High folic acid increases cell turnover and lowers differentiation and iron content in human HT29 colon cancer cells

British Journal of Nutrition

Volumn 99, Issue 4, 2008, Pages 703-708

  Pellis, Linette ^a   Dommels, Yvonne ^a   Venema, Dini ^a   van Polanen, Ab ^a   Lips, Esther ^a   Baykus, Hakan ^a   Kok, Frans ^a   Kampman, Ellen ^a   Keijer, Jaap ^a  

^a WAGENINGEN UNIVERSITY   (Netherlands)

Author keywords

Cell turnover; Folate; Gene expression; Iron metabolism

Indexed keywords

COMPLEMENTARY DNA; CYANOCOBALAMIN; FOLIC ACID; IRON; TRACE ELEMENT; UVOMORULIN;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL ASSAY; CELL DIFFERENTIATION; CELL GROWTH; CELL LEVEL; CELL METABOLISM; CELL PROLIFERATION; COLON CANCER; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; IRON METABOLISM; MICROARRAY ANALYSIS; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; VITAMIN SUPPLEMENTATION;

CELL DIFFERENTIATION; CELL PROLIFERATION; COLONIC NEOPLASMS; DIETARY SUPPLEMENTS; EPITHELIAL CELLS; FOLIC ACID; GENE EXPRESSION PROFILING; HT29 CELLS; HUMANS; IRON; METHIONINE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; TETRAHYDROFOLATES; VITAMIN B 12; VITAMIN B COMPLEX;

ANIMALIA;

EID: 40449137046     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114507824147     Document Type: Article

References (47)

