Functional expression of 4-1BB (CD137) in the inflammatory tissue in Crohn's disease

Clinical Immunology

Volumn 112, Issue 3, 2004, Pages 239-246

  Maerten, Philippe ^a   Geboes, Karel ^a   Hertogh, Gert De ^a   Shen, Chong ^a   Cadot, Pascal ^a   Bullens, Dominique M A ^a   Assche, Gert Van ^a   Penninckx, Freddy ^a   Rutgeerts, Paul ^a   Ceuppens, Jan L ^a  

^a UNIVERSITY HOSPITALS LEUVEN   (Belgium)

Author keywords

4 1BB; CD137; Costimulation; Crohn's disease; IFN ; Lamina propria; Proliferation

Indexed keywords

CD137 ANTIGEN; MESSENGER RNA;

ADOLESCENT; ADULT; AGED; ARTICLE; CELL PROLIFERATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CROHN DISEASE; CYTOKINE PRODUCTION; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; LAMINA PROPRIA; MAJOR CLINICAL STUDY; MALE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; T LYMPHOCYTE; ULCERATIVE COLITIS;

4-1BB LIGAND; ADULT; AGED; ANTIGENS, CD; ANTIGENS, CD137; CELL DIVISION; CROHN DISEASE; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; INFLAMMATION; INTERFERON TYPE II; INTESTINES; KINETICS; LYMPH NODES; MALE; MIDDLE AGED; RECEPTORS, NERVE GROWTH FACTOR; RECEPTORS, TUMOR NECROSIS FACTOR; RNA, MESSENGER; T-LYMPHOCYTES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 4043141532     PISSN: 15216616     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clim.2004.04.009     Document Type: Article

References (41)

