injected mice. Trans Proc 1993 25 : 717 718.
11. Hale DA, Gottschalk R, Fukuzaki T, Wood ML, Maki T, Monaco AP. Superiority of rapamycin (Sirolimus) over cyclosporine in augmenting allograft and xenograft survival in mice treated with antilymphocyte serum and donor specific bone marrow. Transplantation 1997 63 : 359 364.
12. Hale DA, Gottschalk R, Umemura A, Maki T, Monaco AP. Establishment of stable multilineage hematopoietic chimerism and donor-specific tolerance without irradiation: A unique role for sirolimus. Transplantation 2000 69 : 1242 1251.
13. Douek DC, McFarland RD, Keiser PH et al. Changes in thymic function with age and during the treatment of HIV infection. Nature 1998 396 : 690 695.
14. McFarland RD, Douek DC, Koup RA, Picker LJ. Identification of human recent thymic emigrant phenotype. Proc Natl Acad Sci USA 2000 97 : 4215 4220.
15. Burrows SR, Khanna R, Burrows JM, Moss DJ. An alloresponse in humans is dominated by cytotoxic T lymphocytes (CTL) cross-reactive with a single Epstein-Barr virus CTL epitope: Implications for graft-versus-host disease. J Exp Med 1994 179 : 1155 1161.
16. Burrows SR, Silins SL, Khanna R et al. Cross-reactive memory T cells for Epstein-Barr virus augment the alloresponse to common human leukocyte antigens: Degenerate recognition of major histocompatibility complex-bound peptide by T cells and its role in alloreactivity. Eur J Immunol 1997 27 : 1726 1736.
17. Cecka JM. Living donor transplants. Clin Transpl 1995 363 377.
18. Kupiec-Weglinski JW. Graft rejection in sensitized recipients. Ann Transplant 1996 1 : 34 40.
19. Baid S, Saidman SL, Tolkoff-Rubin N et al. Managing the highly sensitized transplant recipient and B cell tolerance. Curr Opin Immunol 2001 13 : 577 581.
20. Wood ML, Monaco AP, Gozzo JJ, Liegeois A. Use of homozygous allogenic bone marrow for induction of tolerance with antilymphocyte serum: Dose and timing. Transplant Proc 1971 3 : 676 679.
21. Hale DA, Gottschalk R, Wood ML, Maki T, Monaco AP. Determination of an improved sirolimus (rapamycin) based regimen for induction of allograft tolerance in mice treated with antilymphocyte serum and donor specific bone marrow. Transplantation 1998 65 : 473 479.
22. Billingham RE, Brent L, Medawar PB. The technique of free skin grafting in mammals. J Exp Bio 1951 28 : 385.
23. Akiba H, Oshima H, Takeda K et al. CD28-independent costimulation of T cells by OX40 ligand and CD70 on activated B cells. J Immunol 1999 162 : 7058 7066.
24. Tanaka T, Tsudo M, Karasuyama H et al. A novel monoclonal antibody against murine IL-2 receptor b-chain: Characterization of receptor expression in normal lymphoid cells and EL-4 cells. J Immunol 1991 147 : 2222 2228.
25. Wells AD, Gudmundsdottir H, Turka LA. Following the fate of individual T cells throughout activation and clonal expansion: Signals from T cell receptor and CD28 differentially regulate the induction and duration of a proliferative response. J Clin Invest 1997 100 : 3173 3183.
26. Paterson DJ, Jefferies WA, Green JR et al. Antigens of activated rat lymphocytes including a molecule of 50,000 Mr detected only on CD4 positive T blasts. Mol Immunol 1987 24 : 1281 1290.
27. Mallett S, Barclay S, Barclay AN. Characterization of the MRC OX40 antigen of activated CD4 positive T lymphocytes: A molecule related to nerve growth factor receptor. EMBO J 1990 9 : 1063 1068.
28. Prell RA, Evans DE, Thalhofer C, Shi T, Funatake C, Weinberg AD. OX40 mediated memory T cell generation is TNF receptor-associated factor 2 dependent. J Immunol 2003 171 : 5997 6005.
29. Sugamura K, Ishii N, Weinberg AD. Therapeutic targeting of the effector T cell costimulatory molecule OX40. Nature Rev Immunol 2004 4 : 420 431.
30. Cho BK, Wang C, Sugawa S, Eisen HN, Chen J. Functional differences between memory and naive CD8 T cells. Proc Natl Acad Sci USA 1999 96 : 2976 2981.