1. Zeisel SH (2000) Choline: An essential nutrient for humans. Nutrition 16, 669-671.
2. Gu L, Wu J, Qiu L, Jennings CD & Li G-M (2002) Involvement of DNA mismatch repair in folate deficiency induced apoptosis. J Nutr Biochem 13, 355-363.
3. 12. Prog Nutr Soc 58, 441-448.
4. Li G-M Presnell SR & Gu L (2003) Folate deficiency, mismatch repair-dependent apoptosis and human disease. J Nutr Biochem 14 568-575.
5. Kim YI (1999) Folate and carcinogenesis: Evidence, mechanisms, and - implications. J Nutr Biochem 10, 66-88.
6. Van.Guelpen B, Hultdin J, Johansson I, Hallmanś G, Stenling R, Riboli E, Winkvist A & PAlmqvist R (2006) Low folate levels may protect against colorectal cancer. Gut 55, 1461-1466.
7. 12 in health and disease. Nutr Rev 62, S3-S13.
8. Lucock M (2000) Folic acid: Nutritional biochemistry, molecular biology, and role in disease processes. Mol Genet Metab 71, 121-138.
9. Bashir O, FitzGerald AJ & Goodlad RA(2004) Both suboptimal and elevated vitamin intake increase intestinal neoplasia and alter crypt, fission in the ApacMin/+ mouse. Carcinogenesis 25, 1507-1515.
10. Kim YI (2004) Folate, colorectal carcinogenesis, and DNA methylation: lessons from animal studies. Environ Mol Mutagen 44, 10-25.
11. Kim YI (2003) Role of folate in colon cancer development and progression. J Nutr 133, Suppl. 1, 3731S-3739S.
12. Kim YI (2006) Folate: A magic bullet or a double edged sword for colorectal, cancer prevention? Gut 55, 1387-1389.
13. Kim YI (2007) Folate and colorectal cancer: An evidence-based critical review. Mol Nutr Food Res 51, 267-292.
14. Rampersaud GC, Kauwell GPA & Bailey LB (2003) Folate: A key to optimizing health and reducing disease risk in the elderly. J Am Coll Nutr 22, 1-8.
15. Hayashi I, Sohn K-J, Stempak JM, Croxford R & Kim Y-I (2007) Folate deficiency induces coll-specific changes in the steady-state transcript levels of genes involved in folate metabolism and 1-carbon transfer reactions in human colonic epithelial cells. J Nutr 137, 607-613.
16. Courtemanche C, Huang AC, Elson-Schwab I, Kerry N, Ng BY & Ames BN (2004) Folate deficiency- and ionizing radiation cause DNA breaks in primary human lymphocytes: A comparison. FASEB J 18, 209-211.
17. Jhaveri MS, Wagner C & Trepel JB (2001) Impact of extracellular folate levels on global gene expression. Mol Pharmacol 60, 1288-1295.
18. Novakovic P, Stempak JM, Sohn K-J & Kim Y-I (2006) Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer i cells. Carcinogenesis 27, 916-924.
19. Charrier, L, Jarry A, Toquet C, Bou-Hanna C, Chedorge M, Denis M, Vallette G & Laboisse CL (2062) Growth phase-dependent expression, of ICAD-L/DFF45 modulates the pattern of apoptosis in human colonic cancer cells. Cancer Res 62, 2169-2174.
20. Gueddari N, Favre G, Marmouget q, Soula G & Le Gaillard F (1996) Involvement of tyrosine kinase activity in the low-density lipoprotein receptor expression in human lung adenocarcinoma cell line A549. Biochimie 78, 874-881.
21. Viallard V, Lacombe C, Trocheris V, Tabacik C & Aliau S (1990) Metabolism of low-density lipoprotein in differentiated and undifferentiated HT29 colon cancer cells. Int J Cancer 46, 320-325.
22. Konings EJM (1999) A validated liquid chromatographic method for determining folates in vegetables, milk powder, liver and flour. J AOAC Int 82, 119-127.
23. Melnyk S, Pogribna M, Pogribny IP, Yi P & James SJ (2000) Measurement of plasma and intracellular S-adenosylmethionine and S-adenosylhomocysteine utilizing coulometric electrochemical detection: Alterations with plasma homocysteine and pyridoxal 5′-phosphate concentrations. Clin Chem 46, 265-272.
24. Huveneers Oorsprong MBM, Hooganboom LAP & Kuiper HA (1997) The use of the MTT test for determining the cytotoxicity of veterinary drugs in pig hepatocytes. Toxicol In Vitro 11, 385-391
25. Pellis L, Franssen-van Hal NL, Burema J & Keijer J (2003) The intraclass correlation coefficient applied for evaluation of data correction, labeling methods, and rectal biopsy sampling in DNA microarray experiments. Physiol Genomics 16, 99-106.
26. Sohn KJ, Stempak JM, Reid S, Shirwadkar S, Mason JB & Kim YI (2003) The effect of dietary folate on genomic and p53-specific DNA methylation in rat colon. Carcinogenesis 24, 81-90.
27. Mason JB (2003) Biomarkers of nutrient exposure and status in one-carbon (methyl) metabolism. J Nutr 133, 941S-947S.
28. Valasek MA & Repa JJ (2005) The power of real-time PCR. Adv Physiol Educ 29, 151-159.
29. Huang RFS, Ho YH, Lin HL, Wei JS & Liu TZ (1999) Folate deficiency induces a cell cycle-specific apoptosis in HepG2 cells. J Nutr 129, 25-31.
30. Singh R, Fouladi-Nashta AA, Halliday, DLN, Barrett DA & Sinclair KD (2006) Methotrexate induced-differentiation in colon cancer cells is primarily due to purine deprivation. J Cell Biochem 99, 146-155.
31. Crott JW, Choi SW, Ordovas JM, Ditelberg JS & Mason JB (2004) Effects of dietary folate and aging on gene expression in the colonic mucosa of rats: Implications for carcinogenesis. Carcinogenesis 25, 69-76.
32. Augenlicht LH, Bordonaro M, Heerdt BO, Mariadson J & Velcich A (1999) Cellular mechanisms of risk and transformation. Ann N Y Acad Sci 889, 20-31.
33. Penta JS, Johnson FM, Wachsman JT & Copeland WC (2001) Mitochandrial DNA in human malignancy. Mutat Res 488, 119-133.
34. Arends JW (2000) Molecular interactions in the Vogelstein model of colorectal carcinoma. J Pathol 190, 412-416.
35. Le Leu RK, Young GP & McIntosh GH (2000) Folate deficiency reduces the development of colorectal cancer in rats. Carcinogenesis 21, 2261-2265.
36. van den Donk. M, Buijsse B, van den Berg SW, Ocke MC, Harryvan JL, Nagengast FM, Kok FJ & Kampman E, (2005). Dietary intake of folate and riboflavin, MTHFR C677T genotype, and colorectal adenoma risk: A Dutch case-control study. Cancer Epidemiol Biomarkers Prev 14, 1562-1566.
37. Kim YI (2004) Will mandatory folic acid fortification prevent or promote cancer? Am J Clin Nutr 80, 1123-1128.
38. Khosraviani K, Weir HP, Hamilton P, Moorebead J & Williamson K (2002) Effect of folate supplementation on mucosal cell proliferation in high risk patients for colon cancer. Gut 51, 195-109.
39. Hirohashi S (1998) Inactivation of the E-cadherin-mediated cell adhesion system in human cancers. Am J Pathol 153, 333-339.
40. Lind GE, Thorstensen L, Lovig T, Meting GI, Hamelin R, Rognum TO, Esteller M & Lothe RA (2004) A CpG island hypermethylation profile of primary colorectal carcinomas and colon cancer cell lines. Mol Cancer 3, 28.
41. Buda A & Pignatelli M (2004) Cytoskeletal-network in colon cancer: From genes to clinical appheation. Int J Biochem Cell Biol 36, 759-765.
42. Wright AJA, Finglas PM & Southon S (2001) Proposed mandatory fortification of the UK diet with folic acid: Have potential risks been underestimated? Trends Food Sci Technol 12, 313-321.
43. Westerman DA, Evans D & Metz J (1999) Neutrophil hypersegmentation in iron deficiency anaemia: A case-control study. Br J Haematol 161, 512-515.
44. Oppenheim EW, Adelman C, Liu X. & Stoyer PJ (2001) Heavy chain ferritin enhances serine hydroxymethyltransferase expression and de novo thymidine biosynthesis. J Bliol Chem 276, 19655-19861.
45. Vitale JJ, Streiff RR & Hellerstein EE (1965) Folate metabolism and iron deficency. Lancet 286, 393-394.
46. Oppenheim EW, Nasrallah IM, Mastri MG & Stover PJ (2000) Mimosine is a cell-specific antagonist of folate metabolism, J Biol Chem 275 19268-19274.
47. Picciano MF (2003) Pregnancy and lactation: Physiological adjustments, nutritional requirements and the role of dietary supplements. J Nutr 133, 1997S-2002S.