Antigen processing and presentation in transplantation

Current Opinion in Immunology

Volumn 8, Issue 5, 1996, Pages 681-687

  Auchincloss Jr, Hugh ^a   Sultan, Heena ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; B LYMPHOCYTE; GRAFT REJECTION; GRAFT SURVIVAL; HISTOCOMPATIBILITY; HUMAN; IMMUNOLOGICAL TOLERANCE; REVIEW; XENOGRAFT;

EID: 0030272420     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-7915(96)80086-0     Document Type: Article

References (52)

1. Auchincloss H Jr, Sachs DH. Transplantation and graft rejection. Paul WE. Fundamental Immunology. 1993;1099-1142 Raven Press, New York.
2. Warrens AN, Lombardi G, Lechler RI. MHC and alloreactivity: presentation and recognition of major and minor histocompatibility antigens. Transplant Immunol. 2:1994;102-107.
3. Lafferty KJ, Bootes A, Dart G, Talmage DW. Effect of organ culture on the survival of thyroid allografts in mice. Transplantation. 22:1976;138-149.
4. Shoskes DA, Wood KJ. Indirect presentation of MHC antigens in transplantation. Immunol Today. 15:1994;32-38.
5. La Rosa FG, Talmage DW. The failure of a major histocompatibility antigen to stimulate a thyroid allograft reaction after culture in oxygen. J Exp Med. 157:1983;898-906.
6. Bevan MJ. Cross-priming for a secondary cytotoxic response to minor H antigens with H-2 congenic cells which do not cross-react in the cytotoxic assay. J Exp Med. 143:1976;1283-1288.
7. Sayegh MH, Watschinger B, Carpenter CB. Mechanisms of T cell recognition of alloantigen: the role of peptides. Transplantation. 57:1994;1295-1302.
8. + helper T cells and self antigen-presenting cells in the mouse. J Exp Med. 172:1990;567-575.
9. + T cells. J Exp Med. 170:1989;991-996.
10. Gill RG. The role of direct and indirect antigen presentation in the response to islet xenografts. Transplant Proc. 24:1992;642-643.
11. of special interest Benham AM, Sawyer GJ, Fabre JW. Indirect T cell allorecognition of donor antigens contributes to the rejection of vascularized kidney allografts. Transplantation. 59:1995;1028-1032 These authors demonstrate the rapid rejection of vascularized allografts in animals that have been sensitized by the indirect pathway.
12. Fangmann J, Dalchau R, Fabre JW. Rejection of skin allografts by indirect allorecognition of donor class I major histocompatibility complex peptides. J Exp Med. 175:1992;1521-1529.
13. Reed EF, Hong B, Ho E, Harris PE, Weinberger J, Suciu-Foca N. Monitoring of soluble HLA alloantigens and anti-HLA antibodies identifies heart allograft recipients at risk of transplant-associated coronary artery disease. Transplantation. 61:1996;566-572.
14. + T cells in major histocompatibility complex class II-deficient mice. Science. 253:1991;1417-1420.
15. Auchincloss H Jr, Lee R, Shea S, Markowitz JS, Grusby MJ, Glimcher LH. The role of 'indirect' recognition in initiating rejection of skin grafts from major histocompatibility complex class II-deficient mice. Proc Natl Acad Sci USA. 90:1993;3373-3377.
16. Lee RS, Grusby MJ, Glimcher LH, Winn HJ, Auchincloss H Jr. Indirect recognition by helper cells can induce donor-specific cytotoxic T lymphocytes in vivo. J Exp Med. 179:1994;865-872.
17. Sayegh MH, Perico N, Gallon L, Imberti O, Hancock WW, Remuzzi G, Carpenter CB. Mechanisms of acquired thymic unresponsiveness of renal allografts. Transplantation. 58:1994;125-132.
18. of outstanding interest Steele DJR, Laufer TM, Smiley ST, Ando Y, Grusby MJ, Glimcher LH, Auchincloss H Jr. Two levels of help for B cell alloantibody production. J Exp Med. 183:1996;699-703 This article demonstrates that the indirect response is required for alloantibody class switching. The results emphasize the importance of the indirect response in alloreactivity.
19. Benichou G, Takizawa AP, Ho TP, Killion CC, McMillan M, Sercarz EE. Immunogenicity and tolerogenicity of self-major histocompatibility complex peptides. J Exp Med. 172:1990;1341-1346.