31. Nelson BH, Willerford DM. Biology of the interleukin-2 receptor. Adv Immunol 1998 70 : 1 81.
32. Madakamutil LT, Christen U, Lena CJ et al. CD8αα-mediated survival and differentiation of CD8 memory T cell precursors. Science 2004 304 : 590 593.
33. Pearl JP, Parris J, Hale DA et al. Immunocompetent T-cells with a memory-like phenotype are the dominant cell type following antibody-mediated T-cell depletion. Am J Transpl 2005 5 : 465 474.
34. Sallusto F, Lenig D, Forster R, Lipp M, Lanzavecchia A. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 1999 401 : 708 712.
35. Masopust D, Vezys V, Marzo AL, Lefrancois L. Preferential localization of effector memory cells in nonlymphoid tissue. Science 2001 291 : 2413 2417.
36. Reinhardt RL, Khoruts A, Merica R, Zell T, Jenkins MK. Visualizing the generation of memory CD4 T cells in the whole body. Nature 2001 410 : 101 105.
37. Naujahr DC, Chen C, Huang X et al. Accelerated memory cell homeostasis during T cell depletion and approaches to overcome it. J Immunol 2006 176 : 4632 4639.
38. Preville X, Flacher M, LeMauff B et al. Mechanisms involved in antithymocyte globulin immunosuppressive activity in a nonhuman primate model. Transplantation 2001 71 : 460 468.
39. Genestier L, Fournel S, Flacher M, Assossou O, Revillard JP, Bonnefoy-Berard N. Induction of Fas (Apo-1, CD95)-mediated apoptosis of activated lymphocytes by polyclonal antithymocyte globulins. Blood 1998 91 : 2360 2368.
40. Ford ML, Koehn BH, Wagener ME et al. Antigen-specific precursor frequency impacts T cell proliferation, differentiation, and requirement for costimulation. J Exp Med 2007 204 : 299 309.
41. Vu MD, Clarkson MR, Yagita H, Turka LA, Sayegh MH, Li XC. Critical, but conditional, role of OX40 in memory T cell-mediated rejection. J Immunol 2006 176 : 1394 1401.
42. Tomita Y, Sachs DH, Khan A, Sykes M. Additional monoclonal antibody (mAB) injections can replace thymic irradiation to allo induction of mixed chimerism and tolerance in mice receiving bone marrow transplantation after conditioning with anti-T cell mABs and 3-Gy whole body irradiation. Transplantation 1996 61 : 469 477.
43. Rifa'i M, Kawamoto Y, Nakashima I, Suzuki H. Essential roles of CD8+CD122+ regulatory T cells in the maintenance of T cell homeostasis. J Exp Med 2004 200 : 1123 1134.
44. Endharti AT, Rifa'I M, Shi Z et al. Cutting edge: CD8+CD122+ regulatory T cells produce IL-10 to suppress IFV-g production and proliferation of CD8+ T cells. J Immunol 2005 175 : 7093 7097.
45. Bettelli E, Carrier Y, Gao W et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 2006 441 : 235 238.
46. Kaech SM, Hemby S, Kersh E, Ahmed R. Molecular and functional profiling of memory CD8 T cell differentiation. Cell 2002 111 : 837 851.
47. Wherry EJ, Teichgraber V, Becker TC et al. Lineage relationship and protective immunity of memory CD8 T cell subsets. Nat Immunol 2003 4 : 225 234.
48. Masopust D, Ahmed R. Reflections on CD8 T-cell activation and memory. Immunol Res 2004 29 : 151 160.
49. Zhang Y, Joe G, Hexner E, Zhu J, Emerson SG. Alloreactive memory T cells are responsible for the persistence of graft-versus-host disease. J Immunol 2005 174 : 3051 3058.
50. Yamada A, Salama AD, Sayegh NH. The role of novel T cell costimulatory pathways in autoimmunity and transplantation. J Am Soc Nephrol 2002 13 : 559 575.
51. Demirci G, Amanullah F, Kewalaramani R et al. Critical role of OX40 in CD28 and CD154-independent rejection. J Immunol 2004 172 : 1691 1698.
52. Yuan X, Salama AD, Dong V et al. The role of the CD134-CD134 ligand costimulatory pathway in alloimmune responses in vivo. J Immunol 2003 170 : 2949 2955.