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Volumn 4, Issue 21, 2002, Pages 3611-3614

Diamine-catalyzed asymmetric Michael additions of aldehydes and ketones to nitrostyrene

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ARTICLE;

EID: 0000220483     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol026543q     Document Type: Article
Times cited : (339)

References (36)
  • 1
    • 0003280270 scopus 로고
    • Conjugate addition reaction in organic synthesis
    • Pergamon Press: Oxford
    • Perlmutter, P. Conjugate Addition Reaction in Organic Synthesis; Tetrahedron Organic Chemistry Series 9; Pergamon Press: Oxford, 1992.
    • (1992) Tetrahedron Organic Chemistry Series , vol.9
    • Perlmutter, P.1
  • 20
    • 0034596452 scopus 로고    scopus 로고
    • For our pan, we have confirmed the implication of enamine in the addition of 3,3-dimethylbutyraldehyde catalyzed by pyrrolidine, which showed the presence of the corresponding enamine by GC-MS
    • Bui, T.; Barbas, C. F., III. Tetrahedron Lett. 2000, 41, 6951. For our pan, we have confirmed the implication of enamine in the addition of 3,3-dimethylbutyraldehyde catalyzed by pyrrolidine, which showed the presence of the corresponding enamine by GC-MS.
    • (2000) Tetrahedron Lett. , vol.41 , pp. 6951
    • Bui, T.1    Barbas C.F. III2
  • 25
    • 0042269938 scopus 로고    scopus 로고
    • Dinitro-adduct: (Equation Presented)
    • Dinitro-adduct: (Equation Presented)
  • 26
    • 0042771119 scopus 로고    scopus 로고
    • note
    • The best enantioselectivity for addition of acetone to nitrostyrene was obtained with the more sterically hindered N-cyclohexyl-2,2′-bipyrrolidine in the presence of pTSA (0.15 equiv) (89%, 30% ee).
  • 31
    • 0043272401 scopus 로고    scopus 로고
    • note
    • For the determination of the absolute configuration, see Supporting Information.


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