1. Bouma G., Strober W. The immunological and genetic basis of inflammatory bowel disease. Nat. Rev., Immunol. 3:2003;521-533
2. Mowat A.M. Anatomical basis of tolerance and immunity to intestinal antigens. Nat. Rev., Immunol. 3:2003;331-341
3. Podolsky D.K. Inflammatory bowel disease. N. Engl. J. Med. 347:2002;417-429
4. Bonen D.K., Cho J.H. The genetics of inflammatory bowel disease. Gastroenterology. 124:2003;521-536
5. Geboes K. From inflammation to lesion. Acta Gastro-Enterol. Belg. 57:1994;273-284
6. Papadakis K.A., Targan S.R. Current theories on the causes of inflammatory bowel disease. Gastroenterol. Clin. North Am. 28:1999;283-296
7. Stronkhorst A., Radema S., Yong S.L., Bijl H., ten Berge I.J., Tytgat G.N., van Deventer S.J. CD4 antibody treatment in patients with active Crohn's disease: a phase 1 dose finding study. Gut. 40:1997;320-327
8. Vinay D.S., Kwon B.S. Role of 4-1BB in immune responses. Semin. Immunol. 10:1998;481-489
9. Alderson M.R., Smith C.A., Tough T.W., Davis-Smith T., Armitage R.J., Falk B., Roux E., Baker E., Sutherland G.R., Din W.S. Molecular and biological characterization of human 4-1BB and its ligand. Eur. J. Immunol. 24:1994;2219-2227
10. Schwarz H., Valbracht J., Tuckwell J., von Kempis J., Lotz M. ILA, the human 4-1BB homologue, is inducible in lymphoid and other cell lineages. Blood. 85:1995;1043-1052
11. Kienzle G., von Kempis J. CD137 (ILA/4-1BB), expressed by primary human monocytes, induces monocyte activation and apoptosis of B lymphocytes. Int. Immunol. 12:2000;73-82
12. Melero I., Johnston J.V., Shufford W.W., Mittler R.S., Chen L. NK1.1 cells express 4-1BB (CDw137) costimulatory molecule and are required for tumor immunity elicited by anti-4-1BB monoclonal antibodies. Cell Immunol. 190:1998;167-172
13. Wilcox R.A., Chapoval A.I., Gorski K.S., Otsuji M., Shin T., Flies D.B., Tamada K., Mittler R.S., Tsuchiya H., Pardoll D.M., Chen L. Cutting edge: expression of functional CD137 receptor by dendritic cells. J. Immunol. 168:2002;4262-4267
14. Goodwin R.G., Din W.S., Davis-Smith T., Anderson D.M., Gimpel S.D., Sato T.A., Maliszewski C.R., Brannan C.I., Copeland N.G., Jenkins N.A., et al. Molecular cloning of a ligand for the inducible T cell gene 4-1BB: a member of an emerging family of cytokines with homology to tumor necrosis factor. Eur. J. Immunol. 23:1993;2631-2641
15. Hurtado J.C., Kim Y.J., Kwon B.S. Signals through 4-1BB are costimulatory to previously activated splenic T cells and inhibit activation-induced cell death. J. Immunol. 158:1997;2600-2609
16. Cannons J.L., Lau P., Ghumman B., DeBenedette M.A., Yagita H., Okumura K., Watts T.H. 4-1BB ligand induces cell division, sustains survival, and enhances effector function of CD4 and CD8 T cells with similar efficacy. J. Immunol. 167:2001;1313-1324
17. Kim Y.J., Kim S.H., Mantel P., Kwon B.S. Human 4-1BB regulates CD28 co-stimulation to promote Th1 cell responses. Eur. J. Immunol. 28:1998;881-890
18. Wen T., Bukczynski J., Watts T.H. 4-1BB ligand-mediated costimulation of human T cells induces CD4 and CD8 T cell expansion, cytokine production, and the development of cytolytic effector function. J. Immunol. 168:2002;4897-4906
19. Sun Y., Lin X., Chen H.M., Wu Q., Subudhi S.K., Chen L., Fu Y.X. Administration of agonistic anti-4-1BB monoclonal antibody leads to the amelioration of experimental autoimmune encephalomyelitis. J. Immunol. 168:2002;1457-1465
20. Langstein J., Schwarz H. Identification of CD137 as a potent monocyte survival factor. J. Leukocyte Biol. 65:1999;829-833
21. Shuford W.W., Klussman K., Tritchler D.D., Loo D.T., Chalupny J., Siadak A.W., Brown T.J., Emswiler J., Raecho H., Larsen C.P., Pearson T.C., Ledbetter J.A., Aruffo A., Mittler R.S. 4-1BB costimulatory signals preferentially induce CD8+ T cell proliferation and lead to the amplification in vivo of cytotoxic T cell responses. J. Exp. Med. 186:1997;47-55
22. Tan J.T., Whitmire J.K., Ahmed R., Pearson T.C., Larsen C.P. 4-1BB ligand, a member of the TNF family, is important for the generation of antiviral CD8 T cell responses. J. Immunol. 163:1999;4859-4868
23. Foell J., Strahotin S., O'Neil S.P., McCausland M.M., Suwyn C., Haber M., Chander P.N., Bapat A.S., Yan X.J., Chiorazzi N., Hoffmann M.K., Mittler R.S. CD137 costimulatory T cell receptor engagement reverses acute disease in lupus-prone NZB × NZW F1 mice. J. Clin. Invest. 111:2003;1505-1518