20. Benichou G, Takizawa PA, Olson Ca, McMillan M, Sercarz EE. Donor major histocompatibility complex (MHC) peptides are presented by recipients MHC molecules during graft rejection. J Exp Med. 175:1992;918-924.
21. Watschinger B, Gallon L, Carpenter CB, Sayegh MH. Mechanisms of allorecognition: in vivo primed T cells recognize major histocompatibility complex polymorphisms presented as peptides by responder antigen-presenting cells. Transplantation. 57:1994;572-576.
22. of special interest Gallon L, Watschinger B, Murphy B, Akalin E, Sayegh MH, Carpenter CB. The indirect pathway of allorecognition: the occurrence of self-restricted T cell recognition of allo-MHC peptides early in acute renal allograft rejection and its inhibition by conventional immunosuppression. Transplantation. 59:1995;612-616 This paper illustrates several points regarding the indirect pathway: first, the accelerated rejection of rat renal allografts subsequent to sensitization with allo-MHC peptides; second, the susceptibility of the indirect pathway to conventional immunosuppressive therapy; and third, the role of recipient genotype in allorecognition.
23. Benham AM, Fabre JW. Elucidation of key peptide determinants involved in an indirect T-cell allorecognition pathway of rat kidney allograft rejection. Transplant Proc. 27:1995;547-548.
24. Benham A, Fabre JW. Fine specificity of peptide determinants for indirect T cell recognition of class I MHC alloantigens. Transplantation. 58:1994;1236-1240.
25. + cell and B cell responses after cardiac allograft rejection. Transplantation. 59:1995;401-410 These authors demonstrate the indirect presentation of MHC class I peptides during the rejection of cardiac allografts in the rat.
26. of special interest Terness P, Dufter C, Otto G, Opelz G. Induction of acute rejection by indirect recognition of donor MHC antigens. Transplant Proc. 27:1995;457-458 This group, like [25], demonstrates the role of indirect recognition of donor MHC antigens in induction of acute cardiac allograft rejection in an otherwise weakly imcompatible donor-recipient rat combination.
27. of special interest Chowdhury NC, Jin M, Hardy MA, Oluwole SF. Donor-specific unresponsiveness to murine cardiac allografts induced by intrathymic-soluble alloantigens is dependent on alternate pathway of antigen presentation. J Surg Res. 59:1995;91-96 This article, along with [17], is another example in which donor-specific unresponsiveness is achieved by the induction of intrathymic soluble alloantigens via the indirect pathway.
28. + treatment. The result suggest again that tolerance induced by indirect responses may be sufficient to prevent the graft rejection.
29. Suciu-Foca N, Liu Z, Harris PE, Reed EF, Cohen DJ, Benstein JA, Benvenisty AI, Mancini D, Michler RE, Rose EA, et al. Indirect recognition of native HLA alloantigens and B-cell help. Transplant Proc. 27:1995;455-456.
30. Reed EF, Tugulea SL, Suciu-Foca N. Infulence of HLA class I and class II antigens on the peripheral T-cell receptor repetoire. Hum Immunol. 40:1994;111-122.
31. Liu Z, Braunstein NS, Susiu-Foca N. T cell recognition of allopeptides in context of syngenic MHC. J Immunol. 148:1992;35-40.
32. Adams PW, Lee HS, Waldman WJ, Sedmak DD, Orosz CG. Alloantigenicity of human endothelial cells III. Quantitated indirect presentation of endothelial alloantigens to human helper T lymphocytes. Transplantation. 58:1994;476-483.
33. Page C, Thompson C, Yacoumb M, Rose M. Human endothelial stimulation of allogeneic T cells via a CTLA-4 independent pathway. Transpl Immunol. 2:1994;342-347.
34. Auchincloss H Jr, Mayer T, Ghobrial R, Winn HJ. T cell subsets, bm mutants, and the mechanism of allogeneic sking graft rejection. Immunol Res. 8:1989;149-164.
