Effects of inhibition of PDE4 and TNF-α on local and remote injuries following ischaemia and reperfusion injury

British Journal of Pharmacology

Volumn 134, Issue 5, 2001, Pages 985-994

  Souza, Danielle G ^a   Cassali, Geovanni D ^a   Poole, Steve ^b   Teixeira, Mauro M ^a  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^b NATIONAL INSTITUTE FOR BIOLOGICAL STANDARDS AND CONTROL   (United Kingdom)

Author keywords

IL 10; IL 1 ; Ischaemia and reperfusion injury; PDE4 inhibitors; Rolipram; TNF

Indexed keywords

ARTIFLO; CILOMILAST; INTERLEUKIN 1BETA; INTERLEUKIN 6; LEUKOTRIENE B4; MYELOPEROXIDASE; PHOSPHODIESTERASE INHIBITOR; PHOSPHODIESTERASE IV; ROLIPRAM; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA ANTIBODY; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BLOOD VESSEL PERMEABILITY; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; GASTROINTESTINAL HEMORRHAGE; INTESTINE ISCHEMIA; LETHALITY; LUNG INJURY; MALE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; SERUM;

EID: 0035167833     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704336     Document Type: Article

References (39)

1. Reversal of pulmonary capillary ischemia-reperfusion injury by rolipram, cAMP phosphodiesterase inhibitor
2. SB 207499 (Ariflo), a potent and selective second-generation phosphodiesterase 4 inhibitor: In vitro anti-inflammatory actions
3. Splanchnic origin of cytokines in a porcine model of mesenteric ischemia-reperfusion
4. Reduced ischemia-reperfusion injury with rolipram in rat cadaver lung donors: Effect of cyclic adenosine monophosphate
5. Pentoxifylline attenuates pulmonary macromolecular leakage after intestinal ischemia-reperfusion
6. Effects of a cyclic adenosine monophosphate phosphodiesterase inhibitor, DN-9693, on myocardial reperfusion injury
7. Effects of tachykinin NK1- or PAF-receptor blockade on the lung injury induced by scorpion venom
8. Anti-inflammatory actives of cAMP-elevating agents: Enhancement of IL-10 synthesis and concurrent suppression of TNF production
9. Theophylline improves functional recovery of isolated rat lungs after hypothermic preservation
10. Antibodies to cachectin/tumor necrosis factor reduce interleukin 1 beta and interleukin 6 appearance during lethal bacteremia
11. Effects of the PDE4 inhibitor rolipram in a rat model of arthritis
12. IL-10 induced in the reperfused myocardium and may modulate the reaction to injury
13. Resident cardiac mast cells degranulate and release preformed TNF-alpha, initiating the cytokine cascade in experimental canine myocardial ischemia/reperfusion
14. TNF-α potentiates oxidant and reperfusion-induced endothelial cell injury
15. Anti -tumor necrosis factor-alpha improves myocardial recovery after ischemia and reperfusion
16. Endotoxin-stimulated production of rat hypothalamic interleukin-1 beta in vivo and in vitro, measured by specific immunoradiometric assay
17. Anticytokine therapies for acute inflammation and the systemic inflammatory response syndrome: IL-10 and ischemia/reperfusion injury as a new paradigm
18. Cyclic nucleotide phosphodiesterase type IV participates in the regulation of IL-10 and in the subsequent inhibition of TNF-alpha and IL-6 release by endotoxin-stimulated macrophages
19. Rolipram, a cyclic amp-selective phosphodiesterase inhibitor, reduces neuronal damage following cerebral ischemia in the gerbil
20. Modulation of TNF alpha and IL-1 beta from endotoxin-stimulated monocytes by selective PDE isozyme inhibitors
21. Pentoxifylline reduces venular leukocyte adherence ('reflow paradox') bur not microvascular 'no reflow' in hepatic ischemia/reperfusion
22. Protection by pentoxifylline against normothermic liver ischemia/reperfusion in rats
23. Differential inhibitory mechanism of cyclic AMP on TNF-α and IL-12 synthesis by macrophages exposed to microbial stimuli
24. Rat interleukin 6: Expression in recombinant Escherichia coli, purification and development of a novel ELISA
25. Rat tumour necrosis factor-alpha: Expression in recombinant Pichia pastoris, purification, characterization and development of a novel ELISA
26. Requirements for tumor necrosis factor-α and interleukin-1 in limb ischemia/reperfusion injury and associated lung injury
27. Soluble tumor necrosis factor receptors reduce bowel ischemia-induced lung permeability and neutrophil sequestration
28. Immunosuppressive and anti-inflammatory effects of cyclic AMP phosphodiesterase (PDE) type 4 inhibitors
29. Effects of a BLT receptor antagonist on local and remote reperfusion injuries after transient ischemia of the superior mesenteric artery in rats
30. Effects of the PAF receptor antagonist UK74505 on local and remote reperfusion injuries following ischaemia mesenteric artery in the rat
31. 2
32. Effect of phosphodiesterase isoenzyme inhibitors on cutaneous inflammation in the guinea pig
33. 4) inhibitors: Anti-inflammatory drugs of the future?
34. Phosphodiesterase isozymes: Molecular targets for novel antiasthma agents
35. Differential regulation of human monocyte-derived TNF alpha and IL-1 beta by type IV cAMP-phosphodiesterase (cAMP-PDE) inhibitors
36. Inhibition of complement C5 reduces local and remote organ injury after intestinal ischemia/reperfusion in the rat
37. Pharmacological approaches to reperfusion injury
38. Monoclonal antibody to tumor necrosis factor-α attenuates hemodynamic dysfunction secondary to intestinal ischemia/reperfusion in rats
39. IL-6 release after intestinal ischemia/reperfusion in rats is under partial control of TNF