24. Blazar B.R., Kwon B.S., Panoskaltsis-Mortari A., Kwak K.B., Peschon J.J., Taylor P.A. Ligation of 4-1BB (CDw137) regulates graft-versus-host disease, graft-versus-leukemia, and graft rejection in allogeneic bone marrow transplant recipients. J. Immunol. 166:2001;3174-3183
25. Salih H.R., Schmetzer H.M., Burke C., Starling G.C., Dunn R., Pelka-Fleischer R., Nuessler V., Kiener P.A. Soluble CD137 (4-1BB) ligand is released following leukocyte activation and is found in sera of patients with hematological malignancies. J. Immunol. 167:2001;4059-4066
26. Michel J., Langstein J., Hofstadter F., Schwarz H. A soluble form of CD137 (ILA/4-1BB), a member of the TNF receptor family, is released by activated lymphocytes and is detectable in sera of patients with rheumatoid arthritis. Eur. J. Immunol. 28:1998;290-295
27. Giulietti A., Overbergh L., Valckx D., Decallonne B., Bouillon R., Mathieu C. An overview of real-time quantitative PCR: applications to quantify cytokine gene expression. Methods. 25:2001;386-401
28. Liu Z., Colpaert S., D'Haens G.R., Kasran A., de Boer M., Rutgeerts P., Geboes K., Ceuppens J.L. Hyperexpression of CD40 ligand (CD154) in inflammatory bowel disease and its contribution to pathogenic cytokine production. J. Immunol. 163:1999;4049-4057
29. Fais S., Capobianchi M.R., Pallone F., Di Marco P., Boirivant M., Dianzani F., Torsoli A. Spontaneous release of interferon gamma by intestinal lamina propria lymphocytes in Crohn's disease. Kinetics of in vitro response to interferon gamma inducers. Gut. 32:1991;403-407
30. Breese E., Braegger C.P., Corrigan C.J., Walker-Smith J.A., MacDonald T.T. Interleukin-2- and interferon-gamma-secreting T cells in normal and diseased human intestinal mucosa. Immunology. 78:1993;127-131
31. Fuss I.J., Neurath M., Boirivant M., Klein J.S., de la Motte C., Strong S.A., Fiocchi C., Strober W. Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5. J. Immunol. 157:1996;1261-1270
32. Colpaert S., Vastraelen K., Liu Z., Maerten P., Shen C., Penninckx F., Geboes K., Rutgeerts P., Ceuppens J.L. In vitro analysis of IGN-gamma and IL-12 production and their effects in ileal Crohn's disease. Eur. Cytokine Network. 13:2002;431-437
33. Maerten P., Liu Z., Ceuppens J.L. Targeting of costimulatory molecules as a therapeutic approach in inflammatory bowel disease. BioDrugs. 17:2003;395-411
34. Sato T., Kanai T., Watanabe M., Sakuraba A., Okamoto S., Nakai T., Okazawa A., Inoue N., Totsuka T., Yamazaki M., Kroczek R.A., Fukushima T., Ishii H., Hibi T. Hyperexpression of inducible costimulator and its contribution on lamina propria T cells in inflammatory bowel disease. Gastroenterology. 126:2004;829-839
35. Souza H.S., Elia C.C., Spencer J., MacDonald T.T. Expression of lymphocyte-endothelial receptor-ligand pairs, alpha4beta7/MAdCAM-1 and OX40/OX40 ligand in the colon and jejunum of patients with inflammatory bowel disease. Gut. 45:1999;856-863
36. Jacquot S., Modigliani R., Kuzniak I., Boumsell L., Bensussan A. Enhanced CD3 monoclonal antibody induced proliferation of colonic mucosal T lymphocytes in Crohn's disease patients free of corticosteroid or immunosuppressor treatment. Clin. Immunol. Immunopathol. 79:1996;20-24
37. Liu Z., Geboes K., Colpaert S., D'Haens G.R., Rutgeerts P., Ceuppens J.L. IL-15 is highly expressed in inflammatory bowel disease and regulates local T cell-dependent cytokine production. J. Immunol. 164:2000;3608-3615
38. Kanai T., Watanabe M., Okazawa A., Nakamaru K., Okamoto M., Naganuma M., Ishii H., Ikeda M., Kurimoto M., Hibi T. Interleukin 18 is a potent proliferative factor for intestinal mucosal lymphocytes in Crohn's disease. Gastroenterology. 119:2000;1514-1523
39. Fiocchi C. Inflammatory bowel disease: etiology and pathogenesis. Gastroenterology. 115:1998;182-205
40. Lenschow D.J., Walunas T.L., Bluestone J.A. CD28/B7 system of T cell costimulation. Annu. Rev. Immunol. 14:1996;233-258
41. Maerten P., Shen C., Colpaert S., Liu Z., Bullens D.A., van Assche G., Penninckx F., Geboes K., Vanham G., Rutgeerts P., Ceuppens J.L. Involvement of interleukin 18 in Crohn's disease: evidence from in vitro analysis of human gut inflammatory cells and from experimental colitis models. Clin. Exp. Immunol. 135:2004;310-317