35. of special interest Kalhs P, White JS, Gervassi A, Storb R, Bean MA. in vitro recall of proliferative and cytolytic responses to minor histocompatibility antigens by dendritic cell enriched canine peripheral blood mononuclear cells. Transplantation. 59:1995;112-118 This study highlight the importance of the type APC used in antigen pre-sentation and demonstrates the direct in vitro presentation of minor antigens by dendritic cells after priming in a canine model.
36. + T cell priming in various systems.
37. of special interest Parker DC. T cell-dependent B-cell activation. Annu Rev Immunol. 11:1993;331-360.
38. Bevan MJ. Antigen presentation to cytotoxic T lymphocytes in vivo. J Exp Med. 182:1995;639-641 The author summarizes some of the recent studies on the MHC class I presentation of exogenous peptides.
39. Mitchison NA, O'Malley C. Three-cell-type clusters of T cells with antigen-presenting cells best explain the epitope linkage and noncognate requirements of the in vivo cytolytic response. Eur J Immunol. 17:1987;1579-1583.
40. Keene J-A, Forman J. Helper activity is required for the in vivo generation of cytotoxic T lymphocytes. J Exp Med. 155:1982;768-782.
41. Rosenberg AS, Mizuochi T, Sharrow SO, Singer A. Phenotype, specificity, and function of T cell subsets and T cell interaction involved in skin allograft rejection. J Exp Med. 165:1987;1296-1315.
42. Rosenberg AS, Singer A. Evidence that the effector mechanism of skin allograft rejection is antigen-specific. Proc Natl Acad Sci USA. 85:1988;7739-7742.
43. Doody DP, Stenger KS, Winn JH. Immunologically nospecific mechanisms of tissue destruction in the rejection of skin grafts. J Exp Med. 179:1994;1645-1652.
44. + cells. The results demonstrate that skin graft rejection only occurs very slowly when effector cells cannot recognize antigens expressed in the graft itself.
45. of special interest Campos L, Naji A, Deli BC, Kern JH, Kim JI, Barker CF, Markmann JF. Survival of MHC-deficient mouse heterotopic cardiac allografts. Transplantation. 59:1995;187-191 The survival of MHC-deficient heart grafts reported here suggested that an indirect effector mechanism cannot cause destruction of these grafts.
46. Markmann JF, Bassiri H, Desai NM, Odorico JS, Kim JI, Coller BH, Smithies O, Barker CF. Indefinite survival of MHC class I deficient murine pancreatic islet allograft. Transplantation. 54:1992;1085-1089.
47. Markmann JF, Campos L, Bhandoola A, Kim JI, Desai NM, Bassari H, Claytor BR, Barker CF. Genetically engineered grafts to study xenoimmunity: a role for indirect antigen presentation in the destruction of major histocompatibility complex antigen deficient xenografts. Surgery. 116:1994;242-249.
48. Lafferty K, Prowse S, Simeonovic C, Warren HS. Paul WE, Fathman CG, Metzgar H. Immunobioloby of Tissue Transplantation: a Return to the Passenger Leucocyte Concept. 1983;143-173 Palo Alto, California. Annual Reviews.
49. Jenkins MK, Schwartz RH. Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo. J Exp Med. 165:1987;302-319.
50. of outstanding interest Sayegh MH, Akalin E, Hancock WW, Russell ME, Carpenter CB, Linsley PS, Turka LA. CD28-B7 blockade after alloantigenic challenge in vivo inhibits Th1 cytokines but spares Th2. J Exp Med. 181:1995;1869-1874 This article illustrates that blockade of the CD28-B7 pathway after alloanti-genic challenge induces donor-specific acceptance of vascularized organ allografts. Also, it shows that blockade inhibits Th1 but spares Th2 responses in vivo.
51. Baliga P, Chavin KD, Qin L, Woodward J, Lin J, Linsley PS, Bromberg JS. CTLA4Ig prolongs allograft survival while suppressin cell-mediated immunity. Transplantation. 58:1994;1082-1090.
52. Steinman RM, Witmer-Pack M, Inaba K. Dendritic cells: antigen presentation, accessory function and clinical relevance. Adv Exp Med Biol. 329:1993;1-9.