Superiority of sirolimus (rapamycin) over cyclosporine in augmenting allograft and xenograft survival in mice treated with antilymphocyte serum and donor-specific bone marrow

Transplantation

Volumn 63, Issue 3, 1997, Pages 359-364

  Hale, Douglas A ^a   Gottschalk, Rita ^a   Fukuzaki, Takayuki ^a   Wood, Mary L ^a   Maki, Takashi ^a   Monaco, Anthony P ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSPORIN A; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; LYMPHOCYTE ANTIBODY; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; RAPAMYCIN;

ALLOGRAFT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE MARROW TRANSPLANTATION; CONTROLLED STUDY; DRUG EFFICACY; ENZYME LINKED IMMUNOSORBENT ASSAY; FULL THICKNESS SKIN GRAFT; GRAFT REJECTION; GRAFT SURVIVAL; HISTOINCOMPATIBILITY; IMMUNOSUPPRESSIVE TREATMENT; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MIXED LYMPHOCYTE REACTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SKIN TRANSPLANTATION; SURVIVAL TIME; XENOGRAFT;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTILYMPHOCYTE SERUM; BONE MARROW TRANSPLANTATION; CYCLOSPORINE; CYTOKINES; GRAFT ENHANCEMENT, IMMUNOLOGIC; GRAFT SURVIVAL; HISTOCOMPATIBILITY ANTIGENS CLASS I; HISTOCOMPATIBILITY ANTIGENS CLASS II; HISTOCOMPATIBILITY TESTING; LYMPHOCYTE ACTIVATION; LYMPHOCYTE CULTURE TEST, MIXED; MICE; MICE, INBRED A; MICE, INBRED AKR; MICE, INBRED C3H; MICE, INBRED C57BL; MICE, INBRED DBA; POLYENES; SIROLIMUS; SKIN TRANSPLANTATION; TISSUE DONORS; TRANSPLANTATION, HETEROLOGOUS; TRANSPLANTATION, HOMOLOGOUS;

EID: 0031026734     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-199702150-00005     Document Type: Article

References (21)

1. Wood ML, Monaco AP, Gozzo JJ, Liegeois A. Use of homozygous allogeneic bone marrow for induction of tolerance with antilymphocyte serum: dose and timing. Transplant Proc 1971; 3: 676.
2. Hartner WC, De Fazio SR, Maki T, Markees TG, Monaco AP, Gozzo JJ. Prolongation of renal allograft survival in antilymphocyte-serum-treated dogs by postoperative injection of density-gradient-fractionated donor bone marrow. Transplantation 1986; 42: 593.
3. Thomas FT, Carver FM, Foil MB, et al. Long-term incompatible kidney survival in outbred higher primates without chronic immunosuppression. Ann Surg 1983; 198: 370.
4. Thomas JM, Carver M, Cunningham P, Sash C, Park K, Thomas F. Promotion of incompatible allograft acceptance in rhesus monkeys given posttransplant antithymocyte globulin and donor bone marrow: II. Effects of adjuvant immunosuppressive drugs [Published erratum appears in Transplantation 1989; 47(5): 928]. Transplantation 1989; 47: 209.
5. Maki T, Gottschalk R, Wood ML, Monaco AP. Specific unresponsiveness to skin allografts in anti-lymphocyte serum treated, marrow injected mice: participation of donor marrow-derived suppressor T cells. J Immunol 1981; 127: 1433.
6. Wood ML, Gottschalk R, Monaco AP. The effect of cyclosporine on the induction of unresponsiveness in antilymphocyte serum-treated, marrow injected mice. Transplantation 1988; 46: 449.
7. Bobbio SA, Wood ML, Monaco AP. Significant augmentation of specific unresponsiveness by sirolimus in ALS-treated, bone marrow injected mice. Transplant Sci 1993; 3: 51.
8. Barber WH, Mankin JA, Laskow DA, et al. Long-term results of a controlled prospective study with transfusion of donor-specific bone marrow in 57 cadaveric renal allograft recipients. Transplantation 1991; 51: 70.
9. Billingham RE, Brent L, Medawar PB. The technique of free skin grafting in mammals. J Exp Biol 1951; 28: 385.
10. Monaco AP, Wood ML, Gray JG, Russell PS. Studies on heterologous antilymphocyte serum in mice: II. Effect on the immune response. J Immunol 1966; 96: 229.
11. De Fazio SR, Plowey J, Hartner WC, Gozzo JJ. Effect of single-dose, late treatment with sirolimus on skin allograft survival in ALS- and donor bone marrow cell-treated mice. Transplant Proc 1994; 26: 3102.
12. Jeyarajah DR, Schmeisser FS, Kadakia RA, Thistlethwaite JR. Prolongation of skin xenograft survival with concomitant donor bone marrow transplantation. Transplant Proc 1994; 26: 1201.
13. Ildstad ST, Wren SM, Stephany D, Sachs DH. Effect of selective T cell depletions in mixed xenogeneic reconstitution on specific hyporeactivity to transplantation across a species barrier. Transplantation 1986; 41: 372.
14. Tomita Y, Sachs DH, Sykes M. Myelosuppressive conditioning is required to achieve engraftment of pluripotent stem cells contained in moderate doses of syngeneic bone marrow. Blood 1994; 83: 939.
15. Sykes M, Sachs DH. Bone marrow transplantation as a means of inducing tolerance [Review]. Semin Immunol 1990; 2: 401.
16. Ildstad ST, Wren SM, Sharrow SO, Stephany D, Sachs DH. In vivo and in vitro characterization of specific hyporeactivity to skin xenografts in mixed xenogeneically reconstituted mice(B10 + F344 rat → B10). J Exp Med 1984; 160: 1820.
17. Santos GW, Cole LJ. Effects of donor and host lymphoid and myeloid tissue injections in lethally X-irradiated mice treated with rat bone marrow. J Natl Cancer Inst 1958; 21: 279.
18. Nickerson P, Pacheco-Silva A, O'Connell PJ, Steurer W, Rubin Kelly V, Strom TB. Analysis of cytokine transcripts in pancreatic islet cell allografts during rejection and tolerance induction. Transplant Proc 1993; 25: 984.
19. Takeuchi T, Lowry RP, Konieczny B. Heart allografts in murine systems. Transplantation 1992; 53: 1281.
20. Nickerson P, Steurer W, Steiger J, Zheng X, Steele AW, Strom TB. Cytokines and the Th1/Th2 paradigm in transplantation. Curr Opin Immunol 1994; 6: 757.
21. Chen H, Wu J, Luo H, Daloze P. Synergistic effect of sirolimus and cyclosporine in pancreaticoduodenal transplantation in the rat. Transplant Proc 1992; 24: 892.